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Protein Page:
Epb4.2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Epb4.2 Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported. Belongs to the transglutaminase superfamily. Transglutaminase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Chromosomal Location of Human Ortholog: 15q15-q21
Cellular Component: cortical cytoskeleton; cytoskeleton; plasma membrane
Molecular Function: protein binding; protein-glutamine gamma-glutamyltransferase activity; structural constituent of cytoskeleton; ATP binding
Biological Process: spleen development; regulation of cell shape; iron ion homeostasis; erythrocyte maturation; hemoglobin metabolic process; cell morphogenesis; peptide cross-linking
Reference #:  P16452 (UniProtKB)
Alt. Names/Synonyms: E42P; EPB42; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; erythrocyte surface protein band 4.2; MGC116735; MGC116737; P4.2; PA; SPH5
Gene Symbols: EPB42
Molecular weight: 77,009 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
Select Structure to View Below

Epb4.2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 S82-gl TQATFPIsSLGDRKW
0 1 K200 LRLLSKDKQVEKWSQ
0 1 K223 GALLHFLKEQRVLPT
0 1 Q225 LLHFLKEQRVLPTPQ
0 1 R226 LHFLKEQRVLPTPQT
0 1 N243 TQEGALLNKRRGsVP
0 5 S248-p LLNKRRGsVPILRQW
0 2 T291-p IPARVVTtFAsAQGT
0 1 S294-p RVVTtFAsAQGTGGR
0 2 T375-p VRAVKEGtLGLTPAV
0 1 T403 WKCCEDGTLELtDsN
0 1 T403-p WKCCEDGtLELtDsN
0 1 T407-p EDGtLELtDsNtKYV
0 1 S409-p GtLELtDsNtKYVGN
0 1 T411-p LELtDsNtKYVGNNI
0 1 Y435-p CEDITQNyKYPEGSL
0 1 T560-p ERNPPENtFLRLtAM
0 1 T565-p ENtFLRLtAMATHSE
0 1 H570 RLtAMATHSESNLSC
0 1 K593-m2 CRPHLAIkMPEKAEQ
0 1 S690 TVVAPELSA______
  Epb4.2 iso2  
S7-p _MGQGEPsQRSTGLA
S112 TQATFPISSLGDRKW
K230 LRLLSKDKQVEKWSQ
K253 GALLHFLKEQRVLPT
Q255 LLHFLKEQRVLPTPQ
R256 LHFLKEQRVLPTPQT
N273 TQEGALLNKRRGsVP
S278-p LLNKRRGsVPILRQW
T321 IPARVVTTFASAQGT
S324 RVVTTFASAQGTGGR
T405 VRAVKEGTLGLTPAV
T433 WKCCEDGTLELTDSN
T433 WKCCEDGTLELTDSN
T437 EDGTLELTDSNTKYV
S439 GTLELTDSNTKYVGN
T441 LELTDSNTKYVGNNI
Y465 CEDITQNYKYPEGSL
T590 ERNPPENTFLRLTAM
T595 ENTFLRLTAMATHSE
H600 RLTAMATHSESNLSC
K623 CRPHLAIKMPEKAEQ
S720 TVVAPELSA______
  mouse

 
- gap
S82 TQAIFPISSLGDQKG
K200-ub LKLLSMDkQVKDWNQ
K223-ub GALLHALkKksVLPI
K225-ub LLHALkKksVLPISQ
S226-p LHALkKksVLPISQT
Y243-p AQEGALLyKRRGsVP
S248-p LLyKRRGsVPILRQW
T291 IPARVVTTFDSAQGT
S294 RVVTTFDSAQGTVGS
E375 VRAVKEGELQLDPAV
K403-ub WKCCEDGkLELTNSN
K403 WKCCEDGKLELTNSN
T407 EDGkLELTNSNRKDV
S409 GkLELTNSNRKDVGN
R411 LELTNSNRKDVGNCI
Y435 CEDITQNYKYPAGSL
S560 EQTPPENSFLRVTAM
T565 ENSFLRVTAMARySH
Y570-p RVTAMARySHTSLSC
E593 GKPDLIIEMPKRAAQ
S690 LVVAPEVSV______
  rat

 
- under review  
S82 TQAIFPISSLGDKKG
K200 LNLLSVDKQVKDWSQ
K223 GALLHALKKKSVLPI
K225 LLHALKKKSVLPISQ
S226 LHALKKKSVLPISQT
Y243 AQQGALLYKRRGSVP
S248 LLYKRRGSVPILRQW
T291 IPARVVTTFDSAQGT
S294 RVVTTFDSAQGTNGS
D375 VKAVKEGDLQLDPAV
K403 WKCCEDGKLELTNSN
K403 WKCCEDGKLELTNSN
T407 EDGKLELTNSNRKNV
S409 GKLELTNSNRKNVGN
R411 LELTNSNRKNVGNSI
Y435 CEDITQNYKYPEGSL
T558 EQNPPENTFLRVTAM
T563 ENTFLRVTAMARHSH
H568 RVTAMARHSHAGFSC
E591 SRPNLVIEMPKRATQ
S688-p LVVAPEVsV______
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