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Protein Page:
AFAP1L2 (human)

Overview
AFAP1L2 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Activator protein
Cellular Component: cytoplasm
Molecular Function: protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding
Biological Process: positive regulation of interleukin-8 production; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of mitotic cell cycle; regulation of interleukin-6 production; inflammatory response
Reference #:  Q8N4X5 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; FLJ14564; KIAA1914; XB130
Gene Symbols: AFAP1L2
Molecular weight: 91,300 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AFAP1L2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y54‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 178 Y54-p SSSSDEEyIyMNKVt
0 114 Y56-p SSDEEyIyMNKVtIN
0 3 T61-p yIyMNKVtINKQQNA
0 1 S70 NKQQNAESQGKAPEE
0 1 A113 IPERKQLAIPKTEsP
0 6 S119-p LAIPKTEsPEGYyEE
0 17 Y124-p TEsPEGYyEEAEPYD
0 1 S142 NEDGEAVSSSYESYD
0 1 S147 AVSSSYESYDEEDGS
0 1 Y161-p SKGKSAPyQWPSPEA
0 1 Y301-p KPDIAEKyLSASEyG
0 4 Y307-p KyLSASEyGSSVDGH
0 29 S344-p MNLGRKKstsLEPVE
0 8 T345-p NLGRKKstsLEPVER
0 8 S346-p LGRKKstsLEPVERS
0 5 S358-p ERSLETSsyLNVLVN
0 34 Y359-p RSLETSsyLNVLVNS
0 332 Y383-p RDNHLHFyQDRNRSK
0 1 S397-p KVAQQPLsLVGCEVV
0 92 S408-p CEVVPDPsPDHLysF
0 1395 Y413-p DPsPDHLysFRILHK
0 157 S414-p PsPDHLysFRILHKG
0 2 T456-p KTDPEEFtyDyVDAD
0 4 Y457-p TDPEEFtyDyVDADR
0 50 Y459-p PEEFtyDyVDADRVS
0 8 S484-p LLMQRKFsEPNTYID
0 1 T488 RKFsEPNTYIDGLPS
0 6 Y537-p ERESDRVyLDLtPVK
0 1 T541-p DRVyLDLtPVKSFLH
0 2 S796-p TLKNRPLsVVVTGKG
  mouse

 
Y54-p SSSSDEEyIyMNKVS
Y56-p SSDEEyIyMNKVSVN
S61 yIyMNKVSVNGEQNS
S70 NGEQNSASPDKVPEE
T113-p IPERKQPtVPKIEsP
S119-p PtVPKIEsPEGYyEE
Y124-p IEsPEGYyEEAEPFD
S142-p NEDGEAVsSSYEsYD
S147-p AVsSSYEsYDEDENS
Y161 SKGKAAPYQWPSPEA
Y301 KPDIAEKYLSAAEYG
Y307 KYLSAAEYGITINGH
S344-p MNLGRKKstsLEPPE
T345-p NLGRKKstsLEPPER
S346-p LGRKKstsLEPPERS
S358 ERSLETSSYLNVLVN
Y359 RSLETSSYLNVLVNS
Y383-p RDSHLHFyQDRNRSK
S397 KVAQQPLSLVGCDVL
S408-p CDVLPDPsPDHLysF
Y413-p DPsPDHLysFRILHN
S414-p PsPDHLysFRILHNG
T456 KTDPEELTyDyVDAE
Y457-p TDPEELTyDyVDAER
Y459-p PEELTyDyVDAERVS
S484-p LLMQRKFsEPNtYID
T488-p RKFsEPNtYIDGLPS
Y537-p GSEPDRVyLDLTPVK
T541 DRVyLDLTPVKSFLH
S803-p VLKNRPLsVMVTGKG
  rat

 
Y54 SSSSDEEYIYMNKVA
Y56 SSDEEYIYMNKVAVN
A61 YIYMNKVAVNKEQNP
S70-p NKEQNPAsPDKVPEE
T114 IPERKQPTIPKIESP
S120 PTIPKIESPEGYYEE
Y125 IESPEGYYEEAEPFD
S143 NEDGEAVSSSYESYD
S148 AVSSSYESYDEEESS
Y162 SKGKTAPYQWPSPEA
Y302 KPDIAEKYMSASEYG
Y308 KYMSASEYGITTDGH
S345-p MNLGRKKsTSLEPPD
T346 NLGRKKsTSLEPPDR
S347 LGRKKsTSLEPPDRS
S359 DRSLETSSYLNVLVN
Y360 RSLETSSYLNVLVNS
Y384 RDSHLHFYQDRNRGK
S398 KMAQQPLSLVGCDVL
S409 CDVLPDPSPDHLySF
Y414-p DPSPDHLySFRILHN
S415 PSPDHLySFRILHNG
T457 KTDPEELTYDYVDAE
Y458 TDPEELTYDYVDAER
Y460 PEELTYDYVDAERVS
S485-p LLMQRKFsEPNTYID
T489 RKFsEPNTYIDGLPS
Y544 GSDLDRVYLDLTPVK
T548 DRVYLDLTPVKSFLH
S810 VLKNRPLSVMVTGKG
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