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Fascin (human)

Overview Fascin Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family. Note: This description may include information from UniProtKB. Protein type: Actin binding protein; Cytoskeletal protein; Motility/polarity/chemotaxis Cellular Component: stress fiber; cytosol; cell junction; filopodium; actin cytoskeleton Molecular Function: actin filament binding; protein binding, bridging; protein binding; drug binding; actin binding Biological Process: cell proliferation; actin filament bundle formation; cell migration; cell motility involved in cell locomotion; actin cytoskeleton organization and biogenesis Reference #:  Q16658 (UniProtKB) Alt. Names/Synonyms: 55 kDa actin-bundling protein; actin bundling protein; FAN1; Fascin; fascin 1; fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); FLJ38511; FSCN1; HSN; p55; Singed, drosophila, homolog-like; singed-like (fascin homolog, sea urchin); Singed-like protein; SNL Gene Symbols: FSCN1 Molecular weight: 54,530 Da Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Fascin 1DFC - A/B=1-493 (human) 3LLP - A/B=1-493 (human) 3P53 - A/B=1-493 (human) 4GOV - A/B=1-493 (human) 4GOY - A/B=1-493 (human) 4GP0 - A/B=1-493 (human) 4GP3 - A/B=1-493 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cytoskeletal reorganization: S39‑p molecular association, regulation: S39‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y23-p	LINCGNKyLTAEAFG
0	1		S38-p	FKVNASAssLkKKQI
7	2		S39-p	KVNASAssLkKKQIW
0	18		K41-a	NASAssLkKKQIWTL
0	5		K41	NASAssLKKKQIWTL
0	1		K42	ASAssLkKKQIWTLE
0	8		K74-a	GRYLAADkDGNVTCE
0	8		K74	GRYLAADKDGNVTCE
0	1		S120-p	GGTEDRLsCFAQTVS
0	2		Y145-p	MHPQVNIySVtRKRY
0	1		T148-p	QVNIySVtRKRYAHL
0	1		K220	TLEFRSGKVAFRDCE
0	1		T239-p	APSGPSGtLkAGKAT
0	9		K241-u	SGPSGtLkAGKATkV
0	1		K247-u	LkAGKATkVGKDELF
0	1		K304-a	EIDRDTKkCAFRTHT
0	1		Y314-p	FRTHTGKyWTLTATG
0	1		K353-m2	TLRASNGkFVTSKkN
0	1		K359-u	GkFVTSKkNGQLAAS
0	6		K399-u	HGFIGCRkVTGtLDA
0	1		T403-p	GCRkVTGtLDANRSS
0	2		K464	DYNKVAIKVGGRYLk
0	5		K471	KVGGRYLKGDHAGVL
0	1		K471-a	KVGGRYLkGDHAGVL
0	1		K479-u	GDHAGVLkASAEtVD
0	1		T484-p	VLkASAEtVDPASLW

	mouse
Y23	LISCGNKYLTAEAFG
S38	FKVNASASsLkkKQI
S39-p	KVNASASsLkkKQIW
K41-a	NASASsLkkKQIWTL
K41-u	NASASsLkkKQIWTL
K42-u	ASASsLkkKQIWTLE
K74	GRYLAADKDGNVTCE
K74-u	GRYLAADkDGNVTCE
S120	GGTEDRLSCFAQSVS
Y145	MHPQVNIYSVTRKRY
T148	QVNIYSVTRKRYAHL
K220-u	TLEFRSGkVAFRDCE
T239	APSGPSGTLkAGKAT
K241-u	SGPSGTLkAGKATKV
K247	LkAGKATKVGKDELF
K304	EIDRDTRKCAFRTHT
Y314	FRTHTGKYWTLTATG
K353	TLRASNGKFVTAKKN
K359	GKFVTAKKNGQLAAS
K399-u	HGFIGCRkVTGtLDA
T403-p	GCRkVTGtLDANRSS
K464-u	DYNKVALkVGGRYLk
K471-u	kVGGRYLkGDHAGVL
K471	kVGGRYLKGDHAGVL
K479	GDHAGVLKACAETID
T484	VLKACAETIDPASLW

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