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Protein Page:
SynGAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SynGAP an excitatory synapse-specific RasGAP. Member of the NMDAR signaling complex in excitatory synapses it may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity. ERK activation is up-regulated in neurons from SynGAP knockout mice, whereas P38 MAPK function is depressed. May play a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. Interacts with CAMK2A/CAMK2B and MPDZ. Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Contains a PH domain and a Ras-GAP domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Ras
Cellular Component: cytoplasm; dendritic shaft
Molecular Function: Rab GTPase activator activity; Ras GTPase activator activity; SH3 domain binding
Biological Process: regulation of long-term neuronal synaptic plasticity; positive regulation of Ras GTPase activity; regulation of synapse structure and activity; regulation of MAPKKK cascade; Ras protein signal transduction; dendrite development; regulation of synaptic plasticity; negative regulation of Ras protein signal transduction; visual learning; negative regulation of axonogenesis; negative regulation of neuron apoptosis; positive regulation of Rab GTPase activity; pattern specification process; receptor clustering
Reference #:  Q96PV0 (UniProtKB)
Alt. Names/Synonyms: DKFZp761G1421; KIAA1938; MRD5; Neuronal RasGAP; Ras GTPase-activating protein SynGAP; RASA1; RASA5; SYGP1; synaptic Ras GTPase activating protein 1; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein, 135kDa; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP; SYNGAP1
Gene Symbols: SYNGAP1
Molecular weight: 148,284 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SynGAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S12 RASIHRGSIPAMSYA
0 4 S17 RGSIPAMSYAPFRDV
0 69 Y18 GSIPAMSYAPFRDVR
0 64 Y34 PSMHRTQYVHSPYDR
0 14 S37 HRTQYVHSPYDRPGW
0 88 Y39 TQYVHSPYDRPGWNP
0 1 T85 RNKLLRRTVSVPVEG
0 12 S87 KLLRRTVSVPVEGRP
0 1 R93 VSVPVEGRPHGEHEY
0 26 Y100 RPHGEHEYHLGRSRR
0 1 R104 EHEYHLGRSRRKSVP
0 2 S105 HEYHLGRSRRKSVPG
0 3 S109 LGRSRRKSVPGGKQY
0 18 Y116 SVPGGKQYSMEGAPA
0 14 S117 VPGGKQYSMEGAPAA
0 1 K145-ac KSSIKRTkSQPKLDR
0 1 T153 SQPKLDRTSSFRQIL
0 2 S155 PKLDRTSSFRQILPR
0 1 S176 DRARLMQSFKESHSH
0 1 K241 RSAAERDKWIENLQR
0 1 S302 TSKPRSASGDTVFWG
0 1 K339 DKKRKKDKAGYVGLV
0 33 Y342 RKKDKAGYVGLVTVP
0 2 S371 PVTLPTGSGGSGGMG
0 2 S374 LPTGSGGSGGMGSGG
1 1 S379 GGSGGMGSGGGGGSG
1 0 S385 GSGGGGGSGGGSGGK
1 1 S449-p KGKEEVAsALVHILQ
0 1 T458 LVHILQSTGKAKDFL
0 1 K462 LQSTGKAKDFLSDMA
1 1 S466 GKAKDFLSDMAMSEV
0 2 K492 RENTLATKAIEEYMR
0 1 K507 LIGQKYLKDAIGEFI
0 1 Y518 GEFIRALYESEENCE
0 1 K530 NCEVDPIKCTASSLA
0 1 S571 ELKEVFASWRLRCAE
0 1 K638 QNLANFSKFTSKEDF
0 1 K710 LSKEALLKLGPLPRL
0 1 K710 LSKEALLKLGPLPRL
0 1 T723 RLLNDISTALRNPNI
0 1 P743 RQSERPRPQPVVLRG
0 4 S752 PVVLRGPSAEMQGYM
0 45 Y758 PSAEMQGYMMRDLNS
1 1 S765 YMMRDLNSSIDLQSF
1 3 S766 MMRDLNSSIDLQSFM
1 4 S780 MARGLNSSMDMARLP
0 20 S788 MDMARLPSPTKEKPP
0 6 T790 MARLPSPTKEKPPPP
0 3 K793 LPSPTKEKPPPPPPG
0 31 Y807 GGGKDLFYVSRPPLA
0 4 S809 GKDLFYVSRPPLARS
0 1 R810 KDLFYVSRPPLARSS
0 2 S817 RPPLARSSPAYCTSS
0 61 Y820 LARSSPAYCTSSSDI
0 3 T822 RSSPAYCTSSSDITE
0 3 S823 SSPAYCTSSSDITEP
0 2 S824 SPAYCTSSSDITEPE
0 11 S825 PAYCTSSSDITEPEQ
0 6 T828 CTSSSDITEPEQKML
0 8 K833 DITEPEQKMLSVNKs
1 0 S836 EPEQKMLSVNKsVsM
0 6 K839 QKMLSVNKsVsMLDL
1 1 S840-p KMLSVNKsVsMLDLQ
1 1 S842-p LSVNKsVsMLDLQGD
0 1 S861 RLNSSSVSNLAAVGD
0 1 S872 AVGDLLHSSQASLTA
0 3 S873 VGDLLHSSQASLTAA
0 1 S876 LLHSSQASLTAALGL
0 4 S892 PAPAGRLSQGSGSSI
0 1 S892 PAPAGRLSQGSGSSI
1 5 S895 AGRLSQGSGSSITAA
0 2 S898 LSQGSGSSITAAGMR
0 1 T900 QGSGSSITAAGMRLs
0 2 S907-p TAAGMRLsQMGVttD
0 3 T912-p RLsQMGVttDGVPAQ
0 1 T913-p LsQMGVttDGVPAQQ
0 36 Y982 TFAPFHGYSKSEDLS
0 1 S983 FAPFHGYSKSEDLSS
0 2 S985 PFHGYSKSEDLSSGV
0 5 S1003 PAASILHSHSYSDEF
0 3 S1005 ASILHSHSYSDEFGP
0 7 Y1006 SILHSHSYSDEFGPS
0 1 S1053 PSGPGGGSGGGSGGG
0 1 S1057 GGGSGGGSGGGGGGQ
2 4 S1073 PPLQRGKSQQLTVSA
0 3 S1079 KSQQLTVSAAQKPRP
0 3 K1083 LTVSAAQKPRPSSGN
0 7 S1087 AAQKPRPSSGNLLQS
0 4 S1088 AQKPRPSSGNLLQSP
0 8 S1094 SSGNLLQSPEPSYGP
0 6 S1098 LLQSPEPSYGPARPR
0 18 Y1099 LQSPEPSYGPARPRQ
0 1 S1108 PARPRQQSLSKEGsI
0 2 K1111 PRQQSLSKEGsIGGS
2 4 S1114-p QSLSKEGsIGGSGGS
1 1 S1118 KEGsIGGSGGSGGGG
1 3 S1121 sIGGSGGSGGGGGGG
0 11 K1130 GGGGGGLKPsITKQH
0 1 S1132-p GGGGLKPsITKQHSQ
0 1 T1134 GGLKPsITKQHSQTP
0 2 K1135 GLKPsITKQHSQTPS
1 1 S1138 PsITKQHSQTPSTLN
0 1 S1138 PsITKQHSQTPSTLN
0 1 T1140 ITKQHSQTPSTLNPT
0 1 S1142 KQHSQTPSTLNPTMP
0 2 T1143 QHSQTPSTLNPTMPA
0 1 S1151-p LNPTMPAsERTVAWV
0 1 S1151 LNPTMPASERTVAWV
0 7 S1165 VSNMPHLSADIESAH
0 3 Y1183-p EEYKLKEysKsMDEs
0 2 S1184-p EYKLKEysKsMDEsR
0 2 S1186-p KLKEysKsMDEsRLD
0 2 S1190-p ysKsMDEsRLDRVKE
0 1 K1196 EsRLDRVKEYEEEIH
0 6 Y1198 RLDRVKEYEEEIHSL
0 8 S1204 EYEEEIHSLKERLHM
0 6 Y1219 SNRKLEEYERRLLSQ
0 5 S1225 EYERRLLSQEEQTSK
0 4 K1232 SQEEQTSKILMQYQA
0 6 Y1237 TSKILMQYQARLEQS
0 1 K1255 LRQQQAEKDSQIKsI
0 4 K1260 AEKDSQIKsIIGRLM
0 2 S1261-p EKDSQIKsIIGRLML
0 1 K1288 AEPLPEPKKRLLDAQ
  SynGAP iso2  
S12 RASIHRGSIPAMSYA
S17 RGSIPAMSYAPFRDV
Y18 GSIPAMSYAPFRDVR
Y34 PSMHRTQYVHSPYDR
S37 HRTQYVHSPYDRPGW
Y39 TQYVHSPYDRPGWNP
T85 RNKLLRRTVSVPVEG
S87 KLLRRTVSVPVEGRP
R93 VSVPVEGRPHGEHEY
Y100 RPHGEHEYHLGRSRR
R104 EHEYHLGRSRRKSVP
S105 HEYHLGRSRRKSVPG
S109 LGRSRRKSVPGGKQY
Y116 SVPGGKQYSMEGAPA
S117 VPGGKQYSMEGAPAA
K145 KSSIKRTKSQPKLDR
T153 SQPKLDRTSSFRQIL
S155 PKLDRTSSFRQILPR
S176 DRARLMQSFKESHSH
K241 RSAAERDKWIENLQR
S302 TSKPRSASGDTVFWG
K339 DKKRKKDKAGYVGLV
Y342 RKKDKAGYVGLVTVP
S371 PVTLPTGSGGSGGMG
S374 LPTGSGGSGGMGSGG
S379 GGSGGMGSGGGGGSG
S385 GSGGGGGSGGGSGGK
S449 KGKEEVASALVHILQ
T458 LVHILQSTGKAKDFL
K462 LQSTGKAKDFLSDMA
S466 GKAKDFLSDMAMSEV
K492 RENTLATKAIEEYMR
K507 LIGQKYLKDAIGEFI
Y518 GEFIRALYESEENCE
K530 NCEVDPIKCTASSLA
S571 ELKEVFASWRLRCAE
K638 QNLANFSKFTSKEDF
K710 LSKEALLKLGPLPRL
K710 LSKEALLKLGPLPRL
T723 RLLNDISTALRNPNI
P743 RQSERPRPQPVVLRG
S752 PVVLRGPSAEMQGYM
Y758 PSAEMQGYMMRDLNS
S765 YMMRDLNSSIDLQSF
S766 MMRDLNSSIDLQSFM
S780 MARGLNSSMDMARLP
S788 MDMARLPSPTKEKPP
T790 MARLPSPTKEKPPPP
K793 LPSPTKEKPPPPPPG
Y807 GGGKDLFYVSRPPLA
S809 GKDLFYVSRPPLARS
R810 KDLFYVSRPPLARSS
S817 RPPLARSSPAYCTSS
Y820 LARSSPAYCTSSSDI
T822 RSSPAYCTSSSDITE
S823 SSPAYCTSSSDITEP
S824 SPAYCTSSSDITEPE
S825 PAYCTSSSDITEPEQ
T828 CTSSSDITEPEQKML
K833 DITEPEQKMLSVNKS
S836 EPEQKMLSVNKSVSM
K839 QKMLSVNKSVSMLDL
S840 KMLSVNKSVSMLDLQ
S842 LSVNKSVSMLDLQGD
S861 RLNSSSVSNLAAVGD
S872 AVGDLLHSSQASLTA
S873 VGDLLHSSQASLTAA
S876 LLHSSQASLTAALGL
S892 PAPAGRLSQGSGSSI
S892 PAPAGRLSQGSGSSI
S895 AGRLSQGSGSSITAA
S898 LSQGSGSSITAAGMR
T900 QGSGSSITAAGMRLS
S907 TAAGMRLSQMGVTTD
T912 RLSQMGVTTDGVPAQ
T913 LSQMGVTTDGVPAQQ
Y982 TFAPFHGYSKSEDLS
S983 FAPFHGYSKSEDLSS
S985 PFHGYSKSEDLSSGV
S1003 PAASILHSHSYSDEF
S1005 ASILHSHSYSDEFGP
Y1006 SILHSHSYSDEFGPS
S1053 PSGPGGGSGGGSGGG
S1057 GGGSGGGSGGGGGGQ
S1073 PPLQRGKSQQLTVSA
S1079 KSQQLTVSAAQKPRP
K1083 LTVSAAQKPRPSSGN
S1087 AAQKPRPSSGNLLQS
S1088 AQKPRPSSGNLLQSP
S1094 SSGNLLQSPEPSYGP
S1098 LLQSPEPSYGPARPR
Y1099 LQSPEPSYGPARPRQ
S1108 PARPRQQSLSKEGsI
K1111 PRQQSLSKEGsIGGS
S1114-p QSLSKEGsIGGSGGS
S1118 KEGsIGGSGGSGGGG
S1121 sIGGSGGSGGGGGGG
K1130 GGGGGGLKPsITKQH
S1132-p GGGGLKPsITKQHSQ
T1134 GGLKPsITKQHSQTP
K1135 GLKPsITKQHSQTPS
S1138 PsITKQHSQTPSTLN
S1138 PsITKQHSQTPSTLN
T1140 ITKQHSQTPSTLNPT
S1142 KQHSQTPSTLNPTMP
T1143 QHSQTPSTLNPTMPA
S1151 LNPTMPASERTVAWV
S1151 LNPTMPASERTVAWV
S1165 VSNMPHLSADIESAH
Y1183 EEYKLKEYSKSMDES
S1184 EYKLKEYSKSMDESR
S1186 KLKEYSKSMDESRLD
S1190 YSKSMDESRLDRVKE
K1196 ESRLDRVKEYEEEIH
Y1198 RLDRVKEYEEEIHSL
S1204 EYEEEIHSLKERLHM
Y1219 SNRKLEEYERRLLSQ
S1225 EYERRLLSQEEQTSK
K1232 SQEEQTSKILMQYQA
Y1237 TSKILMQYQARLEQS
K1255 LRQQQAEKDSQIKSI
K1260 AEKDSQIKSIIGSPS
S1261 EKDSQIKSIIGSPSL
- gap
  mouse

 
S12-p RASIHRGsIPAMSyA
S17 RGsIPAMSyAPFRDV
Y18-p GsIPAMSyAPFRDVR
Y34-p PPMHRTQyVHsPyDR
S37-p HRTQyVHsPyDRPGW
Y39-p TQyVHsPyDRPGWNP
T85-p RNKLLRRtVsVPVEG
S87-p KLLRRtVsVPVEGrP
R93-m1 VsVPVEGrPHGEHEy
Y100-p rPHGEHEyHLGrsRR
R104-m1 EHEyHLGrsRRKsVP
S105-p HEyHLGrsRRKsVPG
S109-p LGrsRRKsVPGGKQY
Y116 sVPGGKQYsMEAAPA
S117-p VPGGKQYsMEAAPAA
K145 KSSIKRTKSQPKLDR
T153-p SQPKLDRtSsFRQIL
S155-p PKLDRtSsFRQILPR
S176-p DRARLMQsFKESHSH
K241-ub RSAAERDkWIENLQR
S302-p TSKPRSAsGDTVFWG
K339-ub DKKRKKDkAGyVGLV
Y342-p RKKDkAGyVGLVTVP
S371-p PVTLPTGsGGsGGMG
S374-p LPTGsGGsGGMGsGG
S379-p GGsGGMGsGGGGGsG
S385-p GsGGGGGsGGGSGGK
S449 KGKEEVASALVHILQ
T458 LVHILQSTGKAKDFL
K462 LQSTGKAKDFLSDMA
S466 GKAKDFLSDMAMSEV
K492-ub RENTLATkAIEEYMR
K507-ub LIGQKYLkDAIGEFI
Y518 GEFIRALYESEENCE
K530 NCEVDPIKCTASSLA
S571-p ELKEVFAsWRLRCAE
K638-ub QNLANFSkFTSKEDF
K710 LSKEALLKLGPLPRL
K710-ub LSKEALLkLGPLPRL
T723-p RLLNDIStALRNPNI
S743-p RQSERTRsQPMVLRG
S752-p PMVLRGPsAEMQGyM
Y758-p PsAEMQGyMMRDLNs
S765-p yMMRDLNssIDLQSF
S766-p MMRDLNssIDLQSFM
S780-p MARGLNSsMDMARLP
S788-p MDMARLPsPTKEkPP
T790 MARLPsPTKEkPPPP
K793-ub LPsPTKEkPPPPPPG
Y807-p GGGKDLFyVSrPPLA
S809 GKDLFyVSrPPLARS
R810-m2 KDLFyVSrPPLARSS
S817 rPPLARSSPAyCtss
Y820-p LARSSPAyCtsssDI
T822-p RSSPAyCtsssDItE
S823-p SSPAyCtsssDItEP
S824-p SPAyCtsssDItEPE
S825-p PAyCtsssDItEPEQ
T828-p CtsssDItEPEQkML
K833-ub DItEPEQkMLSVNkS
S836 EPEQkMLSVNkSVSM
K839-ub QkMLSVNkSVSMLDL
S840 kMLSVNkSVSMLDLQ
S842 LSVNkSVSMLDLQGD
S861-p RLNSSSVsNLAAVGD
S872-p AVGDLLHssQAsLTA
S873-p VGDLLHssQAsLTAA
S876-p LLHssQAsLTAALGL
S892-p PAPAGRLsQGsGSsI
S892-gl PAPAGRLsQGsGSsI
S895-p AGRLsQGsGSsITAA
S898-p LsQGsGSsITAAGMR
T900 QGsGSsITAAGMRLs
S907-p TAAGMRLsQMGVtTD
T912-p RLsQMGVtTDGVPAQ
T913 LsQMGVtTDGVPAQQ
Y982-p TFAPFHGysKsEDLS
S983-gl FAPFHGysKsEDLSS
S985-p PFHGysKsEDLSSGV
S1003-p PAASILHsHsySDEF
S1005-p ASILHsHsySDEFGP
Y1006-p SILHsHsySDEFGPS
S1053-p PSGPGGGsGGGsGGG
S1057-p GGGsGGGsGGGQPPP
S1070-p PPLQRGKsQQLTVSA
S1076 KsQQLTVSAAQKPRP
K1080 LTVSAAQKPRPSSGN
S1084 AAQKPRPSSGNLLQS
S1085 AQKPRPSSGNLLQSP
S1091 SSGNLLQSPEPSYGP
S1095 LLQSPEPSYGPARPR
Y1096 LQSPEPSYGPARPRQ
S1105-p PARPRQQsLSkEGsI
K1108-ub PRQQsLSkEGsIGGs
S1111-p QsLSkEGsIGGsGGs
S1115-p kEGsIGGsGGsGGGG
S1118-p sIGGsGGsGGGGGGG
K1127-ub GGGGGGLkPSItKQH
S1129 GGGGLkPSItKQHsQ
T1131-gl GGLkPSItKQHsQtP
K1132 GLkPSItKQHsQtPs
S1135 PSItKQHSQtPstLN
S1135-gl PSItKQHsQtPstLN
T1137-gl ItKQHsQtPstLNPT
S1139-gl KQHsQtPstLNPTMP
T1140-gl QHsQtPstLNPTMPA
S1148 LNPTMPASERTVAWV
S1148-gl LNPTMPAsERTVAWV
S1162-p VSNMPHLsADIESAH
Y1180 EEYKLKEYSKSMDES
S1181 EYKLKEYSKSMDESR
S1183 KLKEYSKSMDESRLD
S1187 YSKSMDESRLDRVkE
K1193-ub ESRLDRVkEYEEEIH
Y1195 RLDRVkEYEEEIHsL
S1201-p EYEEEIHsLKERLHM
Y1216 SNRKLEEYERRLLsQ
S1222-p EYERRLLsQEEQTSk
K1229-ub sQEEQTSkILMQYQA
Y1234 TSkILMQYQARLEQS
K1252 LRQQQVEKDSQIksI
K1257-ub VEKDSQIksIIGRLM
S1258-p EKDSQIksIIGRLML
K1285-ub AEPLPEPkKRLLDAQ
  rat

► Hide Isoforms
 
S12-p RASIHRGsIPAMsyA
S17-p RGsIPAMsyAPFRDV
Y18-p GsIPAMsyAPFRDVR
Y34-p PPMHRTQyVHsPyDR
S37-p HRTQyVHsPyDRPGW
Y39-p TQyVHsPyDRPGWNP
T85 RNKLLRRTVsVPVEG
S87-p KLLRRTVsVPVEGRP
R93 VsVPVEGRPHGEHEy
Y100-p RPHGEHEyHLGRSRR
R104 EHEyHLGRSRRKSVP
S105 HEyHLGRSRRKSVPG
S109 LGRSRRKSVPGGKQy
Y116-p SVPGGKQysMEAAPA
S117-p VPGGKQysMEAAPAA
K145 KSSIKRTKSQPKLDR
T153 SQPKLDRTSSFRQIL
S155 PKLDRTSSFRQILPR
S176 DRARLMQSFKESHSH
K241 RSAAERDKWIENLQR
S302 TSKPRSASGDTVFWG
K339 DKKRKKDKAGyVGLV
Y342-p RKKDKAGyVGLVTVP
S371 PVTLPTGSGGSGGMG
S374 LPTGSGGSGGMGSGG
S379 GGSGGMGSGGGGGSG
S385 GSGGGGGSGGGSGGK
S449 KGKEEVASALVHILQ
T458-p LVHILQStGKAkDFL
K462-ac LQStGKAkDFLsDMA
S466-p GKAkDFLsDMAMSEV
K492-ub RENTLATkAIEEYMR
K507 LIGQKYLKDAIGEFI
Y518-p GEFIRALyESEENCE
K530-ub NCEVDPIkCTASSLA
S571 ELKEVFASWRLRCAE
K638 QNLANFSKFTSKEDF
K710-ac LSKEALLkLGPLPRL
K710 LSKEALLKLGPLPRL
T723 RLLSDISTALRNPNI
S743 RQSERARSQPMVLRG
S752 PMVLRGPSAEMQGyM
Y758-p PSAEMQGyMMRDLNs
S765-p yMMRDLNssIDLQSF
S766-p MMRDLNssIDLQSFM
S780-p MARGLNSsMDMARLP
S788-p MDMARLPsPtKEkPP
T790-p MARLPsPtKEkPPPP
K793-ub LPsPtKEkPPPPPPG
Y807-p GGGKDLFyVsRPPLA
S809-p GKDLFyVsRPPLARS
R810 KDLFyVsRPPLARSs
S817-p RPPLARSsPAyCTSS
Y820-p LARSsPAyCTSSsDI
T822 RSsPAyCTSSsDItE
S823 SsPAyCTSSsDItEP
S824 sPAyCTSSsDItEPE
S825-p PAyCTSSsDItEPEQ
T828-p CTSSsDItEPEQkML
K833-ub DItEPEQkMLSVNkS
S836 EPEQkMLSVNkSVSM
K839-ub QkMLSVNkSVSMLDL
S840 kMLSVNkSVSMLDLQ
S842 LSVNkSVSMLDLQGD
S861 RLNSSSVSNLAAVGD
S872 AVGDLLHSSQASLTA
S873 VGDLLHSSQASLTAA
S876 LLHSSQASLTAALGL
S892-p PAPAGRLsQGsGSSI
S892 PAPAGRLSQGsGSSI
S895-p AGRLsQGsGSSItAA
S898 LsQGsGSSItAAGMR
T900-p QGsGSSItAAGMRLS
S907 tAAGMRLSQMGVTTD
T912 RLSQMGVTTDGVPAQ
T913 LSQMGVTTDGVPAQQ
Y982-p TFAPFHGySKsEDLS
S983 FAPFHGySKsEDLST
S985-p PFHGySKsEDLSTGV
S1003-p PAASILHsHsySDEF
S1005-p ASILHsHsySDEFGP
Y1006-p SILHsHsySDEFGPS
S1053 PSGPGGGSGGGSGGG
S1057 GGGSGGGSGGGGGGQ
S1073-p PPLQRGKsQQLTVsA
S1079-p KsQQLTVsAAQkPRP
K1083-ub LTVsAAQkPRPssGN
S1087-p AAQkPRPssGNLLQs
S1088-p AQkPRPssGNLLQsP
S1094-p ssGNLLQsPEPsyGP
S1098-p LLQsPEPsyGPARPR
Y1099-p LQsPEPsyGPARPRQ
S1108 PARPRQQSLSkEGsI
K1111-ub PRQQSLSkEGsIGGs
S1114-p QSLSkEGsIGGsGGs
S1118-p kEGsIGGsGGsGGGG
S1121-p sIGGsGGsGGGGGGG
K1130-ub GGGGGGLkPSITkQH
S1132 GGGGLkPSITkQHsQ
T1134 GGLkPSITkQHsQTP
K1135-ub GLkPSITkQHsQTPS
S1138-p PSITkQHsQTPSTLN
S1138 PSITkQHSQTPSTLN
T1140 ITkQHsQTPSTLNPT
S1142 kQHsQTPSTLNPTMP
T1143 QHsQTPSTLNPTMPA
S1151 LNPTMPASERTVAWV
S1151 LNPTMPASERTVAWV
S1165-p VSNMPHLsADIESAH
Y1183-p EEYKLKEySKSMDES
S1184 EYKLKEySKSMDESR
S1186 KLKEySKSMDESRLD
S1190 ySKSMDESRLDRVKE
K1196 ESRLDRVKEyEEEIH
Y1198-p RLDRVKEyEEEIHsL
S1204-p EyEEEIHsLKERLHM
Y1219-p SNRKLEEyERRLLsQ
S1225-p EyERRLLsQEEQTSK
K1232 sQEEQTSKILMQyQA
Y1237-p TSKILMQyQARLEQS
K1255-ub LRQQQVEkDSQIKSI
K1260 VEkDSQIKSIIGRLM
S1261 EkDSQIKSIIGRLML
K1288 AEPLPEPKKRLLDAQ
  SynGAP iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y41 SCCFPGEYHLGRSRR
R45 PGEYHLGRSRRKSVP
S46 GEYHLGRSRRKSVPG
S50 LGRSRRKSVPGGKQY
Y57 SVPGGKQYSMEAAPA
S58 VPGGKQYSMEAAPAA
K86 KSSIKRTKSQPKLDR
T94 SQPKLDRTSSFRQIL
S96 PKLDRTSSFRQILPR
S117 DRARLMQSFKESHSH
K182 RSAAERDKWIENLQR
S243 TSKPRSASGDTVFWG
K280 DKKRKKDKAGYVGLV
Y283 RKKDKAGYVGLVTVP
S312 PVTLPTGSGGSGGMG
S315 LPTGSGGSGGMGsGG
S320-p GGSGGMGsGGGGGsG
S326-p GsGGGGGsGGGSGGK
S390-p KGKEEVAsALVHILQ
T399 LVHILQSTGKAKDFL
K403 LQSTGKAKDFLsDMA
S407-p GKAKDFLsDMAMSEV
K433 RENTLATKAIEEYMR
K448 LIGQKYLKDAIGEFI
Y459 GEFIRALYESEENCE
K471 NCEVDPIKCTASSLA
S512 ELKEVFASWRLRCAE
K579 QNLANFSKFTSKEDF
K651 LSKEALLKLGPLPRL
K651 LSKEALLKLGPLPRL
T664 RLLSDISTALRNPNI
S684 RQSERARSQPMVLRG
S693 PMVLRGPSAEMQGYM
Y699 PSAEMQGYMMRDLNS
S706 YMMRDLNSSIDLQSF
S707 MMRDLNSSIDLQSFM
S721 MARGLNSSMDMARLP
S729 MDMARLPSPTKEKPP
T731 MARLPSPTKEKPPPP
K734 LPSPTKEKPPPPPPG
Y748 GGGKDLFYVSRPPLA
S750 GKDLFYVSRPPLARS
R751 KDLFYVSRPPLARSS
S758 RPPLARSSPAYCTSS
Y761 LARSSPAYCTSSSDI
T763 RSSPAYCTSSSDITE
S764 SSPAYCTSSSDITEP
S765 SPAYCTSSSDITEPE
S766 PAYCTSSSDITEPEQ
T769 CTSSSDITEPEQKML
K774 DITEPEQKMLsVNKs
S777-p EPEQKMLsVNKsVsM
K780 QKMLsVNKsVsMLDL
S781-p KMLsVNKsVsMLDLQ
S783-p LsVNKsVsMLDLQGD
S802 RLNSSSVSNLAAVGD
S813 AVGDLLHSSQASLTA
S814 VGDLLHSSQASLTAA
S817 LLHSSQASLTAALGL
S833 PAPAGRLSQGsGSSI
S833 PAPAGRLSQGsGSSI
S836-p AGRLSQGsGSSITAA
S839 LSQGsGSSITAAGMR
T841 QGsGSSITAAGMRLS
S848 TAAGMRLSQMGVTTD
T853 RLSQMGVTTDGVPAQ
T854 LSQMGVTTDGVPAQQ
Y923 TFAPFHGYSKSEDLS
S924 FAPFHGYSKSEDLST
S926 PFHGYSKSEDLSTGV
S944 PAASILHSHSYSDEF
S946 ASILHSHSYSDEFGP
Y947 SILHSHSYSDEFGPS
S994 PSGPGGGSGGGSGGG
S998 GGGSGGGSGGGGGGQ
S1014 PPLQRGKSQQLTVSA
S1020 KSQQLTVSAAQKPRP
K1024 LTVSAAQKPRPSSGN
S1028 AAQKPRPSSGNLLQS
S1029 AQKPRPSSGNLLQSP
S1035 SSGNLLQSPEPSYGP
S1039 LLQSPEPSYGPARPR
Y1040 LQSPEPSYGPARPRQ
S1049 PARPRQQSLSKEGSI
K1052 PRQQSLSKEGSIGGS
S1055 QSLSKEGSIGGSGGS
S1059 KEGSIGGSGGSGGGG
S1062 SIGGSGGSGGGGGGG
K1071 GGGGGGLKPSITKQH
S1073 GGGGLKPSITKQHSQ
T1075 GGLKPSITKQHSQTP
K1076 GLKPSITKQHSQTPS
S1079 PSITKQHSQTPSTLN
S1079 PSITKQHSQTPSTLN
T1081 ITKQHSQTPSTLNPT
S1083 KQHSQTPSTLNPTMP
T1084 QHSQTPSTLNPTMPA
S1092 LNPTMPASERTVAWV
S1092 LNPTMPASERTVAWV
S1106 VSNMPHLSADIESAH
Y1124 EEYKLKEYSKSMDES
S1125 EYKLKEYSKSMDESR
S1127 KLKEYSKSMDESRLD
S1131 YSKSMDESRLDRVKE
K1137 ESRLDRVKEYEEEIH
Y1139 RLDRVKEYEEEIHSL
S1145 EYEEEIHSLKERLHM
Y1160 SNRKLEEYERRLLSQ
S1166 EYERRLLSQEEQTSK
K1173 SQEEQTSKILMQYQA
Y1178 TSKILMQYQARLEQS
K1196 LRQQQVEKDSQIKSI
K1201 VEKDSQIKSIIGRLM
S1202 EKDSQIKSIIGRLML
K1229 AEPLPEPKKRLLDAQ
  SynGAP iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K28 KSSIKRTKSQPKLDR
T36 SQPKLDRTSSFRQIL
S38 PKLDRTSSFRQILPR
S59 DRARLMQSFKESHSH
K124 RSAAERDKWIENLQR
S185 TSKPRSASGDTVFWG
K222 DKKRKKDKAGyVGLV
Y225-p RKKDKAGyVGLVTVP
S254 PVTLPTGSGGSGGMG
S257 LPTGSGGSGGMGSGG
S262 GGSGGMGSGGGGGSG
S268 GSGGGGGSGGGSGGK
S332 KGKEEVASALVHILQ
T341 LVHILQSTGKAkDFL
K345-ac LQSTGKAkDFLSDMA
S349 GKAkDFLSDMAMSEV
K375-ub RENTLATkAIEEYMR
K390 LIGQKYLKDAIGEFI
Y401-p GEFIRALyESEENCE
K413-ub NCEVDPIkCTASSLA
S454 ELKEVFASWRLRCAE
K521 QNLANFSKFTSKEDF
K593-ac LSKEALLkLGPLPRL
K593 LSKEALLKLGPLPRL
T606 RLLSDISTALRNPNI
S626 RQSERARSQPMVLRG
S635 PMVLRGPSAEMQGyM
Y641-p PSAEMQGyMMRDLNS
S648 yMMRDLNSSIDLQSF
S649 MMRDLNSSIDLQSFM
S663 MARGLNSSMDMARLP
S671 MDMARLPSPTKEkPP
T673 MARLPSPTKEkPPPP
K676-ub LPSPTKEkPPPPPPG
Y690-p GGGKDLFyVSRPPLA
S692 GKDLFyVSRPPLARS
R693 KDLFyVSRPPLARSS
S700 RPPLARSSPAyCTSS
Y703-p LARSSPAyCTSSSDI
T705 RSSPAyCTSSSDITE
S706 SSPAyCTSSSDITEP
S707 SPAyCTSSSDITEPE
S708 PAyCTSSSDITEPEQ
T711 CTSSSDITEPEQkML
K716-ub DITEPEQkMLSVNkS
S719 EPEQkMLSVNkSVSM
K722-ub QkMLSVNkSVSMLDL
S723 kMLSVNkSVSMLDLQ
S725 LSVNkSVSMLDLQGD
S744 RLNSSSVSNLAAVGD
S755 AVGDLLHSSQASLTA
S756 VGDLLHSSQASLTAA
S759 LLHSSQASLTAALGL
S775 PAPAGRLSQGSGSSI
S775 PAPAGRLSQGSGSSI
S778 AGRLSQGSGSSITAA
S781 LSQGSGSSITAAGMR
T783 QGSGSSITAAGMRLS
S790 TAAGMRLSQMGVTTD
T795 RLSQMGVTTDGVPAQ
T796 LSQMGVTTDGVPAQQ
Y865-p TFAPFHGySKSEDLS
S866 FAPFHGySKSEDLST
S868 PFHGySKSEDLSTGV
S886 PAASILHSHSySDEF
S888 ASILHSHSySDEFGP
Y889-p SILHSHSySDEFGPS
S936 PSGPGGGSGGGSGGG
S940 GGGSGGGSGGGGGGQ
S956 PPLQRGKSQQLTVSA
S962 KSQQLTVSAAQkPRP
K966-ub LTVSAAQkPRPSSGN
S970 AAQkPRPSSGNLLQS
S971 AQkPRPSSGNLLQSP
S977 SSGNLLQSPEPSyGP
S981 LLQSPEPSyGPARPR
Y982-p LQSPEPSyGPARPRQ
S991 PARPRQQSLSkEGSI
K994-ub PRQQSLSkEGSIGGS
S997 QSLSkEGSIGGSGGS
S1001 kEGSIGGSGGSGGGG
S1004 SIGGSGGSGGGGGGG
K1013-ub GGGGGGLkPSITkQH
S1015 GGGGLkPSITkQHSQ
T1017 GGLkPSITkQHSQTP
K1018-ub GLkPSITkQHSQTPS
S1021 PSITkQHSQTPSTLN
S1021 PSITkQHSQTPSTLN
T1023 ITkQHSQTPSTLNPT
S1025 kQHSQTPSTLNPTMP
T1026 QHSQTPSTLNPTMPA
S1034 LNPTMPASERTVAWV
S1034 LNPTMPASERTVAWV
S1048 VSNMPHLSADIESAH
Y1066 EEYKLKEYSKSMDES
S1067 EYKLKEYSKSMDESR
S1069 KLKEYSKSMDESRLD
S1073 YSKSMDESRLDREyE
R1077 MDESRLDREyEEEIH
Y1079-p ESRLDREyEEEIHSL
S1085 EyEEEIHSLKERLHM
Y1100 SNRKLEEYERRLLSQ
S1106 EYERRLLSQEEQTSK
K1113 SQEEQTSKILMQYQA
Y1118 TSKILMQYQARLEQS
K1136-ub LRQQQVEkDSQIKSI
K1141 VEkDSQIKSIIGSPS
S1142 EkDSQIKSIIGSPSL
- gap
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