an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Transferase
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cell-cell adherens junction; cornified envelope; intrinsic to membrane
Molecular Function: protein binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding
Biological Process: keratinocyte differentiation; cell envelope organization and biogenesis; organ morphogenesis; keratinization; protein modification process; peptide cross-linking
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.