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Protein Page:
TGM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGM1 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Note: This description may include information from UniProtKB.
Protein type: Transferase; EC 2.3.2.13
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cell-cell adherens junction; cornified envelope; intrinsic to membrane
Molecular Function: protein binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding
Biological Process: cell envelope organization and biogenesis; keratinocyte differentiation; organ morphogenesis; keratinization; protein modification process; peptide cross-linking
Reference #:  P22735 (UniProtKB)
Alt. Names/Synonyms: Epidermal TGase; ICR2; KTG; LI; LI1; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGASE; TGase K; TGase-1; TGK; TGM1; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Transglutaminase K; transglutaminase, keratinocyte; Transglutaminase-1
Gene Symbols: TGM1
Molecular weight: 89,787 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below

TGM1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T21 GNPLQPPTTPsPEPE
0 1 T22 NPLQPPTTPsPEPEP
1 3 S24-p LQPPTTPsPEPEPEP
0 1 G33 EPEPEPDGRSRRGGG
0 1 S74 DSRGRGSSSGTRRPG
1 0 S82-p SGTRRPGsRGsDSRR
1 0 S85-p RRPGsRGsDSRRPVs
1 8 S92-p sDSRRPVsRGSGVNA
0 8 S95 RRPVsRGSGVNAAGD
0 3 T104-p VNAAGDGtIREGMLV
0 2 Y134-p REHHTDEyEyDELIV
0 4 Y136-p HHTDEyEyDELIVRR
0 1 K187 HVIIPVGKGGSGGWK
0 1 K199 GWKAQVVKASGQNLN
0 1 Y267-p HEDWRQEyVLNESGR
0 1 Y312-p LDRRGMPyGGRGDPV
0 1 Y365-p SVEILLSyLRTGySV
0 1 Y370-p LSyLRTGySVPYGQC
0 1 T559-p AERKAVEtAAAHGsK
0 1 S565-p EtAAAHGsKPNVyAN
0 11 Y570-p HGsKPNVyANRGSAE
0 1 S755-p ETVTLRQsFVPVRPG
0 4 L805 DAGGDSHLGETIPMA
0 1 S813 GETIPMASRGGA___
  mouse

 
T20-p RSPWQPPttPsPEPE
T21-p SPWQPPttPsPEPEP
S23-p WQPPttPsPEPEPEP
S36-p EPEPDRRsRSRRGGG
S77-p GSRSRGTsSRGRDSR
S83 TsSRGRDSRGGRRPE
G86 RGRDSRGGRRPEsRG
S91-p RGGRRPEsRGsGVNA
S94-p RRPEsRGsGVNAAGD
T103-p VNAAGDGtIREGMLV
F133 REHHTDEFEYDELIV
Y135 HHTDEFEYDELIVRR
K186-ub HVIIPVGkGGSGGWK
K198-ub GWKAQVTkNNGHNLN
Y266 HEDWRQEYVLNESGR
Y311 LDRRGMPYGGRGDPV
Y364 SVEILLSYLRTGYSV
Y369 LSYLRTGYSVPYGQC
K558 AERRAVEKAAAHGSK
S564 EKAAAHGSKPNVYAT
Y569 HGSKPNVYATRDSAE
T754 ETVTLRQTFVPVRPG
S803-p DAGGDSRsGENIPMA
Y811-p GENIPMAyRGGA___
  rat

 
T19 GRSPWQPTTPsPEPE
T20 RSPWQPTTPsPEPEP
S22-p PWQPTTPsPEPEPEP
S35 EPEPDRSSRSRRGGG
S76 GSRSRGTSSRGGGSR
S82 TSSRGGGSRGGDSRG
G85 RGGGSRGGDSRGRDS
S92 GDSRGRDSRGGRRPE
S103-p RRPESRGsGVNAAGD
T112 VNAAGDGTIREGMLV
F142 REHHTDEFEYDELIL
Y144 HHTDEFEYDELILRR
K195 HVIIPVGKGGSGGWK
K207 GWKAQVTKTNGHNLT
Y275 HEDWRQEYVLNESGR
Y320 LDRRGMPYGGRGDPV
Y373 SVEILLSYLRTGYSV
Y378 LSYLRTGYSVPYGQC
K567 AERKAVEKAAAHGSK
S573 EKAAAHGSKPNVYAT
Y578 HGSKPNVYATRDSAE
T763 ETVTLRQTFVPVRPG
S812-p EAVGDSRsGENIPMA
F820 GENIPMAFRGGA___
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