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Protein Page:
FSHR (human)

Overview
FSHR Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Cellular Component: cell surface; plasma membrane; integral to membrane; endosome
Molecular Function: protein binding; peptide hormone binding; follicle-stimulating hormone receptor activity
Biological Process: gonad development; primary ovarian follicle growth; positive regulation of estrogen receptor signaling pathway; locomotory behavior; regulation of chromosome organization and biogenesis; uterus development; G-protein signaling, adenylate cyclase activating pathway; regulation of osteoclast differentiation; negative regulation of bone resorption; female gonad development; neurite development; regulation of protein amino acid phosphorylation; regulation of hormone metabolic process; cellular water homeostasis; male gonad development; spermatogenesis, exchange of chromosomal proteins; female gamete generation; Sertoli cell proliferation; transcytosis; Sertoli cell development; G-protein coupled receptor protein signaling pathway; regulation of MAPKKK cascade; regulation of systemic arterial blood pressure; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway
Reference #:  P23945 (UniProtKB)
Alt. Names/Synonyms: follicle stimulating hormone receptor; Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; FSHR; FSHRO; LGR1; MGC141667; MGC141668; ODG1
Gene Symbols: FSHR
Molecular weight: 78,265 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Select Structure to View Below

FSHR

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y250-p KLRARSTyNLKKLPT
1 0 T470 ITLERWHTITHAMQL
1 0 T472 LERWHTITHAMQLDC
  mouse

 
Y250 KLRARSTYRLKKLPS
T469 ITLERWHTITHAMQL
T471 LERWHTITHAMQLEC
  rat

 
Y250 KLRARSTYRLKKLPN
T469-p ITLERWHtItHAMQL
T471-p LERWHtItHAMQLEC
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