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GFAT (human)

Overview GFAT Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Homotetramer (Potential). Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.6.1.16; Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Amino Acid Metabolism - alanine, aspartate and glutamate Cellular Component: cytosol Molecular Function: amino acid binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate binding Biological Process: dolichol-linked oligosaccharide biosynthetic process; unfolded protein response; glucosamine biosynthetic process; glutamine metabolic process; fructose 6-phosphate metabolic process; post-translational protein modification; carbohydrate biosynthetic process; protein homotetramerization; response to sucrose stimulus; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cellular response to insulin stimulus; energy reserve metabolic process; UDP-N-acetylglucosamine biosynthetic process; protein amino acid N-linked glycosylation via asparagine; negative regulation of glycogen biosynthetic process Reference #:  Q06210 (UniProtKB) Alt. Names/Synonyms: D-fructose-6-phosphate amidotransferase 1; GFA; GFAT; GFAT 1; GFAT1; GFAT1m; GFPT; GFPT1; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine-fructose-6-phosphate transaminase 1; glutamine: fructose-6-phosphate amidotransferase-1; Glutamine:fructose 6 phosphate amidotransferase 1; Hexosephosphate aminotransferase 1 Gene Symbols: GFPT1 Molecular weight: 78,806 Da Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GFAT 2V4M - A/D/C/B=332-699 (human) 2ZJ3 - A=332-699 (human) 2ZJ4 - A=332-699 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2V4M 2ZJ3 2ZJ4  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: S261‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	3		K25-u	EILETLIkGLQRLEY
0	61		K48-u	GFDGGNDkDWEANAC
0	1		K139-u	LKKFLESkGYDFESE
0	1		T149-p	DFESETDtETIAKLV
0	5		K190-u	GAFALVFkSVHFPGQ
2	0		S205-p	AVGTRRGsPLLIGVR
2	0		S235-p	TARTQIGsKFTRWGS
0	1		K248	GSQGERGKDKKGsCN
0	1		K251	GERGKDKKGsCNLsR
0	47		S253-p	RGKDKKGsCNLsRVD
0	22		S257-p	KKGsCNLsRVDsttC
2	521		S261-p	CNLsRVDsttCLFPV
0	177		T262-p	NLsRVDsttCLFPVE
0	74		T263-p	LsRVDsttCLFPVEE
0	1		K345-u	NFSSFMQkEIFEQPE
0	1		K375-u	TVNLGGLkDHIKEIQ
0	1		T467-p	LTVGITNtVGsSIsR
0	1		S470-p	GITNtVGsSIsRETD
0	1		S473-p	NtVGsSIsRETDCGV
0	17		Y553-p	QKLATELyHQKsVLI
0	1		S557-p	TELyHQKsVLIMGRG
0	2		K650-a	TETIKNTkRTIKVPH

	GFAT iso2
K25	EILETLIKGLQRLEY
K48	GFDGGNDKDWEANAC
K139	LKKFLESKGYDFESE
T149	DFESETDTETIAKLV
K190	GAFALVFKSVHFPGQ
S205	AVGTRRGSPLLIGVR
-	gap
K230-u	PILYRTGkDKkGsCN
K233-u	YRTGkDKkGsCNLsR
S235-p	TGkDKkGsCNLsRVD
S239-p	KkGsCNLsRVDsttC
S243-p	CNLsRVDsttCLFPV
T244-p	NLsRVDsttCLFPVE
T245-p	LsRVDsttCLFPVEE
K327	NFSSFMQKEIFEQPE
K357	TVNLGGLKDHIKEIQ
T449	LTVGITNTVGSSISR
S452	GITNTVGSSISRETD
S455	NTVGSSISRETDCGV
Y535	QKLATELYHQKSVLI
S539	TELYHQKSVLIMGRG
K632	TETIKNTKRTIKVPH

	mouse ► Hide Isoforms
K25-u	EILETLIkGLQRLEY
K48-u	GLDGGNDkDWEANAC
K139	LKKFLESKGYDFESE
T149	DFESETDTETIAKLV
K190	GAFALVFKSVHFPGQ
S205	AVGTRRGSPLLIGVR
S235	TARTQIGSTWWGSQA
K246	GSQAERGKDKKGsCG
K249	AERGKDKKGsCGLSR
S251-p	RGKDKKGsCGLSRVD
S255	KKGsCGLSRVDsttC
S259-p	CGLSRVDsttCLFPV
T260-p	GLSRVDsttCLFPVE
T261-p	LSRVDsttCLFPVEE
K343	NFSSFMQKEIFEQPE
K373	TVNLGGLKDHIKEIQ
T465	LTVGITNTVGSSISR
S468	GITNTVGSSISRETD
S471	NTVGSSISRETDCGV
Y551-p	QKLATELyHQKSVLI
S555	TELyHQKSVLIMGRG
K648	TETIKNTKRTIKVPH

	GFAT iso2
K25	EILETLIKGLQRLEY
K48	GLDGGNDKDWEANAC
K139	LKKFLESKGYDFESE
T149	DFESETDTETIAKLV
K190	GAFALVFKSVHFPGQ
S205	AVGTRRGSPLLIGVR
-	gap
K230	PILYRTGKDKKGSCG
K233	YRTGKDKKGSCGLSR
S235	TGKDKKGSCGLSRVD
S239	KKGSCGLSRVDStTC
S243	CGLSRVDStTCLFPV
T244-p	GLSRVDStTCLFPVE
T245	LSRVDStTCLFPVEE
K327	NFSSFMQKEIFEQPE
K357	TVNLGGLKDHIKEIQ
T449	LTVGITNTVGSSISR
S452	GITNTVGSSISRETD
S455	NTVGSSISRETDCGV
Y535	QKLATELYHQKSVLI
S539	TELYHQKSVLIMGRG
K632	TETIKNTKRTIKVPH

	rat
K25	EILETLIKGLQRLEY
K48-u	GLDGGNDkDWEANAC
K139	LKKFLESKGYDFESE
T149	DFESETDTETIAKLV
K190	GAFALVFKSVHFPGQ
S205	AVGTRRGSPLLIGVR
-	gap
K230	PILYRTGKDKKGSCG
K233	YRTGKDKKGSCGLSR
S235	TGKDKKGSCGLSRVD
S239	KKGSCGLSRVDstTC
S243-p	CGLSRVDstTCLFPV
T244-p	GLSRVDstTCLFPVE
T245	LSRVDstTCLFPVEE
K327	NFSSFMQKEIFEQPE
K357	TVNLGGLKDHIKEIQ
T449	LTVGITNTVGSSISR
S452	GITNTVGSSISRETD
S455	NTVGSSISRETDCGV
Y535	QKLATELYHQKSVLI
S539	TELYHQKSVLIMGRG
K632	TETIKNTKRTIKVPH

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