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Protein Page:
FKBP4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FKBP4 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. Note: This description may include information from UniProtKB.
Protein type: EC 5.2.1.8; Isomerase; Chaperone
Cellular Component: microtubule; membrane; cytoplasm; nucleolus; intracellular; cytosol; nucleus
Molecular Function: protein binding, bridging; protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; GTP binding; heat shock protein binding; phosphoprotein binding; tau protein binding; ATP binding; glucocorticoid receptor binding
Biological Process: prostate gland development; male sex differentiation; peptidyl-proline modification; steroid hormone receptor complex assembly; protein peptidyl-prolyl isomerization; protein complex localization; protein folding; androgen receptor signaling pathway; negative regulation of microtubule polymerization or depolymerization; copper ion transport; embryo implantation
Reference #:  Q02790 (UniProtKB)
Alt. Names/Synonyms: 52 kD FK506 binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506 binding protein 52; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP-52; FKBP4; FKBP52; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Hsp56; Immunophilin FKBP52; p52; p59; p59 protein; Peptidyl-prolyl cis-trans isomerase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; peptidylprolyl cis-trans isomerase; PPIase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD
Gene Symbols: FKBP4
Molecular weight: 51,805 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FKBP4
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 76 K28-u EGVDISPkQDEGVLk
0 1 K35 kQDEGVLKVIKREGT
0 8 K35-u kQDEGVLkVIKREGT
0 1 K38 EGVLkVIKREGTGTE
0 2 M46 REGTGTEMPMIGDRV
0 1 K74 FDSSLDRKDkFsFDL
0 2 K76-u SSLDRKDkFsFDLGk
0 1 S78-p LDRKDkFsFDLGkGE
0 2 K83-u kFsFDLGkGEVIkAW
0 1 K88-u LGkGEVIkAWDIAIA
1 0 T143 EFKGEDLTEEEDGGI
0 5 Y161-p IQTRGEGyAKPNEGA
0 2 K181-u LEGYYKDkLFDQREL
0 2 S217-p RMEKGEHsIVyLkPS
0 223 Y220-p KGEHsIVyLkPSyAF
0 2 K222-u EHsIVyLkPSyAFGS
0 2 Y225-p IVyLkPSyAFGSVGk
0 2 K232-a yAFGSVGkEKFQIPP
0 1 K232 yAFGSVGKEKFQIPP
0 1 K244-u IPPNAELkYELHLkS
0 1 K250-u LkYELHLkSFEKAKE
0 1 K274-a LEQSTIVkERGTVYF
0 1 K274-u LEQSTIVkERGTVYF
0 1 K282-a ERGTVYFkEGKyKQA
0 1 K282-u ERGTVYFkEGKyKQA
0 1 Y286-p VYFkEGKyKQALLQy
0 2 Y293-p yKQALLQykKIVSWL
0 1 K294-a KQALLQykKIVSWLE
0 1 S305-p SWLEYESsFSNEEAQ
0 4 K354-u ELDSNNEkGLFRRGE
0 1 K378-a LARADFQkVLQLYPN
0 1 K378-u LARADFQkVLQLYPN
0 2 K387 LQLYPNNKAAkTQLA
0 4 K390-u YPNNKAAkTQLAVCQ
0 2 K409-u RQLAREKkLyANMFE
1 192 Y411-p LAREKkLyANMFERL
0 3 K424-u RLAEEENkAkAEAss
0 1 K426-u AEEENkAkAEAssGD
0 1 S430-p NkAkAEAssGDHPtD
0 3 S431-p kAkAEAssGDHPtDt
0 28 T436-p AssGDHPtDtEMkEE
0 6 T438-p sGDHPtDtEMkEEQK
0 6 K441-u HPtDtEMkEEQKSNt
0 2 T448-p kEEQKSNtAGsQsQV
0 25 S451-p QKSNtAGsQsQVETE
0 14 S453-p SNtAGsQsQVETEA_
  mouse

 
K28-u EGVDISPkQDEGVLk
K35-a kQDEGVLkVIkREGT
K35-u kQDEGVLkVIkREGT
K38-a EGVLkVIkREGTGTE
T46-p REGTGTEtPMIGDRV
K74-u FDSSLDRkDKFsFDL
K76 SSLDRkDKFsFDLGk
S78-p LDRkDKFsFDLGkGE
K83-u KFsFDLGkGEVIKAW
K88 LGkGEVIKAWDIAVA
T143 EFKGEDLTEEEDGGI
Y161 IRTRGEGYARPNDGA
R181 LEGYHKDRLFDQREL
S217 RMEKGEHSIVyLkPS
Y220-p KGEHSIVyLkPSyAF
K222-u EHSIVyLkPSyAFGS
Y225-p IVyLkPSyAFGSVGk
K232 yAFGSVGKERFQIPP
K232-u yAFGSVGkERFQIPP
R244 IPPHAELRYEVRLKS
K250 LRYEVRLKSFEKAKE
K274 LEQSNIVKERGTAYF
K274 LEQSNIVKERGTAYF
K282 ERGTAYFKEGKYKQA
K282 ERGTAYFKEGKYKQA
Y286 AYFKEGKYKQALLQY
Y293 YKQALLQYKKIVSWL
K294 KQALLQYKKIVSWLE
S305 SWLEYESSFSGEEMQ
K354-u ELDSNNEkGLFRRGE
K378 LARADFQKVLQLYPS
K378 LARADFQKVLQLYPS
K387-u LQLYPSNkAAkTQLA
K390-u YPSNkAAkTQLAVCQ
K409-u RQLAREKkLyANMFE
Y411-p LAREKkLyANMFERL
K424-u RLAEEEHkVKAEVAA
K426 AEEEHkVKAEVAAGD
A430 HkVKAEVAAGDHPTD
A431 kVKAEVAAGDHPTDA
T436 VAAGDHPTDAEMkGE
A438 AGDHPTDAEMkGERN
K441-u HPTDAEMkGERNNVA
- gap
N450 ERNNVAENQSRVETE
S452 NNVAENQSRVETEA_
  rat

 
K28 EGVDISPKQDEGVLK
K35 KQDEGVLKVIKREGT
K35 KQDEGVLKVIKREGT
K38 EGVLKVIKREGTGTE
T46 REGTGTETAMIGDRV
K74 FDSSLDRKDKFSFDL
K76 SSLDRKDKFSFDLGK
S78 LDRKDKFSFDLGKGE
K83 KFSFDLGKGEVIKAW
K88 LGKGEVIKAWDIAVA
T143 EFKGEDLTEDEDGGI
Y161 IRTRGEGYARPNDGA
R181 LEGYYNDRLFDQREL
S217 RMEKGEHSIVYLKPS
Y220 KGEHSIVYLKPSYAF
K222 EHSIVYLKPSYAFGS
Y225 IVYLKPSYAFGSVGK
K232 YAFGSVGKERFQIPP
K232 YAFGSVGKERFQIPP
R244 IPPHAELRYEVHLKS
K250 LRYEVHLKSFEKAKA
K274 LEQSNIVKERGTVYF
K274 LEQSNIVKERGTVYF
K282 ERGTVYFKEGKYKQA
K282 ERGTVYFKEGKYKQA
Y286 VYFKEGKYKQALLQY
Y293 YKQALLQYKKIVSWL
K294 KQALLQYKKIVSWLE
S305 SWLEYESSFSGEEMQ
K354 ELDSNNEKGLFRRGE
K378 LARADFQKVLQLYPS
K378 LARADFQKVLQLYPS
K387 LQLYPSNKAAKTQLA
K390 YPSNKAAKTQLAVCQ
K409 RQLAREKKLyANMFE
Y411-p LAREKKLyANMFERL
K424 RLAEEEHKAKTEVAA
K426 AEEEHKAKTEVAAGD
A430 HKAKTEVAAGDHPTD
A431 KAKTEVAAGDHPTDA
T436 VAAGDHPTDAEMKGE
A438 AGDHPTDAEMKGEPN
K441 HPTDAEMKGEPNNVA
- gap
N450 EPNNVAGNQAQVKTE
A452 NNVAGNQAQVKTEA_
  rabbit

 
K28 EGVDISPKQDEGVLK
K35 KQDEGVLKVIKREGT
K35 KQDEGVLKVIKREGT
K38 EGVLKVIKREGTGTE
T46 REGTGTETPMIGDRV
K74 FDSSLDRKDKFSFDL
K76 SSLDRKDKFSFDLGK
S78 LDRKDKFSFDLGKGE
K83 KFSFDLGKGEVIKAW
K88 LGKGEVIKAWDIAVA
T143-p EFKGEDLtDDEDGGI
Y161 IRTRGEGYARPNDGA
R181 LEGYYKDRLFDQREL
S217 RMEKGEHSILYLKPS
Y220 KGEHSILYLKPSYAF
K222 EHSILYLKPSYAFGN
Y225 ILYLKPSYAFGNAGK
K232 YAFGNAGKEKFQIPP
K232 YAFGNAGKEKFQIPP
K244 IPPYAELKYEVHLKS
K250 LKYEVHLKSFEKAKE
K274 LEQSAIVKERGTVYF
K274 LEQSAIVKERGTVYF
K282 ERGTVYFKEGKYKQA
K282 ERGTVYFKEGKYKQA
Y286 VYFKEGKYKQALLQY
Y293 YKQALLQYKKIVSWL
K294 KQALLQYKKIVSWLE
S305 SWLEYESSFSSEEVQ
K354 ELDSNNEKGLFRRGE
K378 LARADFQKVLQLYPS
K378 LARADFQKVLQLYPS
K387 LQLYPSNKAAKAQLA
K390 YPSNKAAKAQLAVCQ
K409 KQIAREKKLYANMFE
Y411 IAREKKLYANMFERL
K424 RLAEEENKAKAEVAA
K426 AEEENKAKAEVAAGD
A430 NKAKAEVAAGDHPMD
A431 KAKAEVAAGDHPMDT
M436 VAAGDHPMDTEMKDE
T438 AGDHPMDTEMKDERN
K441 HPMDTEMKDERNDVA
- gap
S450 ERNDVAGSQSQVETE
S452 NDVAGSQSQVETEA_
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