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Nik (human)

Overview Nik a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB. Protein type: Protein kinase, STE; EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleus; cytosol Molecular Function: NF-kappaB-inducing kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; immune response Reference #:  Q99558 (UniProtKB) Alt. Names/Synonyms: FTDCR1B; HS; HsNIK; M3K14; MAP3K14; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK; serine/threonine protein-kinase; Serine/threonine-protein kinase NIK Gene Symbols: MAP3K14 Molecular weight: 104,042 Da Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Nik 4DN5 - A/B=330-680 (human) 4G3D - A/D/E/B=308-673 (human) 4IDT - A/B=330-680 (human) 4IDV - A/D/C/B=330-680 (human) 4G3C - A/B=329-675 (mouse) 4G3E - A/B=329-675 (mouse) 4G3F - A=345-675 (mouse) 4G3G - A=345-675 (mouse)

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	Sites Implicated In
transcription, altered: T559‑p enzymatic activity, induced: T559‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S48	KLEAVEKSPVFCGKW
0	1		K64-u	ILNDVITkGTAKEGS
1	0		S89	AQAECENSQEFSPTF
0	4		K106-u	RIFIAGSkQYSQSES
1	0		S113	kQYSQSESLDQIPNN
0	1		T125-p	PNNVAHAtEGkMARV
0	1		K128-u	VAHAtEGkMARVCWK
1	0		S153	RKKKSSKSLAHAGVA
0	2		K163-u	HAGVALAkPLPRTPE
0	1		Q212	LGQLCFKQLGEGLRP
0	2		K294-u	LACVDSQkPLPDPHL
1	0		S347	ALQGSVSSGQAHsLt
1	1		S352-p	VSSGQAHsLtSLAKT
0	1		T354-p	SGQAHsLtSLAKTWA
1	0		S355	GQAHsLtSLAKTWAA
2	0		T559-p	TGDYIPGtETHMAPE
0	1		Y682-p	PPPNQANyHQTLHAQ
1	0		-	under review
1	0		S733	KSPPLTLSKEESGMW
1	0		S757	PAPARNPSSPERKAT
1	0		S814	DDSEKNPSKASQSSR
1	0		S817	EKNPSKASQSSRDTL
1	0		S820	PSKASQSSRDTLSSG
1	0		S825	QSSRDTLSSGVHSWS
1	0		S826	SSRDTLSSGVHSWSS
1	0		S867	GVKVQIQSLNGEHLH
0	2		K882-u	IREFHRVkVGDIATG

	mouse
S48-p	KLEAVEKsPVFCGKW
K64	ILNDVITKGTAKDGS
S89-p	AQAECENsQEFSPTF
Q106	RIFIAGSQQYSQSEs
S113-p	QQYSQSEsLDQIPNN
T125	PNNVAHATEGKMARV
K128	VAHATEGKMARVCRR
S153-p	RRKKRSKsLAQAGVA
K163	QAGVALAKPLPRTPE
K212-u	LGHLCFKkQDEGLRP
R295	LAGVSGQRPLPGPPH
S349-p	ALQGSVSsGQAHsLA
S354-p	VSsGQAHsLAsLAKT
A356	sGQAHsLAsLAKTWS
S357-p	GQAHsLAsLAKTWSS
T561	TGDYIPGTETHMAPE
C684	PPQDQATCHQTLPtP
T690-p	TCHQTLPtPPRENPP
S728-p	KAPALNLsKEESGTW
S752-p	PATAKGPsFPDRRAT
S809-p	DDSEKNPsKAsQSsR
S812-p	EKNPsKAsQSsRDTL
S815-p	PsKAsQSsRDTLssG
S820-p	QSsRDTLssGVHSWN
S821-p	SsRDTLssGVHSWNS
S862-p	GVKVQIQsLNGEHLH
K877	IREFHRVKVGDIATG

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