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Protein Page:
TEAD4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TEAD4 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 12p13.3-p13.2
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; muscle development; gene expression; skeletal development
Reference #:  Q15561 (UniProtKB)
Alt. Names/Synonyms: EFTR-2; hRTEF-1B; MGC9014; related transcription enhancer factor 1B; RTEF1; TCF13L1; TEA domain family member 4; TEAD-4; TEAD4; TEF-3; TEF3; TEFR-1; Transcription factor 13-like 1; Transcription factor RTEF-1; transcriptional enhancer factor 1-related; transcriptional enhancer factor 3; Transcriptional enhancer factor TEF-3
Gene Symbols: TEAD4
Molecular weight: 48,329 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEAD4

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S322‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S69-p GRRKIILsDEGKMYG
0 1 K123-ac KLKDQAAkDKALQSM
0 1 S198-p LPLPGFEsPAGPAPS
0 1 S254-p FVHIGQSsPSYSDPY
0 1 K278-ac YDKFPEKkGGLkDLF
0 1 K282-ac PEKkGGLkDLFERGP
1 0 S322-p GVSSQYEsPENMIIT
0 1 Y349-p VEKVETEyARyENGH
0 1 Y352-p VETEyARyENGHySY
0 1 Y357-p ARyENGHySYRIHRS
0 1 S420-p YVFEVSAsEHGAQHH
  mouse

 
T62 GRRKIILTEEGKMYG
K116 KLKDQAAKNKALQSM
S191 LPLPGFESPAGPTPS
S247 FVHISQSSPSYSDPY
K271 YDKFPEKKGGLKELF
K275 PEKKGGLKELFERGP
S315 GVSSQYESPENMIIT
Y342 VEKVETEYARYENGH
Y345 VETEYARYENGHYLY
Y350 ARYENGHYLYRIHRS
S413 YVFEVSASEHGAQHH
  rat

 
S62 GRRKIILSDEGKMYG
K116 KLKDQAAKNKALQSM
S191 LPLPGFESPVGPTPS
S247 FVHISQSSPSYSDPY
K271 YDKFPEKKGGLKELF
K275 PEKKGGLKELFERGP
S315 GVSSQYESLENMIIT
F342 VEKVETEFARYENGH
Y345 VETEFARYENGHYLY
Y350 ARYENGHYLYRIHRS
S413 YVFEVSASEHGAQHH
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