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Protein Page:
SGCA (human)

Overview
SGCA Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D); also known as Duchenne- like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C. Belongs to the sarcoglycan alpha/epsilon family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; sarcoglycan complex; intercellular junction; sarcolemma; lipid raft
Molecular Function: calcium ion binding
Biological Process: muscle development; muscle contraction
Reference #:  Q16586 (UniProtKB)
Alt. Names/Synonyms: 50 kDa dystrophin-associated glycoprotein; 50-DAG; 50DAG; 50kD DAG; A2; Adhalin; ADL; Alpha-sarcoglycan; Alpha-SG; DAG2; DMDA2; Dystroglycan-2; LGMD2D; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SCARMD1; SGCA
Gene Symbols: SGCA
Molecular weight: 42,875 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Select Structure to View Below

SGCA

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S327 LKRDLATSDIQMVHH
0 3 T336 IQMVHHCTIHGNTEE
0 1 S377 RLPPRVDSAQVPLIL
  mouse

 
S327-p LKRDMATsDIQMFHH
S336-p IQMFHHCsIHGNTEE
S377-p RLPPRVDsAQMPLIL
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