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Protein Page:
PKAR1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKAR1A a regulatory subunit of cAMP-regulated protein kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Interacts with RFC2: the complex may be involved in cell survival. Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1). CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Cellular Component: protein complex; membrane; plasma membrane; neuromuscular junction; cytosol; AMP-activated protein kinase complex; cAMP-dependent protein kinase complex
Molecular Function: protein binding; ubiquitin protein ligase binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; cAMP binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; female meiosis; cardiac muscle cell proliferation; sarcomere organization; signal transduction; regulation of transcription from RNA polymerase II promoter; mesoderm formation; phospholipase C activation; negative regulation of meiosis; energy reserve metabolic process; innate immune response; blood coagulation; transmembrane transport; regulation of insulin secretion
Reference #:  P10644 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; CAR; CNC; CNC1; DKFZp779L0468; KAP0; MGC17251; PKR1; PPNAD1; PRKAR1; PRKAR1A; protein kinase A type 1a regulatory subunit; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); Tissue-specific extinguisher 1; TSE1
Gene Symbols: PRKAR1A
Molecular weight: 42,982 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PKAR1A

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S77‑p, S83‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K24-ub ECELYVQkHNIQALL
0 6 K63-ub RLEKEEAkQIQNLQk
0 5 K70-ub kQIQNLQkAGTRtDs
0 1 A71 QIQNLQkAGTRtDsR
0 12 T75-p LQkAGTRtDsREDEI
1 45 S77-p kAGTRtDsREDEIsP
2 298 S83-p DsREDEIsPPPPNPV
0 3 K92-ub PPPNPVVkGRRRRGA
1 1 S101 RRRRGAISAEVYTEE
0 3 K123-ub KVIPKDYkTMAALAk
0 2 K130-ac kTMAALAkAIEKNVL
0 2 K222-ub VKAKTNVkLWGIDRD
0 4 K244-ub GSTLRKRkMYEEFLS
0 6 K252-ub MYEEFLSkVSILESL
0 88 K261-ub SILESLDkWERLTVA
0 2 T338-p MNRPRAAtVVARGPL
0 5 K346-ub VVARGPLkCVkLDRP
0 40 K349-ub RGPLkCVkLDRPRFE
0 5 K367-ac GPCSDILkRNIQQyN
0 3 Y373-p LkRNIQQyNsFVSLS
0 1 S375-p RNIQQyNsFVSLSV_
  mouse

 
K24 ECELYVQKHNIQALL
R63 RLEKEEARQIQCLQk
K70-ub RQIQCLQktGIRtDs
T71-p QIQCLQktGIRtDsR
T75-p LQktGIRtDsREDEI
S77-p ktGIRtDsREDEIsP
S83-p DsREDEIsPPPPNPV
K92-ub PPPNPVVkGRRRRGA
S101-p RRRRGAIsAEVYTEE
K123 KVIPKDYKTMAALAK
K130 KTMAALAKAIEKNVL
K222-ub VKAKTNVkLWGIDRD
K244-ub GSTLRKRkMYEEFLS
K252-ub MYEEFLSkVSILESL
K261-ub SILESLDkWERLTVA
T338-p MNRPRAAtVVARGPL
K346-ub VVARGPLkCVkLDRP
K349-ub RGPLkCVkLDRPRFE
K367 GPCSDILKRNIQQYN
Y373 LKRNIQQYNSFVSLS
S375 RNIQQYNSFVSLSV_
  rat

 
K24 ECELYVQKHNIQALL
R63 RLEKEEARQIQSLQK
K70 RQIQSLQKSGIRtDs
S71 QIQSLQKSGIRtDsR
T75-p LQKSGIRtDsREDEI
S77-p KSGIRtDsREDEIsP
S83-p DsREDEIsPPPPNPV
K92 PPPNPVVKGRRRRGA
S101 RRRRGAISAEVYTEE
K123 KVIPKDYKTMAALAK
K130 KTMAALAKAIEKNVL
K222 VKAKTNVKLWGIDRD
K244 GSTLRKRKMYEEFLS
K252 MYEEFLSKVSILESL
K261 SILESLDKWERLTVA
T338 MNRPRAATVVARGPL
K346 VVARGPLKCVkLDRP
K349-ub RGPLKCVkLDRPRFE
K367 GPCSDILKRNIQQYN
Y373 LKRNIQQYNSFVSLS
S375 RNIQQYNSFVSLSV_
  cow

 
K23 ECELYVQKHNIQALL
K62 KLEKEEAKQIQNLQK
K69 KQIQNLQKAGSRADS
A70 QIQNLQKAGSRADSR
A74 LQKAGSRADSREDEI
S76 KAGSRADSREDEIsP
S82-p DSREDEIsPPPPNPV
K91 PPPNPVVKGRRRRGA
S100-p RRRRGAIsAEVYTEE
K122 KVIPKDYKTMAALAK
K129 KTMAALAKAIEKNVL
K221 VKAKTNVKLWGIDRD
K243 GSTLRKRKMYEEFLS
K251 MYEEFLSKVSILESL
K260 SILESLDKWERLTVA
T337 MNRPRAATVVARGPL
K345 VVARGPLKCVKLDRP
K348 RGPLKCVKLDRPRFE
K366 GPCSDILKRNIQQYN
Y372 LKRNIQQYNSFVSLS
S374 RNIQQYNSFVSLSV_
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