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Protein Page:
CTNNG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CTNNG Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cytoskeletal protein
Cellular Component: desmosome; mitochondrion; basolateral plasma membrane; plasma membrane; cornified envelope; intermediate filament; fascia adherens
Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; structural constituent of cytoskeleton; cell adhesion molecule binding; structural molecule activity
Biological Process: keratinocyte differentiation; cell-cell adhesion; epidermis development; wound healing; apoptosis; intermediate filament organization; peptide cross-linking; cell structure disassembly during apoptosis
Reference #:  P15924 (UniProtKB)
Alt. Names/Synonyms: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I; desmoplakin II; DESP; DP; DPI; DPII; DSP
Gene Symbols: DSP
Molecular weight: 331,774 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Select Structure to View Below

CTNNG

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: S2849‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2 ______MSCNGGSHP
0 1 S7 _MSCNGGSHPRINtL
0 5 T13-p GSHPRINtLGRMIRA
0 1 I18 INtLGRMIRAEsGPD
0 244 S22-p GRMIRAEsGPDLRyE
0 239 Y28-p EsGPDLRyEVtsGGG
0 3 T31-p PDLRyEVtsGGGGtS
0 13 S32-p DLRyEVtsGGGGtSR
0 2 T37-p VtsGGGGtSRMyySR
0 108 Y41-p GGGtSRMyySRRGVI
0 39 Y42-p GGtSRMyySRRGVIt
0 3 V47 MyySRRGVItDQNsD
0 7 T49-p ySRRGVItDQNsDGy
0 151 S53-p GVItDQNsDGyCQTG
0 506 Y56-p tDQNsDGyCQTGtMS
0 1 T61-p DGyCQTGtMSRHQNQ
0 6 K94-u LIVQPELkyGDGIQL
0 202 Y95-p IVQPELkyGDGIQLT
0 2 K140 QPCDAYQKRLLQLQE
0 3 K154-u EQMRALYkAIsVPRV
0 7 S157-p RALYkAIsVPRVRRA
0 125 S165-p VPRVRRAssKGGGGy
0 91 S166-p PRVRRAssKGGGGyt
0 173 Y172-p ssKGGGGytCQsGsG
0 16 T173-p sKGGGGytCQsGsGW
0 35 S176-p GGGytCQsGsGWDEF
0 11 S178-p GytCQsGsGWDEFTK
0 1 K185 sGWDEFTKHVTSECL
0 4 K245-u IKADLREksAIyQLE
0 3 S246-p KADLREksAIyQLEE
0 123 Y249-p LREksAIyQLEEEYE
1 0 S299-p EELLYDWsDKNTNIA
0 1 K441 QVQNLVNKsKKIVQL
0 2 S442-p VQNLVNKsKKIVQLK
0 1 K470 LRALCDYKQDQKIVH
0 1 T792 KVYEARLTEEETVCL
0 1 Y807 DLDKVEAYRCGLKKI
0 1 K829 KSLLATMKTELQKAQ
0 1 K931-u MRFLNEQkNLHSEIS
0 2 K940-a LHSEISGkRDKSEEV
0 1 K949-u DKSEEVQkIAELCAN
0 2 K1033-u DLKLKNTkIEVLEEE
0 47 Y1065-p LDQNLQKyQAECSQF
0 1 K1073 QAECSQFKAKLASLE
0 5 Y1116-p EKITRLTyEIEDEKR
0 3 S1127-p DEKRRRKsVEDRFDQ
0 105 Y1139-p FDQQKNDyDQLQKAR
0 1 K1144 NDyDQLQKARQCEKE
0 1 K1167-a SEKAIKEkEyEIERL
0 55 Y1169-p KAIKEkEyEIERLRV
0 1 T1183-p VLLQEEGtRKREYEN
0 32 Y1199-p LAKVRNHyNEEMSNL
0 1 Y1210 MSNLRNKYETEINIT
0 1 T1212 NLRNKYETEINITKT
0 1 T1217 YETEINITKTtIKEI
0 1 T1220-p EINITKTtIKEISMQ
0 1 K1250-u SRENRDLkDEIVRLN
0 3 Y1391-p KEEDTSGyRAQIDNL
0 4 Y1512-p ARLQRVQyDLQKANS
0 1 K1516 RVQyDLQKANSSATE
0 80 Y1542-p LTRLRIDyERVSQER
0 3 S1658-p QEELRRLssEVEALR
0 1 S1659-p EELRRLssEVEALRR
0 3 S1708-p IEIERLQsLTENLTK
0 1 K1802-m2 SNRIQESkNQCTQVV
0 1 S1841-p DELNRAKsTLEAETR
0 8 Y1981-p KVTAMQLyECQLIDK
0 2 S2022-p AGSIAGAsAsPKEKy
0 5 S2024-p SIAGAsAsPKEKysL
0 3 Y2029-p sAsPKEKysLVEAKR
0 2 S2030-p AsPKEKysLVEAKRK
0 1 S2071-p NEKLTVDsAIARDLI
0 2 Y2087-p FDDRQQIyAAEKAIT
0 11 Y2159-p GLIDRDLyRsLNDPR
0 1 S2161-p IDRDLyRsLNDPRDS
0 4 S2207-p LLSVQKRsMsFQGIR
0 46 S2209-p SVQKRsMsFQGIRQP
0 1 S2225-p TVTELVDsGILRPST
0 2 Y2264-p SSCIAGIyNETTKQK
0 48 Y2275-p TKQKLGIyEAMKIGL
0 14 Y2316-p RLPVEEAykRGLVGI
0 2 K2317-a LPVEEAykRGLVGIE
0 1 K2393-u LPVDIAYkRGYFNEE
0 1 T2460-p VQTSQKNtLRKRRVV
0 5 K2484-a MSVQEAYkKGLIDYE
0 2 T2524-p VVLVDRKtGsQYDIQ
0 1 S2526-p LVDRKtGsQYDIQDA
0 2 S2549-p KFFDQYRsGSLSLTQ
0 1 S2551 FDQYRsGSLSLTQFA
0 1 T2595 ESVSKISTISsVRNL
0 1 S2598-p SKISTISsVRNLtIR
0 3 T2603-p ISsVRNLtIRsssFs
0 14 S2606-p VRNLtIRsssFsDtL
0 7 S2607-p RNLtIRsssFsDtLE
0 11 S2608-p NLtIRsssFsDtLEE
0 11 S2610-p tIRsssFsDtLEESS
0 2 T2612-p RsssFsDtLEESSPI
0 1 S2617 sDtLEESSPIAAIFD
0 1 K2702 FIGFEGVKGKKKMSA
0 1 K2714 MSAAEAVKEKWLPyE
0 1 K2716 AAEAVKEKWLPyEAG
0 2 Y2720-p VKEKWLPyEAGQRFL
0 8 Y2731-p QRFLEFQyLTGGLVD
0 1 K2772 QDTSSYAKILTCPKT
0 1 T2798-p RSMVEDItGLRLLEA
0 2 S2810-p LEAASVSsKGLPsPy
0 1 K2811 EAASVSsKGLPsPyN
0 12 S2815-p VSsKGLPsPyNMssA
0 8 Y2817-p sKGLPsPyNMssAPG
0 33 S2820-p LPsPyNMssAPGsRS
0 36 S2821-p PsPyNMssAPGsRSG
0 26 S2825-p NMssAPGsRSGsRSG
0 1 R2826 MssAPGsRSGsRSGS
0 1 S2827 ssAPGsRSGsRSGSR
0 3 S2829-p APGsRSGsRSGSRSG
0 1 R2847 GSRSGSRRGsFDAtG
1 1 S2849-p RSGSRRGsFDAtGNs
0 1 T2853-p RRGsFDAtGNsSYSY
0 1 S2856-p sFDAtGNsSYSYSYS
0 1 S2868-p SYSFSSSsIGH____
5885 : Phospho-Desmoplakin (Ser165/166) Antibody
5885 : Phospho-Desmoplakin (Ser165/166) Antibody
  mouse

 
S2-p ______MsCNGGsHP
S7-p _MsCNGGsHPRINtL
T13-p GsHPRINtLGRMtRA
T18-p INtLGRMtRAEsGPD
S22-p GRMtRAEsGPDLRyE
Y28-p EsGPDLRyEMTySGG
T31 PDLRyEMTySGGGGG
Y32-p DLRyEMTySGGGGGG
T47-p GGGGGGGtSRTFYSH
F51 GGGtSRTFYSHSRRC
Y52 GGtSRTFYSHSRRCt
T59-p YSHSRRCtVNDQNsD
N61 HSRRCtVNDQNsDGy
S65-p CtVNDQNsDGyCQTG
Y68-p NDQNsDGyCQTGtMS
T73-p DGyCQTGtMSRHQNQ
K106 LIAQPELKFGEGMQL
F107 IAQPELKFGEGMQLA
K152-u QPCDAYQkRLLQLQE
K166-u EQMRALYkAISVPRV
S169 RALYkAISVPRVRRA
S177-p VPRVRRAssKGAGGy
S178-p PRVRRAssKGAGGyT
Y184-p ssKGAGGyTCQsGSG
T185 sKGAGGyTCQsGSGW
S188-p AGGyTCQsGSGWDEF
S190 GyTCQsGSGWDEFTk
K197-u SGWDEFTkRLTGECL
K257 IKADLREKSAIYQLE
S258 KADLREKSAIYQLEE
Y261 LREKSAIYQLEEEYE
S311 EELLYDWSDKNTNIA
K453-u QVQNLVNkSKKIVQL
S454 VQNLVNkSKKIVQLK
K482-u LRALCDYkQDQKIVH
T804 KVYEARLTEEETVCL
Y819 DLDKVEAYRCGLKKI
K841-u KSLLATMkTELQKAQ
K943 MRFLNEQKNLHSEIS
K952 LHSEISGKRDKSEEV
K961 DKSEEVHKIAELCAN
K1045-u DLKLKNTkIEVLEEE
Y1077 LDQNLQKYQAECSQF
K1085-u QAECSQFkAKLVSLE
Y1128 EKITRLTYEIEDEKR
T1139 DEKRRRKTVEDRFDQ
Y1151-p FDQQKNDyDQLQkAR
K1156-u NDyDQLQkARQCEKE
K1179 SEKAIKEKEYEIERL
Y1181 KAIKEKEYEIERLRV
A1195 VLLQEEGARKREYEN
Y1211 LAKVRNHYNEEMSNL
Y1222-p MSNLRNKyEtEINIt
T1224-p NLRNKyEtEINItKT
T1229-p yEtEINItKTTIKEI
T1232 EINItKTTIKEISMQ
K1262 SRENRDLKDEIVRLN
Y1403 KEEDTSGYRAQIDNL
Y1524-p SKLQRVQyDLQkANN
K1528-u RVQyDLQkANNSATE
Y1554-p LTRLRIDyERVSQER
S1670-p QEELRRLsLDVEALR
L1671 EELRRLsLDVEALRR
S1720-p IEIERLQsLTENLTK
K1814 SNRIQESKSQCTQVV
A1853 DELNRAKATLEAESR
Y1993 KVTAMQLYECQLIDK
S2034 AGAIAGASASPKEKY
S2036 AIAGASASPKEKYSL
Y2041 SASPKEKYSLVEAKR
S2042 ASPKEKYSLVEAKRK
N2083 NEKLTVDNAVARDLI
Y2099-p FDDRQQIyTAEKAIT
Y2171 GLIDRDLYRSLNDPR
S2173 IDRDLYRSLNDPRDS
S2219-p LLSVQKRsMsFQGIR
S2221-p SVQKRsMsFQGIRQP
S2237 TVTELVDSGILRPST
Y2276 SSCIAGIYNETTKQK
Y2287 TKQKLGIYEAMKIGL
Y2328 RLPVEEAYkRGLVGI
K2329-a LPVEEAYkRGLVGIE
K2405 LPVDMAYKRGYFNEE
T2472 VQTSQKNTLRKRRVV
K2496 MSVQEAYKKGLIDYD
T2536 VVLVDRKTGsQYDIQ
S2538-p LVDRKTGsQYDIQDA
S2561 KFFDQYRSGsLSLTQ
S2563-p FDQYRSGsLSLTQFA
T2607-p DSVSKIStISsVRNL
S2610-p SKIStISsVRNLtIR
T2615-p ISsVRNLtIRsssLs
S2618-p VRNLtIRsssLsDPL
S2619-p RNLtIRsssLsDPLE
S2620-p NLtIRsssLsDPLEE
S2622-p tIRsssLsDPLEESs
P2624 RsssLsDPLEESsPI
S2629-p sDPLEESsPIAAIFD
K2714-u FIGFEGVkGKKKMSA
K2726-u MSAAEAVkEkWLPYE
K2728-u AAEAVkEkWLPYEAG
Y2732 VkEkWLPYEAGQRFL
F2743 QRFLEFQFLTGGLVD
K2784-u QDISSYAkILTCPKT
T2810 RSMVEDITGLRLLEA
S2822-p LEAASVSskGLPsPy
K2823-u EAASVSskGLPsPyN
S2827-p VSskGLPsPyNMsAP
Y2829-p skGLPsPyNMsAPGs
S2832-p LPsPyNMsAPGsrsG
- gap
S2836-p yNMsAPGsrsGsRSG
R2837-m1 NMsAPGsrsGsRSGS
S2838-p MsAPGsrsGsRSGSR
S2840-p APGsrsGsRSGSRSG
R2858-m1 GSRSGSRrGSFDATG
S2860 RSGSRrGSFDATGNS
T2864 RrGSFDATGNSSYSY
S2867 SFDATGNSSYSYSYS
S2879 SYSFSSSSIGGY___
5885 : Phospho-Desmoplakin (Ser165/166) Antibody
5885 : Phospho-Desmoplakin (Ser165/166) Antibody
  rat

 
S2 ______MSCNGGSHP
S7 _MSCNGGSHPRINTL
T13 GSHPRINTLGRMTRA
T18 INTLGRMTRAEsGPD
S22-p GRMTRAEsGPDLRYE
Y28 EsGPDLRYEMTYSGG
T31 PDLRYEMTYSGGGGG
Y32 DLRYEMTYSGGGGGG
T46 GGGGGGGTSRMYYSR
Y50 GGGTSRMYYSRRCtV
Y51 GGTSRMYYSRRCtVN
T56-p MYYSRRCtVNDQNSD
N58 YSRRCtVNDQNSDGY
S62 CtVNDQNSDGYCQTG
Y65 NDQNSDGYCQTGTMS
T70 DGYCQTGTMSRHQNQ
K103 LIAQPELKFGEGIQL
F104 IAQPELKFGEGIQLA
K149 QPCDAYQKRLLQLQE
K163 EQMRALYKAISAPRV
S166 RALYKAISAPRVRRA
S174-p APRVRRAssKGGYTC
S175-p PRVRRAssKGGYTCQ
Y179 RAssKGGYTCQSGSG
T180 AssKGGYTCQSGSGW
S183 KGGYTCQSGSGWDEF
S185 GYTCQSGSGWDEFTK
K192 SGWDEFTKRLTGECL
K252 IKADLREKSAIyQLE
S253 KADLREKSAIyQLEE
Y256-p LREKSAIyQLEEEYE
S306 EELLYDWSDKNTNIA
K448 QVQNLVNKSKKIVQL
S449 VQNLVNKSKKIVQLK
K477 LRALCDYKQDQKIVH
T799-p KVYEARLtEEETVCL
Y814-p DLDKVEAyRCGLKKI
K836 KSLLATMKTELQKAQ
K938 MRFLNEQKNLHNEIS
K947 LHNEISGKRDKSEEV
K956 DKSEEVHKIAELCAN
K1040 DLKLKNTKIEVLEEE
Y1072-p LDQNLQKyQAECSQF
K1080 QAECSQFKAKLVSLE
Y1123 EKITRLTYEIEDEKR
T1134 DEKRRRKTVEDRFDQ
Y1146 FDQQKNDYDQLQKAR
K1151 NDYDQLQKARQCEKE
K1174 SEKAIKEKEYEIERL
Y1176 KAIKEKEYEIERLRV
A1190 VLLQEEGARKREYEN
Y1206 LAKVRNHYNEEMSNL
Y1217 MSNLRNKYETEINIT
T1219 NLRNKYETEINITKT
T1224 YETEINITKTTIKEI
T1227 EINITKTTIKEISMQ
K1257 SRENRDLKDEIVRLN
Y1398 KEEDTSGYRAQIDNL
Y1519 SKLQRVQYDLQKANN
K1523 RVQYDLQKANNSATE
Y1549-p LTRLRIDyERVSQER
S1665 QEELRRLSLDVEALR
L1666 EELRRLSLDVEALRR
S1715 IEIERLQSLTENLTK
K1809 SNRIQESKSQCTQVV
A1848 DELNRAKATLEAETR
Y1988 KVTAMQLYECQLIDK
S2029 AGAIAGASASPKEKY
S2031 AIAGASASPKEKYSL
Y2036 SASPKEKYSLVEAKR
S2037 ASPKEKYSLVEAKRK
N2078 NEKLTVDNAIARDLI
Y2094 FDDRQQIYTAEKAIT
Y2166 GLIDRDLYRSLNDPR
S2168 IDRDLYRSLNDPRDS
S2214 LLSVQKRSMsFQGIR
S2216-p SVQKRSMsFQGIRQP
S2232 TVTELVDSGILRPST
Y2271 SSCIAGIYNETTKQK
Y2282 TKQKLGIYEAMKIGL
Y2323 RLPVEEAYKRGLVGI
K2324 LPVEEAYKRGLVGIE
K2400 LPVDMAYKRGYFNEE
T2467 VQTSQKNTLRKRRVV
K2491 MSVQEAYKKGLIDYE
T2531 VVLVDRKTGSQYDIQ
S2533 LVDRKTGSQYDIQDA
S2556-p KFFDQYRsGsLSLTQ
S2558-p FDQYRsGsLSLTQFA
T2602 ESVSKISTISSVRNL
S2605 SKISTISSVRNLTIR
T2610 ISSVRNLTIRsssLs
S2613-p VRNLTIRsssLsDPL
S2614-p RNLTIRsssLsDPLE
S2615-p NLTIRsssLsDPLEE
S2617-p TIRsssLsDPLEESS
P2619 RsssLsDPLEESSPI
S2624 sDPLEESSPIAAIFD
K2709 FIGFEGVKGKKKMSA
K2721 MSAAEAVKEKWLPYE
K2723 AAEAVKEKWLPYEAG
Y2727 VKEKWLPYEAGQRFL
F2738 QRFLEFQFLTGGLVD
K2779 QDISSYAKILTCPKT
T2805 RSMVEDITGLRLLEA
S2817 LEAASVSSKGLPSPY
K2818 EAASVSSKGLPSPYN
S2822 VSSKGLPSPYNMsAP
Y2824 SKGLPSPYNMsAPGs
S2827-p LPSPYNMsAPGsRSG
- gap
S2831-p YNMsAPGsRSGSRSG
R2832 NMsAPGsRSGSRSGS
S2833 MsAPGsRSGSRSGSR
S2835 APGsRSGSRSGSRSG
R2853 GSRSGSRRGSFDATG
S2855 RSGSRRGSFDATGNS
T2859 RRGSFDATGNSSYSY
S2862 SFDATGNSSYSYSYS
S2874 SYSFSSSSIGY____
5885 : Phospho-Desmoplakin (Ser165/166) Antibody
5885 : Phospho-Desmoplakin (Ser165/166) Antibody
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