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Protein Page:
Nik (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Nik a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Cellular Component: cytosol
Molecular Function: NF-kappaB-inducing kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; T cell costimulation; MAPKKK cascade; immune response; protein amino acid phosphorylation
Reference #:  Q99558 (UniProtKB)
Alt. Names/Synonyms: FTDCR1B; HS; HsNIK; M3K14; MAP3K14; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK; serine/threonine protein-kinase; Serine/threonine-protein kinase NIK
Gene Symbols: MAP3K14
Molecular weight: 104,042 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Nik

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: T559‑p
enzymatic activity, induced: T559‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y40-p GKKQSSVyKLEAVEK
1 0 S48 KLEAVEKSPVFCGKW
0 1 K64-ub ILNDVITkGTAKEGS
1 0 S89 AQAECENSQEFSPTF
0 4 K106-ub RIFIAGSkQYSQSES
1 0 S113 kQYSQSESLDQIPNN
0 1 T125-p PNNVAHAtEGkMARV
0 1 K128-ub VAHAtEGkMARVCWK
1 0 S153 RKKKSSKSLAHAGVA
0 2 K163-ub HAGVALAkPLPRTPE
0 1 Q212 LGQLCFKQLGEGLRP
0 2 K294-ub LACVDSQkPLPDPHL
1 0 S347 ALQGSVSSGQAHsLt
1 1 S352-p VSSGQAHsLtSLAKT
0 1 T354-p SGQAHsLtSLAKTWA
1 0 S355 GQAHsLtSLAKTWAA
2 0 T559-p TGDYIPGtETHMAPE
0 1 S643-p KEPIHRVsAAELGGK
0 1 Y682-p PPPNQANyHQTLHAQ
1 0 A688 NyHQTLHAQPRELSP
1 0 S733 KSPPLTLSKEESGMW
1 0 S757 PAPARNPSSPERKAT
1 0 S814 DDSEKNPSKASQSSR
1 0 S817 EKNPSKASQSSRDTL
1 0 S820 PSKASQSSRDTLSSG
1 0 S825 QSSRDTLSSGVHSWS
1 0 S826 SSRDTLSSGVHSWSS
1 0 S867 GVKVQIQSLNGEHLH
0 2 K882-ub IREFHRVkVGDIATG
  mouse

 
F40 GKKQSCIFKLEAVEK
S48-p KLEAVEKsPVFCGKW
K64 ILNDVITKGTAKDGS
S89-p AQAECENsQEFSPTF
Q106 RIFIAGSQQYSQSEs
S113-p QQYSQSEsLDQIPNN
T125 PNNVAHATEGKMARV
K128 VAHATEGKMARVCRR
S153-p RRKKRSKsLAQAGVA
K163 QAGVALAKPLPRTPE
K212-ub LGHLCFKkQDEGLRP
R295 LAGVSGQRPLPGPPH
S349-p ALQGSVSsGQAHsLA
S354-p VSsGQAHsLAsLAKT
A356 sGQAHsLAsLAKTWS
S357-p GQAHsLAsLAKTWSS
T561 TGDYIPGTETHMAPE
S645 KEPVHRASAMELRRK
C684 PPQDQATCHQTLPtP
T690-p TCHQTLPtPPRENPP
S728-p KAPALNLsKEESGTW
S752-p PATAKGPsFPDRRAT
S809-p DDSEKNPsKAsQSsR
S812-p EKNPsKAsQSsRDTL
S815-p PsKAsQSsRDTLssG
S820-p QSsRDTLssGVHSWN
S821-p SsRDTLssGVHSWNS
S862-p GVKVQIQsLNGEHLH
K877 IREFHRVKVGDIATG
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