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SynGAP (human)

Overview SynGAP an excitatory synapse-specific RasGAP. Member of the NMDAR signaling complex in excitatory synapses it may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity. ERK activation is up-regulated in neurons from SynGAP knockout mice, whereas P38 MAPK function is depressed. May play a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. Interacts with CAMK2A/CAMK2B and MPDZ. Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Contains a PH domain and a Ras-GAP domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: GTPase activating protein, Ras Cellular Component: cytoplasm; dendritic shaft Molecular Function: Rab GTPase activator activity; phospholipid binding; Ras GTPase activator activity; SH3 domain binding Biological Process: regulation of long-term neuronal synaptic plasticity; regulation of synaptic plasticity; pattern specification process; receptor clustering; positive regulation of Ras GTPase activity; regulation of MAPKKK cascade; regulation of synapse structure and activity; Ras protein signal transduction; dendrite development; negative regulation of Ras protein signal transduction; visual learning; negative regulation of axonogenesis; negative regulation of apoptosis Reference #:  Q96PV0 (UniProtKB) Alt. Names/Synonyms: DKFZp761G1421; KIAA1938; MRD5; Neuronal RasGAP; Ras GTPase-activating protein SynGAP; RASA1; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; SYNGAP1 Gene Symbols: SYNGAP1 Molecular weight: 148,284 Da Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SynGAP 3BXJ - A/B=252-734 (rat)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S12	RASIHRGSIPAMSYA
0	68		Y18	GSIPAMSYAPFRDVR
0	64		Y34-p	PSMHRTQyVHsPyDR
0	1		S37-p	HRTQyVHsPyDRPGW
0	88		Y39-p	TQyVHsPyDRPGWNP
0	1		T85-p	RNKLLRRtVSVPVEG
0	5		S87	KLLRRtVSVPVEGRP
0	1		R93	VSVPVEGRPHGEHEY
0	25		Y100	RPHGEHEYHLGRsRR
0	1		R104	EHEYHLGRsRRKsVP
0	2		S105-p	HEYHLGRsRRKsVPG
0	3		S109-p	LGRsRRKsVPGGKQY
0	19		Y116	sVPGGKQYsMEGAPA
0	7		S117-p	VPGGKQYsMEGAPAA
0	1		K145-a	KSSIKRTkSQPKLDR
0	1		T153-p	SQPKLDRtSsFRQIL
0	2		S155-p	PKLDRtSsFRQILPR
0	1		S176	DRARLMQSFKESHSH
0	1		K241	RSAAERDKWIENLQR
0	1		S302	TSKPRSASGDTVFWG
0	1		K339	DKKRKKDKAGyVGLV
0	33		Y342-p	RKKDKAGyVGLVTVP
0	2		S371	PVTLPTGSGGSGGMG
0	2		S374	LPTGSGGSGGMGSGG
1	1		S379	GGSGGMGSGGGGGSG
1	0		S385	GSGGGGGSGGGSGGK
1	1		S449-p	KGKEEVAsALVHILQ
0	1		K462-a	LQSTGKAkDFLSDMA
1	0		S466	GKAkDFLSDMAMSEV
0	2		K492	RENTLATKAIEEYMR
0	1		K507	LIGQKYLKDAIGEFI
0	1		Y518	GEFIRALYESEENCE
0	1		K530	NCEVDPIKCTASSLA
0	1		S571	ELKEVFASWRLRCAE
0	1		K638	QNLANFSKFTSKEDF
0	1		K710-a	LSKEALLkLGPLPRL
0	1		K710	LSKEALLKLGPLPRL
0	1		T723	RLLNDISTALRNPNI
0	1		P743	RQSERPRPQPVVLRG
0	4		S752	PVVLRGPSAEMQGYM
0	45		Y758	PSAEMQGYMMRDLNS
1	1		S765	YMMRDLNSSIDLQSF
1	3		S766	MMRDLNSSIDLQSFM
1	4		S780	MARGLNSSMDMARLP
0	1		S788	MDMARLPSPTKEKPP
0	3		K793	LPSPTKEKPPPPPPG
0	31		Y807-p	GGGKDLFyVSRPPLA
0	61		Y820-p	LARSSPAyCTSSSDI
0	3		T822	RSSPAyCTSSSDItE
0	3		S823	SSPAyCTSSSDItEP
0	2		S824	SPAyCTSSSDItEPE
0	5		S825	PAyCTSSSDItEPEQ
0	5		T828-p	CTSSSDItEPEQKML
0	8		K833	DItEPEQKMLSVNKs
1	0		S836	EPEQKMLSVNKsVsM
0	6		K839	QKMLSVNKsVsMLDL
1	1		S840-p	KMLSVNKsVsMLDLQ
1	1		S842-p	LSVNKsVsMLDLQGD
0	1		S861	RLNSSSVSNLAAVGD
0	1		S872	AVGDLLHSSQASLTA
0	3		S873	VGDLLHSSQASLTAA
0	1		S876	LLHSSQASLTAALGL
0	5		S892-p	PAPAGRLsQGSGSSI
0	1		S892	PAPAGRLSQGSGSSI
1	6		S895	AGRLsQGSGSSITAA
0	1		S897	RLsQGSGSSITAAGM
0	2		S898	LsQGSGSSITAAGMR
0	2		S907-p	TAAGMRLsQMGVttD
0	3		T912-p	RLsQMGVttDGVPAQ
0	1		T913-p	LsQMGVttDGVPAQQ
0	39		Y982-p	TFAPFHGySKSEDLS
0	1		S983	FAPFHGySKSEDLSS
0	1		S985	PFHGySKSEDLSSGV
0	2		S1003	PAASILHSHSySDEF
0	2		S1005	ASILHSHSySDEFGP
0	21		Y1006-p	SILHSHSySDEFGPS
0	1		S1053	PSGPGGGSGGGSGGG
0	1		S1057	GGGSGGGSGGGGGGQ
2	3		S1073	PPLQRGKSQQLTVSA
0	3		K1083	LTVSAAQKPRPSSGN
0	23		Y1099-p	LQSPEPSyGPARPRQ
0	1		S1108-p	PARPRQQsLSKEGsI
0	2		K1111	PRQQsLSKEGsIGGS
2	4		S1114-p	QsLSKEGsIGGSGGS
1	1		S1118	KEGsIGGSGGSGGGG
1	3		S1121	sIGGSGGSGGGGGGG
0	11		K1130	GGGGGGLKPsITKQH
0	1		S1132-p	GGGGLKPsITKQHSQ
0	1		T1134	GGLKPsITKQHSQTP
0	2		K1135	GLKPsITKQHSQTPS
1	1		S1138	PsITKQHSQTPSTLN
0	1		S1138	PsITKQHSQTPSTLN
0	1		T1140	ITKQHSQTPSTLNPT
0	1		S1142	KQHSQTPSTLNPTMP
0	2		T1143	QHSQTPSTLNPTMPA
0	1		S1151	LNPTMPASERTVAWV
0	5		S1165	VSNMPHLSADIESAH
0	2		Y1178	AHIEREEYKLKEysK
0	1		Y1183-p	EEYKLKEysKsMDEs
0	1		S1184-p	EYKLKEysKsMDEsR
0	1		S1186-p	KLKEysKsMDEsRLD
0	1		S1190-p	ysKsMDEsRLDRVKE
0	1		K1196	EsRLDRVKEYEEEIH
0	6		Y1198	RLDRVKEYEEEIHSL
0	6		S1204	EYEEEIHSLKERLHM
0	6		S1225-p	EYERRLLsQEEQTSK
0	4		K1232	sQEEQTSKILMQYQA
0	6		Y1237	TSKILMQYQARLEQS
0	1		K1255	LRQQQAEKDSQIKsI
0	4		K1260	AEKDSQIKsIIGRLM
0	2		S1261-p	EKDSQIKsIIGRLML
0	1		K1288	AEPLPEPKKRLLDAQ

	SynGAP iso2
S12	RASIHRGSIPAMSYA
Y18	GSIPAMSYAPFRDVR
Y34	PSMHRTQYVHSPYDR
S37	HRTQYVHSPYDRPGW
Y39	TQYVHSPYDRPGWNP
T85	RNKLLRRTVSVPVEG
S87	KLLRRTVSVPVEGRP
R93	VSVPVEGRPHGEHEY
Y100	RPHGEHEYHLGRSRR
R104	EHEYHLGRSRRKSVP
S105	HEYHLGRSRRKSVPG
S109	LGRSRRKSVPGGKQY
Y116	SVPGGKQYSMEGAPA
S117	VPGGKQYSMEGAPAA
K145	KSSIKRTKSQPKLDR
T153	SQPKLDRTSSFRQIL
S155	PKLDRTSSFRQILPR
S176	DRARLMQSFKESHSH
K241	RSAAERDKWIENLQR
S302	TSKPRSASGDTVFWG
K339	DKKRKKDKAGYVGLV
Y342	RKKDKAGYVGLVTVP
S371	PVTLPTGSGGSGGMG
S374	LPTGSGGSGGMGSGG
S379	GGSGGMGSGGGGGSG
S385	GSGGGGGSGGGSGGK
S449	KGKEEVASALVHILQ
K462	LQSTGKAKDFLSDMA
S466	GKAKDFLSDMAMSEV
K492	RENTLATKAIEEYMR
K507	LIGQKYLKDAIGEFI
Y518	GEFIRALYESEENCE
K530	NCEVDPIKCTASSLA
S571	ELKEVFASWRLRCAE
K638	QNLANFSKFTSKEDF
K710	LSKEALLKLGPLPRL
K710	LSKEALLKLGPLPRL
T723	RLLNDISTALRNPNI
P743	RQSERPRPQPVVLRG
S752	PVVLRGPSAEMQGYM
Y758	PSAEMQGYMMRDLNS
S765	YMMRDLNSSIDLQSF
S766	MMRDLNSSIDLQSFM
S780	MARGLNSSMDMARLP
S788	MDMARLPSPTKEKPP
K793	LPSPTKEKPPPPPPG
Y807	GGGKDLFYVSRPPLA
Y820	LARSSPAYCTSSSDI
T822	RSSPAYCTSSSDITE
S823	SSPAYCTSSSDITEP
S824	SPAYCTSSSDITEPE
S825	PAYCTSSSDITEPEQ
T828	CTSSSDITEPEQKML
K833	DITEPEQKMLSVNKS
S836	EPEQKMLSVNKSVSM
K839	QKMLSVNKSVSMLDL
S840	KMLSVNKSVSMLDLQ
S842	LSVNKSVSMLDLQGD
S861	RLNSSSVSNLAAVGD
S872	AVGDLLHSSQASLTA
S873	VGDLLHSSQASLTAA
S876	LLHSSQASLTAALGL
S892	PAPAGRLSQGSGSSI
S892	PAPAGRLSQGSGSSI
S895	AGRLSQGSGSSITAA
S897	RLSQGSGSSITAAGM
S898	LSQGSGSSITAAGMR
S907	TAAGMRLSQMGVTTD
T912	RLSQMGVTTDGVPAQ
T913	LSQMGVTTDGVPAQQ
Y982	TFAPFHGYSKSEDLS
S983	FAPFHGYSKSEDLSS
S985	PFHGYSKSEDLSSGV
S1003	PAASILHSHSYSDEF
S1005	ASILHSHSYSDEFGP
Y1006	SILHSHSYSDEFGPS
S1053	PSGPGGGSGGGSGGG
S1057	GGGSGGGSGGGGGGQ
S1073	PPLQRGKSQQLTVSA
K1083	LTVSAAQKPRPSSGN
Y1099	LQSPEPSYGPARPRQ
S1108	PARPRQQSLSKEGsI
K1111	PRQQSLSKEGsIGGS
S1114-p	QSLSKEGsIGGSGGS
S1118	KEGsIGGSGGSGGGG
S1121	sIGGSGGSGGGGGGG
K1130	GGGGGGLKPsITKQH
S1132-p	GGGGLKPsITKQHSQ
T1134	GGLKPsITKQHSQTP
K1135	GLKPsITKQHSQTPS
S1138	PsITKQHSQTPSTLN
S1138	PsITKQHSQTPSTLN
T1140	ITKQHSQTPSTLNPT
S1142	KQHSQTPSTLNPTMP
T1143	QHSQTPSTLNPTMPA
S1151	LNPTMPASERTVAWV
S1165	VSNMPHLSADIESAH
Y1178	AHIEREEYKLKEYSK
Y1183	EEYKLKEYSKSMDES
S1184	EYKLKEYSKSMDESR
S1186	KLKEYSKSMDESRLD
S1190	YSKSMDESRLDRVKE
K1196	ESRLDRVKEYEEEIH
Y1198	RLDRVKEYEEEIHSL
S1204	EYEEEIHSLKERLHM
S1225	EYERRLLSQEEQTSK
K1232	SQEEQTSKILMQYQA
Y1237	TSKILMQYQARLEQS
K1255	LRQQQAEKDSQIKSI
K1260	AEKDSQIKSIIGSPS
S1261	EKDSQIKSIIGSPSL
-	gap

	mouse
S12-p	RASIHRGsIPAMSyA
Y18-p	GsIPAMSyAPFRDVR
Y34-p	PPMHRTQyVHsPyDR
S37-p	HRTQyVHsPyDRPGW
Y39-p	TQyVHsPyDRPGWNP
T85-p	RNKLLRRtVsVPVEG
S87-p	KLLRRtVsVPVEGrP
R93-m1	VsVPVEGrPHGEHEy
Y100-p	rPHGEHEyHLGrsRR
R104-m1	EHEyHLGrsRRKsVP
S105-p	HEyHLGrsRRKsVPG
S109-p	LGrsRRKsVPGGKQY
Y116	sVPGGKQYsMEAAPA
S117-p	VPGGKQYsMEAAPAA
K145	KSSIKRTKSQPKLDR
T153-p	SQPKLDRtSsFRQIL
S155-p	PKLDRtSsFRQILPR
S176-p	DRARLMQsFKESHSH
K241-u	RSAAERDkWIENLQR
S302-p	TSKPRSAsGDTVFWG
K339-u	DKKRKKDkAGyVGLV
Y342-p	RKKDkAGyVGLVTVP
S371-p	PVTLPTGsGGsGGMG
S374-p	LPTGsGGsGGMGsGG
S379-p	GGsGGMGsGGGGGsG
S385-p	GsGGGGGsGGGSGGK
S449	KGKEEVASALVHILQ
K462	LQSTGKAKDFLSDMA
S466	GKAKDFLSDMAMSEV
K492-u	RENTLATkAIEEYMR
K507-u	LIGQKYLkDAIGEFI
Y518	GEFIRALYESEENCE
K530	NCEVDPIKCTASSLA
S571-p	ELKEVFAsWRLRCAE
K638-u	QNLANFSkFTSKEDF
K710	LSKEALLKLGPLPRL
K710-u	LSKEALLkLGPLPRL
T723-p	RLLNDIStALRNPNI
S743-p	RQSERTRsQPMVLRG
S752-p	PMVLRGPsAEMQGyM
Y758-p	PsAEMQGyMMRDLNs
S765-p	yMMRDLNssIDLQSF
S766-p	MMRDLNssIDLQSFM
S780-p	MARGLNSsMDMARLP
S788-p	MDMARLPsPTKEkPP
K793-u	LPsPTKEkPPPPPPG
Y807-p	GGGKDLFyVSRPPLA
Y820-p	LARSSPAyCtsssDI
T822-p	RSSPAyCtsssDItE
S823-p	SSPAyCtsssDItEP
S824-p	SPAyCtsssDItEPE
S825-p	PAyCtsssDItEPEQ
T828-p	CtsssDItEPEQkML
K833-u	DItEPEQkMLSVNkS
S836	EPEQkMLSVNkSVSM
K839-u	QkMLSVNkSVSMLDL
S840	kMLSVNkSVSMLDLQ
S842	LSVNkSVSMLDLQGD
S861-p	RLNSSSVsNLAAVGD
S872-p	AVGDLLHssQAsLTA
S873-p	VGDLLHssQAsLTAA
S876-p	LLHssQAsLTAALGL
S892-p	PAPAGRLsQGsGSsI
S892-g	PAPAGRLsQGsGSsI
S895-p	AGRLsQGsGSsITAA
S897	RLsQGsGSsITAAGM
S898-p	LsQGsGSsITAAGMR
S907-p	TAAGMRLsQMGVtTD
T912-p	RLsQMGVtTDGVPAQ
T913	LsQMGVtTDGVPAQQ
Y982-p	TFAPFHGysKsEDLS
S983-g	FAPFHGysKsEDLSS
S985-p	PFHGysKsEDLSSGV
S1003-p	PAASILHsHsySDEF
S1005-p	ASILHsHsySDEFGP
Y1006-p	SILHsHsySDEFGPS
S1053-p	PSGPGGGsGGGsGGG
S1057-p	GGGsGGGsGGGQPPP
S1070-p	PPLQRGKsQQLTVSA
K1080	LTVSAAQKPRPSSGN
Y1096	LQSPEPSYGPARPRQ
S1105-p	PARPRQQsLSkEGsI
K1108-u	PRQQsLSkEGsIGGs
S1111-p	QsLSkEGsIGGsGGs
S1115-p	kEGsIGGsGGsGGGG
S1118-p	sIGGsGGsGGGGGGG
K1127-u	GGGGGGLkPSItKQH
S1129	GGGGLkPSItKQHsQ
T1131-g	GGLkPSItKQHsQtP
K1132	GLkPSItKQHsQtPs
S1135	PSItKQHSQtPstLN
S1135-g	PSItKQHsQtPstLN
T1137-g	ItKQHsQtPstLNPT
S1139-g	KQHsQtPstLNPTMP
T1140-g	QHsQtPstLNPTMPA
S1148-g	LNPTMPAsERTVAWV
S1162-p	VSNMPHLsADIESAH
Y1175	AHIEREEYKLKEYSK
Y1180	EEYKLKEYSKSMDES
S1181	EYKLKEYSKSMDESR
S1183	KLKEYSKSMDESRLD
S1187	YSKSMDESRLDRVkE
K1193-u	ESRLDRVkEYEEEIH
Y1195	RLDRVkEYEEEIHsL
S1201-p	EYEEEIHsLKERLHM
S1222-p	EYERRLLsQEEQTSk
K1229-u	sQEEQTSkILMQYQA
Y1234	TSkILMQYQARLEQS
K1252	LRQQQVEKDSQIksI
K1257-u	VEKDSQIksIIGRLM
S1258-p	EKDSQIksIIGRLML
K1285-u	AEPLPEPkKRLLDAQ

	rat ► Hide Isoforms
S12	RASIHRGSIPAMSyA
Y18-p	GSIPAMSyAPFRDVR
Y34-p	PPMHRTQyVHSPyDR
S37	HRTQyVHSPyDRPGW
Y39-p	TQyVHSPyDRPGWNP
T85	RNKLLRRTVSVPVEG
S87	KLLRRTVSVPVEGRP
R93	VSVPVEGRPHGEHEy
Y100-p	RPHGEHEyHLGRSRR
R104	EHEyHLGRSRRKSVP
S105	HEyHLGRSRRKSVPG
S109	LGRSRRKSVPGGKQy
Y116-p	SVPGGKQySMEAAPA
S117	VPGGKQySMEAAPAA
K145	KSSIKRTKSQPKLDR
T153	SQPKLDRTSSFRQIL
S155	PKLDRTSSFRQILPR
S176	DRARLMQSFKESHSH
K241	RSAAERDKWIENLQR
S302	TSKPRSASGDTVFWG
K339	DKKRKKDKAGyVGLV
Y342-p	RKKDKAGyVGLVTVP
S371	PVTLPTGSGGSGGMG
S374	LPTGSGGSGGMGSGG
S379	GGSGGMGSGGGGGSG
S385	GSGGGGGSGGGSGGK
S449	KGKEEVASALVHILQ
K462-a	LQSTGKAkDFLSDMA
S466	GKAkDFLSDMAMSEV
K492-u	RENTLATkAIEEYMR
K507	LIGQKYLKDAIGEFI
Y518-p	GEFIRALyESEENCE
K530-u	NCEVDPIkCTASSLA
S571	ELKEVFASWRLRCAE
K638	QNLANFSKFTSKEDF
K710-a	LSKEALLkLGPLPRL
K710	LSKEALLKLGPLPRL
T723	RLLSDISTALRNPNI
S743	RQSERARSQPMVLRG
S752	PMVLRGPSAEMQGyM
Y758-p	PSAEMQGyMMRDLNs
S765-p	yMMRDLNssIDLQSF
S766-p	MMRDLNssIDLQSFM
S780-p	MARGLNSsMDMARLP
S788	MDMARLPSPTKEkPP
K793-u	LPSPTKEkPPPPPPG
Y807-p	GGGKDLFyVSRPPLA
Y820-p	LARSSPAyCTSSSDI
T822	RSSPAyCTSSSDITE
S823	SSPAyCTSSSDITEP
S824	SPAyCTSSSDITEPE
S825	PAyCTSSSDITEPEQ
T828	CTSSSDITEPEQkML
K833-u	DITEPEQkMLSVNkS
S836	EPEQkMLSVNkSVSM
K839-u	QkMLSVNkSVSMLDL
S840	kMLSVNkSVSMLDLQ
S842	LSVNkSVSMLDLQGD
S861	RLNSSSVSNLAAVGD
S872	AVGDLLHSSQASLTA
S873	VGDLLHSSQASLTAA
S876	LLHSSQASLTAALGL
S892-p	PAPAGRLsQGsGsSI
S892	PAPAGRLSQGsGsSI
S895-p	AGRLsQGsGsSITAA
S897-p	RLsQGsGsSITAAGM
S898	LsQGsGsSITAAGMR
S907	TAAGMRLSQMGVTTD
T912	RLSQMGVTTDGVPAQ
T913	LSQMGVTTDGVPAQQ
Y982-p	TFAPFHGySKSEDLS
S983	FAPFHGySKSEDLST
S985	PFHGySKSEDLSTGV
S1003	PAASILHSHSySDEF
S1005	ASILHSHSySDEFGP
Y1006-p	SILHSHSySDEFGPS
S1053	PSGPGGGSGGGSGGG
S1057	GGGSGGGSGGGGGGQ
S1073-p	PPLQRGKsQQLTVSA
K1083-u	LTVSAAQkPRPSSGN
Y1099-p	LQSPEPSyGPARPRQ
S1108	PARPRQQSLSkEGsI
K1111-u	PRQQSLSkEGsIGGs
S1114-p	QSLSkEGsIGGsGGs
S1118-p	kEGsIGGsGGsGGGG
S1121-p	sIGGsGGsGGGGGGG
K1130-u	GGGGGGLkPSITkQH
S1132	GGGGLkPSITkQHsQ
T1134	GGLkPSITkQHsQTP
K1135-u	GLkPSITkQHsQTPS
S1138-p	PSITkQHsQTPSTLN
S1138	PSITkQHSQTPSTLN
T1140	ITkQHsQTPSTLNPT
S1142	kQHsQTPSTLNPTMP
T1143	QHsQTPSTLNPTMPA
S1151	LNPTMPASERTVAWV
S1165	VSNMPHLSADIESAH
Y1178-p	AHIEREEyKLKEYSK
Y1183	EEyKLKEYSKSMDES
S1184	EyKLKEYSKSMDESR
S1186	KLKEYSKSMDESRLD
S1190	YSKSMDESRLDRVKE
K1196	ESRLDRVKEyEEEIH
Y1198-p	RLDRVKEyEEEIHSL
S1204	EyEEEIHSLKERLHM
S1225-p	EYERRLLsQEEQTSK
K1232	sQEEQTSKILMQyQA
Y1237-p	TSKILMQyQARLEQS
K1255-u	LRQQQVEkDSQIKSI
K1260	VEkDSQIKSIIGRLM
S1261	EkDSQIKSIIGRLML
K1288	AEPLPEPKKRLLDAQ

	SynGAP iso3
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
Y41	SCCFPGEYHLGRSRR
R45	PGEYHLGRSRRKSVP
S46	GEYHLGRSRRKSVPG
S50	LGRSRRKSVPGGKQY
Y57	SVPGGKQYSMEAAPA
S58	VPGGKQYSMEAAPAA
K86	KSSIKRTKSQPKLDR
T94	SQPKLDRTSSFRQIL
S96	PKLDRTSSFRQILPR
S117	DRARLMQSFKESHSH
K182	RSAAERDKWIENLQR
S243	TSKPRSASGDTVFWG
K280	DKKRKKDKAGYVGLV
Y283	RKKDKAGYVGLVTVP
S312	PVTLPTGSGGSGGMG
S315	LPTGSGGSGGMGsGG
S320-p	GGSGGMGsGGGGGsG
S326-p	GsGGGGGsGGGSGGK
S390-p	KGKEEVAsALVHILQ
K403	LQSTGKAKDFLsDMA
S407-p	GKAKDFLsDMAMSEV
K433	RENTLATKAIEEYMR
K448	LIGQKYLKDAIGEFI
Y459	GEFIRALYESEENCE
K471	NCEVDPIKCTASSLA
S512	ELKEVFASWRLRCAE
K579	QNLANFSKFTSKEDF
K651	LSKEALLKLGPLPRL
K651	LSKEALLKLGPLPRL
T664	RLLSDISTALRNPNI
S684	RQSERARSQPMVLRG
S693	PMVLRGPSAEMQGYM
Y699	PSAEMQGYMMRDLNS
S706	YMMRDLNSSIDLQSF
S707	MMRDLNSSIDLQSFM
S721	MARGLNSSMDMARLP
S729	MDMARLPSPTKEKPP
K734	LPSPTKEKPPPPPPG
Y748	GGGKDLFYVSRPPLA
Y761	LARSSPAYCTSSSDI
T763	RSSPAYCTSSSDITE
S764	SSPAYCTSSSDITEP
S765	SPAYCTSSSDITEPE
S766	PAYCTSSSDITEPEQ
T769	CTSSSDITEPEQKML
K774	DITEPEQKMLsVNKs
S777-p	EPEQKMLsVNKsVsM
K780	QKMLsVNKsVsMLDL
S781-p	KMLsVNKsVsMLDLQ
S783-p	LsVNKsVsMLDLQGD
S802	RLNSSSVSNLAAVGD
S813	AVGDLLHSSQASLTA
S814	VGDLLHSSQASLTAA
S817	LLHSSQASLTAALGL
S833	PAPAGRLSQGsGSSI
S833	PAPAGRLSQGsGSSI
S836-p	AGRLSQGsGSSITAA
S838	RLSQGsGSSITAAGM
S839	LSQGsGSSITAAGMR
S848	TAAGMRLSQMGVTTD
T853	RLSQMGVTTDGVPAQ
T854	LSQMGVTTDGVPAQQ
Y923	TFAPFHGYSKSEDLS
S924	FAPFHGYSKSEDLST
S926	PFHGYSKSEDLSTGV
S944	PAASILHSHSYSDEF
S946	ASILHSHSYSDEFGP
Y947	SILHSHSYSDEFGPS
S994	PSGPGGGSGGGSGGG
S998	GGGSGGGSGGGGGGQ
S1014	PPLQRGKSQQLTVSA
K1024	LTVSAAQKPRPSSGN
Y1040	LQSPEPSYGPARPRQ
S1049	PARPRQQSLSKEGSI
K1052	PRQQSLSKEGSIGGS
S1055	QSLSKEGSIGGSGGS
S1059	KEGSIGGSGGSGGGG
S1062	SIGGSGGSGGGGGGG
K1071	GGGGGGLKPSITKQH
S1073	GGGGLKPSITKQHSQ
T1075	GGLKPSITKQHSQTP
K1076	GLKPSITKQHSQTPS
S1079	PSITKQHSQTPSTLN
S1079	PSITKQHSQTPSTLN
T1081	ITKQHSQTPSTLNPT
S1083	KQHSQTPSTLNPTMP
T1084	QHSQTPSTLNPTMPA
S1092	LNPTMPASERTVAWV
S1106	VSNMPHLSADIESAH
Y1119	AHIEREEYKLKEYSK
Y1124	EEYKLKEYSKSMDES
S1125	EYKLKEYSKSMDESR
S1127	KLKEYSKSMDESRLD
S1131	YSKSMDESRLDRVKE
K1137	ESRLDRVKEYEEEIH
Y1139	RLDRVKEYEEEIHSL
S1145	EYEEEIHSLKERLHM
S1166	EYERRLLSQEEQTSK
K1173	SQEEQTSKILMQYQA
Y1178	TSKILMQYQARLEQS
K1196	LRQQQVEKDSQIKSI
K1201	VEKDSQIKSIIGRLM
S1202	EKDSQIKSIIGRLML
K1229	AEPLPEPKKRLLDAQ

	SynGAP iso5
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K28	KSSIKRTKSQPKLDR
T36	SQPKLDRTSSFRQIL
S38	PKLDRTSSFRQILPR
S59	DRARLMQSFKESHSH
K124	RSAAERDKWIENLQR
S185	TSKPRSASGDTVFWG
K222	DKKRKKDKAGyVGLV
Y225-p	RKKDKAGyVGLVTVP
S254	PVTLPTGSGGSGGMG
S257	LPTGSGGSGGMGSGG
S262	GGSGGMGSGGGGGSG
S268	GSGGGGGSGGGSGGK
S332	KGKEEVASALVHILQ
K345-a	LQSTGKAkDFLSDMA
S349	GKAkDFLSDMAMSEV
K375-u	RENTLATkAIEEYMR
K390	LIGQKYLKDAIGEFI
Y401-p	GEFIRALyESEENCE
K413-u	NCEVDPIkCTASSLA
S454	ELKEVFASWRLRCAE
K521	QNLANFSKFTSKEDF
K593-a	LSKEALLkLGPLPRL
K593	LSKEALLKLGPLPRL
T606	RLLSDISTALRNPNI
S626	RQSERARSQPMVLRG
S635	PMVLRGPSAEMQGyM
Y641-p	PSAEMQGyMMRDLNS
S648	yMMRDLNSSIDLQSF
S649	MMRDLNSSIDLQSFM
S663	MARGLNSSMDMARLP
S671	MDMARLPSPTKEkPP
K676-u	LPSPTKEkPPPPPPG
Y690-p	GGGKDLFyVSRPPLA
Y703-p	LARSSPAyCTSSSDI
T705	RSSPAyCTSSSDITE
S706	SSPAyCTSSSDITEP
S707	SPAyCTSSSDITEPE
S708	PAyCTSSSDITEPEQ
T711	CTSSSDITEPEQkML
K716-u	DITEPEQkMLSVNkS
S719	EPEQkMLSVNkSVSM
K722-u	QkMLSVNkSVSMLDL
S723	kMLSVNkSVSMLDLQ
S725	LSVNkSVSMLDLQGD
S744	RLNSSSVSNLAAVGD
S755	AVGDLLHSSQASLTA
S756	VGDLLHSSQASLTAA
S759	LLHSSQASLTAALGL
S775-p	PAPAGRLsQGsGsSI
S775	PAPAGRLSQGsGsSI
S778-p	AGRLsQGsGsSITAA
S780-p	RLsQGsGsSITAAGM
S781	LsQGsGsSITAAGMR
S790	TAAGMRLSQMGVTTD
T795	RLSQMGVTTDGVPAQ
T796	LSQMGVTTDGVPAQQ
Y865-p	TFAPFHGySKSEDLS
S866	FAPFHGySKSEDLST
S868	PFHGySKSEDLSTGV
S886	PAASILHSHSySDEF
S888	ASILHSHSySDEFGP
Y889-p	SILHSHSySDEFGPS
S936	PSGPGGGSGGGSGGG
S940	GGGSGGGSGGGGGGQ
S956	PPLQRGKSQQLTVSA
K966-u	LTVSAAQkPRPSSGN
Y982-p	LQSPEPSyGPARPRQ
S991	PARPRQQSLSkEGSI
K994-u	PRQQSLSkEGSIGGS
S997	QSLSkEGSIGGSGGS
S1001	kEGSIGGSGGSGGGG
S1004	SIGGSGGSGGGGGGG
K1013-u	GGGGGGLkPSITkQH
S1015	GGGGLkPSITkQHSQ
T1017	GGLkPSITkQHSQTP
K1018-u	GLkPSITkQHSQTPS
S1021	PSITkQHSQTPSTLN
S1021	PSITkQHSQTPSTLN
T1023	ITkQHSQTPSTLNPT
S1025	kQHSQTPSTLNPTMP
T1026	QHSQTPSTLNPTMPA
S1034	LNPTMPASERTVAWV
S1048	VSNMPHLSADIESAH
Y1061-p	AHIEREEyKLKEYSK
Y1066	EEyKLKEYSKSMDES
S1067	EyKLKEYSKSMDESR
S1069	KLKEYSKSMDESRLD
S1073	YSKSMDESRLDREyE
-	under review
Y1079-p	ESRLDREyEEEIHSL
S1085	EyEEEIHSLKERLHM
S1106-p	EYERRLLsQEEQTSK
K1113	sQEEQTSKILMQyQA
Y1118-p	TSKILMQyQARLEQS
K1136-u	LRQQQVEkDSQIKSI
K1141	VEkDSQIKSIIGSPS
S1142	EkDSQIKSIIGSPSL
-	gap

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