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IKK-beta (rat)

Overview IKK-beta a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.10; Other group; IKK family Cellular Component: internal side of plasma membrane; intracellular membrane-bound organelle; cytoplasm; IkappaB kinase complex; nucleus; lipid raft Molecular Function: protein binding; IkappaB kinase activity; protein heterodimerization activity; kinase activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: skeletal muscle contraction; response to drug; B cell homeostasis; response to toxin; regulation of I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; protein amino acid phosphorylation; activation of NF-kappaB transcription factor Reference #:  Q9QY78 (UniProtKB) Alt. Names/Synonyms: AIM-1; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK-B; IKK-beta; IKK2; Ikkb; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta Gene Symbols: Ikbkb Molecular weight: 86,866 Da Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IKK-beta 3BRT - A/C=701-730 (human) 3BRV - A/C=701-745 (human) Substrate Sequence Logo

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S181‑p enzymatic activity, induced: S181‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat
1	0		K163	GEKRLIHKIIDLGYA
24	0		S177-p	AKELDQGsLCTsFVG
2	0		T180	LDQGsLCTsFVGTLQ
49	0		S181-p	DQGsLCTsFVGTLQY
4	0		Y188	sFVGTLQYLAPELLE
4	0		Y199	ELLEQQKYTVTVDYW
0	1		S409	TPRPQPESVSCVLQE
0	1		S411	RPQPESVSCVLQEPK
0	1		S466	LRNNSCLSKMKNAMA
0	1		A471	CLSKMKNAMASTAQQ
0	1		R498	QIDLEKYREQTEFGI
0	3		K555	QRSPMGRKQGGTLDD
0	1		S600	LLLQAIQSFEKKVRV
0	1		Y609	EKKVRVIYSQLSKTV
0	1		K659	KELWNLLKIACSKVR
0	4		S670	SKVRGPVSGsPDSMN
0	31		S672-p	VRGPVSGsPDSMNVS
0	2		S675	PVSGsPDSMNVSRLS
1	1		S679	sPDSMNVSRLSHPGH
1	0		S682	SMNVSRLSHPGHLMS
1	1		S689	SHPGHLMSQPSSACD
1	1		S692	GHLMSQPSSACDSLP
1	0		S697	QPSSACDSLPDSDKK
1	0		S701	ACDSLPDSDKKSEEL
1	0		S705	LPDSDKKSEELVAEA
1	0		S733	TVKQQDRSFTTLDWS
1	0		S733	TVKQQDRSFTTLDWS
1	0		S740	SFTTLDWSWLQMEDE
2	0		C750	QMEDEERCGLEQACD

	human
K163-u	GEQRLIHkIIDLGYA
S177-p	AKELDQGsLCtsFVG
T180-a	LDQGsLCtsFVGTLQ
S181-p	DQGsLCtsFVGTLQy
Y188-p	sFVGTLQyLAPELLE
Y199-p	ELLEQQKyTVTVDYW
S409-p	SPRPQPEsVsCILQE
S411-p	RPQPEsVsCILQEPK
S466	LRNNSCLSKMKNsMA
S471-p	CLSKMKNsMASMSQQ
S498	QIDLEKYSEQTEFGI
K555	QRSPMGRKQGGTLDD
S600-p	LLLQAIQsFEKKVRV
Y609-p	EKKVRVIyTQLSKTV
K659-a	KELWNLLkIACSKVR
S670-p	SKVRGPVsGsPDsMN
S672-p	VRGPVsGsPDsMNAs
S675-p	PVsGsPDsMNAsRLS
S679-p	sPDsMNAsRLSQPGQ
S682	sMNAsRLSQPGQLMs
S689-p	SQPGQLMsQPsTASN
S692-p	GQLMsQPsTASNSLP
S697	QPsTASNSLPEPAKK
P701	ASNSLPEPAKKSEEL
S705	LPEPAKKSEELVAEA
S733-p	TVREQDQsFTALDWs
S733-g	TVREQDQsFTALDWs
S740-p	sFTALDWsWLQTEEE
S750-p	QTEEEEHsCLEQAS_

	mouse
K163	GEKRLIHKIIDLGYA
S177-p	AKELDQGsLCtsFVG
T180-a	LDQGsLCtsFVGTLQ
S181-p	DQGsLCtsFVGTLQy
Y188-p	sFVGTLQyLAPELLE
Y199-p	ELLEQQKyTVTVDYW
S409	TPRPPPESVSCILQE
S411	RPPPESVSCILQEPK
S466-p	LRNNSCLsKMKNAMA
A471	CLsKMKNAMASTAQQ
K498-u	QIDLEKYkEQTEFGI
K555-u	QRSPMGRkQGGTLDD
S600	LLLQAIQSFEKKVRV
Y609	EKKVRVIYTQLSKTV
K659	KELWNLLKIACSKVR
S670	SKVRGPVSGsPDsMN
S672-p	VRGPVSGsPDsMNVs
S675-p	PVSGsPDsMNVsRLs
S679-p	sPDsMNVsRLsHPGQ
S682-p	sMNVsRLsHPGQLMs
S689-p	sHPGQLMsQPsSACD
S692-p	GQLMsQPsSACDsLP
S697-p	QPsSACDsLPEsDKK
S701-p	ACDsLPEsDKKsEEL
S705-p	LPEsDKKsEELVAEA
S733	TVKEQDRSFTTLDWS
S733	TVKEQDRSFTTLDWS
S740	SFTTLDWSWLQMEDE
C750	QMEDEERCSLEQACD

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