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Protein Page:
Fndc5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Fndc5 Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: peroxisomal membrane; endoplasmic reticulum; integral to membrane; plasma membrane; extracellular region
Molecular Function: hormone activity
Biological Process: response to muscle activity
Reference #:  Q8NAU1 (UniProtKB)
Alt. Names/Synonyms: fibronectin type III domain containing 5; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; FNDC5; FRCP2
Gene Symbols: FNDC5
Molecular weight: 23,659 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Select Structure to View Below

Fndc5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K134-ac EAEKMASkNKDEVTM
0 1 K142-ac NKDEVTMkEMGRNQQ
0 1 T152-p GRNQQLRtGEVLIIV
0 1 K192 NNNKEKTKSASETST
0 1 S193 NNKEKTKSASETSTP
0 1 S195 KEKTKSASETSTPEH
0 3 S198 TKSASETSTPEHQGG
0 3 T199 KSASETSTPEHQGGG
  mouse

 
K131 EAEKMASKNKDEVTM
K139 NKDEVTMKEMGRNQQ
T149 GRNQQLRTGEVLIIV
K189-ub NNNKEKTksAsETst
S190-p NNKEKTksAsETstP
S192-p KEKTksAsETstPEH
S195-p TksAsETstPEHQGG
T196-p ksAsETstPEHQGGG
  rat

 
K131 EAEKMASKNKDEVTM
K139 NKDEVTMKEMGRNQQ
T149 GRNQQLRTGEVLIIV
K189 NNNKEKTKSASETst
S190 NNKEKTKSASETstP
S192 KEKTKSASETstPEH
S195-p TKSASETstPEHQGG
T196-p KSASETstPEHQGGG
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