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Protein Page:
TEAD4 (human)

Overview
TEAD4 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; muscle development; gene expression; skeletal development
Reference #:  Q15561 (UniProtKB)
Alt. Names/Synonyms: EFTR-2; hRTEF-1B; MGC9014; related transcription enhancer factor 1B; RTEF1; TCF13L1; TEA domain family member 4; TEAD-4; TEAD4; TEF-3; TEF3; TEFR-1; Transcription factor 13-like 1; Transcription factor RTEF-1; transcriptional enhancer factor 1-related; transcriptional enhancer factor 3; Transcriptional enhancer factor TEF-3
Gene Symbols: TEAD4
Molecular weight: 48,329 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEAD4

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S322‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S322-p GVSSQYEsPENMIIT
  mouse

 
S315 GVSSQYESPENMIIT
  rat

 
S315 GVSSQYESLENMIIT
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