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Protein Page:
Kv1.1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Kv1.1 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Cellular Component: voltage-gated potassium channel complex; cell soma; apical plasma membrane; dendrite; plasma membrane
Molecular Function: protein binding; potassium channel activity; delayed rectifier potassium channel activity; potassium ion transmembrane transporter activity
Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport
Reference #:  Q09470 (UniProtKB)
Alt. Names/Synonyms: AEMK; EA1; HBK1; HUK1; KCNA1; KV1.1; MBK1; MGC126782; MGC138385; MK1; Potassium voltage-gated channel subfamily A member 1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); RBK1; Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1
Gene Symbols: KCNA1
Molecular weight: 56,466 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Select Structure to View Below

Kv1.1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2 ______MTVMSGENV
0 2 S5 ___MTVMSGENVDEA
0 1 S13 GENVDEASAAPGHPQ
0 1 A14 ENVDEASAAPGHPQD
0 1 S23 PGHPQDGSYPRQADH
0 1 K53 LRFETQLKTLAQFPN
0 1 T54 RFETQLKTLAQFPNT
0 1 K67 NTLLGNPKKRMRYFD
0 1 K129 LGEEAMEKFREDEGF
0 1 S445-p DSDLSRRssStMSKS
2 0 S446-p SDLSRRssStMSKSE
0 1 T448-p LSRRssStMSKSEYM
  mouse

 
T2-p ______MtVMsGENA
S5-p ___MtVMsGENADEA
S13-p GENADEAstAPGHPQ
T14-p ENADEAstAPGHPQD
S23-p PGHPQDGsYPRQADH
K53-ub LRFETQLktLAQFPN
T54-p RFETQLktLAQFPNT
K67-ub NTLLGNPkKRMRYFD
K129-ub LGEEAMEkFREDEGF
S445 DSDLSRRSSSTISKS
S446 SDLSRRSSSTISKSE
T448 LSRRSSSTISKSEYM
  rat

 
T2 ______MTVMSGENA
S5 ___MTVMSGENADEA
S13 GENADEASAAPGHPQ
A14 ENADEASAAPGHPQD
S23-p PGHPQDGsYPRQADH
K53 LRFETQLKTLAQFPN
T54 RFETQLKTLAQFPNT
K67 NTLLGNPKKRMRYFD
K129 LGEEAMEKFREDEGF
S445 DSDLSRRSsSTISKS
S446-p SDLSRRSsSTISKSE
T448 LSRRSsSTISKSEYM
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