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ID3 (human)

Overview ID3 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription, coactivator/corepressor Cellular Component: cytoplasm; nucleus Molecular Function: protein dimerization activity; protein domain specific binding; transcription corepressor activity; transcription factor activity; transcription factor binding Biological Process: central nervous system development; transcription, DNA-dependent; positive regulation of apoptosis; regulation of cell cycle; heart development; multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; notochord development; neuron differentiation; odontogenesis; epithelial cell differentiation; response to wounding; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; metanephros development; regulation of DNA replication Reference #:  Q02535 (UniProtKB) Alt. Names/Synonyms: 1R21; BHLHB25; Class B basic helix-loop-helix protein 25; DNA-binding protein inhibitor ID-3; HEIR-1; HEIR1; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; ID3; Inhibitor of DNA binding 3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein Gene Symbols: ID3 Molecular weight: 12,999 Da Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ID3 2LFH - A/B=29-83 (human)

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	Sites Implicated In
cell cycle regulation: S5‑p transcription, altered: S5‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K2-a	______MkALsPVRG
1	9		S5-p	___MkALsPVRGCyE
0	10		Y11-p	LsPVRGCyEAVCCLs
0	1		S18-p	yEAVCCLsERsLAIA
0	1		S21-p	VCCLsERsLAIARGR

	mouse
K2	______MKALSPVRG
S5	___MKALSPVRGCYE
Y11	LSPVRGCYEAVCCLS
S18	YEAVCCLSERSLAIA
S21	VCCLSERSLAIARGR

	rat
K2	______MKALSPVRG
S5	___MKALSPVRGCYE
Y11	LSPVRGCYEAVCCLS
S18	YEAVCCLSERSLAIA
S21	VCCLSERSLAIARGR

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