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Protein Page:
NPY2R (human)

NPY2R Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 4q31
Cellular Component: nonmotile primary cilium; integral to plasma membrane; plasma membrane; cytosol
Molecular Function: peptide YY receptor activity; protein binding; calcium channel regulator activity; neuropeptide Y receptor activity; receptor activity
Biological Process: positive regulation of dopamine secretion; secretion; behavioral fear response; negative regulation of synaptic transmission, glutamatergic; locomotory behavior; positive regulation of peptide secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; negative regulation of cAMP biosynthetic process; cell surface receptor linked signal transduction; neuropeptide signaling pathway; negative regulation of secretion; feeding behavior; positive regulation of smooth muscle contraction; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of sensory perception of pain; negative regulation of neurological process; positive regulation of circadian sleep/wake cycle, non-REM sleep; nitric oxide mediated signal transduction
Reference #:  P49146 (UniProtKB)
Alt. Names/Synonyms: Neuropeptide Y receptor type 2; neuropeptide Y receptor Y2; NPY-Y2 receptor; NPY2-R; NPY2R; Y2 receptor
Gene Symbols: NPY2R
Molecular weight: 42,731 Da
Basal Isoelectric point: 6.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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