a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 126.96.36.199; Protein kinase, Other; Other group; IKK family
Cellular Component: internal side of plasma membrane; intracellular membrane-bound organelle; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft
Molecular Function: protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: response to drug; skeletal muscle contraction; serine phosphorylation of STAT protein; B cell homeostasis; response to toxin; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; protein amino acid phosphorylation; neurite development; activation of NF-kappaB transcription factor
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.