Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ACC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ACC2 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Ligase; EC 6.4.1.2; Mitochondrial; Lipid Metabolism - fatty acid biosynthesis; EC 6.3.4.14; Carbohydrate Metabolism - pyruvate
Cellular Component: mitochondrial outer membrane; endomembrane system; cytosol
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding; biotin binding
Biological Process: response to drug; vitamin metabolic process; acetyl-CoA metabolic process; energy reserve metabolic process; positive regulation of cellular metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; biotin metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process; protein homotetramerization
Reference #:  O00763 (UniProtKB)
Alt. Names/Synonyms: ACACB; ACC-beta; ACC2; ACCB; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; Biotin carboxylase; HACC275
Gene Symbols: ACACB
Molecular weight: 276,541 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ACC2

Protein Structure Not Found.


Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S35-p DSKPITKsKSEANLI
0 1 S44 SEANLIPSQEPFPAS
0 1 P47 NLIPSQEPFPASDNS
0 1 T70-p EGHTLPKtPSQAEPA
0 1 S91-p DAGRRRNsLPPsHQK
0 1 S95-p RRNsLPPsHQKPPRN
0 1 S146 PQGQQAGSPSKEDKK
0 1 S148 GQQAGSPSKEDKKQA
0 1 K153 SPSKEDKKQANIKRQ
0 1 G191 SRESTRKGsRAsLGA
0 1 S192-p RESTRKGsRAsLGAL
0 3 S195-p TRKGsRAsLGALsLE
0 2 S200-p RAsLGALsLEAYLTT
0 1 T207 sLEAYLTTGEAETRV
0 1 G208 LEAYLTTGEAETRVP
1 2 T212 LTTGEAETRVPtMRP
0 1 T216-p EAETRVPtMRPsMsG
0 3 S220-p RVPtMRPsMsGLHLV
22 4 S222-p PtMRPsMsGLHLVKR
0 1 R446 EGLEAAERIGFPLMI
0 2 K454-ac IGFPLMIkASEGGGG
0 1 K466 GGGKGIRKAEsAEDF
0 2 S469-p KGIRKAEsAEDFPIL
0 2 K663-ub ENPDEGFkPSSGTVQ
0 1 K722-ub SNMVVALkELSIRGD
0 1 S808-p GQVLPADsLLNLVDV
0 1 Y861 DGGLLLSYNGNsyTT
0 1 S865-p LLSYNGNsyTTYMKE
0 1 Y866-p LSYNGNsyTTYMKEE
0 1 T895-p FEKENDPtVLRSPSA
0 1 K1059 RIPAPVEKSVRRVMA
0 1 S1165 EQFKPDMSQVLDCIF
0 3 S1340-p NRMTVPIsItNPDLL
0 20 T1342-p MTVPIsItNPDLLRH
0 1 S1350-p NPDLLRHstELFMDS
0 6 T1351-p PDLLRHstELFMDSG
0 1 S1360 LFMDSGFSPLCQRMG
0 1 K1413 LYSEDDCKSLREEPI
0 1 K1450-ac RTFVQSKkNILVDyG
0 2 Y1456-p KkNILVDyGLRRITF
0 2 Y1489-p EFAEDRIyRHLEPAL
0 1 K1528 HLYLGAAKVKEGVEV
0 1 K1530 YLGAAKVKEGVEVTD
0 1 T1639 VKINIRQTTtGSAVP
0 2 T1641-p INIRQTTtGSAVPIR
0 1 T1652 VPIRLFITNESGYyL
0 1 Y1658-p ITNESGYyLDISLyK
0 1 Y1664-p YyLDISLyKEVTDSR
0 1 K1730 MFRQALFKLWGSPDK
0 1 K1737 KLWGSPDKYPKDILT
0 1 K1857 VDPEDPHKGFKYLYL
0 1 K1881 SLNSVHCKHIEEGGE
0 1 K1899 MITDIIGKDDGLGVE
0 1 R2040 EIEFLPSRAPYDPRW
0 1 K2165 RGFSGGMKDMYDQVL
0 1 K2238 PEGTVEIKFRKKDLI
0 1 K2238 PEGTVEIKFRKKDLI
0 1 K2257 RIDPAYKKLMEQLGE
0 1 S2347-p KQEILQAsGELSHVH
0 1 K2407 RENITYLKHDSVLKT
0 1 T2458-p TMDSPASt_______
3661 : Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody
11818 : Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb
  mouse

 
S35 DSKPLTNSKVEANLL
S44-p VEANLLSsEEsLSAS
S47-p NLLSsEEsLSASELS
- gap
S81-p DASQQRNsLPSSCQR
S85 QRNsLPSSCQRPPRN
S136-p PPSQRTVsPsREDRk
S138-p SQRTVsPsREDRkQA
K143-ac sPsREDRkQAHIKRQ
S181-p FQNSSRKssRAsLGT
S182-p QNSSRKssRAsLGTL
S185-p SRKssRAsLGTLsQE
S190-p RAsLGTLsQEAALNt
T197-p sQEAALNtsDPEsHA
S198-p QEAALNtsDPEsHAP
S202-p LNtsDPEsHAPtMRP
T206-p DPEsHAPtMRPsMsG
S210-p HAPtMRPsMsGLHLV
S212-p PtMRPsMsGLHLVKR
K436-ub EGLQAAEkIGFPLMI
K444 IGFPLMIKASEGGGG
K456-ub GGGKGIRkAEsAEDF
S459-p KGIRkAEsAEDFPML
K653-ub ENPDEGFkPSSGTVQ
K712 SNMVVALKELSIRGD
S798 GQVLPADSLLNIVDV
Y851-p DGGLLLSyNGSSYTT
S855 LLSyNGSSYTTYMKE
Y856 LSyNGSSYTTYMKEE
T885 FEKENDPTVLRSPSA
K1049-ub RIPAPVEkAVRRVMA
T1155-p EQFKPDMtQVLDCIF
S1330-p NRMAVPIsVsNPDLL
S1332-p MAVPIsVsNPDLLRH
S1340-p NPDLLRHstELFMDS
T1341-p PDLLRHstELFMDSG
S1350-p LFMDSGFsPLCQRMG
K1403-ub LYSEEDSkSLREEPI
K1440 RAFVQSKKHILVDYG
Y1446 KKHILVDYGLRRITF
Y1479 EFAEDRIYRHLEPAL
K1518-ac HLYLGAAkVkEGLEV
K1520-ub YLGAAkVkEGLEVTD
T1629-p VKINIRQtTsDSAIP
S1631-p INIRQtTsDSAIPIR
T1642-p IPIRLFItNESGYYL
Y1648 ItNESGYYLDISLYR
Y1654 YYLDISLYREVTDSR
K1720-ub MFRQALFkLWGSPEk
K1727-ub kLWGSPEkYPKDILT
K1847-ub VDPEDPHkGFRYLYL
K1871-ub SQNSVHCkHIEDEGE
K1889-ub VIVDVIGkDANLGVE
K2030-ub EIEFTPTkAPYDPRW
K2155-ub RGFSGGMkDMYEQML
K2228-ac PEGTVEIkFRKKDLV
K2228-ub PEGTVEIkFRKKDLV
K2247-ub RIDPVCKkLVGQLGK
S2337 KQEILRASPELNHEH
K2397-ub RENINYLkRDSVLKT
S2448 TTESPASS_______
3661 : Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody
11818 : Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb
  rat

 
S35 DSRPLSNSKVDASLL
S44 VDASLLPSKEESFAS
E47 SLLPSKEESFASDQS
T66 DCSCPLTTPDQEELA
S87 DASQQRNSVPTSHQK
S91 QRNSVPTSHQKPPRN
S142 PQTQRTGSPTREDKK
T144 TQRTGSPTREDKKQA
K149 SPTREDKKQAPIKRQ
G187 FQTSSRKGSRDSLGT
S188 QTSSRKGSRDSLGTC
S191 SRKGSRDSLGTCSQE
S196 RDSLGTCSQEAALNT
T203 SQEAALNTADPESHT
A204 QEAALNTADPESHTP
S208 LNTADPESHTPTMRP
T212 DPESHTPTMRPSMsG
S216 HTPTMRPSMsGLHLV
S218-p PTMRPSMsGLHLVKR
K442 EGLQAAEKVGFPLMI
K450 VGFPLMIKASEGGGG
Q462 GGGKGIRQAESAEDF
S465 KGIRQAESAEDFPCF
K659 ENPDEAFKPSSGTVQ
K718 SNMVVALKELSIRGD
S804 GQVLPADSLLNIVDV
Y857 DGGLLLSYNGSSYTT
S861 LLSYNGSSYTTYMKE
Y862 LSYNGSSYTTYMKEE
T891 FEKENDPTVLRSPSA
K1055 RIPVPVEKAVRRVFA
T1161 EQFKADMTRVLDCIF
N1336 NRMAMPINVsDPDLL
S1338-p MAMPINVsDPDLLRH
S1346 DPDLLRHSKELFMDS
K1347 PDLLRHSKELFMDSG
S1356 LFMDSGFSPLCHQRM
K1410 LYSEEDSKSLQEEPI
K1447 RAFVQSKKHILVDYG
Y1453 KKHILVDYGLRRITF
Y1486 EFAEDRIYRHLEPGL
K1525 HLYLGAAKVKEGLEV
K1527 YLGAAKVKEGLEVTD
T1636 VKINIRQTTSDCAVP
S1638 INIRQTTSDCAVPIR
T1649 VPIRLFITNESGYYL
Y1655 ITNESGYYLDISLYK
Y1661 YYLDISLYKEVTDSR
K1727 MFRQALFKLWGSPEK
K1734 KLWGSPEKYGPDILT
K1854 VDPEDPYKGFRYLYL
K1880 SQNSVHCKHIEDEGE
K1897 IIVDVIGKDSSLGVE
K2038 EIEFTPTKAPYDPRW
K2163 RGFSGGMKDMSEQML
K2236 PEGTVEIKFRKKDLV
K2236 PEGTVEIKFRKKDLV
K2255 RIDPVCKKLLEPAGD
S2345 KQEILRASPELSHEH
K2405 RENLNYLKRDSVLKT
H2456 TTESPASH_______
3661 : Phospho-Acetyl-CoA Carboxylase (Ser79) Antibody
11818 : Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.