a magnesium-dependent ATP-dependent DNA-helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. A member of the RecQ helicase family that is required for genome stability. Participates in DNA replication, recombination and repair. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex which is a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2. Note: This description may include information from UniProtKB.
Protein type: DNA repair; Helicase; EC 188.8.131.52; EC 3.6.1.-; DNA replication
Molecular Function: G-quadruplex DNA binding; ATP-dependent DNA helicase activity; four-way junction helicase activity; protein binding; ATP-dependent 3'-5' DNA helicase activity; p53 binding; ATPase activity; ATP-dependent helicase activity; bubble DNA binding; helicase activity; single-stranded DNA binding; ATP binding
Biological Process: ATP catabolic process; negative regulation of DNA recombination; regulation of binding; positive regulation of transcription, DNA-dependent; DNA double-strand break processing; negative regulation of mitotic recombination; alpha-beta T cell differentiation; negative regulation of cell division; DNA repair; G2 phase of mitotic cell cycle; protein oligomerization; double-strand break repair via homologous recombination; DNA recombination; replication fork processing; replication fork protection; positive regulation of alpha-beta T cell proliferation; regulation of cyclin-dependent protein kinase activity; G2/M transition DNA damage checkpoint; telomere maintenance; response to DNA damage stimulus; response to X-ray
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.