Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 22.214.171.124; Apoptosis; Motility/polarity/chemotaxis
Molecular Function: peptidase activity; cyclin-dependent protein kinase inhibitor activity; phospholipase A2 activator activity; protein binding; protease binding; cysteine-type endopeptidase activity; death receptor binding; protein complex binding; aspartic-type endopeptidase activity
Biological Process: response to nicotine; extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; wound healing; apoptosis; negative regulation of activated T cell proliferation; heart development; response to glucocorticoid stimulus; programmed cell death; response to lipopolysaccharide; negative regulation of B cell proliferation; regulation of caspase activity; proteolysis; response to estradiol stimulus; response to antibiotic; neuron differentiation; extracellular matrix disassembly; sensory perception of sound; learning and/or memory; B cell homeostasis; positive regulation of neuron apoptosis; response to glucose stimulus; erythrocyte differentiation; T cell homeostasis; DNA fragmentation during apoptosis; cell structure disassembly during apoptosis; response to X-ray; response to UV; response to drug; cell fate commitment; hippocampus development; negative regulation of cyclin-dependent protein kinase activity; response to amino acid stimulus; keratinocyte differentiation; neuron apoptosis; response to hydrogen peroxide; response to hypoxia; response to cobalt ion; caspase activation via cytochrome c; platelet formation; response to DNA damage stimulus; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.