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NEUROD1
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulates transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor p21Cip1. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element. Efficient DNA-binding requires dimerization with another bHLH protein. Interacts with RREB1. Interacts with EP300; the interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; Transcription factor |
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Cellular Component: nucleoplasm; cytoplasm; nucleus
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Molecular Function: protein binding; sequence-specific DNA binding; protein heterodimerization activity; double-stranded DNA binding; transcription coactivator activity; chromatin binding; transcription factor binding; transcription factor activity
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Biological Process: response to drug; dentate gyrus development; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; glucose homeostasis; endocrine pancreas development; anterior/posterior pattern formation; embryonic organ morphogenesis; neurogenesis; insulin secretion; response to glucose stimulus; cerebellum development; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade; regulation of insulin secretion; nitric oxide mediated signal transduction; inner ear development; negative regulation of apoptosis
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Reference #:
Q13562 (UniProtKB)
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| Alt. Names/Synonyms: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; BETA2; BHF-1; BHLHA3; Class A basic helix-loop-helix protein 3; MODY6; NDF1; NEUROD; NEUROD1; neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD |
| Gene Symbols: NEUROD1 |
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Molecular weight: 39,920 Da
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Basal Isoelectric point: 5.2
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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