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p53 (human)

Overview p53 a transcription factor and major tumor suppressor that plays a major role in regulating cellular responses to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. More than 50 percent of human tumors contain a mutation or deletion of the TP53 gene. p53 is modified post-translationally at multiple sites. DNA damage induces phosphorylation of p53 at S15, S20 and S37, reducing its interaction with the oncoprotein MDM2. MDM2 inhibits p53 accumulation by targeting it for ubiquitination and proteasomal degradation. Phosphorylated by many kinases including Chk2 and Chk1 at S20, enhancing its tetramerization, stability and activity. The phosphorylation by CAK at S392 is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. Phosphorylation of p53 at S46 regulates the ability of p53 to induce apoptosis. The acetylation of p53 appears to play a positive role in the accumulation of p53 during the stress response. Following DNA damage, p53 becomes acetylated at K382, enhancing its binding to DNA. Deacetylation of p53 can occur through interaction with SIRT1, a deacetylase that may be involved in cellular aging and the DNA damage response. p53 regulates the transcription of a set of genes encoding endosomal proteins that regulate endosomal functions. These include STEAP3 and CHMP4C, which enhance exosome production, and CAV1 and CHMP4C, which produce a more rapid endosomal clearance of the EGFR from the plasma membrane. DNA damage regulates a p53-mediated secretory pathway, increasing the secretion of some proteins such as Hsp90, SERPINE1, SERPINB5, NKEF-A, and CyPA, and inhibiting the secretion of others including CTSL and IGFBP-2. Two alternatively spliced human isoforms have been reported. Isoform 2 is expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor co-regulator; Transcription factor; Motility/polarity/chemotaxis; DNA binding protein; Tumor suppressor; Activator protein Cellular Component: chromatin assembly complex; PML body; transcription factor TFIID complex; protein complex; nuclear matrix; mitochondrion; endoplasmic reticulum; replication fork; cytosol; nucleoplasm; nuclear body; nuclear chromatin; cytoplasm; nucleolus; nucleus; chromatin Molecular Function: identical protein binding; protease binding; protein phosphatase 2A binding; zinc ion binding; p53 binding; protein N-terminus binding; protein kinase binding; transcription factor binding; histone acetyltransferase binding; protein binding; enzyme binding; copper ion binding; histone deacetylase regulator activity; DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; chaperone binding; damaged DNA binding; chromatin binding; transcription factor activity; ATP binding Biological Process: central nervous system development; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation in the thymus; gastrulation; determination of adult life span; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; response to antibiotic; cellular response to glucose starvation; protein localization; negative regulation of neuroblast proliferation; base-excision repair; transforming growth factor beta receptor signaling pathway; protein complex assembly; cell cycle arrest; ER overload response; response to X-ray; release of cytochrome c from mitochondria; somitogenesis; cell aging; rRNA transcription; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of DNA replication; negative regulation of fibroblast proliferation; virus-host interaction; positive regulation of transcription from RNA polymerase II promoter; regulation of mitochondrial membrane permeability; negative regulation of transcription, DNA-dependent; cell cycle checkpoint; negative regulation of apoptosis; G1 DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator; apoptosis; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; response to salt stress; negative regulation of cell proliferation; positive regulation of protein oligomerization; positive regulation of histone deacetylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; T cell proliferation during immune response; double-strand break repair; positive regulation of neuron apoptosis; response to gamma radiation; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein tetramerization; in utero embryonic development; B cell lineage commitment; multicellular organism growth; cell proliferation; T cell lineage commitment; neuron apoptosis; negative regulation of helicase activity; protein import into nucleus, translocation; nucleotide-excision repair; DNA strand renaturation; induction of apoptosis; Ras protein signal transduction; negative regulation of cell growth; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; response to DNA damage stimulus Reference #:  P04637 (UniProtKB) Alt. Names/Synonyms: Antigen NY-CO-13; Cellular tumor antigen p53; FLJ92943; LFS1; P53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; Phosphoprotein p53; TP53; transformation-related protein 53; TRP53; tumor protein p53; Tumor suppressor p53 Gene Symbols: TP53 Molecular weight: 43,653 Da Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Apoptosis  |  Cell Cycle: G1/S Checkpoint  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  Protein Acetylation  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK  |  Warburg Effect Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below p53 1A1U - A/C=324-358 (human) 1AIE - A=326-356 (human) 1C26 - A=325-356 (human) 1DT7 - X/Y=367-388 (human) 1GZH - A/C=95-292 (human) 1H26 - E=376-386 (human) 1HS5 - A/B=324-357 (human) 1JSP - A=367-386 (human) 1KZY - A/B=95-289 (human) 1MA3 - B=372-389 (human) 1OLG - A/B/C/D=319-360 (human) 1OLH - A/B/C/D=319-360 (human) 1PES - A/B/C/D=325-355 (human) 1PET - A/B/C/D=325-355 (human) 1SAE - A/B/C/D=319-360 (human) 1SAF - A/B/C/D=319-360 (human) 1SAG - A/B/C/D=319-360 (human) 1SAH - A/B/C/D=319-360 (human) 1SAI - A/B/C/D=319-360 (human) 1SAJ - A/B/C/D=319-360 (human) 1SAK - A/B/C/D=319-360 (human) 1SAL - A/B/C/D=319-360 (human) 1TSR - A/B/C=94-312 (human) 1TUP - A/B/C=94-312 (human) 1UOL - A/B=94-312 (human) 1XQH - B/F=369-377 (human) 1YC5 - B=372-389 (human) 1YCQ - B=13-29 (human) 1YCR - B=15-29 (human) 1YCS - A=94-292 (human) 2AC0 - A/B/C/D=94-293 (human) 2ADY - A/B=94-293 (human) 2AHI - A/B/C/D=94-293 (human) 2ATA - A/B/C/D=94-293 (human) 2B3G - B=33-60 (human) 2BIM - A/B=94-312 (human) 2BIN - A=94-312 (human) 2BIO - A=94-312 (human) 2BIP - A=94-312 (human) 2BIQ - A=94-312 (human) 2F1X - A/B=360-368 (human) 2FEJ - A=94-297 (human) 2FOJ - B=363-367 (human) 2FOO - B=358-363 (human) 2GS0 - B=20-73 (human) 2H1L - M/N/O/P/Q/R/S/T/U/V/W/X=92-292 (human) 2H2D - B=372-389 (human) 2H2F - B=372-389 (human) 2H4F - D=372-389 (human) 2H4H - B=372-389 (human) 2H4J - D=372-389 (human) 2H59 - D/E=372-389 (human) 2J0Z - A/B/C/D=326-356 (human) 2J10 - A/B/C/D=326-356 (human) 2J11 - A/B/C/D=326-356 (human) 2J1W - A/B=94-312 (human) 2J1X - A/B=94-312 (human) 2J1Y - A/B/C/D=94-293 (human) 2J1Z - A/B=94-312 (human) 2J20 - A/B=94-312 (human) 2J21 - A/B=94-312 (human) 2K8F - B=1-39 (human) 2L14 - B=13-61 (human) 2LY4 - B=1-93 (human) 2OCJ - A/B/C/D=94-312 (human) 2PCX - A=94-292 (human) 2QVQ - A=94-289 (human) 2QXA - A/D/C/B=95-289 (human) 2QXB - A/D/C/B=95-289 (human) 2QXC - A/D/C/B=95-289 (human) 2VUK - A/B=94-312 (human) 2WGX - A/B=94-312 (human) 2X0U - A/B=94-312 (human) 2X0V - A/B=94-312 (human) 2X0W - A/B=94-312 (human) 2XWR - A/B=89-293 (human) 2YBG - A/D/C/B=94-293 (human) 2YDR - P=144-154 (human) 2Z5S - Q/R/P=15-29 (human) 2Z5T - Q/R/P=15-29 (human) 3D05 - A=94-293 (human) 3D06 - A=94-293 (human) 3D07 - A/B=94-293 (human) 3D08 - A=94-293 (human) 3D09 - A=94-293 (human) 3D0A - A/D/C/B=94-293 (human) 3DAB - H/F/D/B=15-29 (human) 3DAC - P/B=17-37 (human) 3IGK - A=94-293 (human) 3IGL - A=94-293 (human) 3KMD - A/C/D/B=92-291 (human) 3KZ8 - A/B=94-293 (human) 3LW1 - P=385-393 (human) 3PDH - D=372-389 (human) 3Q01 - A/B=322-356 (human) 3Q05 - A/D/C/B=321-356 (human) 3Q06 - A/D/C/B=321-354 (human) 3SAK - A/B/C/D=319-360 (human) 3TG5 - B=365-375 (human) 3TS8 - A/D/C/B=321-356 (human) 3ZME - A/B=94-312 (human) 4AGL - A/B=94-312 (human) 4AGM - A/B=94-312 (human) 4AGN - A/B=94-312 (human) 4AGO - A/B=94-312 (human) 4AGP - A/B=94-312 (human) 4AGQ - A/B=94-312 (human) 4FZ3 - B=379-382 (human) 1HU8 - A/B/C=99-284 (mouse) 2GEQ - A/B=92-292 (mouse) 2IOI - A=92-292 (mouse) 2IOM - A=92-292 (mouse) 2IOO - A=92-292 (mouse) 2P52 - A=92-287 (mouse) 3EXJ - A/B=93-289 (mouse) 3EXL - A=93-289 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2OCJ 2PCX 2QVQ 2QXA 2QXB 2QXC 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4FZ3  |  Phospho3D  |  DISEASE 114480 114500 114550 133239 151623 161550 191170 202300 259500 260350 260500 601400  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S6‑p, S9‑p, S15‑p, T18‑p, S20‑p, S37‑p, S46‑p, T55‑p, S269‑p, T284‑p, S315‑p, S392‑p apoptosis, induced: S6‑p, S9‑p, S15‑p, S20‑p, S33‑p, S37‑p, S46‑p, T81‑p, K120‑a, K164‑a, K370‑a, K372‑a, K373‑a, K381‑a, K382‑a, K386‑s, K386‑a, S392‑p apoptosis, inhibited: S46‑p, S183‑p, T211‑p, S215‑p, S315‑p, S376‑p carcinogenesis, induced: S183‑p, T211‑p, S215‑p cell cycle regulation: S9‑p, S15‑p, S20‑p, T55‑p, S183‑p, T211‑p, S215‑p, S315‑p, S376‑p, S378‑p, S392‑p cell growth, altered: S15‑p, S20‑p, S33‑p, S46‑p, S269‑p, S315‑p cell growth, inhibited: S15‑p, S392‑p chromatin organization, altered: S15‑p, S376‑p, S378‑p transcription, altered: S6‑p, S9‑p, S15‑p, T18‑p, S20‑p, S33‑p, S37‑p, S46‑p, T55‑p, T81‑p, K120‑a, K164‑a, S215‑p, S269‑p, T284‑p, S315‑p, S366‑p, K370‑u, K370‑a, K372‑u, K372‑a, K373‑a, K373‑u, S376‑p, S378‑p, K381‑a, K381‑u, K382‑u, K382‑a, K386‑a, K386‑u, K386‑s, T387‑p, S392‑p transcription, induced: S46‑p transcription, inhibited: S183‑p, T211‑p, S215‑p acetylation: S6‑p, S9‑p, S15‑p, T18‑p activation: S6‑p, S15‑p, S20‑p, S33‑p, S37‑p, S46‑p, T55‑p, S315‑p, S366‑p, S371‑p, S376‑p, S378‑p, K386‑s, T387‑p, S392‑p inhibition: S15‑p, S20‑p, S215‑p, S269‑p, S315‑p, S371‑p, S376‑p, S392‑p intracellular localization: S15‑p, S20‑p, T55‑p, K101‑u, K120‑u, K132‑u, K139‑u, K164‑u, S269‑p, S315‑p, K370‑u, K372‑u, K373‑u, S376‑p, S378‑p, K381‑u, K382‑u, K386‑u, S392‑p molecular association, regulation: S15‑p, T18‑p, S20‑p, S33‑p, S37‑p, S46‑p, T55‑p, T81‑p, S315‑p, S366‑p, S371‑p, K373‑a, S376‑p, S378‑p, K382‑m2, K382‑a, T387‑p, S392‑p phosphorylation: S6‑p, S9‑p, S15‑p, S20‑p, S33‑p, S149‑g, S392‑p protein conformation: S15‑p, S37‑p, S215‑p, S269‑p, S315‑p, S392‑p protein degradation: S20‑p, T55‑p, K101‑u, K120‑u, K132‑u, K139‑u, T155‑p, K164‑u, S183‑p, T211‑p, S215‑p, S315‑p, K370‑u, K372‑u, K373‑u, S376‑p, K381‑u, K382‑u, K386‑u protein stabilization: S15‑p, T18‑p, S20‑p, S37‑p, T81‑p, S106‑p, S149‑g, S215‑p, S269‑p, K382‑m2, S392‑p ubiquitination: S149‑g, S183‑p, T211‑p, S215‑p, S269‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
6	0		P4	____MEEPQsDPsVE
30	3		S6-p	__MEEPQsDPsVEPP
33	2		S9-p	EEPQsDPsVEPPLsQ
338	2		S15-p	PsVEPPLsQEtFsDL
27	0		T18-p	EPPLsQEtFsDLWKL
105	1		S20-p	PLsQEtFsDLWKLLP
30	3		S33-p	LPENNVLsPLPsQAM
62	3		S37-p	NVLsPLPsQAMDDLM
79	2		S46-p	AMDDLMLsPDDIEQW
13	0		T55-p	DDIEQWFtEDPGPDE
2	0		D61	FtEDPGPDEAPRMPE
8	2		T81-p	APAPAAPtPAAPAPA
0	2		S99-p	PLSSSVPsQkTYQGs
1	2		K101-u	SSSVPsQkTYQGsYG
1	0		S106-p	sQkTYQGsYGFrLGF
0	1		R110-m1	YQGsYGFrLGFLhSG
0	1		H115-m1	GFrLGFLhSGTAkSV
16	1		K120-a	FLhSGTAkSVTCTYS
1	19		K120-u	FLhSGTAkSVTCTYS
1	1		K132-u	TYSPALNkMFCQLAk
1	0		K139-u	kMFCQLAkTCPVQLW
3	1		S149-p	PVQLWVDstPPPGtR
1	1		S149-g	PVQLWVDstPPPGtR
4	8		T150-p	VQLWVDstPPPGtRV
4	1		T155-p	DstPPPGtRVRAMAI
3	1		K164-a	VRAMAIYkQSQHMTE
1	1		K164-u	VRAMAIYkQSQHMTE
2	0		S183-p	CPHHERCsDSDGLAP
0	1		R209-m1	RVEYLDDrNtFrHsV
1	0		T211-p	EYLDDrNtFrHsVVV
0	1		R213-m1	LDDrNtFrHsVVVPY
4	0		S215-p	DrNtFrHsVVVPYEP
3	0		S269-p	GNLLGRNsFEVRVCA
1	0		T284-p	CPGRDRRtEEENLRk
1	0		K291-u	tEEENLRkkGEPHHE
1	3		K292-a	EEENLRkkGEPHHEL
1	6		K292-u	EEENLRkkGEPHHEL
2	15		K305-a	ELPPGSTkRALPNNt
1	20		K305-u	ELPPGSTkRALPNNt
0	1		T312-p	kRALPNNtsssPQPk
1	3		S313-p	RALPNNtsssPQPkk
1	3		S314-p	ALPNNtsssPQPkkk
38	21		S315-p	LPNNtsssPQPkkkP
0	4		K319-a	tsssPQPkkkPLDGE
1	0		K319-u	tsssPQPkkkPLDGE
32	0		K320-a	sssPQPkkkPLDGEy
2	17		K320-u	sssPQPkkkPLDGEy
1	0		K320-n	sssPQPkkkPLDGEy
2	10		K321-u	ssPQPkkkPLDGEyF
1	0		K321-n	ssPQPkkkPLDGEyF
0	13		Y327-p	kkPLDGEyFTLQIrG
1	0		R333-m	EyFTLQIrGrErFEM
1	0		R335-m2	FTLQIrGrErFEMFR
1	0		R337-m2	LQIrGrErFEMFREL
0	2		K351-u	LNEALELkDAQAGkE
0	1		K357	LkDAQAGKEPGGsRA
0	3		K357-u	LkDAQAGkEPGGsRA
0	1		S362-p	AGkEPGGsRAHsSHL
4	0		S366-p	PGGsRAHsSHLkskk
0	1		-	gap
15	3		K370-a	RAHsSHLkskkGQst
1	0		K370-m	RAHsSHLkskkGQst
3	0		K370-m1	RAHsSHLkskkGQst
2	1		K370-m2	RAHsSHLkskkGQst
2	0		K370-m3	RAHsSHLkskkGQst
9	0		K370-u	RAHsSHLkskkGQst
1	0		K370-n	RAHsSHLkskkGQst
4	0		S371-p	AHsSHLkskkGQsts
16	3		K372-a	HsSHLkskkGQstsR
3	0		K372-m	HsSHLkskkGQstsR
3	0		K372-m1	HsSHLkskkGQstsR
11	0		K372-u	HsSHLkskkGQstsR
1	0		K372-n	HsSHLkskkGQstsR
47	3		K373-a	sSHLkskkGQstsRH
1	0		K373-m1	sSHLkskkGQstsRH
1	0		K373-m2	sSHLkskkGQstsRH
11	0		K373-u	sSHLkskkGQstsRH
1	0		K373-n	sSHLkskkGQstsRH
12	0		S376-p	LkskkGQstsRHkkL
3	0		T377-p	kskkGQstsRHkkLM
15	1		S378-p	skkGQstsRHkkLMF
16	4		K381-a	GQstsRHkkLMFktE
11	0		K381-u	GQstsRHkkLMFktE
89	4		K382-a	QstsRHkkLMFktEG
1	0		K382-m1	QstsRHkkLMFktEG
1	1		K382-m2	QstsRHkkLMFktEG
11	0		K382-u	QstsRHkkLMFktEG
5	3		K386-a	RHkkLMFktEGPDsD
0	1		K386-m1	RHkkLMFktEGPDsD
0	1		K386-m2	RHkkLMFktEGPDsD
9	1		K386-u	RHkkLMFktEGPDsD
10	0		K386-s	RHkkLMFktEGPDsD
4	0		T387-p	HkkLMFktEGPDsD_
2	0		T387	HkkLMFkTEGPDsD_
86	4		S392-p	FktEGPDsD______

	mouse ► Hide Isoforms
S4-p	____MEEsQsDIsLE
S6-p	__MEEsQsDIsLELP
S9-p	EEsQsDIsLELPLsQ
S15-p	IsLELPLsQEtFsGL
T18-p	ELPLsQEtFsGLWKL
S20-p	PLsQEtFsGLWKLLP
P33	LPPEDILPsPHCMDD
S34-p	PPEDILPsPHCMDDL
L43	HCMDDLLLPQDVEEF
-	gap
S55-p	EEFFEGPsEALRVSG
G75	DPVTETPGPVAPAPA
S93	PLSSFVPSQKTYQGN
K95	SSFVPSQKTYQGNYG
N100	SQKTYQGNYGFHLGF
H104	YQGNYGFHLGFLQSG
Q109	GFHLGFLQSGTAkSV
K114-a	FLQSGTAkSVMCTYS
K114	FLQSGTAKSVMCTYS
K126	TYSPPLNKLFCQLAK
K133	KLFCQLAKTCPVQLW
A143	PVQLWVSATPPAGsR
A143	PVQLWVSATPPAGsR
T144	VQLWVSATPPAGsRV
S149-p	SATPPAGsRVRAMAI
K158	VRAMAIYKKSQHMTE
K158	VRAMAIYKKSQHMTE
S177	CPHHERCSDGDGLAP
R203	YPEYLEDRQTFRHSV
T205	EYLEDRQTFRHSVVV
R207	LEDRQTFRHSVVVPY
S209	DRQTFRHSVVVPYEP
S263	GNLLGRDSFEVRVCA
T278	CPGRDRRTEEENFRK
K285	TEEENFRKkEVLCPE
K286	EEENFRKKEVLCPEL
K286-u	EEENFRKkEVLCPEL
K299-a	ELPPGSAkRALPTCT
K299-u	ELPPGSAkRALPTCT
T306	kRALPTCTSAsPPQk
S307	RALPTCTSAsPPQkk
A308	ALPTCTSAsPPQkkk
S309-p	LPTCTSAsPPQkkkP
K313-a	TSAsPPQkkkPLDGE
K313	TSAsPPQKkkPLDGE
K314-a	SAsPPQkkkPLDGEy
K314-u	SAsPPQkkkPLDGEy
K314	SAsPPQkKkPLDGEy
K315-u	AsPPQkkkPLDGEyF
K315	AsPPQkkKPLDGEyF
Y321-p	kkPLDGEyFTLKIRG
R327	EyFTLKIRGRKRFEM
R329	FTLKIRGRKRFEMFR
R331	LKIRGRKRFEMFREL
K345	LNEALELKDAHATEE
E351	LKDAHATEESGDSRA
E351	LKDAHATEESGDSRA
S356	ATEESGDSRAHSSYL
S360	SGDSRAHSSYLkTkk
-	gap
K364	RAHSSYLKTkkGQsT
K364	RAHSSYLKTkkGQsT
K364	RAHSSYLKTkkGQsT
K364	RAHSSYLKTkkGQsT
K364	RAHSSYLKTkkGQsT
K364-u	RAHSSYLkTkkGQsT
K364	RAHSSYLKTkkGQsT
T365	AHSSYLkTkkGQsTs
K366	HSSYLkTKkGQsTsR
K366-m	HSSYLkTkkGQsTsR
K366	HSSYLkTKkGQsTsR
K366-u	HSSYLkTkkGQsTsR
K366	HSSYLkTKkGQsTsR
K367-a	SSYLkTkkGQsTsRH
K367	SSYLkTkKGQsTsRH
K367	SSYLkTkKGQsTsRH
K367-u	SSYLkTkkGQsTsRH
K367	SSYLkTkKGQsTsRH
S370-p	LkTkkGQsTsRHkkT
T371	kTkkGQsTsRHkkTM
S372-p	TkkGQsTsRHkkTMV
K375	GQsTsRHKkTMVkkV
K375-u	GQsTsRHkkTMVkkV
K376-a	QsTsRHkkTMVkkVG
K376	QsTsRHkKTMVkkVG
K376	QsTsRHkKTMVkkVG
K376-u	QsTsRHkkTMVkkVG
K380	RHkkTMVKkVGPDsD
K380	RHkkTMVKkVGPDsD
K380	RHkkTMVKkVGPDsD
K380-u	RHkkTMVkkVGPDsD
K380	RHkkTMVKkVGPDsD
K381	HkkTMVkKVGPDsD_
K381-u	HkkTMVkkVGPDsD_
S386-p	VkkVGPDsD______

	p53 iso2
S7	_MTAMEESQSDISLE
S9	TAMEESQSDISLELP
S12	EESQSDISLELPLSQ
S18	ISLELPLSQETFSGL
T21	ELPLSQETFSGLWKL
S23	PLSQETFSGLWKLLP
P36	LPPEDILPSPHCMDD
S37	PPEDILPSPHCMDDL
L46	HCMDDLLLPQDVEEF
-	gap
S58	EEFFEGPSEALRVSG
G78	DPVTETPGPVAPAPA
S96	PLSSFVPSQKTYQGN
K98	SSFVPSQKTYQGNYG
N103	SQKTYQGNYGFHLGF
H107	YQGNYGFHLGFLQSG
Q112	GFHLGFLQSGTAKSV
K117	FLQSGTAKSVMCTYS
K117	FLQSGTAKSVMCTYS
K129	TYSPPLNKLFCQLAK
K136	KLFCQLAKTCPVQLW
A146	PVQLWVSATPPAGSR
A146	PVQLWVSATPPAGSR
T147	VQLWVSATPPAGSRV
S152	SATPPAGSRVRAMAI
K161	VRAMAIYKKSQHMTE
K161	VRAMAIYKKSQHMTE
S180	CPHHERCSDGDGLAP
R206	YPEYLEDRQTFRHSV
T208	EYLEDRQTFRHSVVV
R210	LEDRQTFRHSVVVPY
S212	DRQTFRHSVVVPYEP
S266	GNLLGRDSFEVRVCA
T281	CPGRDRRTEEENFRK
K288	TEEENFRKKEVLCPE
K289	EEENFRKKEVLCPEL
K289	EEENFRKKEVLCPEL
K302	ELPPGSAKRALPTCT
K302	ELPPGSAKRALPTCT
T309	KRALPTCTSASPPQK
S310	RALPTCTSASPPQKK
A311	ALPTCTSASPPQKKK
S312	LPTCTSASPPQKKKP
K316	TSASPPQKKKPLDGE
K316	TSASPPQKKKPLDGE
K317	SASPPQKKKPLDGEY
K317	SASPPQKKKPLDGEY
K317	SASPPQKKKPLDGEY
K318	ASPPQKKKPLDGEYF
K318	ASPPQKKKPLDGEYF
Y324	KKPLDGEYFTLKIRG
R330	EYFTLKIRGRKRFEM
R332	FTLKIRGRKRFEMFR
R334	LKIRGRKRFEMFREL
K348	LNEALELKDAHATEE
E354	LKDAHATEESGDSRA
E354	LKDAHATEESGDSRA
S359	ATEESGDSRAHSSLQ
S363	SGDSRAHSSLQPRAF
S378-p	QALIKEEsPNC____
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	rat
S4-p	____MEDsQsDMSIE
S6-p	__MEDsQsDMSIELP
S9	EDsQsDMSIELPLsQ
S15-p	MSIELPLsQETFsCL
T18	ELPLsQETFsCLWKL
S20-p	PLsQETFsCLWKLLP
P33	LPPDDILPTTATGsP
S39-p	LPTTATGsPNSMEDL
L48	NSMEDLFLPQDVAEL
-	gap
E60	AELLEGPEEALQVSA
A79	EPGTEAPAPVAPASA
S97	PLSSSVPSQKTYQGN
K99	SSSVPSQKTYQGNYG
N104	SQKTYQGNYGFHLGF
H108	YQGNYGFHLGFLQSG
Q113	GFHLGFLQSGTAKSV
K118	FLQSGTAKSVMCTYS
K118	FLQSGTAKSVMCTYS
K130	TYSISLNKLFCQLAK
K137	KLFCQLAKTCPVQLW
S147	PVQLWVTSTPPPGTR
S147	PVQLWVTSTPPPGTR
T148	VQLWVTSTPPPGTRV
T153	TSTPPPGTRVRAMAI
K162	VRAMAIYKKSQHMTE
K162	VRAMAIYKKSQHMTE
S181	CPHHERCSDGDGLAP
R207	YAEYLDDRQTFRHSV
T209	EYLDDRQTFRHSVVV
R211	LDDRQTFRHSVVVPY
S213	DRQTFRHSVVVPYEP
S267	GNLLGRDSFEVRVCA
T282	CPGRDRRTEEENFRK
K289	TEEENFRKKEEHCPE
K290	EEENFRKKEEHCPEL
K290	EEENFRKKEEHCPEL
K303	ELPPGSAKRALPTST
K303	ELPPGSAKRALPTST
T310	KRALPTSTSSsPQQK
S311	RALPTSTSSsPQQKK
S312	ALPTSTSSsPQQKKK
S313-p	LPTSTSSsPQQKKKP
K317	TSSsPQQKKKPLDGE
K317	TSSsPQQKKKPLDGE
K318	SSsPQQKKKPLDGEY
K318	SSsPQQKKKPLDGEY
K318	SSsPQQKKKPLDGEY
K319	SsPQQKKKPLDGEYF
K319	SsPQQKKKPLDGEYF
Y325	KKPLDGEYFTLKIRG
R331	EYFTLKIRGRERFEM
R333	FTLKIRGRERFEMFR
R335	LKIRGRERFEMFREL
K349	LNEALELKDARAAEE
E355	LKDARAAEESGDSRA
E355	LKDARAAEESGDSRA
S360	AAEESGDSRAHSSYP
S364	SGDSRAHSSYPKTKk
-	gap
K368	RAHSSYPKTKkGQST
K368	RAHSSYPKTKkGQST
K368	RAHSSYPKTKkGQST
K368	RAHSSYPKTKkGQST
K368	RAHSSYPKTKkGQST
K368	RAHSSYPKTKkGQST
K368	RAHSSYPKTKkGQST
T369	AHSSYPKTKkGQSTs
K370	HSSYPKTKkGQSTsR
K370	HSSYPKTKkGQSTsR
K370	HSSYPKTKkGQSTsR
K370	HSSYPKTKkGQSTsR
K370	HSSYPKTKkGQSTsR
K371-a	SSYPKTKkGQSTsRH
K371	SSYPKTKKGQSTsRH
K371	SSYPKTKKGQSTsRH
K371	SSYPKTKKGQSTsRH
K371	SSYPKTKKGQSTsRH
S374	PKTKkGQSTsRHKkP
T375	KTKkGQSTsRHKkPM
S376-p	TKkGQSTsRHKkPMI
K379	GQSTsRHKkPMIKKV
K379	GQSTsRHKkPMIKKV
K380-a	QSTsRHKkPMIKKVG
K380	QSTsRHKKPMIKKVG
K380	QSTsRHKKPMIKKVG
K380	QSTsRHKKPMIKKVG
K384	RHKkPMIKKVGPDsD
K384	RHKkPMIKKVGPDsD
K384	RHKkPMIKKVGPDsD
K384	RHKkPMIKKVGPDsD
K384	RHKkPMIKKVGPDsD
K385	HKkPMIKKVGPDsD_
K385	HKkPMIKKVGPDsD_
S390-p	IKKVGPDsD______

	rabbit
S4	____MEESQSDLSLE
S6	__MEESQSDLSLEPP
S9	EESQSDLSLEPPLSQ
S15	LSLEPPLSQETFSDL
T18	EPPLSQETFSDLWKL
S20	PLSQETFSDLWKLLP
T33	LPENNLLTTSLNPPV
N37	NLLTTSLNPPVDDLL
S45	PPVDDLLSAEDVANW
N54	EDVANWLNEDPEEGL
E58	NWLNEDPEEGLRVPA
A78	APAPAAPALAAPAPA
S96	PLSSSVPSQKTYHGN
K98	SSSVPSQKTYHGNYG
N103	SQKTYHGNYGFRLGF
R107	YHGNYGFRLGFLHSG
H112	GFRLGFLHSGTAKSV
K117	FLHSGTAKSVTCTYS
K117	FLHSGTAKSVTCTYS
K129	TYSPCLNKLFCQLAK
K136	KLFCQLAKTCPVQLW
S146	PVQLWVDSTPPPGTR
S146	PVQLWVDSTPPPGTR
T147	VQLWVDSTPPPGTRV
T152	DSTPPPGTRVRAMAI
K161	VRAMAIYKKSQHMTE
K161	VRAMAIYKKSQHMTE
S180	CPHHERCSDSDGLAP
R206	RAEYLDDRNTFRHSV
T208	EYLDDRNTFRHSVVV
R210	LDDRNTFRHSVVVPY
S212	DRNTFRHSVVVPYEP
S266	GNLLGRNSFEVRVCA
T281	CPGRDRRTEEENFRK
K288	TEEENFRKKGEPCPE
K289	EEENFRKKGEPCPEL
K289	EEENFRKKGEPCPEL
K302	ELPPGSSKRALPTTT
K302	ELPPGSSKRALPTTT
T309	KRALPTTTTDSSPQT
T310	RALPTTTTDSSPQTK
S312	LPTTTTDSSPQTKKK
S313	PTTTTDSSPQTKKKP
K317	TDSSPQTKKKPLDGE
K317	TDSSPQTKKKPLDGE
K318	DSSPQTKKKPLDGEY
K318	DSSPQTKKKPLDGEY
K318	DSSPQTKKKPLDGEY
K319	SSPQTKKKPLDGEYF
K319	SSPQTKKKPLDGEYF
Y325	KKPLDGEYFILKIRG
R331	EYFILKIRGRERFEM
R333	FILKIRGRERFEMFR
R335	LKIRGRERFEMFREL
K349	LNEALELKDAQAEKE
K355	LKDAQAEKEPGGSRA
K355	LKDAQAEKEPGGSRA
S360	AEKEPGGSRAHSSYL
S364	PGGSRAHSSYLKAKK
-	gap
K368	RAHSSYLKAKKGQST
K368	RAHSSYLKAKKGQST
K368	RAHSSYLKAKKGQST
K368	RAHSSYLKAKKGQST
K368	RAHSSYLKAKKGQST
K368	RAHSSYLKAKKGQST
K368	RAHSSYLKAKKGQST
A369	AHSSYLKAKKGQSTS
K370	HSSYLKAKKGQSTSR
K370	HSSYLKAKKGQSTSR
K370	HSSYLKAKKGQSTSR
K370	HSSYLKAKKGQSTSR
K370	HSSYLKAKKGQSTSR
K371	SSYLKAKKGQSTSRH
K371	SSYLKAKKGQSTSRH
K371	SSYLKAKKGQSTSRH
K371	SSYLKAKKGQSTSRH
K371	SSYLKAKKGQSTSRH
S374	LKAKKGQSTSRHKKP
T375	KAKKGQSTSRHKKPM
S376	AKKGQSTSRHKKPMF
K379	GQSTSRHKKPMFKRE
K379	GQSTSRHKKPMFKRE
K380	QSTSRHKKPMFKREG
K380	QSTSRHKKPMFKREG
K380	QSTSRHKKPMFKREG
K380	QSTSRHKKPMFKREG
K384	RHKKPMFKREGPDSD
K384	RHKKPMFKREGPDSD
K384	RHKKPMFKREGPDSD
K384	RHKKPMFKREGPDSD
K384	RHKKPMFKREGPDSD
R385	HKKPMFKREGPDSD_
R385	HKKPMFKREGPDSD_
S390	FKREGPDSD______

	monkey
P4	____MEEPQSDPSIE
S6	__MEEPQSDPSIEPP
S9	EEPQSDPSIEPPLsQ
S15-p	PSIEPPLsQETFSDL
T18	EPPLsQETFSDLWKL
S20	PLsQETFSDLWKLLP
S33-p	LPENNVLsPLPSQAV
S37	NVLsPLPSQAVDDLM
S46	AVDDLMLSPDDLAQW
T55	DDLAQWLTEDPGPDE
D61	LTEDPGPDEAPRMSE
T81	APTPAAPTPAAPAPA
S99	PLSSSVPSQKTYHGS
K101	SSSVPSQKTYHGSYG
S106	SQKTYHGSYGFRLGF
R110	YHGSYGFRLGFLHSG
H115	GFRLGFLHSGTAKSV
K120	FLHSGTAKSVTCTYS
K120	FLHSGTAKSVTCTYS
K132	TYSPDLNKMFCQLAK
K139	KMFCQLAKTCPVQLW
S149	PVQLWVDSTPPPGSR
S149	PVQLWVDSTPPPGSR
T150	VQLWVDSTPPPGSRV
S155	DSTPPPGSRVRAMAI
K164	VRAMAIYKQSQHMTE
K164	VRAMAIYKQSQHMTE
S183	CPHHERCSDSDGLAP
R209	RVEYSDDRNTFRHSV
T211	EYSDDRNTFRHSVVV
R213	SDDRNTFRHSVVVPY
S215	DRNTFRHSVVVPYEP
S269	GNLLGRNSFEVRVCA
T284	CPGRDRRTEEENFRK
K291	TEEENFRKKGEPCHE
K292	EEENFRKKGEPCHEL
K292	EEENFRKKGEPCHEL
K305-a	ELPPGSTkRALPNNT
K305	ELPPGSTKRALPNNT
T312	kRALPNNTSSsPQPk
S313	RALPNNTSSsPQPkK
S314	ALPNNTSSsPQPkKK
S315-p	LPNNTSSsPQPkKKP
K319-a	TSSsPQPkKKPLDGE
K319	TSSsPQPKKKPLDGE
K320	SSsPQPkKKPLDGEY
K320	SSsPQPkKKPLDGEY
K320	SSsPQPkKKPLDGEY
K321	SsPQPkKKPLDGEYF
K321	SsPQPkKKPLDGEYF
Y327	KKPLDGEYFTLQIRG
R333	EYFTLQIRGRERFEM
R335	FTLQIRGRERFEMFR
R337	LQIRGRERFEMFREL
K351	LNEALELKDAQAGkE
K357-a	LKDAQAGkEPAGSRA
K357	LKDAQAGKEPAGSRA
S362	AGkEPAGSRAHSSHL
S366	PAGSRAHSSHLkSkk
-	gap
K370-a	RAHSSHLkSkkGQST
K370	RAHSSHLKSkkGQST
K370	RAHSSHLKSkkGQST
K370	RAHSSHLKSkkGQST
K370	RAHSSHLKSkkGQST
K370	RAHSSHLKSkkGQST
K370	RAHSSHLKSkkGQST
S371	AHSSHLkSkkGQSTS
K372-a	HSSHLkSkkGQSTSR
K372	HSSHLkSKkGQSTSR
K372	HSSHLkSKkGQSTSR
K372	HSSHLkSKkGQSTSR
K372	HSSHLkSKkGQSTSR
K373-a	SSHLkSkkGQSTSRH
K373	SSHLkSkKGQSTSRH
K373	SSHLkSkKGQSTSRH
K373	SSHLkSkKGQSTSRH
K373	SSHLkSkKGQSTSRH
S376	LkSkkGQSTSRHkkF
T377	kSkkGQSTSRHkkFM
S378	SkkGQSTSRHkkFMF
K381-a	GQSTSRHkkFMFkTE
K381	GQSTSRHKkFMFkTE
K382-a	QSTSRHkkFMFkTEG
K382	QSTSRHkKFMFkTEG
K382	QSTSRHkKFMFkTEG
K382	QSTSRHkKFMFkTEG
K386-a	RHkkFMFkTEGPDsD
K386	RHkkFMFKTEGPDsD
K386	RHkkFMFKTEGPDsD
K386	RHkkFMFKTEGPDsD
K386	RHkkFMFKTEGPDsD
T387	HkkFMFkTEGPDsD_
T387	HkkFMFkTEGPDsD_
S392-p	FkTEGPDsD______

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