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Protein Page:
AFAP1L2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AFAP1L2 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator protein; Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: cytoplasm
Molecular Function: protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding
Biological Process: positive regulation of interleukin-8 production; positive regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; regulation of mitotic cell cycle; regulation of interleukin-6 production; inflammatory response
Reference #:  Q8N4X5 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; FLJ14564; KIAA1914; XB130
Gene Symbols: AFAP1L2
Molecular weight: 91,300 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AFAP1L2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y54‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S50-p LYTKSSSsDEEyIyM
1 175 Y54-p SSSsDEEyIyMNKVt
0 108 Y56-p SsDEEyIyMNKVtIN
0 2 T61-p yIyMNKVtINKQQNA
0 2 S70 NKQQNAESQGKAPEE
0 1 A113 IPERKQLAIPKTEsP
0 6 S119-p LAIPKTEsPEGYyEE
0 17 Y124-p TEsPEGYyEEAEPYD
0 1 S142 NEDGEAVSSSYESYD
0 1 S147 AVSSSYESYDEEDGS
0 1 Y161-p SKGKSAPyQWPSPEA
0 13 Y301-p KPDIAEKyLSASEyG
0 4 Y307-p KyLSASEyGSSVDGH
0 29 S344-p MNLGRKKstsLEPVE
0 8 T345-p NLGRKKstsLEPVER
0 8 S346-p LGRKKstsLEPVERS
0 1 S358-p ERSLETSsyLNVLVN
0 25 Y359-p RSLETSsyLNVLVNS
0 316 Y383-p RDNHLHFyQDRNRSK
0 1 S397-p KVAQQPLsLVGCEVV
0 94 S408-p CEVVPDPsPDHLysF
0 1360 Y413-p DPsPDHLysFRILHK
0 129 S414-p PsPDHLysFRILHKG
0 1 S431-p LAKLEAKssEEMGHW
0 1 S432-p AKLEAKssEEMGHWL
0 2 T456-p KTDPEEFtyDyVDAD
0 4 Y457-p TDPEEFtyDyVDADR
0 57 Y459-p PEEFtyDyVDADRVs
0 1 S466-p yVDADRVsCIVSAAK
0 11 S484-p LLMQRKFsEPNTyID
0 1 T488 RKFsEPNTyIDGLPS
0 2 Y489-p KFsEPNTyIDGLPSQ
0 20 Y537-p ERESDRVyLDLtPVK
0 2 T541-p DRVyLDLtPVKSFLH
0 1 Y668-p TEAEVKRytEEKERL
0 1 T669-p EAEVKRytEEKERLE
0 1 K697-ac RKEKRELkETLLKCT
0 1 S767-p TTHLENVsPRPKAVt
0 1 T774-p sPRPKAVtPASAPDC
0 1 T788-p CTPVNSAtTLKNRPL
0 2 S796-p TLKNRPLsVVVTGKG
  mouse

 
S50 LYTKSSSSDEEyIyM
Y54-p SSSSDEEyIyMNKVS
Y56-p SSDEEyIyMNKVSVN
S61 yIyMNKVSVNGEQNS
S70 NGEQNSASPDKVPEE
T113-p IPERKQPtVPKIEsP
S119-p PtVPKIEsPEGYyEE
Y124-p IEsPEGYyEEAEPFD
S142-p NEDGEAVsSSYEsYD
S147-p AVsSSYEsYDEDENS
Y161 SKGKAAPYQWPSPEA
Y301 KPDIAEKYLSAAEYG
Y307 KYLSAAEYGITINGH
S344-p MNLGRKKstsLEPPE
T345-p NLGRKKstsLEPPER
S346-p LGRKKstsLEPPERS
S358 ERSLETSSYLNVLVN
Y359 RSLETSSYLNVLVNS
Y383-p RDSHLHFyQDRNRSK
S397 KVAQQPLSLVGCDVL
S408-p CDVLPDPsPDHLysF
Y413-p DPsPDHLysFRILHN
S414-p PsPDHLysFRILHNG
S431 LAKLEAKSSEEMGHW
S432 AKLEAKSSEEMGHWL
T456 KTDPEELTyDyVDAE
Y457-p TDPEELTyDyVDAER
Y459-p PEELTyDyVDAERVS
S466 yVDAERVSCIVSAAK
S484-p LLMQRKFsEPNtYID
T488-p RKFsEPNtYIDGLPS
Y489 KFsEPNtYIDGLPSR
Y537-p GSEPDRVyLDLTPVK
T541 DRVyLDLTPVKSFLH
Y673 TEAEVKRYTEEKERL
T674 EAEVKRYTEEKERLE
K702 RREKRELKETLLRCT
S772 TTHLDNMSPRPQPKA
T781 RPQPKAATPNPPPDS
S795 STPVNSASVLKNRPL
S803-p VLKNRPLsVMVTGKG
  rat

 
S50 LYTKSSSSDEEYIYM
Y54 SSSSDEEYIYMNKVA
Y56 SSDEEYIYMNKVAVN
A61 YIYMNKVAVNKEQNP
S70-p NKEQNPAsPDKVPEE
T114 IPERKQPTIPKIESP
S120 PTIPKIESPEGYYEE
Y125 IESPEGYYEEAEPFD
S143 NEDGEAVSSSYESYD
S148 AVSSSYESYDEEESS
Y162 SKGKTAPYQWPSPEA
Y302 KPDIAEKYMSASEYG
Y308 KYMSASEYGITTDGH
S345-p MNLGRKKsTSLEPPD
T346 NLGRKKsTSLEPPDR
S347 LGRKKsTSLEPPDRS
S359 DRSLETSSYLNVLVN
Y360 RSLETSSYLNVLVNS
Y384 RDSHLHFYQDRNRGK
S398 KMAQQPLSLVGCDVL
S409 CDVLPDPSPDHLySF
Y414-p DPSPDHLySFRILHN
S415 PSPDHLySFRILHNG
S432 LAKLEAKSSEEMGHW
S433 AKLEAKSSEEMGHWL
T457 KTDPEELTYDYVDAE
Y458 TDPEELTYDYVDAER
Y460 PEELTYDYVDAERVS
S467 YVDAERVSCIVSAAK
S485-p LLMQRKFsEPNTYID
T489 RKFsEPNTYIDGLPS
Y490 KFsEPNTYIDGLPSR
Y544 GSDLDRVYLDLtPVK
T548-p DRVYLDLtPVKSFLH
Y680 TEAEVKRYTEEKRRL
T681 EAEVKRYTEEKRRLE
K709 RREKRELKETLLRCT
S779 TTHLDNMSPRPQPKA
T788 RPQPKAATPTSTPDS
S802 STPVNSASVLKNRPL
S810 VLKNRPLSVMVTGKG
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