a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, STE; EC 126.96.36.199; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytosol
Molecular Function: NF-kappaB-inducing kinase activity; MAP kinase kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; activation of MAPK activity; T cell costimulation; MAPKKK cascade; immune response; protein amino acid phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.