Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Homotetramer (Potential). Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 188.8.131.52
Biological Process: dolichol-linked oligosaccharide biosynthetic process; unfolded protein response; glucosamine biosynthetic process; glutamine metabolic process; fructose 6-phosphate metabolic process; post-translational protein modification; carbohydrate biosynthetic process; protein homotetramerization; response to sucrose stimulus; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cellular response to insulin stimulus; energy reserve metabolic process; UDP-N-acetylglucosamine biosynthetic process; protein amino acid N-linked glycosylation via asparagine; circadian regulation of gene expression; negative regulation of glycogen biosynthetic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.