May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Cellular Component: extracellular space; proteinaceous extracellular matrix; protein complex; extracellular region
Molecular Function: collagen binding; protein binding; zinc ion binding; metalloendopeptidase activity; fibronectin binding; protein complex binding
Biological Process: response to nicotine; extracellular matrix organization and biogenesis; macrophage differentiation; positive regulation of apoptosis; tissue remodeling; response to lipopolysaccharide; proteolysis; anatomical structure regression; response to estradiol stimulus; extracellular matrix disassembly; response to radiation; cell growth; skeletal development; positive regulation of keratinocyte migration; response to drug; ossification; response to retinoic acid; positive regulation of synaptic plasticity; collagen catabolic process; positive regulation of angiogenesis; response to hyperoxia; response to ethanol; response to heat; response to mechanical stimulus; response to hypoxia; response to oxidative stress; embryo implantation; transformation of host cell by virus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.