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axin 1
is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin-1 functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Wild-type axin 1 can induce apoptosis in hepatocellular and colorectal cancer cells. Is downregulated during progression of esophageal squamous cell carcinoma. Mutation of the axin-1 gene is associated with hepatocellular carcinoma, anaplastic thyroid cancer, medulloblastoma and colorectal cancer. May have a role in oncogenesis in Hodgkin lymphoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
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Cellular Component: perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasmic membrane-bound vesicle; cytoplasm; postsynaptic density; plasma membrane; cytoplasmic vesicle; cell cortex; beta-catenin destruction complex; cytosol; nucleus; lateral plasma membrane
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Molecular Function: protein C-terminus binding; identical protein binding; protein homodimerization activity; protein self-association; p53 binding; beta-catenin binding; protein kinase binding; GTPase activator activity; protein binding; signal transducer activity; enzyme binding; ubiquitin protein ligase binding; protein complex scaffold; SMAD binding
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Biological Process: cell death; protein polyubiquitination; negative regulation of Wnt receptor signaling pathway; embryonic eye morphogenesis; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; dorsal/ventral axis specification; negative regulation of protein metabolic process; nucleocytoplasmic transport; Wnt receptor signaling pathway through beta-catenin; olfactory placode formation; cytoplasmic microtubule organization and biogenesis; activation of JNK activity; sensory perception of sound; positive regulation of ubiquitin-protein ligase activity; Wnt receptor signaling pathway involved in forebrain neuron fate commitment; protein catabolic process; protein homooligomerization; axial mesoderm formation; in utero embryonic development; muscle cell development; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; optic placode formation; positive regulation of peptidyl-serine phosphorylation; cellular protein complex assembly; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; forebrain anterior/posterior pattern formation; activation of protein kinase activity; positive regulation of protein catabolic process; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; positive regulation of GTPase activity
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Reference #:
O15169 (UniProtKB)
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| Alt. Names/Synonyms: AXIN; axin 1; Axin-1; AXIN1; Axis inhibition protein 1; axis inhibitor 1; AXN1; fused, mouse, homolog of; hAxin; MGC52315 |
| Gene Symbols: AXIN1 |
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Molecular weight: 95,635 Da
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Basal Isoelectric point: 6.5
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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