Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC 220.127.116.11; Isomerase
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component: nucleoplasm; microtubule; endoplasmic reticulum membrane; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding, bridging; protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; GTP binding; heat shock protein binding; phosphoprotein binding; tau protein binding; copper-dependent protein binding; ATP binding; glucocorticoid receptor binding
Biological Process: prostate gland development; male sex differentiation; steroid hormone receptor complex assembly; protein peptidyl-prolyl isomerization; protein complex localization; protein folding; negative regulation of microtubule polymerization; negative regulation of microtubule polymerization or depolymerization; androgen receptor signaling pathway; copper ion transport; embryo implantation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.