Home

calpain 2 (human)

Overview calpain 2 Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; EC 3.4.22.53; Protease Cellular Component: cytoplasm; plasma membrane; chromatin; nucleus Molecular Function: protein binding; protein heterodimerization activity; cytoskeletal protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; cysteine-type peptidase activity Biological Process: blastocyst development; response to hypoxia; proteolysis; myoblast fusion Reference #:  P17655 (UniProtKB) Alt. Names/Synonyms: Calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; Calpain-2 catalytic subunit; Calpain-2 large subunit; CAN2; CANP 2; CANP2; CANPL2; CANPml; CAPN2; FLJ39928; M-calpain; mCANP; Millimolar-calpain Gene Symbols: CAPN2 Molecular weight: 79,995 Da Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease  |  Apoptosis  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below calpain 2 1KFU - L=1-700 (human) 1KFX - L=1-700 (human) 2NQA - A=43-346 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KFU 1KFX 2NQA  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
cell adhesion, altered: S50‑p cell motility, altered: S50‑p, S369‑p, T370‑p inhibition: S369‑p, T370‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K7-a	_MAGIAAkLAKDREA
0	1		K26-u	GSHDRAIkYLNQDyE
0	1		Y32-p	IkYLNQDyEALRNEC
2	0		S50-p	GTLFQDPsFPAIPSA
0	4		K61-a	IPSALGFkELGPYSS
0	1		K69-u	ELGPYSSkTRGIEWK
0	3		K260-u	ITFQKLVkGHAYSVT
0	2		K280-u	ESNGSLQkLIRIRNP
0	1		Y353-p	DTLTSDTykkWKLTk
0	19		K354-a	TLTSDTykkWKLTkM
0	5		K355-a	LTSDTykkWKLTkMD
0	1		K360-u	ykkWKLTkMDGNWRR
1	2		S369-p	DGNWRRGstAGGCRN
2	0		T370-p	GNWRRGstAGGCRNy
0	1		Y377-p	tAGGCRNyPNTFWMN
1	0		K390-s	MNPQYLIkLEEEDED
0	1		T464-p	RARERSDtFINLREV
0	1		K476-u	REVLNRFkLPPGEYI
0	1		S586-p	IMVDMLDsDGsGKLG
0	1		S589-p	DMLDsDGsGKLGLKE
0	1		Y611-p	IQKYQKIyREIDVDR
0	1		T621-p	IDVDRSGtMNSyEMR
0	2		Y625-p	RSGtMNSyEMRKALE
0	3		K674-u	VRLETLFkIFKQLDP

	mouse
K7	_MAGIAIKLAKDREA
K26	GSHERAIKYLNQDYE
Y32	IKYLNQDYETLRNEC
S50-p	GALFQDPsFPALPSS
K61	LPSSLGYKELGPYSS
K69	ELGPYSSKTRGIEWK
K260-u	VTYQKLVkGHAYSVT
K280-u	ESSGSLQkLIRIRNP
Y353	DTLTCDSYkkWKLTK
K354-a	TLTCDSYkkWKLTKM
K355-a	LTCDSYkkWKLTKMD
K360	YkkWKLTKMDGNWRR
S369-p	DGNWRRGstAGGCRN
T370-p	GNWRRGstAGGCRNy
Y377-p	tAGGCRNyPNTFWMN
K390	MNPQYLIKLEEEDED
T464	RARERSDTFINLREV
K476	REVLNRFKLPPGEYV
E586	IMVDMLDEDGSGKLG
S589	DMLDEDGSGKLGLKE
Y611	IQKYQKIYREIDVDR
T621	IDVDRSGTMNSYEMR
Y625	RSGTMNSYEMRKALE
K674-u	VRLETLFkIFKQLDP

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.