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Protein Page:
CD44 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD44 Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Receptor, misc.
Cellular Component: Golgi apparatus; cell surface; basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane
Molecular Function: collagen binding; protein binding; transmembrane receptor activity; hyaluronic acid binding; hyalurononglucosaminidase activity
Biological Process: extracellular matrix organization and biogenesis; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; glycosaminoglycan metabolic process; cell-matrix adhesion; cytokine and chemokine mediated signaling pathway; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; extracellular matrix disassembly; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell adhesion; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; leukocyte migration; healing during inflammatory response; hyaluronan metabolic process; negative regulation of apoptosis
Reference #:  P16070 (UniProtKB)
Alt. Names/Synonyms: antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen (homing function and Indian blood group system); CD44 molecule (Indian blood group); CDw44; CDW44 antigen; cell adhesion molecule; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; Epican; Extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; Hyaluronate receptor; IN; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; PGP-1; PGP-I; Pgp1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I
Gene Symbols: CD44
Molecular weight: 81,538 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD44

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S697‑p, S704‑p, S706‑p
cytoskeletal reorganization: S672‑p
transcription, induced: S706‑p
activity, induced: S706‑p
intracellular localization: S704‑p, S706‑p
molecular association, regulation: S672‑p, S704‑p, S706‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T62-p AFNSTLPtMAQMEKA
0 1 T163-p VQKGEYRtNPEDIYP
0 1 S171-p NPEDIYPsNPtDDDV
0 1 T174-ga DIYPsNPtDDDVSSG
0 1 S183-p DDVSSGSsSERSSTS
0 1 T197-ga SGGYIFYtFstVHPI
0 1 S199-ga GYIFYtFstVHPIPD
0 1 T200-ga YIFYtFstVHPIPDE
0 1 T222-p STDRIPAtTLMSTSA
0 1 T318-ga TPRAFDHtKQNQDWt
0 1 T325-ga tKQNQDWtQWNPsHs
0 1 S330-ga DWtQWNPsHsNPEVL
0 1 S332-ga tQWNPsHsNPEVLLQ
0 1 Y412-p GNRWHEGyRQTPKED
0 1 Y412-ga GNRWHEGyRQTPKED
0 1 S420-p RQTPKEDsHsttGtA
0 1 S422-ga TPKEDsHsttGtAAA
0 1 T423-ga PKEDsHsttGtAAAs
0 1 T424-ga KEDsHsttGtAAAsA
0 1 T426-ga DsHsttGtAAAsAHt
0 1 S430-ga ttGtAAAsAHtsHPM
0 1 T433-ga tAAAsAHtsHPMQGR
0 1 S434-ga AAAsAHtsHPMQGRT
0 1 S458-ga TDFFNPIsHPMGRGH
0 1 S514-ga QSNSQSFstSHEGLE
0 1 T515-ga SNSQSFstSHEGLEE
0 1 T528-ga EEDKDHPttSTLTSS
0 1 T529-ga EDKDHPttSTLTSSN
0 1 T541-ga SSNRNDVtGGRRDPN
0 1 S550-ga GRRDPNHsEGsttLL
0 1 S553-ga DPNHsEGsttLLEGy
0 1 T554-ga PNHsEGsttLLEGyt
0 1 T555-ga NHsEGsttLLEGyts
0 1 Y560-ga sttLLEGytsHYPHt
0 1 T561-ga ttLLEGytsHYPHtK
0 1 S562-ga tLLEGytsHYPHtKE
0 1 T567-ga ytsHYPHtKEsRtFI
0 1 S570-ga HYPHtKEsRtFIPVt
0 1 T572-p PHtKEsRtFIPVtsA
0 1 T572-ga PHtKEsRtFIPVtsA
0 1 T577-ga sRtFIPVtsAKtGsF
0 1 S578-ga RtFIPVtsAKtGsFG
0 1 T581-ga IPVtsAKtGsFGVTA
0 1 S583-ga VtsAKtGsFGVTAVT
2 0 S672-p AVCIAVNsRRRCGQK
0 7 K681-ub RRCGQKKkLVINsGN
0 10 S686-p KKkLVINsGNGAVED
0 7 A690 VINsGNGAVEDRkPs
0 1 K695-ub NGAVEDRkPsGLNGE
1 31 S697-p AVEDRkPsGLNGEAs
3 14 S704-p sGLNGEAsksQEMVH
0 7 K705-ub GLNGEAsksQEMVHL
10 59 S706-p LNGEAsksQEMVHLV
0 13 K715-ub EMVHLVNkESsEtPD
0 5 S718-p HLVNkESsEtPDQFM
0 7 T720-p VNkESsEtPDQFMtA
0 3 T726-p EtPDQFMtADETRNL
0 1 N735 DETRNLQNVDMkIGV
0 41 K739-ub NLQNVDMkIGV____
  CD44 iso30  
T62 AFNSTLPTMAQMEKA
T163 VQKGEYRTNPEDIYP
S171 NPEDIYPSNPTDDDV
T174 DIYPSNPTDDDVSSG
S183 DDVSSGSSSERSSTS
T197 SGGYIFYTFSTVHPI
S199 GYIFYTFSTVHPIPD
T200 YIFYTFSTVHPIPDE
T222 STDRIPATTLMSTSA
T318 TPRAFDHTKQNQDWT
T325 TKQNQDWTQWNPSHS
S330 DWTQWNPSHSNPEVL
S332 TQWNPSHSNPEVLLQ
Y412 GNRWHEGYRQTPKED
Y412 GNRWHEGYRQTPKED
S420 RQTPKEDSHSTTGTA
S422 TPKEDSHSTTGTAAA
T423 PKEDSHSTTGTAAAS
T424 KEDSHSTTGTAAASA
T426 DSHSTTGTAAASAHT
S430 TTGTAAASAHTSHPM
T433 TAAASAHTSHPMQGR
S434 AAASAHTSHPMQGRT
S458 TDFFNPISHPMGRGH
S514 QSNSQSFSTSHEGLE
T515 SNSQSFSTSHEGLEE
T528 EEDKDHPTTSTLTSS
T529 EDKDHPTTSTLTSSN
T541 SSNRNDVTGGRRDPN
S550 GRRDPNHSEGSTTLL
S553 DPNHSEGSTTLLEGY
T554 PNHSEGSTTLLEGYT
T555 NHSEGSTTLLEGYTS
Y560 STTLLEGYTSHYPHT
T561 TTLLEGYTSHYPHTK
S562 TLLEGYTSHYPHTKE
T567 YTSHYPHTKESRTFI
S570 HYPHTKESRTFIPVT
T572 PHTKESRTFIPVTSA
T572 PHTKESRTFIPVTSA
T577 SRTFIPVTSAKTGSF
S578 RTFIPVTSAKTGSFG
T581 IPVTSAKTGSFGVTA
S583 VTSAKTGSFGVTAVT
S672 AVCIAVNSRRRCGQK
K681 RRCGQKKKLVINSGN
S686 KKKLVINSGNGAVED
A690 VINSGNGAVEDRKPS
K695 NGAVEDRKPSGLNGE
S697 AVEDRKPSGLNGEAS
S704 SGLNGEASKSQEMVH
K705 GLNGEASKSQEMVHL
S706 LNGEASKSQEMVHLV
K715 EMVHLVNKESSETPD
S718 HLVNKESSETPDQFM
T720 VNKESSETPDQFMTA
T726 ETPDQFMTADETRNL
N735 DETRNLQNVDMKIGV
K739 NLQNVDMKIGV____
  mouse

► Hide Isoforms
 
T64-p AFNSTLPtMDQMKLA
T166 SKKGEYRTHQEDIDA
S174 HQEDIDASNIIDDDV
I177 DIDASNIIDDDVSSG
T186 DDVSSGSTIEKSTPE
T199 PEGYILHTYLPTEQP
L201 GYILHTYLPTEQPTG
T203 ILHTYLPTEQPTGDQ
S225 STLATIASTVHSKSH
T356 TPRVSARTEDNQDWT
T363 TEDNQDWTQWKPNHS
N368 DWTQWKPNHSNPEVL
S370 TQWKPNHSNPEVLLQ
N447 QNGWQGKNPPTPSED
N447 QNGWQGKNPPTPSED
S455 PPTPSEDSHVTEGTT
V457 TPSEDSHVTEGTTAS
T458 PSEDSHVTEGTTASA
E459 SEDSHVTEGTTASAH
T461 DSHVTEGTTASAHNN
S464 VTEGTTASAHNNHPS
N467 GTTASAHNNHPSQRI
N468 TTASAHNNHPSQRIT
S492 TDFFDPISHPMGQGH
S547 QSHSQNFSTLHGEPE
T548 SHSQNFSTLHGEPEE
T561 EEDENYPTTSILPSS
T562 EDENYPTTSILPSST
K574 SSTKSSAKDARRGGS
T584 RRGGSLPTDTTTSVE
T586 GGSLPTDTTTSVEGY
T587 GSLPTDTTTSVEGYT
T588 SLPTDTTTSVEGYTF
Y593 TTTSVEGYTFQYPDT
T594 TTSVEGYTFQYPDTM
F595 TSVEGYTFQYPDTME
T600 YTFQYPDTMENGTLF
N603 QYPDTMENGTLFPVT
T605 PDTMENGTLFPVTPA
T605 PDTMENGTLFPVTPA
T610 NGTLFPVTPAKTEVF
P611 GTLFPVTPAKTEVFG
T614 FPVTPAKTEVFGETE
V616 VTPAKTEVFGETEVT
S708 AVCIAVNSRRRCGQK
K717 RRCGQKKKLVINGGN
G722 KKKLVINGGNGtVED
T726-p VINGGNGtVEDRKPs
K731 NGtVEDRKPsELNGE
S733-p tVEDRKPsELNGEAs
S740-p sELNGEAsKsQEMVH
K741 ELNGEAsKsQEMVHL
S742-p LNGEAsKsQEMVHLV
K751-ub EMVHLVNkEPsEtPD
S754-p HLVNkEPsEtPDQCM
T756-p VNkEPsEtPDQCMTA
T762 EtPDQCMTADETRNL
S771-p DETRNLQsVDMKIGV
K775 NLQsVDMKIGV____
  CD44 iso2  
T64 AFNSTLPTMDQMKLA
T166 SKKGEYRTHQEDIDA
S174 HQEDIDASNIIDDDV
I177 DIDASNIIDDDVSSG
T186 DDVSSGSTIEKSTPE
T199 PEGYILHTYLPTEQP
L201 GYILHTYLPTEQPTG
T203 ILHTYLPTEQPTGDQ
- gap
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- gap
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- gap
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- gap
- gap
- gap
- gap
- gap
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- gap
- gap
- gap
- gap
- gap
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- gap
- gap
- gap
- gap
S293 AVCIAVNSRRRCGQK
K302 RRCGQKKKLVINGGN
G307 KKKLVINGGNGTVED
T311 VINGGNGTVEDRKPS
K316 NGTVEDRKPSELNGE
S318 TVEDRKPSELNGEAs
S325-p SELNGEAsKsQEMVH
K326 ELNGEAsKsQEMVHL
S327-p LNGEAsKsQEMVHLV
K336 EMVHLVNKEPSETPD
S339 HLVNKEPSETPDQCM
T341 VNKEPSETPDQCMTA
T347 ETPDQCMTADETRNL
S356 DETRNLQSVDMKIGV
K360 NLQSVDMKIGV____
  rat

 
T65 AFNTTLPTMAQMELA
T167 SKKGEYRTHQEDIDA
S175 HQEDIDASNIIDEDV
I178 DIDASNIIDEDVSSG
T187 EDVSSGSTIEKSTPE
T200 PEGYILHTDLPTSQP
L202 GYILHTDLPTSQPTG
T204 ILHTDLPTSQPTGDR
T226 STLATIATTPWVSAH
T234 TPWVSAHTKQNQERT
T241 TKQNQERTQWNPIHS
I246 ERTQWNPIHSNPEVL
S248 TQWNPIHSNPEVLLQ
N328 ENEWQGKNPPTPSED
N328 ENEWQGKNPPTPSED
S336 PPTPSEDSHVTEGTT
V338 TPSEDSHVTEGTTAS
T339 PSEDSHVTEGTTASA
E340 SEDSHVTEGTTASAH
T342 DSHVTEGTTASAHNN
S345 VTEGTTASAHNNHPS
N348 GTTASAHNNHPSQRM
N349 TTASAHNNHPSQRMT
S373 TDFFDPISHPMGQGH
- gap
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- gap
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- gap
- gap
- gap
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- gap
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- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S433 AVCIAVNSRRRCGQK
K442 RRCGQKKKLVINsGN
S447-p KKKLVINsGNGtVED
T451-p VINsGNGtVEDRKPs
K456 NGtVEDRKPsELNGE
S458-p tVEDRKPsELNGEAS
S465 sELNGEASKsQEMVH
K466 ELNGEASKsQEMVHL
S467-p LNGEASKsQEMVHLV
K476 EMVHLVNKEPTETPD
T479 HLVNKEPTETPDQFM
T481 VNKEPTETPDQFMTA
T487 ETPDQFMTADETRNL
S496 DETRNLQSVDMKIGV
K500 NLQSVDMKIGV____
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