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Protein Page:
NDRG2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NDRG2 a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Cellular Component: Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; nucleolus; microtubule organizing center; nucleus; cytosol
Molecular Function: protein binding
Biological Process: substantia nigra development; Wnt receptor signaling pathway; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation
Reference #:  Q9UN36 (UniProtKB)
Alt. Names/Synonyms: cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N-myc downstream regulator 2; NDR1-related protein NDR2; NDRG family member 2; NDRG2; Protein NDRG2; Protein Syld709613; SYLD; syld709613 protein
Gene Symbols: NDRG2
Molecular weight: 40,798 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NDRG2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T10 ELQEVQITEEKPLLP
0 1 K13 EVQITEEKPLLPGQt
0 2 T20-p KPLLPGQtPEAAKEA
0 1 K25 GQtPEAAKEAELAAR
0 1 K25 GQtPEAAKEAELAAR
0 129 Y47-p THSVETPyGSVTFTV
0 3 S49 SVETPyGSVTFTVYG
0 1 T53 PyGSVTFTVYGTPKP
0 54 Y55 GSVTFTVYGTPKPKR
0 1 T57 VTFTVYGTPKPKRPA
0 1 K216 GNSELIQKYRNIITH
0 1 S276-p DAVVECNsKLDPTQT
0 1 K287 PTQTSFLKMADSGGQ
0 1 K302 PQLTQPGKLTEAFKy
0 1 Y309-p KLTEAFKyFLQGMGY
0 3 Y316 yFLQGMGYMAsSCMt
0 3 S319-p QGMGYMAsSCMtRLs
0 5 S320 GMGYMAsSCMtRLsR
0 7 T323-p YMAsSCMtRLsRsRt
0 36 S326-p sSCMtRLsRsRtAsL
0 112 S328-p CMtRLsRsRtAsLts
1 244 T330-p tRLsRsRtAsLtsAA
2 382 S332-p LsRsRtAsLtsAAsV
0 94 T334-p RsRtAsLtsAAsVDG
0 98 S335-p sRtAsLtsAAsVDGN
0 158 S338-p AsLtsAAsVDGNRsR
0 27 N342 sAAsVDGNRsRsRtL
0 47 S344-p AsVDGNRsRsRtLsQ
1 85 S346-p VDGNRsRsRtLsQss
2 193 T348-p GNRsRsRtLsQssEs
1 286 S350-p RsRsRtLsQssEsGt
0 158 S352-p RsRtLsQssEsGtLs
0 188 S353-p sRtLsQssEsGtLss
0 55 S355-p tLsQssEsGtLssGP
0 34 T357-p sQssEsGtLssGPPG
0 6 S359-p ssEsGtLssGPPGHt
0 7 S360-p sEsGtLssGPPGHtM
0 3 T366-p ssGPPGHtMEVsC__
0 5 S370-p PGHtMEVsC______
  mouse

 
T10-p ELQEVQItEEkPLLP
K13-ac EVQItEEkPLLPGQT
T20 kPLLPGQTPETAkEA
K25-ac GQTPETAkEAELAAR
K25-ub GQTPETAkEAELAAR
Y47-p THSVETPyGSVTFtV
S49 SVETPyGSVTFtVYG
T53-p PyGSVTFtVYGtPKP
Y55 GSVTFtVYGtPKPKR
T57-p VTFtVYGtPKPKRPA
K216-ac GNSELIQkYRGIIQH
S276 DAVVECNSKLDPTQT
K287-ub PTQTSFLkMADSGGQ
K302-ub PQLTQPGkLTEAFKY
Y309 kLTEAFKYFLQGMGy
Y316-p YFLQGMGyMAssCMt
S319-p QGMGyMAssCMtRLs
S320-p GMGyMAssCMtRLsR
T323-p yMAssCMtRLsRsRt
S326-p ssCMtRLsRsRtAsL
S328-p CMtRLsRsRtAsLts
T330-p tRLsRsRtAsLtsAA
S332-p LsRsRtAsLtsAAsI
T334-p RsRtAsLtsAAsIDG
S335-p sRtAsLtsAAsIDGs
S338-p AsLtsAAsIDGsRsR
S342-p sAAsIDGsRsRsRtL
S344-p AsIDGsRsRsRtLsQ
S346-p IDGsRsRsRtLsQss
T348-p GsRsRsRtLsQssEs
S350-p RsRsRtLsQssEsGt
S352-p RsRtLsQssEsGtLP
S353-p sRtLsQssEsGtLPs
S355-p tLsQssEsGtLPsGP
T357-p sQssEsGtLPsGPPG
P359 ssEsGtLPsGPPGHt
S360-p sEsGtLPsGPPGHtM
T366-p PsGPPGHtMEVsC__
S370-p PGHtMEVsC______
  rat

 
T10-p ELQEVQItEEkPLLP
K13-ac EVQItEEkPLLPGQt
T20-p kPLLPGQtPEAAKEA
K25 GQtPEAAKEAELAAR
K25 GQtPEAAKEAELAAR
Y47-p THSVETPyGsVTFTV
S49-p SVETPyGsVTFTVyG
T53 PyGsVTFTVyGTPKP
Y55-p GsVTFTVyGTPKPKR
T57 VTFTVyGTPKPKRPA
K216 GNSELIQKYRSLITH
S276 DAVVECNSKLDPTQT
K287 PTQTSFLKMADSGGQ
K302 PQLTQPGKLTEAFKY
Y309 KLTEAFKYFVQGMGY
Y316 YFVQGMGYMASSCMT
S319 QGMGYMASSCMTRLs
S320 GMGYMASSCMTRLsR
T323 YMASSCMTRLsRsRt
S326-p SSCMTRLsRsRtAsL
S328-p CMTRLsRsRtAsLts
T330-p TRLsRsRtAsLtsAA
S332-p LsRsRtAsLtsAAsI
T334-p RsRtAsLtsAAsIDG
S335-p sRtAsLtsAAsIDGs
S338-p AsLtsAAsIDGsRsR
S342-p sAAsIDGsRsRsRtL
S344-p AsIDGsRsRsRtLsQ
S346-p IDGsRsRsRtLsQss
T348-p GsRsRsRtLsQssES
S350-p RsRsRtLsQssESGT
S352-p RsRtLsQssESGTLP
S353-p sRtLsQssESGTLPS
S355 tLsQssESGTLPSGP
T357 sQssESGTLPSGPPG
P359 ssESGTLPSGPPGHT
S360 sESGTLPSGPPGHTM
T366 PSGPPGHTMEVSC__
S370 PGHTMEVSC______
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