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Protein Page:
ACC2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ACC2 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pyruvate; Lipid Metabolism - fatty acid biosynthesis; EC 6.3.4.14; EC 6.4.1.2; Ligase; Carbohydrate Metabolism - propanoate; Mitochondrial
Cellular Component: mitochondrial outer membrane; endomembrane system; cytosol
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; biotin binding; ATP binding
Biological Process: response to drug; vitamin metabolic process; acetyl-CoA metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; biotin metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process; protein homotetramerization
Reference #:  O00763 (UniProtKB)
Alt. Names/Synonyms: ACACB; ACC-beta; ACC2; ACCB; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; Biotin carboxylase; HACC275
Gene Symbols: ACACB
Molecular weight: 276,541 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACC2

Protein Structure Not Found.


Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S44 SEANLIPSQEPFPAS
0 1 P47 NLIPSQEPFPASDNS
0 1 S146 PQGQQAGSPSKEDKK
0 1 S148 GQQAGSPSKEDKKQA
0 1 G191 SRESTRKGSRASLGA
0 2 S195 TRKGSRASLGALSLE
0 1 S200 RASLGALSLEAYLTT
0 1 T207 SLEAYLTTGEAETRV
0 1 G208 LEAYLTTGEAETRVP
1 2 T212 LTTGEAETRVPTMRP
1 2 S220-p RVPTMRPsMsGLHLV
21 3 S222-p PTMRPsMsGLHLVKR
0 1 R446 EGLEAAERIGFPLMI
0 2 K454-a IGFPLMIkASEGGGG
0 1 K466 GGGKGIRKAESAEDF
0 1 S469 KGIRKAESAEDFPIL
0 2 K663-u ENPDEGFkPSSGTVQ
0 1 S865-p LLSYNGNsyTTYMKE
0 1 Y866-p LSYNGNsyTTYMKEE
0 1 K1059 RIPAPVEKSVRRVMA
0 3 S1340-p NRMTVPIsItNPDLL
0 19 T1342-p MTVPIsItNPDLLRH
0 6 T1351-p PDLLRHStELFMDSG
0 1 S1360 LFMDSGFSPLCQRMG
0 1 K1413 LYSEDDCKSLREEPI
0 2 Y1456-p KKNILVDyGLRRITF
0 2 Y1489-p EFAEDRIyRHLEPAL
0 1 K1530 YLGAAKVKEGVEVTD
0 2 T1641-p INIRQTTtGSAVPIR
0 1 K1730 MFRQALFKLWGSPDK
0 1 K1737 KLWGSPDKYPKDILT
0 1 K1857 VDPEDPHKGFKYLYL
0 1 K1881 SLNSVHCKHIEEGGE
0 1 K1899 MITDIIGKDDGLGVE
0 1 R2040 EIEFLPSRAPYDPRW
0 1 K2165 RGFSGGMKDMYDQVL
0 1 K2238 PEGTVEIKFRKKDLI
0 1 K2257 RIDPAYKKLMEQLGE
0 1 K2407 RENITYLKHDSVLKT
3661 : Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody
11818 : Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb
  mouse

 
S44-p VEANLLSsEEsLSAS
S47-p NLLSsEEsLSASELS
S136-p PPSQRTVsPsREDRK
S138-p SQRTVsPsREDRKQA
S181-p FQNSSRKsSRAsLGT
S185-p SRKsSRAsLGTLsQE
S190-p RAsLGTLsQEAALNt
T197-p sQEAALNtsDPEsHA
S198-p QEAALNtsDPEsHAP
S202-p LNtsDPEsHAPTMRP
S210-p HAPTMRPsMsGLHLV
S212-p PTMRPsMsGLHLVKR
K436-u EGLQAAEkIGFPLMI
K444 IGFPLMIKASEGGGG
K456-u GGGKGIRkAEsAEDF
S459-p KGIRkAEsAEDFPML
K653-u ENPDEGFkPSSGTVQ
S855 LLSYNGSSYTTYMKE
Y856 LSYNGSSYTTYMKEE
K1049-u RIPAPVEkAVRRVMA
S1330-p NRMAVPIsVsNPDLL
S1332-p MAVPIsVsNPDLLRH
T1341-p PDLLRHStELFMDSG
S1350-p LFMDSGFsPLCQRMG
K1403-u LYSEEDSkSLREEPI
Y1446 KKHILVDYGLRRITF
Y1479 EFAEDRIYRHLEPAL
K1520-u YLGAAKVkEGLEVTD
S1631-p INIRQTTsDSAIPIR
K1720-u MFRQALFkLWGSPEk
K1727-u kLWGSPEkYPKDILT
K1847-u VDPEDPHkGFRYLYL
K1871-u SQNSVHCkHIEDEGE
K1889-u VIVDVIGkDANLGVE
K2030-u EIEFTPTkAPYDPRW
K2155-u RGFSGGMkDMYEQML
K2228-u PEGTVEIkFRKKDLV
K2247-u RIDPVCKkLVGQLGK
K2397-u RENINYLkRDSVLKT
3661 : Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody
11818 : Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb
  rat

 
S44 VDASLLPSKEESFAS
E47 SLLPSKEESFASDQS
S142 PQTQRTGSPTREDKK
T144 TQRTGSPTREDKKQA
G187 FQTSSRKGSRDSLGT
S191 SRKGSRDSLGTCSQE
S196 RDSLGTCSQEAALNT
T203 SQEAALNTADPESHT
A204 QEAALNTADPESHTP
S208 LNTADPESHTPTMRP
S216 HTPTMRPSMsGLHLV
S218-p PTMRPSMsGLHLVKR
K442 EGLQAAEKVGFPLMI
K450 VGFPLMIKASEGGGG
Q462 GGGKGIRQAESAEDF
S465 KGIRQAESAEDFPCF
K659 ENPDEAFKPSSGTVQ
S861 LLSYNGSSYTTYMKE
Y862 LSYNGSSYTTYMKEE
K1055 RIPVPVEKAVRRVFA
N1336 NRMAMPINVsDPDLL
S1338-p MAMPINVsDPDLLRH
K1347 PDLLRHSKELFMDSG
S1356 LFMDSGFSPLCHQRM
K1410 LYSEEDSKSLQEEPI
Y1453 KKHILVDYGLRRITF
Y1486 EFAEDRIYRHLEPGL
K1527 YLGAAKVKEGLEVTD
S1638 INIRQTTSDCAVPIR
K1727 MFRQALFKLWGSPEK
K1734 KLWGSPEKYGPDILT
K1854 VDPEDPYKGFRYLYL
K1880 SQNSVHCKHIEDEGE
K1897 IIVDVIGKDSSLGVE
K2038 EIEFTPTKAPYDPRW
K2163 RGFSGGMKDMSEQML
K2236 PEGTVEIKFRKKDLV
K2255 RIDPVCKKLLEPAGD
K2405 RENLNYLKRDSVLKT
3661 : Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody
11818 : Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb
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