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Protein Page:
SynGAP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SynGAP an excitatory synapse-specific RasGAP. Member of the NMDAR signaling complex in excitatory synapses it may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity. ERK activation is up-regulated in neurons from SynGAP knockout mice, whereas P38 MAPK function is depressed. May play a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. Interacts with CAMK2A/CAMK2B and MPDZ. Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Contains a PH domain and a Ras-GAP domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Ras
Cellular Component: cytoplasm; dendritic shaft
Molecular Function: Rab GTPase activator activity; SH3 domain binding; Ras GTPase activator activity
Biological Process: regulation of long-term neuronal synaptic plasticity; positive regulation of Ras GTPase activity; regulation of MAPKKK cascade; regulation of synapse structure and activity; Ras protein signal transduction; dendrite development; negative regulation of Ras protein signal transduction; regulation of synaptic plasticity; visual learning; negative regulation of axonogenesis; negative regulation of neuron apoptosis; receptor clustering; pattern specification process
Reference #:  Q96PV0 (UniProtKB)
Alt. Names/Synonyms: DKFZp761G1421; KIAA1938; MRD5; Neuronal RasGAP; Ras GTPase-activating protein SynGAP; RASA1; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; SYNGAP1
Gene Symbols: SYNGAP1
Molecular weight: 148,284 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SynGAP

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 68 Y18 GSIPAMSYAPFRDVR
0 64 Y34 PSMHRTQYVHSPYDR
0 88 Y39 TQYVHSPYDRPGWNP
0 5 S87 KLLRRTVSVPVEGRP
0 25 Y100 RPHGEHEYHLGRSRR
0 2 S105 HEYHLGRSRRKSVPG
0 3 S109 LGRSRRKSVPGGKQY
0 19 Y116 SVPGGKQYSMEGAPA
0 7 S117 VPGGKQYSMEGAPAA
0 2 S155 PKLDRTSSFRQILPR
0 1 S176 DRARLMQSFKESHSH
0 1 S302 TSKPRSASGDTVFWG
0 1 K339 DKKRKKDKAGYVGLV
0 33 Y342 RKKDKAGYVGLVTVP
0 2 S371 PVTLPTGSGGSGGMG
0 2 S374 LPTGSGGSGGMGSGG
1 1 S379 GGSGGMGSGGGGGSG
1 0 S385 GSGGGGGSGGGSGGK
1 1 S449-p KGKEEVAsALVHILQ
1 0 S466 GKAKDFLSDMAMSEV
0 2 K492 RENTLATKAIEEYMR
0 1 K507 LIGQKYLKDAIGEFI
0 1 S571 ELKEVFASWRLRCAE
0 1 K638 QNLANFSKFTSKEDF
0 1 K710 LSKEALLKLGPLPRL
0 1 T723 RLLNDISTALRNPNI
0 1 P743 RQSERPRPQPVVLRG
0 4 S752 PVVLRGPSAEMQGYM
0 45 Y758 PSAEMQGYMMRDLNS
1 1 S765 YMMRDLNSSIDLQSF
1 3 S766 MMRDLNSSIDLQSFM
1 4 S780 MARGLNSSMDMARLP
0 3 K793 LPSPTKEKPPPPPPG
0 31 Y807 GGGKDLFYVSRPPLA
0 1 R810 KDLFYVSRPPLARSS
0 61 Y820 LARSSPAYCTSSSDI
0 3 T822 RSSPAYCTSSSDITE
0 3 S823 SSPAYCTSSSDITEP
0 2 S824 SPAYCTSSSDITEPE
0 5 S825 PAYCTSSSDITEPEQ
0 5 T828 CTSSSDITEPEQKML
0 8 K833 DITEPEQKMLSVNKs
1 0 S836 EPEQKMLSVNKsVsM
0 6 K839 QKMLSVNKsVsMLDL
1 1 S840-p KMLSVNKsVsMLDLQ
1 1 S842-p LSVNKsVsMLDLQGD
0 3 S873 VGDLLHSSQASLTAA
0 1 S876 LLHSSQASLTAALGL
0 5 S892 PAPAGRLSQGSGSSI
0 1 S892 PAPAGRLSQGSGSSI
1 6 S895 AGRLSQGSGSSITAA
0 2 S898 LSQGSGSSITAAGMR
0 2 S907-p TAAGMRLsQMGVtTD
0 3 T912-p RLsQMGVtTDGVPAQ
0 39 Y982 TFAPFHGYSKSEDLS
0 1 S983 FAPFHGYSKSEDLSS
0 1 S985 PFHGYSKSEDLSSGV
0 2 S1003 PAASILHSHSYSDEF
0 2 S1005 ASILHSHSYSDEFGP
0 21 Y1006 SILHSHSYSDEFGPS
0 1 S1053 PSGPGGGSGGGSGGG
0 1 S1057 GGGSGGGSGGGGGGQ
2 3 S1073 PPLQRGKSQQLTVSA
0 3 K1083 LTVSAAQKPRPSSGN
0 23 Y1099 LQSPEPSYGPARPRQ
0 2 K1111 PRQQSLSKEGsIGGS
2 4 S1114-p QSLSKEGsIGGSGGS
1 1 S1118 KEGsIGGSGGSGGGG
1 3 S1121 sIGGSGGSGGGGGGG
0 11 K1130 GGGGGGLKPSITKQH
0 1 T1134 GGLKPSITKQHSQTP
0 2 K1135 GLKPSITKQHSQTPS
1 1 S1138 PSITKQHSQTPSTLN
0 1 S1138 PSITKQHSQTPSTLN
0 1 T1140 ITKQHSQTPSTLNPT
0 1 S1142 KQHSQTPSTLNPTMP
0 2 T1143 QHSQTPSTLNPTMPA
0 1 S1151 LNPTMPASERTVAWV
0 5 S1165 VSNMPHLSADIESAH
0 2 Y1178 AHIEREEYKLKEYSK
0 1 K1196 ESRLDRVKEYEEEIH
0 6 Y1198 RLDRVKEYEEEIHSL
0 6 S1204 EYEEEIHSLKERLHM
0 6 S1225 EYERRLLSQEEQTSK
0 4 K1232 SQEEQTSKILMQYQA
0 6 Y1237 TSKILMQYQARLEQS
0 4 K1260 AEKDSQIKsIIGRLM
0 2 S1261-p EKDSQIKsIIGRLML
  SynGAP iso2  
Y18 GSIPAMSYAPFRDVR
Y34 PSMHRTQYVHSPYDR
Y39 TQYVHSPYDRPGWNP
S87 KLLRRTVSVPVEGRP
Y100 RPHGEHEYHLGRSRR
S105 HEYHLGRSRRKSVPG
S109 LGRSRRKSVPGGKQY
Y116 SVPGGKQYSMEGAPA
S117 VPGGKQYSMEGAPAA
S155 PKLDRTSSFRQILPR
S176 DRARLMQSFKESHSH
S302 TSKPRSASGDTVFWG
K339 DKKRKKDKAGYVGLV
Y342 RKKDKAGYVGLVTVP
S371 PVTLPTGSGGSGGMG
S374 LPTGSGGSGGMGSGG
S379 GGSGGMGSGGGGGSG
S385 GSGGGGGSGGGSGGK
S449 KGKEEVASALVHILQ
S466 GKAKDFLSDMAMSEV
K492 RENTLATKAIEEYMR
K507 LIGQKYLKDAIGEFI
S571 ELKEVFASWRLRCAE
K638 QNLANFSKFTSKEDF
K710 LSKEALLKLGPLPRL
T723 RLLNDISTALRNPNI
P743 RQSERPRPQPVVLRG
S752 PVVLRGPSAEMQGYM
Y758 PSAEMQGYMMRDLNS
S765 YMMRDLNSSIDLQSF
S766 MMRDLNSSIDLQSFM
S780 MARGLNSSMDMARLP
K793 LPSPTKEKPPPPPPG
Y807 GGGKDLFYVSRPPLA
R810 KDLFYVSRPPLARSS
Y820 LARSSPAYCTSSSDI
T822 RSSPAYCTSSSDITE
S823 SSPAYCTSSSDITEP
S824 SPAYCTSSSDITEPE
S825 PAYCTSSSDITEPEQ
T828 CTSSSDITEPEQKML
K833 DITEPEQKMLSVNKS
S836 EPEQKMLSVNKSVSM
K839 QKMLSVNKSVSMLDL
S840 KMLSVNKSVSMLDLQ
S842 LSVNKSVSMLDLQGD
S873 VGDLLHSSQASLTAA
S876 LLHSSQASLTAALGL
S892 PAPAGRLSQGSGSSI
S892 PAPAGRLSQGSGSSI
S895 AGRLSQGSGSSITAA
S898 LSQGSGSSITAAGMR
S907 TAAGMRLSQMGVTTD
T912 RLSQMGVTTDGVPAQ
Y982 TFAPFHGYSKSEDLS
S983 FAPFHGYSKSEDLSS
S985 PFHGYSKSEDLSSGV
S1003 PAASILHSHSYSDEF
S1005 ASILHSHSYSDEFGP
Y1006 SILHSHSYSDEFGPS
S1053 PSGPGGGSGGGSGGG
S1057 GGGSGGGSGGGGGGQ
S1073 PPLQRGKSQQLTVSA
K1083 LTVSAAQKPRPSSGN
Y1099 LQSPEPSYGPARPRQ
K1111 PRQQSLSKEGsIGGS
S1114-p QSLSKEGsIGGSGGS
S1118 KEGsIGGSGGSGGGG
S1121 sIGGSGGSGGGGGGG
K1130 GGGGGGLKPSITKQH
T1134 GGLKPSITKQHSQTP
K1135 GLKPSITKQHSQTPS
S1138 PSITKQHSQTPSTLN
S1138 PSITKQHSQTPSTLN
T1140 ITKQHSQTPSTLNPT
S1142 KQHSQTPSTLNPTMP
T1143 QHSQTPSTLNPTMPA
S1151 LNPTMPASERTVAWV
S1165 VSNMPHLSADIESAH
Y1178 AHIEREEYKLKEYSK
K1196 ESRLDRVKEYEEEIH
Y1198 RLDRVKEYEEEIHSL
S1204 EYEEEIHSLKERLHM
S1225 EYERRLLSQEEQTSK
K1232 SQEEQTSKILMQYQA
Y1237 TSKILMQYQARLEQS
K1260 AEKDSQIKSIIGSPS
S1261 EKDSQIKSIIGSPSL
  mouse

 
Y18-p GSIPAMSyAPFRDVR
Y34-p PPMHRTQyVHSPyDR
Y39-p TQyVHSPyDRPGWNP
S87-p KLLRRTVsVPVEGRP
Y100-p RPHGEHEyHLGRsRR
S105-p HEyHLGRsRRKsVPG
S109-p LGRsRRKsVPGGKQY
Y116 sVPGGKQYsMEAAPA
S117-p VPGGKQYsMEAAPAA
S155-p PKLDRTSsFRQILPR
S176-p DRARLMQsFKESHSH
S302-p TSKPRSAsGDTVFWG
K339-u DKKRKKDkAGyVGLV
Y342-p RKKDkAGyVGLVTVP
S371-p PVTLPTGsGGsGGMG
S374-p LPTGsGGsGGMGsGG
S379-p GGsGGMGsGGGGGsG
S385-p GsGGGGGsGGGSGGK
S449 KGKEEVASALVHILQ
S466 GKAKDFLSDMAMSEV
K492-u RENTLATkAIEEYMR
K507-u LIGQKYLkDAIGEFI
S571-p ELKEVFAsWRLRCAE
K638-u QNLANFSkFTSKEDF
K710-u LSKEALLkLGPLPRL
T723-p RLLNDIStALRNPNI
S743-p RQSERTRsQPMVLRG
S752-p PMVLRGPsAEMQGyM
Y758-p PsAEMQGyMMRDLNs
S765-p yMMRDLNssIDLQSF
S766-p MMRDLNssIDLQSFM
S780-p MARGLNSsMDMARLP
K793-u LPSPTKEkPPPPPPG
Y807-p GGGKDLFyVSrPPLA
R810-m2 KDLFyVSrPPLARSS
Y820-p LARSSPAyCtsssDI
T822-p RSSPAyCtsssDItE
S823-p SSPAyCtsssDItEP
S824-p SPAyCtsssDItEPE
S825-p PAyCtsssDItEPEQ
T828-p CtsssDItEPEQkML
K833-u DItEPEQkMLSVNkS
S836 EPEQkMLSVNkSVSM
K839-u QkMLSVNkSVSMLDL
S840 kMLSVNkSVSMLDLQ
S842 LSVNkSVSMLDLQGD
S873-p VGDLLHSsQAsLTAA
S876-p LLHSsQAsLTAALGL
S892-p PAPAGRLsQGsGSsI
S892-gl PAPAGRLsQGsGSsI
S895-p AGRLsQGsGSsITAA
S898-p LsQGsGSsITAAGMR
S907-p TAAGMRLsQMGVtTD
T912-p RLsQMGVtTDGVPAQ
Y982-p TFAPFHGysKsEDLS
S983-gl FAPFHGysKsEDLSS
S985-p PFHGysKsEDLSSGV
S1003-p PAASILHsHsySDEF
S1005-p ASILHsHsySDEFGP
Y1006-p SILHsHsySDEFGPS
S1053-p PSGPGGGsGGGsGGG
S1057-p GGGsGGGsGGGQPPP
S1070-p PPLQRGKsQQLTVSA
K1080 LTVSAAQKPRPSSGN
Y1096 LQSPEPSYGPARPRQ
K1108-u PRQQSLSkEGsIGGs
S1111-p QSLSkEGsIGGsGGs
S1115-p kEGsIGGsGGsGGGG
S1118-p sIGGsGGsGGGGGGG
K1127-u GGGGGGLkPSItKQH
T1131-gl GGLkPSItKQHsQtP
K1132 GLkPSItKQHsQtPs
S1135 PSItKQHSQtPstLN
S1135-gl PSItKQHsQtPstLN
T1137-gl ItKQHsQtPstLNPT
S1139-gl KQHsQtPstLNPTMP
T1140-gl QHsQtPstLNPTMPA
S1148-gl LNPTMPAsERTVAWV
S1162-p VSNMPHLsADIESAH
Y1175 AHIEREEYKLKEYSK
K1193-u ESRLDRVkEYEEEIH
Y1195 RLDRVkEYEEEIHsL
S1201-p EYEEEIHsLKERLHM
S1222-p EYERRLLsQEEQTSk
K1229-u sQEEQTSkILMQYQA
Y1234 TSkILMQYQARLEQS
K1257-u VEKDSQIksIIGRLM
S1258-p EKDSQIksIIGRLML
  rat

► Hide Isoforms
 
Y18-p GSIPAMSyAPFRDVR
Y34-p PPMHRTQyVHSPyDR
Y39-p TQyVHSPyDRPGWNP
S87 KLLRRTVSVPVEGRP
Y100-p RPHGEHEyHLGRSRR
S105 HEyHLGRSRRKSVPG
S109 LGRSRRKSVPGGKQy
Y116-p SVPGGKQySMEAAPA
S117 VPGGKQySMEAAPAA
S155 PKLDRTSSFRQILPR
S176 DRARLMQSFKESHSH
S302 TSKPRSASGDTVFWG
K339 DKKRKKDKAGyVGLV
Y342-p RKKDKAGyVGLVTVP
S371 PVTLPTGSGGSGGMG
S374 LPTGSGGSGGMGSGG
S379 GGSGGMGSGGGGGSG
S385 GSGGGGGSGGGSGGK
S449 KGKEEVASALVHILQ
S466 GKAKDFLSDMAMSEV
K492-u RENTLATkAIEEYMR
K507 LIGQKYLKDAIGEFI
S571 ELKEVFASWRLRCAE
K638 QNLANFSKFTSKEDF
K710 LSKEALLKLGPLPRL
T723 RLLSDISTALRNPNI
S743 RQSERARSQPMVLRG
S752 PMVLRGPSAEMQGyM
Y758-p PSAEMQGyMMRDLNs
S765-p yMMRDLNssIDLQSF
S766-p MMRDLNssIDLQSFM
S780-p MARGLNSsMDMARLP
K793-u LPSPTKEkPPPPPPG
Y807-p GGGKDLFyVSRPPLA
R810 KDLFyVSRPPLARSS
Y820-p LARSSPAyCTSSSDI
T822 RSSPAyCTSSSDITE
S823 SSPAyCTSSSDITEP
S824 SPAyCTSSSDITEPE
S825 PAyCTSSSDITEPEQ
T828 CTSSSDITEPEQkML
K833-u DITEPEQkMLSVNkS
S836 EPEQkMLSVNkSVSM
K839-u QkMLSVNkSVSMLDL
S840 kMLSVNkSVSMLDLQ
S842 LSVNkSVSMLDLQGD
S873 VGDLLHSSQASLTAA
S876 LLHSSQASLTAALGL
S892-p PAPAGRLsQGsGSSI
S892 PAPAGRLSQGsGSSI
S895-p AGRLsQGsGSSITAA
S898 LsQGsGSSITAAGMR
S907 TAAGMRLSQMGVTTD
T912 RLSQMGVTTDGVPAQ
Y982-p TFAPFHGySKSEDLS
S983 FAPFHGySKSEDLST
S985 PFHGySKSEDLSTGV
S1003 PAASILHSHSySDEF
S1005 ASILHSHSySDEFGP
Y1006-p SILHSHSySDEFGPS
S1053 PSGPGGGSGGGSGGG
S1057 GGGSGGGSGGGGGGQ
S1073-p PPLQRGKsQQLTVSA
K1083-u LTVSAAQkPRPSSGN
Y1099-p LQSPEPSyGPARPRQ
K1111-u PRQQSLSkEGsIGGs
S1114-p QSLSkEGsIGGsGGs
S1118-p kEGsIGGsGGsGGGG
S1121-p sIGGsGGsGGGGGGG
K1130-u GGGGGGLkPSITkQH
T1134 GGLkPSITkQHsQTP
K1135-u GLkPSITkQHsQTPS
S1138-p PSITkQHsQTPSTLN
S1138 PSITkQHSQTPSTLN
T1140 ITkQHsQTPSTLNPT
S1142 kQHsQTPSTLNPTMP
T1143 QHsQTPSTLNPTMPA
S1151 LNPTMPASERTVAWV
S1165 VSNMPHLSADIESAH
Y1178-p AHIEREEyKLKEYSK
K1196 ESRLDRVKEyEEEIH
Y1198-p RLDRVKEyEEEIHSL
S1204 EyEEEIHSLKERLHM
S1225-p EYERRLLsQEEQTSK
K1232 sQEEQTSKILMQyQA
Y1237-p TSKILMQyQARLEQS
K1260 VEKDSQIKSIIGRLM
S1261 EKDSQIKSIIGRLML
  SynGAP iso3  
- gap
- gap
- gap
- gap
Y41 SCCFPGEYHLGRSRR
S46 GEYHLGRSRRKSVPG
S50 LGRSRRKSVPGGKQY
Y57 SVPGGKQYSMEAAPA
S58 VPGGKQYSMEAAPAA
S96 PKLDRTSSFRQILPR
S117 DRARLMQSFKESHSH
S243 TSKPRSASGDTVFWG
K280 DKKRKKDKAGYVGLV
Y283 RKKDKAGYVGLVTVP
S312 PVTLPTGSGGSGGMG
S315 LPTGSGGSGGMGsGG
S320-p GGSGGMGsGGGGGsG
S326-p GsGGGGGsGGGSGGK
S390-p KGKEEVAsALVHILQ
S407-p GKAKDFLsDMAMSEV
K433 RENTLATKAIEEYMR
K448 LIGQKYLKDAIGEFI
S512 ELKEVFASWRLRCAE
K579 QNLANFSKFTSKEDF
K651 LSKEALLKLGPLPRL
T664 RLLSDISTALRNPNI
S684 RQSERARSQPMVLRG
S693 PMVLRGPSAEMQGYM
Y699 PSAEMQGYMMRDLNS
S706 YMMRDLNSSIDLQSF
S707 MMRDLNSSIDLQSFM
S721 MARGLNSSMDMARLP
K734 LPSPTKEKPPPPPPG
Y748 GGGKDLFYVSRPPLA
R751 KDLFYVSRPPLARSS
Y761 LARSSPAYCTSSSDI
T763 RSSPAYCTSSSDITE
S764 SSPAYCTSSSDITEP
S765 SPAYCTSSSDITEPE
S766 PAYCTSSSDITEPEQ
T769 CTSSSDITEPEQKML
K774 DITEPEQKMLsVNKs
S777-p EPEQKMLsVNKsVsM
K780 QKMLsVNKsVsMLDL
S781-p KMLsVNKsVsMLDLQ
S783-p LsVNKsVsMLDLQGD
S814 VGDLLHSSQASLTAA
S817 LLHSSQASLTAALGL
S833 PAPAGRLSQGsGSSI
S833 PAPAGRLSQGsGSSI
S836-p AGRLSQGsGSSITAA
S839 LSQGsGSSITAAGMR
S848 TAAGMRLSQMGVTTD
T853 RLSQMGVTTDGVPAQ
Y923 TFAPFHGYSKSEDLS
S924 FAPFHGYSKSEDLST
S926 PFHGYSKSEDLSTGV
S944 PAASILHSHSYSDEF
S946 ASILHSHSYSDEFGP
Y947 SILHSHSYSDEFGPS
S994 PSGPGGGSGGGSGGG
S998 GGGSGGGSGGGGGGQ
S1014 PPLQRGKSQQLTVSA
K1024 LTVSAAQKPRPSSGN
Y1040 LQSPEPSYGPARPRQ
K1052 PRQQSLSKEGSIGGS
S1055 QSLSKEGSIGGSGGS
S1059 KEGSIGGSGGSGGGG
S1062 SIGGSGGSGGGGGGG
K1071 GGGGGGLKPSITKQH
T1075 GGLKPSITKQHSQTP
K1076 GLKPSITKQHSQTPS
S1079 PSITKQHSQTPSTLN
S1079 PSITKQHSQTPSTLN
T1081 ITKQHSQTPSTLNPT
S1083 KQHSQTPSTLNPTMP
T1084 QHSQTPSTLNPTMPA
S1092 LNPTMPASERTVAWV
S1106 VSNMPHLSADIESAH
Y1119 AHIEREEYKLKEYSK
K1137 ESRLDRVKEYEEEIH
Y1139 RLDRVKEYEEEIHSL
S1145 EYEEEIHSLKERLHM
S1166 EYERRLLSQEEQTSK
K1173 SQEEQTSKILMQYQA
Y1178 TSKILMQYQARLEQS
K1201 VEKDSQIKSIIGRLM
S1202 EKDSQIKSIIGRLML
  SynGAP iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S38 PKLDRTSSFRQILPR
S59 DRARLMQSFKESHSH
S185 TSKPRSASGDTVFWG
K222 DKKRKKDKAGyVGLV
Y225-p RKKDKAGyVGLVTVP
S254 PVTLPTGSGGSGGMG
S257 LPTGSGGSGGMGSGG
S262 GGSGGMGSGGGGGSG
S268 GSGGGGGSGGGSGGK
S332 KGKEEVASALVHILQ
S349 GKAKDFLSDMAMSEV
K375-u RENTLATkAIEEYMR
K390 LIGQKYLKDAIGEFI
S454 ELKEVFASWRLRCAE
K521 QNLANFSKFTSKEDF
K593 LSKEALLKLGPLPRL
T606 RLLSDISTALRNPNI
S626 RQSERARSQPMVLRG
S635 PMVLRGPSAEMQGyM
Y641-p PSAEMQGyMMRDLNS
S648 yMMRDLNSSIDLQSF
S649 MMRDLNSSIDLQSFM
S663 MARGLNSSMDMARLP
K676-u LPSPTKEkPPPPPPG
Y690-p GGGKDLFyVSRPPLA
R693 KDLFyVSRPPLARSS
Y703-p LARSSPAyCTSSSDI
T705 RSSPAyCTSSSDITE
S706 SSPAyCTSSSDITEP
S707 SPAyCTSSSDITEPE
S708 PAyCTSSSDITEPEQ
T711 CTSSSDITEPEQkML
K716-u DITEPEQkMLSVNkS
S719 EPEQkMLSVNkSVSM
K722-u QkMLSVNkSVSMLDL
S723 kMLSVNkSVSMLDLQ
S725 LSVNkSVSMLDLQGD
S756 VGDLLHSSQASLTAA
S759 LLHSSQASLTAALGL
S775-p PAPAGRLsQGsGSSI
S775 PAPAGRLSQGsGSSI
S778-p AGRLsQGsGSSITAA
S781 LsQGsGSSITAAGMR
S790 TAAGMRLSQMGVTTD
T795 RLSQMGVTTDGVPAQ
Y865-p TFAPFHGySKSEDLS
S866 FAPFHGySKSEDLST
S868 PFHGySKSEDLSTGV
S886 PAASILHSHSySDEF
S888 ASILHSHSySDEFGP
Y889-p SILHSHSySDEFGPS
S936 PSGPGGGSGGGSGGG
S940 GGGSGGGSGGGGGGQ
S956 PPLQRGKSQQLTVSA
K966-u LTVSAAQkPRPSSGN
Y982-p LQSPEPSyGPARPRQ
K994-u PRQQSLSkEGSIGGS
S997 QSLSkEGSIGGSGGS
S1001 kEGSIGGSGGSGGGG
S1004 SIGGSGGSGGGGGGG
K1013-u GGGGGGLkPSITkQH
T1017 GGLkPSITkQHSQTP
K1018-u GLkPSITkQHSQTPS
S1021 PSITkQHSQTPSTLN
S1021 PSITkQHSQTPSTLN
T1023 ITkQHSQTPSTLNPT
S1025 kQHSQTPSTLNPTMP
T1026 QHSQTPSTLNPTMPA
S1034 LNPTMPASERTVAWV
S1048 VSNMPHLSADIESAH
Y1061-p AHIEREEyKLKEYSK
R1077 MDESRLDREyEEEIH
Y1079-p ESRLDREyEEEIHSL
S1085 EyEEEIHSLKERLHM
S1106-p EYERRLLsQEEQTSK
K1113 sQEEQTSKILMQyQA
Y1118-p TSKILMQyQARLEQS
K1141 VEKDSQIKSIIGSPS
S1142 EKDSQIKSIIGSPSL
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