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PTPN2 (human)

Overview PTPN2 a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis Cellular Component: nucleoplasm; endoplasmic reticulum Molecular Function: protein binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity Biological Process: cytokine and chemokine mediated signaling pathway; insulin receptor signaling pathway; protein amino acid dephosphorylation Reference #:  P17706 (UniProtKB) Alt. Names/Synonyms: protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPN2; PTPT; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC-PTP; TCELLPTP; TCPTP; Tyrosine-protein phosphatase non-receptor type 2 Gene Symbols: PTPN2 Molecular weight: 48,473 Da Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states

Select Structure to View Below PTPN2 1L8K - A=1-314 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y22-p	QRRWQPLyLEIRNES
0	2		Y32-p	IRNESHDyPHRVAkF
0	1		K38-a	DyPHRVAkFPENRNR
0	2		S52-p	RNRYRDVsPyDHSRV
0	2		Y54-p	RYRDVsPyDHSRVkL
0	5		K60-u	PyDHSRVkLQNAEND
0	1		S72-p	ENDYINAsLVDIEEA
0	1		K245-u	KGDDINIkQVLLNMR
0	1		T261-p	YRMGLIQtPDQLRFS
0	1		C278	AIIEGAKCIKGDSSI
0	9		S293-p	QKRWKELsKEDLsPA
0	23		S298-p	ELsKEDLsPAFDHsP
1	21		S304-p	LsPAFDHsPNKIMtE
0	1		T310-p	HsPNKIMtEkYNGNR
0	1		K312-a	PNKIMtEkYNGNRIG
0	1		L320	YNGNRIGLEEEKLTG
0	1		S335	DRCTGLSSKMQDtME
0	1		T340-p	LSSKMQDtMEENSES
0	1		Y384-p	RKRKRWLyWQPILTK

	PTPN2 iso2
Y22	QRRWQPLYLEIRNES
Y32	IRNESHDYPHRVAKF
K38	DYPHRVAKFPENRNR
S52	RNRYRDVSPYDHSRV
Y54	RYRDVSPYDHSRVKL
K60	PYDHSRVKLQNAEND
S72	ENDYINASLVDIEEA
K245	KGDDINIKQVLLNMR
T261	YRMGLIQTPDQLRFS
C278	AIIEGAKCIKGDSSI
S293	QKRWKELSKEDLSPA
S298	ELSKEDLSPAFDHsP
S304-p	LSPAFDHsPNKIMTE
T310	HsPNKIMTEKYNGNR
K312	PNKIMTEKYNGNRIG
L320	YNGNRIGLEEEKLTG
S335	DRCTGLSSKMQDTME
T340	LSSKMQDTMEENSES
-	gap

	mouse
Y22	QCRWQPLYLEIRNES
Y32	IRNESHDYPHRVAKF
K38	DYPHRVAKFPENRNR
S52	RNRYRDVSPYDHSRV
Y54	RYRDVSPYDHSRVKL
K60	PYDHSRVKLQSTEND
S72	ENDYINASLVDIEEA
K245	KGEDVNVKQLLLNMR
T261	YRMGLIQTPDQLRFS
Y278-p	AIIEGAKyTKGDSNI
S293-p	QKRWKELsKEDLsPI
S298-p	ELsKEDLsPICDHSQ
S304	LsPICDHSQNRVMVE
V310	HSQNRVMVEKYNGKR
K312	QNRVMVEKYNGKRIG
S320-p	YNGKRIGsEDEKLTG
S330-p	EKLTGLPsKVQDTVE
T335	LPsKVQDTVEESSES
Y379	RKRKRWLYWQPILTK

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