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Hic-5 (human)

Overview Hic-5 Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Up-regulated by TNF and hydrogen peroxide. Expressed in platelets, smooth muscle and prostate stromal cells. Belongs to the paxillin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Cellular Component: extracellular matrix; focal adhesion; cytoskeleton; nuclear matrix; cytoplasm; intracellular Molecular Function: protein binding; Roundabout binding; androgen receptor binding; zinc ion binding; transcription coactivator activity Biological Process: transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; cell fate commitment; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; ubiquitin-dependent SMAD protein catabolic process; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; epithelial cell differentiation; androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; cell adhesion Reference #:  O43294 (UniProtKB) Alt. Names/Synonyms: Androgen receptor coactivator 55 kDa protein; androgen receptor coactivator ARA55; Androgen receptor-associated protein of 55 kDa; ARA55; Hic-5; HIC5; Hydrogen peroxide-inducible clone 5 protein; TGFB1I1; TGFI1; transforming growth factor beta 1 induced transcript 1; Transforming growth factor beta-1-induced transcript 1 protein; TSC-5 Gene Symbols: TGFB1I1 Molecular weight: 49,814 Da Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Hic-5

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	Sites Implicated In
transcription, altered: Y60‑p inhibition: Y60‑p molecular association, regulation: Y60‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	14		T33-p	ERPAEPLtPPPsyGH
0	1		S37-p	EPLtPPPsyGHQPQT
1	2		Y38-p	PLtPPPsyGHQPQTG
0	3		T44	syGHQPQTGSGESSG
0	3		A52	GSGESSGASGDKDHL
3	20		Y60-p	SGDKDHLystVCKPR
0	6		S61-p	GDKDHLystVCKPRs
0	1		T62-p	DKDHLystVCKPRsP
0	7		S68-p	stVCKPRsPKPAAPA
0	1		S122-p	FPSSKVAsGEQKEDQ
0	20		S137-p	SEDKKRPsLPssPsP
0	10		S140-p	KKRPsLPssPsPGLP
1	21		S141-p	KRPsLPssPsPGLPK
0	11		S143-p	PsLPssPsPGLPKAS
0	1		S164	ELDRLMASLSDFRVQ
0	4		S186	PTQPPVVSSTNEGsP
0	2		T188	QPPVVSSTNEGsPsP
0	2		S192-p	VSSTNEGsPsPPEPT
0	6		S194-p	STNEGsPsPPEPTGK
0	1		T199	sPsPPEPTGKGSLDT
0	1		G200	PsPPEPTGKGSLDTM
0	4		S403-p	HFHARRGsLCATCGL
0	1		S418-p	PVTGRCVsALGRRFH
0	1		K458-u	YCQPCFLkLFG____

	mouse
T33-p	ERPPETLtPPPPyGH
P37	ETLtPPPPyGHQPQt
Y38-p	TLtPPPPyGHQPQtG
T44-p	PyGHQPQtGSGESSG
T52-p	GSGESSGtTGDKDHL
Y60-p	TGDKDHLysTVCKPR
S61-p	GDKDHLysTVCKPRs
T62	DKDHLysTVCKPRsP
S68-p	sTVCKPRsPKPVAPV
E122	FPSSKMAEGEEKEDQ
T137	SEDKSSPTVPPsPFP
P140	KSSPTVPPsPFPAPS
S141-p	SSPTVPPsPFPAPSK
F143	PTVPPsPFPAPSKPS
S164-p	ELDRLMAsLSDFRVQ
S186-p	PPQPPAAsPtREGCP
T188-p	QPPAAsPtREGCPsP
C192	AsPtREGCPsPPGQt
S194-p	PtREGCPsPPGQtsK
T199-p	CPsPPGQtsKGSLDT
S200-p	PsPPGQtsKGSLDTM
S403-p	HFHAQRGsLCATCGL
S418-p	PVTGRCVsALGRRFH
K458	YCQPCFLKLFG____

	rat
T33	ERPPETLTPPPPYGH
P37	ETLTPPPPYGHQPQT
Y38	TLTPPPPYGHQPQTG
T44	PYGHQPQTGSGESSG
A52	GSGESSGASGDKDHL
Y60	SGDKDHLYSTVCKPR
S61	GDKDHLYSTVCKPRS
T62	DKDHLYSTVCKPRSP
S68	STVCKPRSPKSVAPV
E122	FPSSKMAEGEGKEDQ
T137	SEDKSITTVPSSTFP
S140	KSITTVPSSTFPAPS
S141	SITTVPSSTFPAPSK
T142	ITTVPSSTFPAPSKP
S164	ELDRLMASLSDFRVQ
S186	PPQPPAVSPTREGCP
T188	QPPAVSPTREGCPsP
C192	VSPTREGCPsPPGQT
S194-p	PTREGCPsPPGQTNK
T199	CPsPPGQTNKGSLDT
N200	PsPPGQTNKGSLDTM
S403	HFHAQRGSLCATCGL
S418	PVTGRCVSALGRRFH
K458	YCQPCFLKLFG____

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