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Protein Page:
p53 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p53 a transcription factor and major tumor suppressor that plays a major role in regulating cellular responses to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. More than 50 percent of human tumors contain a mutation or deletion of the TP53 gene. p53 is modified post-translationally at multiple sites. DNA damage induces phosphorylation of p53 at S15, S20 and S37, reducing its interaction with the oncoprotein MDM2. MDM2 inhibits p53 accumulation by targeting it for ubiquitination and proteasomal degradation. Phosphorylated by many kinases including Chk2 and Chk1 at S20, enhancing its tetramerization, stability and activity. The phosphorylation by CAK at S392 is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. Phosphorylation of p53 at S46 regulates the ability of p53 to induce apoptosis. The acetylation of p53 appears to play a positive role in the accumulation of p53 during the stress response. Following DNA damage, p53 becomes acetylated at K382, enhancing its binding to DNA. Deacetylation of p53 can occur through interaction with SIRT1, a deacetylase that may be involved in cellular aging and the DNA damage response. p53 regulates the transcription of a set of genes encoding endosomal proteins that regulate endosomal functions. These include STEAP3 and CHMP4C, which enhance exosome production, and CAV1 and CHMP4C, which produce a more rapid endosomal clearance of the EGFR from the plasma membrane. DNA damage regulates a p53-mediated secretory pathway, increasing the secretion of some proteins such as Hsp90, SERPINE1, SERPINB5, NKEF-A, and CyPA, and inhibiting the secretion of others including CTSL and IGFBP-2. Two alternatively spliced human isoforms have been reported. Isoform 2 is expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor co-regulator; Transcription factor; Activator protein; Tumor suppressor; Motility/polarity/chemotaxis
Cellular Component: transcription factor TFIID complex; PML body; nuclear matrix; protein complex; mitochondrion; endoplasmic reticulum; replication fork; cytosol; nucleoplasm; nuclear body; mitochondrial matrix; cytoplasm; nuclear chromatin; nucleolus; chromatin; nucleus
Molecular Function: identical protein binding; protease binding; protein phosphatase 2A binding; zinc ion binding; p53 binding; protein N-terminus binding; receptor tyrosine kinase binding; protein phosphatase binding; transcription factor binding; protein kinase binding; histone acetyltransferase binding; protein binding; histone deacetylase regulator activity; enzyme binding; copper ion binding; DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; chaperone binding; damaged DNA binding; chromatin binding; transcription factor activity; ATP binding
Biological Process: central nervous system development; viral reproduction; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation in the thymus; gastrulation; determination of adult life span; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to antibiotic; regulation of apoptosis; cellular response to glucose starvation; protein localization; negative regulation of neuroblast proliferation; base-excision repair; transforming growth factor beta receptor signaling pathway; protein complex assembly; cell cycle arrest; ER overload response; response to X-ray; release of cytochrome c from mitochondria; somitogenesis; chromatin assembly; cell aging; rRNA transcription; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of DNA replication; negative regulation of fibroblast proliferation; embryonic organ development; positive regulation of transcription from RNA polymerase II promoter; regulation of mitochondrial membrane permeability; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; regulation of tissue remodeling; G1 DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator; apoptosis; negative regulation of transcription from RNA polymerase II promoter; response to salt stress; positive regulation of protein oligomerization; negative regulation of cell proliferation; positive regulation of histone deacetylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; T cell proliferation during immune response; positive regulation of neuron apoptosis; double-strand break repair; response to gamma radiation; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein tetramerization; Notch signaling pathway; in utero embryonic development; multicellular organism growth; B cell lineage commitment; cell proliferation; neuron apoptosis; T cell lineage commitment; negative regulation of helicase activity; nucleotide-excision repair; protein import into nucleus, translocation; DNA strand renaturation; Ras protein signal transduction; negative regulation of cell growth; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; response to DNA damage stimulus
Reference #:  P04637 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-13; Cellular tumor antigen p53; FLJ92943; LFS1; P53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; Phosphoprotein p53; TP53; transformation-related protein 53; TRP53; tumor protein p53; Tumor suppressor p53
Gene Symbols: TP53
Molecular weight: 43,653 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling  |  Protein Acetylation  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p53

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S6‑p, S9‑p, S15‑p, T18‑p, S20‑p, S37‑p, S46‑p, T55‑p, S269‑p, T284‑p, S315‑p, S392‑p
apoptosis, induced: S6‑p, S9‑p, S15‑p, S20‑p, S33‑p, S37‑p, S46‑p, T81‑p, K120‑ac, K164‑ac, K370‑ac, K372‑ac, K373‑ac, K381‑ac, K382‑ac, K386‑sm, K386‑ac, S392‑p
apoptosis, inhibited: S46‑p, S183‑p, T211‑p, S215‑p, S315‑p, S376‑p
carcinogenesis, induced: S183‑p, T211‑p, S215‑p
cell cycle regulation: S9‑p, S15‑p, S20‑p, T55‑p, S183‑p, T211‑p, S215‑p, S315‑p, S376‑p, S378‑p, S392‑p
cell growth, altered: S15‑p, S20‑p, S33‑p, S46‑p, S269‑p, S315‑p
cell growth, inhibited: S15‑p, S392‑p
chromatin organization, altered: S15‑p, S376‑p, S378‑p
DNA repair, induced: S37‑p, S46‑p
transcription, altered: S6‑p, S9‑p, S15‑p, T18‑p, S20‑p, S33‑p, S37‑p, S46‑p, T55‑p, T81‑p, K120‑ac, K164‑ac, S215‑p, S269‑p, S315‑p, S366‑p, K370‑ac, K372‑ac, K373‑ac, K381‑ac, K382‑ac, K386‑ac, K386‑sm, T387‑p, S392‑p
transcription, induced: S15‑p, S37‑p, S46‑p, T81‑p, K120‑ac, S315‑p, K373‑ac, S376‑p, S378‑p, K382‑ac, K386‑ub
transcription, inhibited: S15‑p, S37‑p, T55‑p, S183‑p, T211‑p, S215‑p, S269‑p, T284‑p, K370‑ub, K372‑ub, K373‑ub, K381‑ub, K382‑ub, K386‑ub
acetylation: S6‑p, S9‑p, S15‑p, T18‑p
activity, induced: S6‑p, S15‑p, S20‑p, S33‑p, S37‑p, S46‑p, T55‑p, S315‑p, S366‑p, S371‑p, S376‑p, S378‑p, K386‑sm, T387‑p, S392‑p
activity, inhibited: S15‑p, S20‑p, S215‑p, S269‑p, S315‑p, S371‑p, S376‑p, S392‑p
intracellular localization: S15‑p, S20‑p, T55‑p, K101‑ub, K120‑ub, K132‑ub, K139‑ub, K164‑ub, S269‑p, S315‑p, K370‑ub, K372‑ub, K373‑ub, S376‑p, S378‑p, K381‑ub, K382‑ub, K386‑ub, S392‑p
molecular association, regulation: S15‑p, T18‑p, S20‑p, S33‑p, S37‑p, S46‑p, T55‑p, T81‑p, S315‑p, S366‑p, S371‑p, K373‑ac, S376‑p, S378‑p, K382‑m2, K382‑ac, T387‑p, S392‑p
phosphorylation: S6‑p, S9‑p, S15‑p, S20‑p, S33‑p, S149‑gl, S392‑p
protein conformation: S15‑p, S37‑p, S215‑p, S269‑p, S315‑p, S392‑p
protein degradation: S20‑p, T55‑p, K101‑ub, K120‑ub, K132‑ub, K139‑ub, T155‑p, K164‑ub, S183‑p, T211‑p, S215‑p, S315‑p, K370‑ub, K372‑ub, K373‑ub, S376‑p, K381‑ub, K382‑ub, K386‑ub
protein stabilization: S15‑p, T18‑p, S20‑p, S37‑p, T81‑p, S106‑p, S149‑gl, S215‑p, S269‑p, K382‑m2, S392‑p
ubiquitination: S149‑gl, S183‑p, T211‑p, S215‑p, S269‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
6 0 P4 ____MEEPQsDPsVE
31 4 S6-p __MEEPQsDPsVEPP
34 3 S9-p EEPQsDPsVEPPLsQ
357 2 S15-p PsVEPPLsQEtFsDL
28 0 T18-p EPPLsQEtFsDLWKL
110 1 S20-p PLsQEtFsDLWKLLP
30 3 S33-p LPENNVLsPLPsQAM
65 3 S37-p NVLsPLPsQAMDDLM
83 2 S46-p AMDDLMLsPDDIEQW
15 0 T55-p DDIEQWFtEDPGPDE
2 0 D61 FtEDPGPDEAPRMPE
8 2 T81-p APAPAAPtPAAPAPA
0 2 S99-p PLSSSVPsQkTYQGs
1 2 K101-ub SSSVPsQkTYQGsYG
1 0 S106-p sQkTYQGsYGFrLGF
0 1 R110-m1 YQGsYGFrLGFLhSG
0 1 H115-m1 GFrLGFLhSGTAkSV
23 1 K120-ac FLhSGTAkSVTCTYS
1 19 K120-ub FLhSGTAkSVTCTYS
1 1 K132-ub TYSPALNkMFCQLAk
1 0 K139-ub kMFCQLAkTCPVQLW
3 1 S149-p PVQLWVDstPPPGtR
1 1 S149-gl PVQLWVDstPPPGtR
4 8 T150-p VQLWVDstPPPGtRV
4 1 T155-p DstPPPGtRVRAMAI
4 1 K164-ac VRAMAIYkQSQHMTE
1 1 K164-ub VRAMAIYkQSQHMTE
2 0 S183-p CPHHERCsDSDGLAP
0 1 R209-m1 RVEYLDDrNtFrHsV
1 0 T211-p EYLDDrNtFrHsVVV
0 1 R213-m1 LDDrNtFrHsVVVPY
4 0 S215-p DrNtFrHsVVVPYEP
0 1 C229 PPEVGSDCTTIHYNY
0 1 Y234 SDCTTIHYNYMCNSS
3 0 S269-p GNLLGRNsFEVRVCA
1 0 T284-p CPGRDRRtEEENLRk
1 0 K291-ub tEEENLRkkGEPHHE
1 3 K292-ac EEENLRkkGEPHHEL
1 6 K292-ub EEENLRkkGEPHHEL
2 15 K305-ac ELPPGSTkRALPNNt
1 20 K305-ub ELPPGSTkRALPNNt
0 1 T312-p kRALPNNtsssPQPk
1 4 S313-p RALPNNtsssPQPkk
1 4 S314-p ALPNNtsssPQPkkk
38 24 S315-p LPNNtsssPQPkkkP
0 4 K319-ac tsssPQPkkkPLDGE
1 0 K319-ub tsssPQPkkkPLDGE
39 0 K320-ac sssPQPkkkPLDGEy
2 17 K320-ub sssPQPkkkPLDGEy
1 0 K320-ne sssPQPkkkPLDGEy
2 10 K321-ub ssPQPkkkPLDGEyF
1 0 K321-ne ssPQPkkkPLDGEyF
0 14 Y327-p kkPLDGEyFTLQIrG
1 0 R333-me EyFTLQIrGrErFEM
1 0 R335-m2 FTLQIrGrErFEMFR
1 0 R337-m2 LQIrGrErFEMFREL
0 2 K351-ub LNEALELkDAQAGkE
0 1 K357 LkDAQAGKEPGGsRA
0 3 K357-ub LkDAQAGkEPGGsRA
0 1 S362-p AGkEPGGsRAHsSHL
4 0 S366-p PGGsRAHsSHLkskk
15 3 K370-ac RAHsSHLkskkGQst
1 0 K370-me RAHsSHLkskkGQst
3 0 K370-m1 RAHsSHLkskkGQst
2 1 K370-m2 RAHsSHLkskkGQst
2 0 K370-m3 RAHsSHLkskkGQst
9 0 K370-ub RAHsSHLkskkGQst
1 0 K370-ne RAHsSHLkskkGQst
4 0 S371-p AHsSHLkskkGQsts
16 3 K372-ac HsSHLkskkGQstsR
3 0 K372-me HsSHLkskkGQstsR
3 0 K372-m1 HsSHLkskkGQstsR
11 0 K372-ub HsSHLkskkGQstsR
1 0 K372-ne HsSHLkskkGQstsR
59 3 K373-ac sSHLkskkGQstsRH
1 0 K373-m1 sSHLkskkGQstsRH
1 0 K373-m2 sSHLkskkGQstsRH
11 0 K373-ub sSHLkskkGQstsRH
1 0 K373-ne sSHLkskkGQstsRH
12 0 S376-p LkskkGQstsRHkkL
3 0 T377-p kskkGQstsRHkkLM
15 1 S378-p skkGQstsRHkkLMF
21 4 K381-ac GQstsRHkkLMFktE
11 0 K381-ub GQstsRHkkLMFktE
111 4 K382-ac QstsRHkkLMFktEG
1 0 K382-m1 QstsRHkkLMFktEG
1 1 K382-m2 QstsRHkkLMFktEG
11 0 K382-ub QstsRHkkLMFktEG
5 3 K386-ac RHkkLMFktEGPDsD
0 1 K386-m1 RHkkLMFktEGPDsD
0 1 K386-m2 RHkkLMFktEGPDsD
9 1 K386-ub RHkkLMFktEGPDsD
12 0 K386-sm RHkkLMFktEGPDsD
4 0 T387-p HkkLMFktEGPDsD_
2 0 T387 HkkLMFkTEGPDsD_
0 1 - gap
90 5 S392-p FktEGPDsD______
9285 : Phospho-p53 (Ser6) Antibody
9288 : Phospho-p53 (Ser9) Antibody
4030 : Phospho-p53 (Ser15) (16G8) Mouse mAb (Biotinylated)
8514 : Phospho-p53 (Ser15) (16G8) Mouse mAb (PE Conjugate)
8695 : Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor(R) 647 Conjugate)
9235 : Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor(R) 488 Conjugate)
9284 : Phospho-p53 (Ser15) Antibody
9286 : Phospho-p53 (Ser15) (16G8) Mouse mAb
9481 : Phospho-p53 (Ser15) (16G8) Mouse mAb (Alexa Fluor(R) 555 Conjugate)
2529 : Phospho-p53 (Thr18) Antibody
9287 : Phospho-p53 (Ser20) Antibody
2526 : Phospho-p53 (Ser33) Antibody
9289 : Phospho-p53 (Ser37) Antibody
2521 : Phospho-p53 (Ser46) Antibody
2676 : Phospho-p53 (Thr81) Antibody
2528 : Phospho-p53 (Ser315) Antibody
2525 : Acetyl-p53 (Lys382) Antibody
2570 : Acetyl-p53 (Lys379) Antibody
9281 : Phospho-p53 (Ser392) Antibody
  mouse

► Hide Isoforms
 
S4-p ____MEEsQsDIsLE
S6-p __MEEsQsDIsLELP
S9-p EEsQsDIsLELPLsQ
S15-p IsLELPLsQEtFsGL
T18-p ELPLsQEtFsGLWKL
S20-p PLsQEtFsGLWKLLP
P33 LPPEDILPsPHCMDD
S34-p PPEDILPsPHCMDDL
L43 HCMDDLLLPQDVEEF
- gap
S55-p EEFFEGPsEALRVSG
G75 DPVTETPGPVAPAPA
S93 PLSSFVPSQKTYQGN
K95 SSFVPSQKTYQGNYG
N100 SQKTYQGNYGFHLGF
H104 YQGNYGFHLGFLQSG
Q109 GFHLGFLQSGTAkSV
K114-ac FLQSGTAkSVMCTYS
K114 FLQSGTAKSVMCTYS
K126 TYSPPLNKLFCQLAK
K133 KLFCQLAKTCPVQLW
A143 PVQLWVSATPPAGsR
A143 PVQLWVSATPPAGsR
T144 VQLWVSATPPAGsRV
S149-p SATPPAGsRVRAMAI
K158 VRAMAIYKKSQHMTE
K158 VRAMAIYKKSQHMTE
S177 CPHHERCSDGDGLAP
R203 YPEYLEDRQTFRHSV
T205 EYLEDRQTFRHSVVV
R207 LEDRQTFRHSVVVPY
S209 DRQTFRHSVVVPYEP
Y223-p PPEAGSEyTTIHyKY
Y228-p SEyTTIHyKYMCNSS
S263 GNLLGRDSFEVRVCA
T278 CPGRDRRTEEENFRK
K285 TEEENFRKkEVLCPE
K286 EEENFRKKEVLCPEL
K286-ub EEENFRKkEVLCPEL
K299-ac ELPPGSAkRALPTCT
K299-ub ELPPGSAkRALPTCT
T306 kRALPTCTsAsPPQk
S307-p RALPTCTsAsPPQkk
A308 ALPTCTsAsPPQkkk
S309-p LPTCTsAsPPQkkkP
K313-ac TsAsPPQkkkPLDGE
K313 TsAsPPQKkkPLDGE
K314-ac sAsPPQkkkPLDGEy
K314-ub sAsPPQkkkPLDGEy
K314 sAsPPQkKkPLDGEy
K315-ub AsPPQkkkPLDGEyF
K315 AsPPQkkKPLDGEyF
Y321-p kkPLDGEyFTLKIRG
R327 EyFTLKIRGRKRFEM
R329 FTLKIRGRKRFEMFR
R331 LKIRGRKRFEMFREL
K345 LNEALELKDAHATEE
E351 LKDAHATEESGDSRA
E351 LKDAHATEESGDSRA
S356 ATEESGDSRAHSSYL
S360 SGDSRAHSSYLkTkk
K364 RAHSSYLKTkkGQsT
K364 RAHSSYLKTkkGQsT
K364 RAHSSYLKTkkGQsT
K364 RAHSSYLKTkkGQsT
K364 RAHSSYLKTkkGQsT
K364-ub RAHSSYLkTkkGQsT
K364 RAHSSYLKTkkGQsT
T365 AHSSYLkTkkGQsTs
K366 HSSYLkTKkGQsTsR
K366-me HSSYLkTkkGQsTsR
K366 HSSYLkTKkGQsTsR
K366-ub HSSYLkTkkGQsTsR
K366 HSSYLkTKkGQsTsR
K367-ac SSYLkTkkGQsTsRH
K367 SSYLkTkKGQsTsRH
K367 SSYLkTkKGQsTsRH
K367-ub SSYLkTkkGQsTsRH
K367 SSYLkTkKGQsTsRH
S370-p LkTkkGQsTsRHkkT
T371 kTkkGQsTsRHkkTM
S372-p TkkGQsTsRHkkTMV
K375 GQsTsRHKkTMVkkV
K375-ub GQsTsRHkkTMVkkV
K376-ac QsTsRHkkTMVkkVG
K376 QsTsRHkKTMVkkVG
K376 QsTsRHkKTMVkkVG
K376-ub QsTsRHkkTMVkkVG
K380 RHkkTMVKkVGPDsD
K380 RHkkTMVKkVGPDsD
K380 RHkkTMVKkVGPDsD
K380-ub RHkkTMVkkVGPDsD
K380 RHkkTMVKkVGPDsD
K381 HkkTMVkKVGPDsD_
K381-ub HkkTMVkkVGPDsD_
- gap
S386-p VkkVGPDsD______
9285 : Phospho-p53 (Ser6) Antibody
9284 : Phospho-p53 (Ser15) Antibody
9286 : Phospho-p53 (Ser15) (16G8) Mouse mAb
12571 : Phospho-p53 (Ser15) (D4S1H) XP(R) Rabbit mAb (Mouse Specific)
9287 : Phospho-p53 (Ser20) Antibody
2570 : Acetyl-p53 (Lys379) Antibody
9281 : Phospho-p53 (Ser392) Antibody
  p53 iso2  
S7 _MTAMEESQSDISLE
S9 TAMEESQSDISLELP
S12 EESQSDISLELPLsQ
S18-p ISLELPLsQETFSGL
T21 ELPLsQETFSGLWKL
S23 PLsQETFSGLWKLLP
P36 LPPEDILPSPHCMDD
S37 PPEDILPSPHCMDDL
L46 HCMDDLLLPQDVEEF
- gap
S58 EEFFEGPSEALRVSG
G78 DPVTETPGPVAPAPA
S96 PLSSFVPSQKTYQGN
K98 SSFVPSQKTYQGNYG
N103 SQKTYQGNYGFHLGF
H107 YQGNYGFHLGFLQSG
Q112 GFHLGFLQSGTAkSV
K117-ac FLQSGTAkSVMCTYS
K117 FLQSGTAKSVMCTYS
K129 TYSPPLNKLFCQLAK
K136 KLFCQLAKTCPVQLW
A146 PVQLWVSATPPAGSR
A146 PVQLWVSATPPAGSR
T147 VQLWVSATPPAGSRV
S152 SATPPAGSRVRAMAI
K161 VRAMAIYKKSQHMTE
K161 VRAMAIYKKSQHMTE
S180 CPHHERCSDGDGLAP
R206 YPEYLEDRQTFRHSV
T208 EYLEDRQTFRHSVVV
R210 LEDRQTFRHSVVVPY
S212 DRQTFRHSVVVPYEP
Y226 PPEAGSEYTTIHYKY
Y231 SEYTTIHYKYMCNSS
S266 GNLLGRDSFEVRVCA
T281 CPGRDRRTEEENFRK
K288 TEEENFRKKEVLCPE
K289 EEENFRKKEVLCPEL
K289 EEENFRKKEVLCPEL
K302 ELPPGSAKRALPTCT
K302 ELPPGSAKRALPTCT
T309 KRALPTCTSASPPQK
S310 RALPTCTSASPPQKk
A311 ALPTCTSASPPQKkK
S312 LPTCTSASPPQKkKP
K316 TSASPPQKkKPLDGE
K316 TSASPPQKkKPLDGE
K317-ac SASPPQKkKPLDGEY
K317 SASPPQKKKPLDGEY
K317 SASPPQKKKPLDGEY
K318 ASPPQKkKPLDGEYF
K318 ASPPQKkKPLDGEYF
Y324 kKPLDGEYFTLKIRG
R330 EYFTLKIRGRKRFEM
R332 FTLKIRGRKRFEMFR
R334 LKIRGRKRFEMFREL
K348 LNEALELKDAHATEE
E354 LKDAHATEESGDSRA
E354 LKDAHATEESGDSRA
S359 ATEESGDSRAHSSLQ
S363 SGDSRAHSSLQPRAF
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K375-sm RAFQALIkEEsPNC_
- gap
- gap
S378-p QALIkEEsPNC____
- gap
  rat

 
S4-p ____MEDsQsDMsIE
S6-p __MEDsQsDMsIELP
S9-p EDsQsDMsIELPLsQ
S15-p MsIELPLsQEtFsCL
T18-p ELPLsQEtFsCLWKL
S20-p PLsQEtFsCLWKLLP
P33 LPPDDILPTTATGsP
S39-p LPTTATGsPNSMEDL
L48 NSMEDLFLPQDVAEL
- gap
E60 AELLEGPEEALQVSA
A79 EPGTEAPAPVAPASA
S97 PLSSSVPSQKTYQGN
K99 SSSVPSQKTYQGNYG
N104 SQKTYQGNYGFHLGF
H108 YQGNYGFHLGFLQSG
Q113 GFHLGFLQSGTAkSV
K118-ac FLQSGTAkSVMCTYS
K118 FLQSGTAKSVMCTYS
K130 TYSISLNKLFCQLAK
K137 KLFCQLAKTCPVQLW
S147 PVQLWVTSTPPPGTR
S147 PVQLWVTSTPPPGTR
T148 VQLWVTSTPPPGTRV
T153 TSTPPPGTRVRAMAI
K162 VRAMAIYKKSQHMTE
K162 VRAMAIYKKSQHMTE
S181 CPHHERCSDGDGLAP
R207 YAEYLDDRQTFRHSV
T209 EYLDDRQTFRHSVVV
R211 LDDRQTFRHSVVVPY
S213 DRQTFRHSVVVPYEP
Y227 PPEVGSDYTTIHYKY
Y232 SDYTTIHYKYMCNSS
S267 GNLLGRDSFEVRVCA
T282 CPGRDRRTEEENFRK
K289 TEEENFRKKEEHCPE
K290 EEENFRKKEEHCPEL
K290 EEENFRKKEEHCPEL
K303 ELPPGSAKRALPTST
K303 ELPPGSAKRALPTST
T310 KRALPTSTSSsPQQK
S311 RALPTSTSSsPQQKK
S312 ALPTSTSSsPQQKKK
S313-p LPTSTSSsPQQKKKP
K317 TSSsPQQKKKPLDGE
K317 TSSsPQQKKKPLDGE
K318 SSsPQQKKKPLDGEY
K318 SSsPQQKKKPLDGEY
K318 SSsPQQKKKPLDGEY
K319 SsPQQKKKPLDGEYF
K319 SsPQQKKKPLDGEYF
Y325 KKPLDGEYFTLKIRG
R331 EYFTLKIRGRERFEM
R333 FTLKIRGRERFEMFR
R335 LKIRGRERFEMFREL
K349 LNEALELKDARAAEE
E355 LKDARAAEESGDSRA
E355 LKDARAAEESGDSRA
S360 AAEESGDSRAHSSYP
S364 SGDSRAHSSYPKTKk
K368 RAHSSYPKTKkGQST
K368 RAHSSYPKTKkGQST
K368 RAHSSYPKTKkGQST
K368 RAHSSYPKTKkGQST
K368 RAHSSYPKTKkGQST
K368 RAHSSYPKTKkGQST
K368 RAHSSYPKTKkGQST
T369 AHSSYPKTKkGQSTs
K370 HSSYPKTKkGQSTsR
K370 HSSYPKTKkGQSTsR
K370 HSSYPKTKkGQSTsR
K370 HSSYPKTKkGQSTsR
K370 HSSYPKTKkGQSTsR
K371-ac SSYPKTKkGQSTsRH
K371 SSYPKTKKGQSTsRH
K371 SSYPKTKKGQSTsRH
K371 SSYPKTKKGQSTsRH
K371 SSYPKTKKGQSTsRH
S374 PKTKkGQSTsRHkkP
T375 KTKkGQSTsRHkkPM
S376-p TKkGQSTsRHkkPMI
K379-ac GQSTsRHkkPMIKKV
K379 GQSTsRHKkPMIKKV
K380-ac QSTsRHkkPMIKKVG
K380 QSTsRHkKPMIKKVG
K380 QSTsRHkKPMIKKVG
K380 QSTsRHkKPMIKKVG
K384 RHkkPMIKKVGPDsD
K384 RHkkPMIKKVGPDsD
K384 RHkkPMIKKVGPDsD
K384 RHkkPMIKKVGPDsD
K384 RHkkPMIKKVGPDsD
K385 HkkPMIKKVGPDsD_
K385 HkkPMIKKVGPDsD_
- gap
S390-p IKKVGPDsD______
9284 : Phospho-p53 (Ser15) Antibody
9286 : Phospho-p53 (Ser15) (16G8) Mouse mAb
12571 : Phospho-p53 (Ser15) (D4S1H) XP(R) Rabbit mAb (Mouse Specific)
  rabbit

 
S4 ____MEESQSDLSLE
S6 __MEESQSDLSLEPP
S9 EESQSDLSLEPPLSQ
S15 LSLEPPLSQETFSDL
T18 EPPLSQETFSDLWKL
S20 PLSQETFSDLWKLLP
T33 LPENNLLTTSLNPPV
N37 NLLTTSLNPPVDDLL
S45 PPVDDLLSAEDVANW
N54 EDVANWLNEDPEEGL
E58 NWLNEDPEEGLRVPA
A78 APAPAAPALAAPAPA
S96 PLSSSVPSQKTYHGN
K98 SSSVPSQKTYHGNYG
N103 SQKTYHGNYGFRLGF
R107 YHGNYGFRLGFLHSG
H112 GFRLGFLHSGTAKSV
K117 FLHSGTAKSVTCTYS
K117 FLHSGTAKSVTCTYS
K129 TYSPCLNKLFCQLAK
K136 KLFCQLAKTCPVQLW
S146 PVQLWVDSTPPPGTR
S146 PVQLWVDSTPPPGTR
T147 VQLWVDSTPPPGTRV
T152 DSTPPPGTRVRAMAI
K161 VRAMAIYKKSQHMTE
K161 VRAMAIYKKSQHMTE
S180 CPHHERCSDSDGLAP
R206 RAEYLDDRNTFRHSV
T208 EYLDDRNTFRHSVVV
R210 LDDRNTFRHSVVVPY
S212 DRNTFRHSVVVPYEP
C226 PPEVGSDCTTIHYNY
Y231 SDCTTIHYNYMCNSS
S266 GNLLGRNSFEVRVCA
T281 CPGRDRRTEEENFRK
K288 TEEENFRKKGEPCPE
K289 EEENFRKKGEPCPEL
K289 EEENFRKKGEPCPEL
K302 ELPPGSSKRALPTTT
K302 ELPPGSSKRALPTTT
T309 KRALPTTTTDSSPQT
T310 RALPTTTTDSSPQTK
S312 LPTTTTDSSPQTKKK
S313 PTTTTDSSPQTKKKP
K317 TDSSPQTKKKPLDGE
K317 TDSSPQTKKKPLDGE
K318 DSSPQTKKKPLDGEY
K318 DSSPQTKKKPLDGEY
K318 DSSPQTKKKPLDGEY
K319 SSPQTKKKPLDGEYF
K319 SSPQTKKKPLDGEYF
Y325 KKPLDGEYFILKIRG
R331 EYFILKIRGRERFEM
R333 FILKIRGRERFEMFR
R335 LKIRGRERFEMFREL
K349 LNEALELKDAQAEKE
K355 LKDAQAEKEPGGSRA
K355 LKDAQAEKEPGGSRA
S360 AEKEPGGSRAHSSYL
S364 PGGSRAHSSYLKAKK
K368 RAHSSYLKAKKGQST
K368 RAHSSYLKAKKGQST
K368 RAHSSYLKAKKGQST
K368 RAHSSYLKAKKGQST
K368 RAHSSYLKAKKGQST
K368 RAHSSYLKAKKGQST
K368 RAHSSYLKAKKGQST
A369 AHSSYLKAKKGQSTS
K370 HSSYLKAKKGQSTSR
K370 HSSYLKAKKGQSTSR
K370 HSSYLKAKKGQSTSR
K370 HSSYLKAKKGQSTSR
K370 HSSYLKAKKGQSTSR
K371 SSYLKAKKGQSTSRH
K371 SSYLKAKKGQSTSRH
K371 SSYLKAKKGQSTSRH
K371 SSYLKAKKGQSTSRH
K371 SSYLKAKKGQSTSRH
S374 LKAKKGQSTSRHKKP
T375 KAKKGQSTSRHKKPM
S376 AKKGQSTSRHKKPMF
K379 GQSTSRHKKPMFKRE
K379 GQSTSRHKKPMFKRE
K380 QSTSRHKKPMFKREG
K380 QSTSRHKKPMFKREG
K380 QSTSRHKKPMFKREG
K380 QSTSRHKKPMFKREG
K384 RHKKPMFKREGPDSD
K384 RHKKPMFKREGPDSD
K384 RHKKPMFKREGPDSD
K384 RHKKPMFKREGPDSD
K384 RHKKPMFKREGPDSD
R385 HKKPMFKREGPDSD_
R385 HKKPMFKREGPDSD_
- gap
S390 FKREGPDSD______
  monkey

 
P4 ____MEEPQSDPSIE
S6 __MEEPQSDPSIEPP
S9 EEPQSDPSIEPPLsQ
S15-p PSIEPPLsQETFSDL
T18 EPPLsQETFSDLWKL
S20 PLsQETFSDLWKLLP
S33-p LPENNVLsPLPSQAV
S37 NVLsPLPSQAVDDLM
S46 AVDDLMLSPDDLAQW
T55 DDLAQWLTEDPGPDE
D61 LTEDPGPDEAPRMSE
T81 APTPAAPTPAAPAPA
S99 PLSSSVPSQKTYHGS
K101 SSSVPSQKTYHGSYG
S106 SQKTYHGSYGFRLGF
R110 YHGSYGFRLGFLHSG
H115 GFRLGFLHSGTAKSV
K120 FLHSGTAKSVTCTYS
K120 FLHSGTAKSVTCTYS
K132 TYSPDLNKMFCQLAK
K139 KMFCQLAKTCPVQLW
S149 PVQLWVDSTPPPGSR
S149 PVQLWVDSTPPPGSR
T150 VQLWVDSTPPPGSRV
S155 DSTPPPGSRVRAMAI
K164 VRAMAIYKQSQHMTE
K164 VRAMAIYKQSQHMTE
S183 CPHHERCSDSDGLAP
R209 RVEYSDDRNTFRHSV
T211 EYSDDRNTFRHSVVV
R213 SDDRNTFRHSVVVPY
S215 DRNTFRHSVVVPYEP
C229 PPEVGSDCTTIHYNY
Y234 SDCTTIHYNYMCNSS
S269 GNLLGRNSFEVRVCA
T284 CPGRDRRTEEENFRK
K291 TEEENFRKKGEPCHE
K292 EEENFRKKGEPCHEL
K292 EEENFRKKGEPCHEL
K305-ac ELPPGSTkRALPNNT
K305 ELPPGSTKRALPNNT
T312 kRALPNNTSSsPQPk
S313 RALPNNTSSsPQPkK
S314 ALPNNTSSsPQPkKK
S315-p LPNNTSSsPQPkKKP
K319-ac TSSsPQPkKKPLDGE
K319 TSSsPQPKKKPLDGE
K320 SSsPQPkKKPLDGEY
K320 SSsPQPkKKPLDGEY
K320 SSsPQPkKKPLDGEY
K321 SsPQPkKKPLDGEYF
K321 SsPQPkKKPLDGEYF
Y327 KKPLDGEYFTLQIRG
R333 EYFTLQIRGRERFEM
R335 FTLQIRGRERFEMFR
R337 LQIRGRERFEMFREL
K351 LNEALELKDAQAGkE
K357-ac LKDAQAGkEPAGSRA
K357 LKDAQAGKEPAGSRA
S362 AGkEPAGSRAHSSHL
S366 PAGSRAHSSHLkSkk
K370-ac RAHSSHLkSkkGQST
K370 RAHSSHLKSkkGQST
K370 RAHSSHLKSkkGQST
K370 RAHSSHLKSkkGQST
K370 RAHSSHLKSkkGQST
K370 RAHSSHLKSkkGQST
K370 RAHSSHLKSkkGQST
S371 AHSSHLkSkkGQSTS
K372-ac HSSHLkSkkGQSTSR
K372 HSSHLkSKkGQSTSR
K372 HSSHLkSKkGQSTSR
K372 HSSHLkSKkGQSTSR
K372 HSSHLkSKkGQSTSR
K373-ac SSHLkSkkGQSTSRH
K373 SSHLkSkKGQSTSRH
K373 SSHLkSkKGQSTSRH
K373 SSHLkSkKGQSTSRH
K373 SSHLkSkKGQSTSRH
S376 LkSkkGQSTSRHkkF
T377 kSkkGQSTSRHkkFM
S378 SkkGQSTSRHkkFMF
K381-ac GQSTSRHkkFMFkTE
K381 GQSTSRHKkFMFkTE
K382-ac QSTSRHkkFMFkTEG
K382 QSTSRHkKFMFkTEG
K382 QSTSRHkKFMFkTEG
K382 QSTSRHkKFMFkTEG
K386-ac RHkkFMFkTEGPDsD
K386 RHkkFMFKTEGPDsD
K386 RHkkFMFKTEGPDsD
K386 RHkkFMFKTEGPDsD
K386 RHkkFMFKTEGPDsD
T387 HkkFMFkTEGPDsD_
T387 HkkFMFkTEGPDsD_
- gap
S392-p FkTEGPDsD______
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