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axin 2 (human)

Overview axin 2 is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: centrosome; cytoplasmic microtubule; cytoplasmic membrane-bound vesicle; cytoplasm; postsynaptic density; plasma membrane; cell cortex; beta-catenin destruction complex; nucleus Molecular Function: signal transducer activity; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity Biological Process: cell death; intramembranous ossification; mRNA stabilization; dorsal/ventral axis specification; maintenance of DNA repeat elements; bone mineralization; odontogenesis; cell proliferation; negative regulation of cell proliferation; regulation of mismatch repair; positive regulation of protein kinase activity; negative regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of GTPase activity Reference #:  Q9Y2T1 (UniProtKB) Alt. Names/Synonyms: Axil; axin 2; Axin-2; Axin-like protein; AXIN2; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC10366; MGC126582 Gene Symbols: AXIN2 Molecular weight: 93,558 Da Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below axin 2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 114500 604025 608615  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K80-u	SPLTRWTkSLHSLLG
0	1		Y138-p	AKAIYKRyIENNSIV
0	1		S146-p	IENNSIVsKQLKPAT
0	1		Y156-p	LKPATKTyIRDGIKK
0	1		S348-p	VKANGQVsLPHFPRT
0	1		Y460	QSPGVGRYSPRSRSP
0	1		S464	VGRYSPRSRSPDHHH
0	1		Y549-p	FCPGGSEyYCYSKCK
0	1		K633-a	SERQSKPkPHSAQST
0	1		K792-a	SLTLGHFkEQLSkKG
0	1		K797-a	HFkEQLSkKGNYRYY
0	1		K806-a	GNYRYYFkKASDEFA
0	1		K838-u	YEGRILGkVERID__

	mouse
K80	SPLTRWTKSLHSLLG
Y138	AKAIYKRYIENNSVV
S146	IENNSVVSKQLKPAT
Y156	LKPATKTYIRDGIKK
S348	VKANGQVSLPHFPRT
Y460-p	QSPGVGRySPRsRSP
S464-p	VGRySPRsRSPDHHH
Y547	LCPGGTDYYCYSKCK
K631	SERQSKSKPHSAQSI
K789	SLTLGHFKEQLSKKG
K794	HFKEQLSKKGNYRYY
K803	GNYRYYFKKASDEFA
K835	YEGRILGKVERID__

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