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Protein Page:
GFAT (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GFAT Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Homotetramer (Potential). Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.6.1.16; Transferase; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Amino Acid Metabolism - alanine, aspartate and glutamate
Cellular Component: cytosol
Molecular Function: amino acid binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate binding
Biological Process: dolichol-linked oligosaccharide biosynthetic process; unfolded protein response; glucosamine biosynthetic process; glutamine metabolic process; fructose 6-phosphate metabolic process; post-translational protein modification; carbohydrate biosynthetic process; protein homotetramerization; response to sucrose stimulus; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cellular response to insulin stimulus; energy reserve metabolic process; UDP-N-acetylglucosamine biosynthetic process; protein amino acid N-linked glycosylation via asparagine; negative regulation of glycogen biosynthetic process
Reference #:  Q06210 (UniProtKB)
Alt. Names/Synonyms: D-fructose-6-phosphate amidotransferase 1; GFA; GFAT; GFAT 1; GFAT1; GFAT1m; GFPT; GFPT1; Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine-fructose-6-phosphate transaminase 1; glutamine: fructose-6-phosphate amidotransferase-1; Glutamine:fructose 6 phosphate amidotransferase 1; Hexosephosphate aminotransferase 1
Gene Symbols: GFPT1
Molecular weight: 78,806 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GFAT

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S261‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 K25-u EILETLIkGLQRLEY
0 61 K48-u GFDGGNDkDWEANAC
0 1 S103-p WATHGEPsPVNSHPQ
0 1 K139-u LKKFLESkGYDFESE
0 5 K190-u GAFALVFkSVHFPGQ
2 1 S205-p AVGTRRGsPLLIGVR
2 0 S235-p TARTQIGsKFTRWGS
0 47 S253-p RGKDKKGsCNLsRVD
0 22 S257-p KKGsCNLsRVDsttC
2 527 S261-p CNLsRVDsttCLFPV
0 177 T262-p NLsRVDsttCLFPVE
0 74 T263-p LsRVDsttCLFPVEE
0 1 K345-u NFSSFMQkEIFEQPE
0 1 K375-u TVNLGGLkDHIKEIQ
0 1 T467-p LTVGITNtVGSSISR
0 18 Y553-p QKLATELyHQKSVLI
0 2 K650-a TETIKNTkRTIKVPH
  GFAT iso2  
K25 EILETLIKGLQRLEY
K48 GFDGGNDKDWEANAC
S103 WATHGEPSPVNSHPQ
K139 LKKFLESKGYDFESE
K190 GAFALVFKSVHFPGQ
S205 AVGTRRGSPLLIGVR
- gap
S235-p TGKDKKGsCNLsRVD
S239-p KKGsCNLsRVDsttC
S243-p CNLsRVDsttCLFPV
T244-p NLsRVDsttCLFPVE
T245-p LsRVDsttCLFPVEE
K327 NFSSFMQKEIFEQPE
K357 TVNLGGLKDHIKEIQ
T449 LTVGITNTVGSSISR
Y535 QKLATELYHQKSVLI
K632 TETIKNTKRTIKVPH
  mouse

► Hide Isoforms
 
K25-u EILETLIkGLQRLEY
K48-u GLDGGNDkDWEANAC
N103 WATHGEPNPVNSHPQ
K139 LKKFLESKGYDFESE
K190 GAFALVFKSVHFPGQ
S205 AVGTRRGSPLLIGVR
S235 TARTQIGSTWWGSQA
S251-p RGKDKKGsCGLsRVD
S255-p KKGsCGLsRVDsttC
S259-p CGLsRVDsttCLFPV
T260-p GLsRVDsttCLFPVE
T261-p LsRVDsttCLFPVEE
K343 NFSSFMQKEIFEQPE
K373 TVNLGGLKDHIKEIQ
T465 LTVGITNTVGSSISR
Y551-p QKLATELyHQKSVLI
K648 TETIKNTKRTIKVPH
  GFAT iso2  
K25 EILETLIKGLQRLEY
K48 GLDGGNDKDWEANAC
N103 WATHGEPNPVNSHPQ
K139 LKKFLESKGYDFESE
K190 GAFALVFKSVHFPGQ
S205 AVGTRRGSPLLIGVR
- gap
S235 TGKDKKGSCGLSRVD
S239 KKGSCGLSRVDStTC
S243 CGLSRVDStTCLFPV
T244-p GLSRVDStTCLFPVE
T245 LSRVDStTCLFPVEE
K327 NFSSFMQKEIFEQPE
K357 TVNLGGLKDHIKEIQ
T449 LTVGITNTVGSSISR
Y535 QKLATELYHQKSVLI
K632 TETIKNTKRTIKVPH
  rat

 
K25 EILETLIKGLQRLEY
K48-u GLDGGNDkDWEANAC
S103 WATHGEPSPVNSHPQ
K139 LKKFLESKGYDFESE
K190 GAFALVFKSVHFPGQ
S205 AVGTRRGSPLLIGVR
- gap
S235 TGKDKKGSCGLSRVD
S239 KKGSCGLSRVDstTC
S243-p CGLSRVDstTCLFPV
T244-p GLSRVDstTCLFPVE
T245 LSRVDstTCLFPVEE
K327 NFSSFMQKEIFEQPE
K357 TVNLGGLKDHIKEIQ
T449 LTVGITNTVGSSISR
Y535 QKLATELYHQKSVLI
K632 TETIKNTKRTIKVPH
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