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Protein Page:
Doublecortin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Doublecortin Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Interacts with tubulin. Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: microtubule; microtubule associated complex; neuron projection; cytoskeleton; cytosol
Molecular Function: protein binding; microtubule binding; protein kinase binding
Biological Process: nervous system development; axon guidance; central nervous system development; axon extension; dendrite morphogenesis; neuron migration; central nervous system projection neuron axonogenesis; brain development
Reference #:  O43602 (UniProtKB)
Alt. Names/Synonyms: DBCN; DC; DCX; doublecortex; doublecortin; Doublin; Lis-X; Lissencephalin-X; LISX; Neuronal migration protein doublecortin; SCLH; XLIS
Gene Symbols: DCX
Molecular weight: 49,318 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Doublecortin

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S128‑p, S378‑p
molecular association, regulation: S128‑p, S378‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 2 S109-p SRMNGLPsPtHSAHC
0 2 T111-p MNGLPsPtHSAHCSF
3 0 S128-p TRTLQALsNEkkAKK
0 1 K131-ac LQALsNEkkAKKVRF
0 1 K132-ac QALsNEkkAKKVRFY
0 1 Y145-p FYRNGDRyFKGIVYA
0 1 S155-p GIVYAVSsDRFRSFD
0 1 S171 LLADLTRSLSDNINL
0 2 S173 ADLTRSLSDNINLPQ
0 2 Y184-p NLPQGVRyIyTIDGS
0 1 Y186-p PQGVRyIyTIDGSRK
0 1 S191 yIyTIDGSRKIGSMD
0 1 S246 APQSLASSNSAQARE
0 1 S248 QSLASSNSAQARENK
0 1 T284-p RVLLNKKtAHsFEQV
0 3 S287-p LNKKtAHsFEQVLTD
0 1 T303-p TEAIKLEtGVVKKLY
1 1 S346 RYAQDDFSLDENECR
1 1 S368-p ATAGPKAsPTPQKTS
1 2 T370 AGPKAsPTPQKTSAK
5 6 S378-p PQKTSAKsPGPMRRS
0 1 S385 sPGPMRRSKSPADSA
1 6 S387 GPMRRSKSPADSANG
0 1 S391 RSKSPADSANGTsSS
0 1 S396-p ADSANGTsSSQLsTP
0 1 S398 SANGTsSSQLsTPKs
0 1 S401-p GTsSSQLsTPKsKQs
3 2 T402 TsSSQLsTPKsKQsP
0 6 S405-p SQLsTPKsKQsPIsT
5 16 S408-p sTPKsKQsPIsTPTs
0 1 S411-p KsKQsPIsTPTsPGS
1 3 T412 sKQsPIsTPTsPGSL
0 4 T414 QsPIsTPTsPGSLRk
3 19 S415-p sPIsTPTsPGSLRkH
0 4 S418 sTPTsPGSLRkHkDL
0 1 K421-ac TsPGSLRkHkDLYLP
0 1 K423-ac PGSLRkHkDLYLPLS
0 3 S430 kDLYLPLSLDDSDSL
0 2 S434 LPLSLDDSDSLGDSM
0 2 S440 DSDSLGDSM______
4605 : Phospho-Doublecortin (Ser297) Antibody
3453 : Phospho-Doublecortin (Ser334) Antibody
14053 : Phospho-Doublecortin (Ser334) (D11B10) Rabbit mAb
  Doublecortin iso2  
S28 SRMNGLPSPTHSAHC
T30 MNGLPSPTHSAHCSF
S47 TRTLQALSNEKKAKK
K50 LQALSNEKKAKKVRF
K51 QALSNEKKAKKVRFY
Y64 FYRNGDRYFKGIVYA
S74 GIVYAVSSDRFRSFD
S90 LLADLTRSLSDNINL
S92 ADLTRSLSDNINLPQ
Y103 NLPQGVRYIYTIDGS
Y105 PQGVRYIYTIDGSRK
S110 YIYTIDGSRKIGSMD
S165 APQSLASSNSAQARE
S167 QSLASSNSAQARENK
T203 RVLLNKKTAHSFEQV
S206 LNKKTAHSFEQVLTD
T222 TEAIKLETGVVKKLY
S265 RYAQDDFSLDENECR
S287 ATAGPKASPTPQKTS
T289 AGPKASPTPQKTSAK
S297 PQKTSAKSPGPMRRS
S304 SPGPMRRSKsPADSA
S306-p GPMRRSKsPADSANG
S310 RSKsPADSANGTSSS
S315 ADSANGTSSSQLStP
S317 SANGTSSSQLStPKS
S320 GTSSSQLStPKSKQs
T321-p TSSSQLStPKSKQsP
S324 SQLStPKSKQsPISt
S327-p StPKSKQsPIStPTs
S330 KSKQsPIStPTsPGS
T331-p SKQsPIStPTsPGSL
T333 QsPIStPTsPGSLRk
S334-p sPIStPTsPGSLRkH
S337 StPTsPGSLRkHkDL
K340-ac TsPGSLRkHkDLYLP
K342-ac PGSLRkHkDLYLPLS
S349 kDLYLPLSLDDSDSL
S353 LPLSLDDSDSLGDSM
S359 DSDSLGDSM______
3453 : Phospho-Doublecortin (Ser334) Antibody
14053 : Phospho-Doublecortin (Ser334) (D11B10) Rabbit mAb
  mouse

► Hide Isoforms
 
S28-p SRMNGLPsPTHSAHC
T30 MNGLPsPTHSAHCSF
S47-p TRTLQALsNEKKAKK
K50 LQALsNEKKAKKVRF
K51 QALsNEKKAKKVRFY
Y64 FYRNGDRYFKGIVYA
S74 GIVYAVSSDRFRSFD
S90 LLADLTRSLsDNINL
S92-p ADLTRSLsDNINLPQ
Y103 NLPQGVRYIYTIDGS
Y105 PQGVRYIYTIDGSRK
S110 YIYTIDGSRKIGSMD
S165-p APQSLASsNsAQARE
S167-p QSLASsNsAQARENK
T203 RVLLNKKTAHsFEQV
S206-p LNKKTAHsFEQVLTD
T222 TEAIKLETGVVKKLY
S265-p RYAQDDFsLDENECR
S287-p AAAGPKAsPtPQKTS
T289-p AGPKAsPtPQKTSAK
S297-p PQKTSAKsPGPMRRS
S304 sPGPMRRSKsPADsG
S306-p GPMRRSKsPADsGND
S310-p RSKsPADsGNDQDAN
S320 DQDANGTSSsQLStP
S322-p DANGTSSsQLStPKs
S325 GTSSsQLStPKsKQs
T326-p TSSsQLStPKsKQsP
S329-p sQLStPKsKQsPISt
S332-p StPKsKQsPIStPts
S335 KsKQsPIStPtsPGs
T336-p sKQsPIStPtsPGsL
T338-p QsPIStPtsPGsLRK
S339-p sPIStPtsPGsLRKH
S342-p StPtsPGsLRKHKVD
K345 tsPGsLRKHKVDLYL
K347 PGsLRKHKVDLYLPL
S355-p VDLYLPLsLDDsDSL
S359-p LPLsLDDsDSLGDsM
S365-p DsDSLGDsM______
4605 : Phospho-Doublecortin (Ser297) Antibody
3453 : Phospho-Doublecortin (Ser334) Antibody
14053 : Phospho-Doublecortin (Ser334) (D11B10) Rabbit mAb
  Doublecortin iso3  
S28 SRMNGLPSPTHSAHC
T30 MNGLPSPTHSAHCSF
S47 TRTLQALSNEKKAKK
K50 LQALSNEKKAKKVRF
K51 QALSNEKKAKKVRFY
Y64 FYRNGDRYFKGIVYA
S74 GIVYAVSSDRFRSFD
S90 LLADLTRSLSDNINL
S92 ADLTRSLSDNINLPQ
Y103 NLPQGVRYIYTIDGS
Y105 PQGVRYIYTIDGSRK
S110 YIYTIDGSRKIGSMD
S165 APQSLASSNSAQARE
S167 QSLASSNSAQARENK
T203 RVLLNKKTAHSFEQV
S206 LNKKTAHSFEQVLTD
T222 TEAIKLETGVVKKLY
S265 RYAQDDFSLDENECR
S287 AAAGPKASPTPQKTS
T289 AGPKASPTPQKTSAK
S297 PQKTSAKSPGPMRRs
S304-p SPGPMRRsKsPADSA
S306-p GPMRRsKsPADSANG
S310 RsKsPADSANGTSSS
S315 ADSANGTSSSQLStP
S317 SANGTSSSQLStPKS
S320 GTSSSQLStPKSKQs
T321-p TSSSQLStPKSKQsP
S324 SQLStPKSKQsPIST
S327-p StPKSKQsPISTPTS
S330 KSKQsPISTPTSPGS
T331 SKQsPISTPTSPGSL
T333 QsPISTPTSPGSLRK
S334 sPISTPTSPGSLRKH
S337 STPTSPGSLRKHKDL
K340 TSPGSLRKHKDLYLP
K342 PGSLRKHKDLYLPLs
S349-p KDLYLPLsLDDsDSL
S353-p LPLsLDDsDSLGDsM
S359-p DsDSLGDsM______
3453 : Phospho-Doublecortin (Ser334) Antibody
14053 : Phospho-Doublecortin (Ser334) (D11B10) Rabbit mAb
  rat

 
S28 SRMNGLPSPTHSAHC
T30 MNGLPSPTHSAHCSF
S47 TRTLQALSNEKKAKK
K50 LQALSNEKKAKKVRF
K51 QALSNEKKAKKVRFY
Y64 FYRNGDRYFKGIVYA
S74 GIVYAVSSDRFRSFD
S90-p LLADLTRsLsDNINL
S92-p ADLTRsLsDNINLLQ
Y103-p NLLQGVRyIYTIDGs
Y105 LQGVRyIYTIDGsRK
S110-p yIYTIDGsRKIGSMD
S165 APQSLASSNSAQARE
S167 QSLASSNSAQARENK
T203 RVLLNKKTAHSFEQV
S206 LNKKTAHSFEQVLTD
T222 TEAIKLETGVVKKLY
S265 RYAQDDFSLDENECR
S287 ATAGPKASPTPQKTS
T289 AGPKASPTPQKTSAK
S297 PQKTSAKSPGPMRRS
S304 SPGPMRRSKSPADSG
S306 GPMRRSKSPADSGND
S310 RSKSPADSGNDQDAN
S320 DQDANGTSSSQLSTP
S322 DANGTSSSQLSTPKS
S325 GTSSSQLSTPKSKQs
T326 TSSSQLSTPKSKQsP
S329 SQLSTPKSKQsPIST
S332-p STPKSKQsPISTPTs
S335 KSKQsPISTPTsPGS
T336 SKQsPISTPTsPGSL
T338 QsPISTPTsPGSLRK
S339-p sPISTPTsPGSLRKH
S342 STPTsPGSLRKHKDL
K345 TsPGSLRKHKDLYLP
K347 PGSLRKHKDLYLPLS
S354 KDLYLPLSLDDSDSL
S358 LPLSLDDSDSLGDSM
S364 DSDSLGDSM______
4605 : Phospho-Doublecortin (Ser297) Antibody
3453 : Phospho-Doublecortin (Ser334) Antibody
14053 : Phospho-Doublecortin (Ser334) (D11B10) Rabbit mAb
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