Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
axin 2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
axin 2 is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: centrosome; cytoplasmic microtubule; cytoplasmic membrane-bound vesicle; postsynaptic density; cytoplasm; plasma membrane; cell cortex; beta-catenin destruction complex; nucleus
Molecular Function: signal transducer activity; protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity
Biological Process: odontogenesis; negative regulation of cell proliferation; cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; dorsal/ventral axis specification; negative regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity
Reference #:  Q9Y2T1 (UniProtKB)
Alt. Names/Synonyms: Axil; axin 2; Axin-2; Axin-like protein; AXIN2; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Gene Symbols: AXIN2
Molecular weight: 93,558 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

axin 2

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S70-p GEPEGRAsPDsPLTR
0 1 S73-p EGRAsPDsPLTRWTk
0 1 K80-ub sPLTRWTkSLHSLLG
0 1 S146-p IENNSIVsKQLKPAT
0 1 S348-p VKANGQVsLPHFPRT
0 1 Y460 QSPGVGRYSPRSRSP
0 1 S464 VGRYSPRSRSPDHHH
0 1 Y549-p FCPGGSEyYCYSKCK
0 1 K633-ac SERQSKPkPHSAQST
0 1 K792-ac SLTLGHFkEQLSkKG
0 1 K797-ac HFkEQLSkKGNYRYY
0 1 K806-ac GNYRYYFkKASDEFA
0 1 K838-ub YEGRILGkVERID__
  mouse

 
S70 GEPEGRASPDSPLTR
S73 EGRASPDSPLTRWTK
K80 SPLTRWTKSLHSLLG
S146 IENNSVVSKQLKPAT
S348 VKANGQVSLPHFPRT
Y460-p QSPGVGRySPRsRSP
S464-p VGRySPRsRSPDHHH
Y547 LCPGGTDYYCYSKCK
K631 SERQSKSKPHSAQSI
K789 SLTLGHFKEQLSKKG
K794 HFKEQLSKKGNYRYY
K803 GNYRYYFKKASDEFA
K835 YEGRILGKVERID__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.