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PKAR1A (human)

Overview PKAR1A a regulatory subunit of cAMP-regulated protein kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Interacts with RFC2: the complex may be involved in cell survival. Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1). CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Note: This description may include information from UniProtKB. Protein type: Protein kinase, regulatory subunit Cellular Component: protein complex; neuromuscular junction; cytosol; cAMP-dependent protein kinase complex Molecular Function: protein binding; ubiquitin protein ligase binding; cAMP-dependent protein kinase regulator activity; cAMP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; regulation of transcription from RNA polymerase II promoter; mesoderm formation; phospholipase C activation; energy reserve metabolic process; blood coagulation; transmembrane transport; regulation of insulin secretion Reference #:  P10644 (UniProtKB) Alt. Names/Synonyms: cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; CAR; CNC; CNC1; DKFZp779L0468; KAP0; MGC17251; PKR1; PPNAD1; PRKAR1; PRKAR1A; protein kinase A type 1a regulatory subunit; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); Tissue-specific extinguisher 1; TSE1 Gene Symbols: PRKAR1A Molecular weight: 42,982 Da Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  GPCRs Signaling to MAPK/Erk  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKAR1A 1APK - A=2-380 (cow) 1BPK - A=2-380 (cow) 1NE4 - A=95-377 (cow) 1NE6 - A=95-377 (cow) 1PVK - A=114-245 (cow) 1RGS - A=93-380 (cow) 1RL3 - A/B=93-380 (cow) 1U7E - B=92-245 (cow) 2EZW - A/B=13-62 (cow) 2QCS - B=91-380 (cow) 3FHI - B=92-245 (cow) 3IIA - A=92-245 (cow) 3IM3 - A=13-62 (cow) 3IM4 - A/B=13-62 (cow) 3PLQ - A=92-245 (cow) 3PNA - A/B=92-245 (cow) 3PVB - B=85-244 (cow)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 160980 188550 188830 255960 610489  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: S83‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K24-u	ECELYVQkHNIQALL
0	6		K63-u	RLEKEEAkQIQNLQk
0	5		K70-u	kQIQNLQkAGTRtDs
0	9		T75-p	LQkAGTRtDsREDEI
0	38		S77-p	kAGTRtDsREDEIsP
1	281		S83-p	DsREDEIsPPPPNPV
0	3		K92-u	PPPNPVVkGRRRRGA
1	1		S101	RRRRGAISAEVYTEE
0	3		K123-u	KVIPKDYkTMAALAk
0	2		K130-a	kTMAALAkAIEKNVL
0	2		K222-u	VKAKTNVkLWGIDRD
0	4		K244-u	GSTLRKRkMYEEFLS
0	6		K252-u	MYEEFLSkVSILESL
0	88		K261-u	SILESLDkWERLTVA
0	2		T338-p	MNRPRAAtVVARGPL
0	5		K346-u	VVARGPLkCVkLDRP
0	40		K349-u	RGPLkCVkLDRPRFE
0	5		K367-a	GPCSDILkRNIQQyN
0	3		Y373-p	LkRNIQQyNsFVSLS
0	1		S375-p	RNIQQyNsFVSLSV_

	mouse
K153	ECELYVQKHNIQALL
R192	RLEKEEARQIQCLQk
K199-u	RQIQCLQkTGIRtDs
T204-p	LQkTGIRtDsREDEI
S206-p	kTGIRtDsREDEIsP
S212-p	DsREDEIsPPPPNPV
K221-u	PPPNPVVkGRRRRGA
S230-p	RRRRGAIsAEVYTEE
K252	KVIPKDYKTMAALAK
K259	KTMAALAKAIEKNVL
K351-u	VKAKTNVkLWGIDRD
K373-u	GSTLRKRkMYEEFLS
K381-u	MYEEFLSkVSILESL
K390-u	SILESLDkWERLTVA
T467-p	MNRPRAAtVVARGPL
K475-u	VVARGPLkCVkLDRP
K478-u	RGPLkCVkLDRPRFE
K496	GPCSDILKRNIQQYN
Y502	LKRNIQQYNSFVSLS
S504	RNIQQYNSFVSLSV_

	rat
K24	ECELYVQKHNIQALL
R63	RLEKEEARQIQSLQK
K70	RQIQSLQKSGIRtDs
T75-p	LQKSGIRtDsREDEI
S77-p	KSGIRtDsREDEIsP
S83-p	DsREDEIsPPPPNPV
K92	PPPNPVVKGRRRRGA
S101	RRRRGAISAEVYTEE
K123	KVIPKDYKTMAALAK
K130	KTMAALAKAIEKNVL
K222	VKAKTNVKLWGIDRD
K244	GSTLRKRKMYEEFLS
K252	MYEEFLSKVSILESL
K261	SILESLDKWERLTVA
T338	MNRPRAATVVARGPL
K346	VVARGPLKCVkLDRP
K349-u	RGPLKCVkLDRPRFE
K367	GPCSDILKRNIQQYN
Y373	LKRNIQQYNSFVSLS
S375	RNIQQYNSFVSLSV_

	cow
K23	ECELYVQKHNIQALL
K62	KLEKEEAKQIQNLQK
K69	KQIQNLQKAGSRADS
A74	LQKAGSRADSREDEI
S76	KAGSRADSREDEIsP
S82-p	DSREDEIsPPPPNPV
K91	PPPNPVVKGRRRRGA
S100-p	RRRRGAIsAEVYTEE
K122	KVIPKDYKTMAALAK
K129	KTMAALAKAIEKNVL
K221	VKAKTNVKLWGIDRD
K243	GSTLRKRKMYEEFLS
K251	MYEEFLSKVSILESL
K260	SILESLDKWERLTVA
T337	MNRPRAATVVARGPL
K345	VVARGPLKCVKLDRP
K348	RGPLKCVKLDRPRFE
K366	GPCSDILKRNIQQYN
Y372	LKRNIQQYNSFVSLS
S374	RNIQQYNSFVSLSV_

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