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MMP9 (human)

Overview MMP9 May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB. Protein type: EC 3.4.24.35; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Cellular Component: extracellular space; proteinaceous extracellular matrix; protein complex; extracellular region Molecular Function: collagen binding; protein binding; zinc ion binding; metalloendopeptidase activity; fibronectin binding; protein complex binding Biological Process: response to nicotine; extracellular matrix organization and biogenesis; macrophage differentiation; positive regulation of apoptosis; tissue remodeling; response to lipopolysaccharide; proteolysis; anatomical structure regression; response to estradiol stimulus; extracellular matrix disassembly; response to radiation; cell growth; skeletal development; positive regulation of keratinocyte migration; response to drug; ossification; response to retinoic acid; positive regulation of synaptic plasticity; collagen catabolic process; positive regulation of angiogenesis; response to hyperoxia; response to ethanol; response to heat; response to mechanical stimulus; response to hypoxia; response to oxidative stress; embryo implantation; transformation of host cell by virus Reference #:  P14780 (UniProtKB) Alt. Names/Synonyms: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; CLG4B; Gelatinase B; GELB; macrophage gelatinase; MANDP2; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix metalloproteinase-9; MMP-9; MMP9; type V collagenase Gene Symbols: MMP9 Molecular weight: 78,458 Da Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  GPCRs Signaling to MAPK/Erk Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MMP9 1GKC - A/B=107-249 (human) 1GKD - A/B=107-249 (human) 1ITV - A/B=513-707 (human) 1L6J - A=20-444 (human) 1LKG - A=1-707 (human) 2OVX - A/B=110-249 (human) 2OVZ - A/B=110-249 (human) 2OW0 - A/B=110-249 (human) 2OW1 - A/B=110-249 (human) 2OW2 - A/B=110-249 (human) 4H1Q - A/B=391-444 (human) 4H2E - A/B=391-444 (human) 4H3X - A/B=391-444 (human) 4H82 - A/D/C/B=391-444 (human) 4HMA - A/B=391-444 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA  |  ENZYME  |  Phospho3D  |  DISEASE 120361 603932  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y241-p	FIFEGRSySACTTDG
0	1		S628-p	RGKMLLFsGRRLWRF

	mouse
Y241	FTFEGRSYSACTTDG
S646	LGKALLFSKGRVWRF

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