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Protein Page:
TAF15 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAF15 RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Translation; RNA binding protein
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; nucleotide binding
Biological Process: positive regulation of transcription, DNA-dependent
Reference #:  Q92804 (UniProtKB)
Alt. Names/Synonyms: 68 kDa TATA-binding protein-associated factor; hTAFII68; Npl3; RBP56; RBP56/CSMF fusion; RNA-binding protein 56; TAF(II)68; TAF15; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; TAF2N; TAFII68; TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56); TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA-binding protein-associated factor 2N; TBP-associated factor 15
Gene Symbols: TAF15
Molecular weight: 61,830 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAF15

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y50-p DSSYGQNySGYSSYG
0 5 Y70-p YSQSYGGyENQKQss
0 1 S76-p GyENQKQssysQQPy
0 2 S77-p yENQKQssysQQPyN
0 53 Y78-p ENQKQssysQQPyNN
0 20 S79-p NQKQssysQQPyNNQ
0 28 Y83-p ssysQQPyNNQGQQQ
0 2 S94-p GQQQNMEssGsQGGR
0 6 S95-p QQQNMEssGsQGGRA
0 40 S97-p QNMEssGsQGGRAPs
0 1 S104-p sQGGRAPsYDQPDyG
0 1 Y110-p PsYDQPDyGQQDsyD
0 1 S115-p PDyGQQDsyDQQSGY
0 1 Y116-p DyGQQDsyDQQSGYD
0 2 Y135-p SYDEQSNyDQQHdSy
0 1 D140-ca SNyDQQHdSySQNQQ
0 1 Y142-p yDQQHdSySQNQQSy
0 2 Y149-p ySQNQQSyHSQRENY
0 2 S157-p HSQRENYsHHtQDDR
0 2 T160-p RENYsHHtQDDRRDV
0 1 Y170-p DRRDVSRyGEDNrGy
0 1 R175-m1 SRyGEDNrGyGGsQG
0 1 Y177-p yGEDNrGyGGsQGGG
0 4 S180-p DNrGyGGsQGGGrGr
0 9 R185-m1 GGsQGGGrGrGGyDK
0 1 R185-m2 GGsQGGGrGrGGyDK
0 11 R187-m1 sQGGGrGrGGyDKDG
0 1 Y190-p GGrGrGGyDKDGrGP
0 1 R195-m1 GGyDKDGrGPMtGss
0 1 T199-p KDGrGPMtGssGGDr
0 2 S201-p GrGPMtGssGGDrGG
0 1 S202-p rGPMtGssGGDrGGF
0 23 R206-m1 tGssGGDrGGFKNFG
0 3 R206-m2 tGssGGDrGGFKNFG
0 2 Y218-p NFGGHRDyGPRtDAD
0 3 T222-p HRDyGPRtDADsESD
0 2 S226-p GPRtDADsESDNsDN
0 3 S231-p ADsESDNsDNNTIFV
0 2 K265-ub GIIKTNKkTGkPMIN
0 2 K268-ac KTNKkTGkPMINLYT
0 1 K268-ub KTNKkTGkPMINLYT
0 1 K277-m2 MINLYTDkDTGKPKG
0 1 K277-ub MINLYTDkDTGKPKG
0 2 K297-ub FDDPPSAkAAIDWFD
0 7 K306-ac AIDWFDGkEFHGNII
0 1 K306-ub AIDWFDGkEFHGNII
0 8 R326-m1 TRRPEFMrGGGsGGG
0 1 S330-p EFMrGGGsGGGRrGR
0 1 R335-m1 GGsGGGRrGRGGYRG
0 1 K354-ac QGRGGDPkSGDWVCP
0 5 S375-p MNFARRNsCNQCNEP
0 1 R388-m1 EPRPEDSrPSGGDFr
0 4 R395-m1 rPSGGDFrGrGYGGE
0 2 R397-m1 SGGDFrGrGYGGErG
0 1 R397-m2 SGGDFrGrGYGGErG
0 2 R403-m1 GrGYGGErGYRGRGG
0 2 R415-m1 RGGRGGDrGGyGGDR
0 1 Y418-p RGGDrGGyGGDRSGG
0 2 Y427-p GDRSGGGyGGDrSsG
0 2 R431-m1 GGGyGGDrSsGGGys
0 4 S433-p GyGGDrSsGGGysGD
0 4 Y437-p DrSsGGGysGDRSGG
0 2 S438-p rSsGGGysGDRSGGG
0 3 Y446-p GDRSGGGyGGDRSGG
0 10 R450 GGGyGGDRSGGGyGG
0 4 Y455-p GDRSGGGyGGDrGGG
0 35 R459-m1 GGGyGGDrGGGyGGD
0 4 Y463-p GGDrGGGyGGDrGGG
0 17 R467-m1 GGGyGGDrGGGyGGD
0 2 R467-m2 GGGyGGDrGGGyGGD
0 3 Y471-p GGDrGGGyGGDrGGG
0 32 R475-m1 GGGyGGDrGGGyGGD
0 2 R475-m2 GGGyGGDrGGGyGGD
0 3 Y479-p GGDrGGGyGGDrGGy
0 31 R483-m1 GGGyGGDrGGyGGDr
0 2 R483-m2 GGGyGGDrGGyGGDr
0 4 Y486-p yGGDrGGyGGDrGGG
0 16 R490-m1 rGGyGGDrGGGyGGD
0 3 Y494-p GGDrGGGyGGDrGGy
0 13 R498-m1 GGGyGGDrGGyGGDr
0 4 Y501-p yGGDrGGyGGDrGGy
0 6 R505-m1 rGGyGGDrGGyGGDr
0 2 Y508-p yGGDrGGyGGDrGGy
0 5 R512-m1 rGGyGGDrGGyGGDr
0 1 Y515-p yGGDrGGyGGDrGGY
0 4 R519-m1 rGGyGGDrGGYGGDR
0 14 R528-m1 GYGGDRSrGGyGGDr
0 10 R528-m2 GYGGDRSrGGyGGDr
0 1 Y531-p GDRSrGGyGGDrGGG
0 24 R535-m1 rGGyGGDrGGGSGYG
0 9 R535-m2 rGGyGGDrGGGSGYG
0 1 R553-m1 SGGYGGDrsGGGYGG
0 2 S554-p GGYGGDrsGGGYGGD
0 1 Y558 GDrsGGGYGGDrGGG
0 21 R562-m1 GGGYGGDrGGGYGGD
0 1 R562-m2 GGGYGGDrGGGYGGD
0 1 - gap
0 2 Y566 GGDrGGGYGGDrGGY
0 5 R570-m1 GGGYGGDrGGYGGKM
0 3 R570-m2 GGGYGGDrGGYGGKM
0 1 Y573 YGGDrGGYGGKMGGr
0 1 R580-m1 YGGKMGGrNDyRNDQ
0 1 Y583-p KMGGrNDyRNDQRNR
  mouse

 
Y50 DSSYGQNYGGYSGYG
Y70 YSQSYGSYENQKQSS
S76 SYENQKQSSYGQQSY
S77 YENQKQSSYGQQSYN
Y78 ENQKQSSYGQQSYNN
G79 NQKQSSYGQQSYNNQ
Y83 SSYGQQSYNNQGQQN
S93 QGQQNTESSGGQGGR
S94 GQQNTESSGGQGGRA
G96 QNTESSGGQGGRAPS
S103 GQGGRAPSYGQSDYG
Y109 PSYGQSDYGQQDSYD
S114 SDYGQQDSYDQQSGY
Y115 DYGQQDSYDQQSGYD
Y134 SYDEQSNYQQHDSYN
D138 QSNYQQHDSYNQNQQ
Y140 NYQQHDSYNQNQQSY
Y147 YNQNQQSYHSQRENY
S155 HSQRENYSHHTQDDR
T158 RENYSHHTQDDRRDV
Y168 DRRDVSRYGEDNRGY
R173 SRYGEDNRGYGGSQG
Y175 YGEDNRGYGGSQGGG
S178 DNRGYGGSQGGGrGr
R183-m1 GGSQGGGrGrGGYDK
R183 GGSQGGGRGrGGYDK
R185-m1 SQGGGrGrGGYDKDG
Y188 GGrGrGGYDKDGRGP
R193 GGYDKDGRGPMTGSS
T197 KDGRGPMTGSSGGDr
S199 GRGPMTGSSGGDrGG
S200 RGPMTGSSGGDrGGF
R204-m1 TGSSGGDrGGFKNFG
R204-m2 TGSSGGDrGGFKNFG
Y216 NFGGHRDYGPRPDAD
P220 HRDYGPRPDADSESD
S224 GPRPDADSESDNsDN
S229-p ADSESDNsDNNTIFV
K263-ub GIIKTNKkTGKPMIN
K266 KTNKkTGKPMINLYT
K266 KTNKkTGKPMINLYT
K275 MINLYTDKDTGKPKG
K275 MINLYTDKDTGKPKG
K295-ub FDDPPSAkAAIDWFD
K304 AIDWFDGKEFHGNII
K304 AIDWFDGKEFHGNII
R324-m1 TRRPEFMrGGGSGGG
S328 EFMrGGGSGGGRRGR
R333 GGSGGGRRGRGGYRG
K352 QGRGGDPKNGDWVCP
S373 MNFARRNSCNQCNEP
R386 EPRPEDSRPSGGDFR
R393 RPSGGDFRGRGYGGE
R395 SGGDFRGRGYGGERG
R395 SGGDFRGRGYGGERG
R401 GRGYGGERGYRGRGG
R413 RGGRGGDRGGYGGDR
Y416 RGGDRGGYGGDRSGG
Y425 GDRSGGGYGGDRSGG
R429 GGGYGGDRSGGGYGG
- gap
- gap
- gap
Y434 GDRSGGGYGGDrGGS
R438-m1 GGGYGGDrGGSYGGD
Y442 GGDrGGSYGGDrGGY
R446-m1 GGSYGGDrGGYGGDr
- gap
- gap
- gap
Y449 YGGDrGGYGGDrGGS
R453-m1 rGGYGGDrGGSYGGD
R453 rGGYGGDRGGSYGGD
Y457 GGDrGGSYGGDrGGY
R461-m1 GGSYGGDrGGYGGDr
R461 GGSYGGDRGGYGGDr
Y464 YGGDrGGYGGDrGGY
R468-m1 rGGYGGDrGGYGGDr
- gap
- gap
Y471 YGGDrGGYGGDrGGY
R475-m1 rGGYGGDrGGYGGDR
Y478 YGGDrGGYGGDRGGY
R482 rGGYGGDRGGYGGDR
Y485 YGGDRGGYGGDRGGY
R489 RGGYGGDRGGYGGDR
R498-m1 GYGGDRSrGAYGGDr
R498-m2 GYGGDRSrGAYGGDr
Y501 GDRSrGAYGGDrGGS
R505-m1 rGAYGGDrGGSGSGS
R505 rGAYGGDRGGSGSGS
R519 SGGYGGDRsGGyGGD
S520-p GGYGGDRsGGyGGDR
Y523-p GGDRsGGyGGDRsGG
R527 sGGyGGDRsGGyGGD
R527 sGGyGGDRsGGyGGD
S528-p GGyGGDRsGGyGGDr
Y531-p GGDRsGGyGGDrGGY
R535-m1 sGGyGGDrGGYGGKM
R535-m2 sGGyGGDrGGYGGKM
Y538 yGGDrGGYGGKMGGR
R545 YGGKMGGRNDYRNDQ
Y548 KMGGRNDYRNDQRNR
  rat

 
Y50 DSSYGQNYGGYSGYG
Y70 YSQSYGSYENQKQSS
S76 SYENQKQSSYGQQSY
S77 YENQKQSSYGQQSYN
Y78 ENQKQSSYGQQSYNN
G79 NQKQSSYGQQSYNNQ
Y83 SSYGQQSYNNQGQQN
S93 QGQQNTESSGGQGGR
S94 GQQNTESSGGQGGRA
G96 QNTESSGGQGGRAPS
S103 GQGGRAPSYGQSDYG
Y109 PSYGQSDYGQQDSYD
S114 SDYGQQDSYDQQSGY
Y115 DYGQQDSYDQQSGYD
Y134 SYDEQSNYQQHDSYN
D138 QSNYQQHDSYNQNQQ
Y140 NYQQHDSYNQNQQSY
Y147 YNQNQQSYHPQRENY
S155 HPQRENYSHHTQDDR
T158 RENYSHHTQDDRRDM
Y168 DRRDMSRYGEDNRGY
R173 SRYGEDNRGYGGSQG
Y175 YGEDNRGYGGSQGGG
S178 DNRGYGGSQGGGRGR
R183 GGSQGGGRGRGGYDK
R183 GGSQGGGRGRGGYDK
R185 SQGGGRGRGGYDKDG
Y188 GGRGRGGYDKDGRGP
R193 GGYDKDGRGPMTGSS
T197 KDGRGPMTGSSGGDr
S199 GRGPMTGSSGGDrGG
S200 RGPMTGSSGGDrGGF
R204-m1 TGSSGGDrGGFKNFG
R204 TGSSGGDRGGFKNFG
Y216 NFGGHRDYGPRPDAD
P220 HRDYGPRPDADSESD
S224 GPRPDADSESDNSDN
S229 ADSESDNSDNNTIFV
K263 GIIKTNKKTGKPMIN
K266 KTNKKTGKPMINLYT
K266 KTNKKTGKPMINLYT
K275 MINLYTDKDTGKPKG
K275 MINLYTDKDTGKPKG
K295 FDDPPSAKAAIDWFD
K304 AIDWFDGKEFHGNII
K304 AIDWFDGKEFHGNII
R324 TRRPEFMRGGGSGGG
S328 EFMRGGGSGGGRRGR
R333 GGSGGGRRGRGGYRG
K352 QGRGGDPKNGDWVCP
S373-p MNFARRNsCNQCNEP
R386 EPRPEDSRPSGGDFR
R393 RPSGGDFRGRGYGGE
R395 SGGDFRGRGYGGERG
R395 SGGDFRGRGYGGERG
R401 GRGYGGERGFRGRGG
R413 RGGRGGDRGGYGADR
Y416 RGGDRGGYGADRSGG
Y425 ADRSGGGYGGDRSGG
R429 GGGYGGDRSGGSYGA
- gap
- gap
- gap
Y434 GDRSGGSYGADRSGG
R438 GGSYGADRSGGGYGG
Y443 ADRSGGGYGGDRSGG
R447 GGGYGGDRSGGGYGG
- gap
- gap
- gap
Y452 GDRSGGGYGGDrGGG
R456-m1 GGGYGGDrGGGYGGD
R456 GGGYGGDRGGGYGGD
Y460 GGDrGGGYGGDrGGY
R464-m1 GGGYGGDrGGYGGDr
R464 GGGYGGDRGGYGGDr
Y467 YGGDrGGYGGDrGGS
R471-m1 rGGYGGDrGGSYGGD
Y475 GGDrGGSYGGDRGGY
R479 GGSYGGDRGGYGGDR
Y482 YGGDRGGYGGDRGGY
R486 RGGYGGDRGGYGGDR
Y489 YGGDRGGYGGDRGGY
R493 RGGYGGDRGGYGGDR
Y496 YGGDRGGYGGDRGGY
R500 RGGYGGDRGGYGGDR
R509 GYGGDRSRGAYGGDr
R509 GYGGDRSRGAYGGDr
Y512 GDRSRGAYGGDrGGG
R516-m1 RGAYGGDrGGGSGGY
R516 RGAYGGDRGGGSGGY
R535 SGGYGGDRGGGYGGD
- gap
Y539 GGDRGGGYGGDrGGy
R543-m1 GGGYGGDrGGyGGDR
R543 GGGYGGDRGGyGGDR
- gap
Y546-p YGGDrGGyGGDRGGy
R550 rGGyGGDRGGyGGKM
R550 rGGyGGDRGGyGGKM
Y553-p yGGDRGGyGGKMGGR
R560 yGGKMGGRNDYRNDQ
Y563 KMGGRNDYRNDQRNR
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