a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; nucleolus; microtubule organizing center; cytosol; nucleus
Molecular Function: protein binding
Biological Process: substantia nigra development; Wnt receptor signaling pathway; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation
Alt. Names/Synonyms: cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N-myc downstream regulator 2; NDR1-related protein NDR2; NDRG family member 2; NDRG2; Protein NDRG2; Protein Syld709613; SYLD; syld709613 protein
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.