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Protein Page:
IKKB (rat)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IKKB a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.10; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family
Cellular Component: internal side of plasma membrane; intracellular membrane-bound organelle; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft
Molecular Function: protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: skeletal muscle contraction; response to drug; serine phosphorylation of STAT protein; B cell homeostasis; response to toxin; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; protein amino acid phosphorylation; neurite development; activation of NF-kappaB transcription factor
Reference #:  Q9QY78 (UniProtKB)
Alt. Names/Synonyms: AIM-1; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK-B; IKK-beta; IKK2; Ikkb; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta
Gene Symbols: Ikbkb
Molecular weight: 86,866 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKKB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: S181‑p
enzymatic activity, induced: S181‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 S4 ____MSWSPSLPTQT
0 1 S6 __MSWSPSLPTQTCG
0 1 T23 EMKERLGTGGFGNVI
1 0 K163 GEKRLIHKIIDLGYA
27 1 S177-p AKELDQGsLCTsFVG
2 1 T180 LDQGsLCTsFVGTLQ
52 1 S181-p DQGsLCTsFVGTLQY
4 0 Y188 sFVGTLQYLAPELLE
4 1 Y199 ELLEQQKYTVTVDYW
0 1 S239 HSKVRQKSEVDIVVS
0 1 S246 SEVDIVVSEDLNGTV
0 1 S256 LNGTVKFSSSSPFPN
0 1 S257 NGTVKFSSSSPFPNN
0 1 S258 GTVKFSSSSPFPNNL
0 1 F261 KFSSSSPFPNNLNSV
0 1 S267 PFPNNLNSVLAERLE
0 1 T324 MVTGTIHTYPVMEDE
0 1 Y325 VTGTIHTYPVMEDES
0 1 S332 YPVMEDESLQSLKTR
0 1 S335 MEDESLQSLKTRIRE
0 1 T344 KTRIREDTGILETDQ
0 1 T368 LLPDKPATQCISDSK
0 1 S393 LVFLFDNSKMSYETQ
0 1 S396 LFDNSKMSYETQITP
0 1 Y397 FDNSKMSYETQITPR
0 1 T399 NSKMSYETQITPRPQ
0 1 T402 MSYETQITPRPQPES
0 2 S409 TPRPQPESVSCVLQE
0 2 S411 RPQPESVSCVLQEPK
0 1 S466 LRNNSCLSKMKNAMA
0 1 A471 CLSKMKNAMASTAQQ
0 1 S474 KMKNAMASTAQQLKA
0 1 A476 KNAMASTAQQLKAKL
0 1 T488 AKLDFFKTSIQIDLE
0 1 S489 KLDFFKTSIQIDLEK
0 1 R498 QIDLEKYREQTEFGI
0 1 S507 QTEFGITSDKLLLAW
0 3 S550 DIVDLQRSPMGRKQG
0 3 K555 QRSPMGRKQGGTLDD
0 1 T559 MGRKQGGTLDDLEEQ
0 1 T583 EKPRDQRTEGDSQDM
0 1 S587 DQRTEGDSQDMVRLL
0 2 S600 LLLQAIQSFEKKVRV
0 2 Y609 EKKVRVIYSQLSKTV
0 1 T610 under review
0 1 R634 PKVEEVVRLMNEDEK
0 1 K659 KELWNLLKIACSKVR
0 10 S670 SKVRGPVSGsPDSMN
0 62 S672-p VRGPVSGsPDSMNVS
0 6 S675 PVSGsPDSMNVSRLS
1 5 S679 sPDSMNVSRLSHPGH
1 1 S682 SMNVSRLSHPGHLMS
1 0 S689 SHPGHLMSQPSSACD
1 0 S692 GHLMSQPSSACDSLP
0 1 S693 HLMSQPSSACDSLPD
0 1 C695 MSQPSSACDSLPDSD
1 1 S697 QPSSACDSLPDSDKK
1 0 S701 ACDSLPDSDKKSEEL
1 0 S705 LPDSDKKSEELVAEA
1 1 S733 TVKQQDRSFTTLDWS
1 0 S733 TVKQQDRSFTTLDWS
0 1 T735 KQQDRSFTTLDWSWL
1 1 S740 SFTTLDWSWLQMEDE
2 0 C750 QMEDEERCGLEQACD
2078 : Phospho-IKKalpha (Ser176)/IKKbeta (Ser177) (C84E11) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
  human

 
S4-p ____MSWsPsLTTQT
S6-p __MSWsPsLTTQTCG
T23-p EMKERLGtGGFGNVI
K163-ub GEQRLIHkIIDLGYA
S177-p AKELDQGsLCtsFVG
T180-p LDQGsLCtsFVGTLQ
S181-p DQGsLCtsFVGTLQy
Y188-p sFVGTLQyLAPELLE
Y199-p ELLEQQKyTVTVDYW
S239-p HSKVRQKsEVDIVVs
S246-p sEVDIVVsEDLNGTV
S256-p LNGTVKFsssLPyPN
S257-p NGTVKFsssLPyPNN
S258-p GTVKFsssLPyPNNL
Y261-p KFsssLPyPNNLNsV
S267-p PyPNNLNsVLAERLE
T324-p MVTGTIHtyPVTEDE
Y325-p VTGTIHtyPVTEDEs
S332-p yPVTEDEsLQsLKAR
S335-p TEDEsLQsLKARIQQ
T344-p KARIQQDtGIPEEDQ
T368-p LIPDKPAtQCISDGK
S393-p LVFLFDNsKItyEtQ
T396-p LFDNsKItyEtQIsP
Y397-p FDNsKItyEtQIsPR
T399-p NsKItyEtQIsPRPQ
S402-p ItyEtQIsPRPQPEs
S409-p sPRPQPEsVsCILQE
S411-p RPQPEsVsCILQEPK
S466 LRNNSCLSKMKNsMA
S471-p CLSKMKNsMAsMsQQ
S474-p KMKNsMAsMsQQLKA
S476-p KNsMAsMsQQLKAKL
T488-p AKLDFFKtsIQIDLE
S489-p KLDFFKtsIQIDLEK
S498 QIDLEKYSEQTEFGI
S507-p QTEFGITsDKLLLAW
S550-p DIVDLQRsPMGRKQG
K555 QRsPMGRKQGGtLDD
T559-p MGRKQGGtLDDLEEQ
T583-p EKPRDQRtEGDsQEM
S587-p DQRtEGDsQEMVRLL
S600-p LLLQAIQsFEKKVRV
Y609-p EKKVRVIytQLSKTV
T610-p KKVRVIytQLSKTVV
S634-p PKVEEVVsLMNEDEK
K659-ac KELWNLLkIACSKVR
S670-p SKVRGPVsGsPDsMN
S672-p VRGPVsGsPDsMNAs
S675-p PVsGsPDsMNAsRLs
S679-p sPDsMNAsRLsQPGQ
S682-p sMNAsRLsQPGQLMS
S689 sQPGQLMSQPStAsN
S692 GQLMSQPStAsNsLP
T693-p QLMSQPStAsNsLPE
S695-p MSQPStAsNsLPEPA
S697-p QPStAsNsLPEPAKK
P701 AsNsLPEPAKKSEEL
S705 LPEPAKKSEELVAEA
S733-p TVREQDQsFtALDWs
S733-gl TVREQDQsFtALDWs
T735-p REQDQsFtALDWsWL
S740-p sFtALDWsWLQTEEE
S750-p QTEEEEHsCLEQAS_
2078 : Phospho-IKKalpha (Ser176)/IKKbeta (Ser177) (C84E11) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
  mouse

 
S4 ____MSWSPSLPTQT
S6 __MSWSPSLPTQTCG
T23 EMKERLGTGGFGNVI
K163 GEKRLIHKIIDLGYA
S177-p AKELDQGsLCtsFVG
T180-p LDQGsLCtsFVGTLQ
S181-p DQGsLCtsFVGTLQy
Y188-p sFVGTLQyLAPELLE
Y199-p ELLEQQKyTVTVDYW
S239 HSKVRQKSEVDIVVS
S246 SEVDIVVSEDLNGAV
S256 LNGAVKFSSSLPFPN
S257 NGAVKFSSSLPFPNN
S258 GAVKFSSSLPFPNNL
F261 KFSSSLPFPNNLNSV
S267 PFPNNLNSVLAERLE
T324 MVTGTVHTYPVTEDE
Y325 VTGTVHTYPVTEDES
S332 YPVTEDESLQSLKTR
S335 TEDESLQSLKTRIQE
T344 KTRIQENTGILETDQ
T368 LLPDKPATQCISDSK
S393 LVFLLDNSKINYETQ
N396 LLDNSKINYETQITP
Y397 LDNSKINYETQITPR
T399 NSKINYETQITPRPP
T402 INYETQITPRPPPES
S409 TPRPPPESVSCILQE
S411 RPPPESVSCILQEPK
S466-p LRNNSCLsKMKNAMA
A471 CLsKMKNAMASTAQQ
S474 KMKNAMASTAQQLKA
A476 KNAMASTAQQLKAKL
T488 AKLDFFKTSIQIDLE
S489 KLDFFKTSIQIDLEK
K498-ub QIDLEKYkEQTEFGI
S507 QTEFGITSDKLLLAW
S550 DIVDLQRSPMGRkQG
K555-ub QRSPMGRkQGGTLDD
T559 MGRkQGGTLDDLEEQ
T583 EKPRDQRTEGDSQEM
S587 DQRTEGDSQEMVRLL
S600 LLLQAIQSFEKKVRV
Y609 EKKVRVIYTQLSKTV
T610 KKVRVIYTQLSKTVV
S634 PKVEEVVSLMNEDER
K659 KELWNLLKIACSKVR
S670 SKVRGPVSGsPDsMN
S672-p VRGPVSGsPDsMNVs
S675-p PVSGsPDsMNVsRLs
S679-p sPDsMNVsRLsHPGQ
S682-p sMNVsRLsHPGQLMs
S689-p sHPGQLMsQPsSACD
S692-p GQLMsQPsSACDsLP
S693 QLMsQPsSACDsLPE
C695 MsQPsSACDsLPEsD
S697-p QPsSACDsLPEsDKK
S701-p ACDsLPEsDKKsEEL
S705-p LPEsDKKsEELVAEA
S733 TVKEQDRSFTTLDWS
S733 TVKEQDRSFTTLDWS
T735 KEQDRSFTTLDWSWL
S740 SFTTLDWSWLQMEDE
C750 QMEDEERCSLEQACD
2078 : Phospho-IKKalpha (Ser176)/IKKbeta (Ser177) (C84E11) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
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