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Protein Page:
ID3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ID3 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; DNA binding protein
Cellular Component: microtubule cytoskeleton; cytoplasm; nucleolus; nucleus
Molecular Function: protein dimerization activity; protein domain specific binding; protein binding; transcription corepressor activity; transcription factor activity; transcription factor binding
Biological Process: muscle development; central nervous system development; transcription, DNA-dependent; positive regulation of apoptosis; regulation of cell cycle; negative regulation of transcription factor activity; multicellular organismal development; heart development; negative regulation of transcription from RNA polymerase II promoter; notochord development; odontogenesis; neuron differentiation; epithelial cell differentiation; response to wounding; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; metanephros development; regulation of DNA replication
Reference #:  Q02535 (UniProtKB)
Alt. Names/Synonyms: 1R21; BHLHB25; Class B basic helix-loop-helix protein 25; DNA-binding protein inhibitor ID-3; HEIR-1; HEIR1; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; ID3; Inhibitor of DNA binding 3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Gene Symbols: ID3
Molecular weight: 12,999 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ID3

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S5‑p
transcription, altered: S5‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K2-ac ______MkALsPVRG
2 12 S5-p ___MkALsPVRGCyE
1 10 Y11-p LsPVRGCyEAVCCLs
1 2 S18-p yEAVCCLsERsLAIA
0 1 S21-p VCCLsERsLAIARGR
1 0 Y48-p LDDMNHCySRLRELV
  mouse

 
K2 ______MKALsPVRG
S5-p ___MKALsPVRGCYE
Y11 LsPVRGCYEAVCCLS
S18 YEAVCCLSERSLAIA
S21 VCCLSERSLAIARGR
Y48 LDDMNHCYSRLRELV
  rat

 
K2 ______MKALSPVRG
S5 ___MKALSPVRGCYE
Y11 LSPVRGCYEAVCCLS
S18 YEAVCCLSERSLAIA
S21 VCCLSERSLAIARGR
Y48 LDDMNHCYSRLRELV
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