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Protein Page:
HSP70 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HSP70 a critical chaperone protein that has a high affinity for unfolded polypeptide chains. It binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In cooperation with other chaperones, hsp70 stabilizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles. Mitochondrial HSP70 is crucial to the import process: mutant forms of HSP70 fail to import precursor proteins. Is anti-apoptotic in sympathetic neurones and mediates this effect primarily by suppressing c-Jun transcriptional signalling. Interacts with tau protein and mediates proper folding of tau. Can promote the degradation of tau protein. Triptolide, a potential therapeutic agent for progression/metastasis of pancreatic cancer, causes pancreatic cancer cell death by induction of apoptosis, an effect mediated by the inhibition of HSP70. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Motility/polarity/chemotaxis; Heat shock protein
Chromosomal Location of Human Ortholog: 6p21.3
Reference #:  P08107 (UniProtKB)
Alt. Names/Synonyms: dnaK-type molecular chaperone HSP70-1; Heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A/1B; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock-induced protein; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70.1/HSP70.2; HSP70I; HSP71; HSP72; HSPA1; HSPA1A; HSPA1B
Gene Symbols: HSPA1A, HSPA1B
Molecular weight: 70,052 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSP70

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: Y525‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K3-ac _____MAkAAAIGID
0 2 K3-ub _____MAkAAAIGID
0 1 T13-p AIGIDLGtTySCVGV
0 50 Y15-p GIDLGtTySCVGVFQ
0 5 S40-p QGNRTTPsyVAFTDT
0 416 Y41-p GNRTTPsyVAFTDTE
0 1 R49-m1 VAFTDTErLIGDAAk
0 1 K56-ac rLIGDAAkNQVALNP
0 34 K56-ub rLIGDAAkNQVALNP
0 105 K71-ac QNTVFDAkRLIGRkF
0 15 K71-ub QNTVFDAkRLIGRkF
0 4 K77-ub AkRLIGRkFGDPVVQ
0 2 S85-p FGDPVVQsDMkhWPF
0 6 K88-ac PVVQsDMkhWPFQVI
1 0 H89-p VVQsDMkhWPFQVIN
0 26 Y107-p KPKVQVSykGETkAF
0 2 K108-ac PKVQVSykGETkAFY
0 16 K108-ub PKVQVSykGETkAFY
0 1 K112-ac VSykGETkAFYPEEI
0 4 K112-ub VSykGETkAFYPEEI
1 0 K126-ac ISSMVLTkMKEIAEA
0 6 K126-ub ISSMVLTkMKEIAEA
0 3 S153-p VPAYFNDsQRQATkD
1 0 K159-ac DsQRQATkDAGVIAG
0 23 K159-ub DsQRQATkDAGVIAG
0 1 K220-ub DDGIFEVkATAGDtH
0 1 T226-p VkATAGDtHLGGEDF
0 68 K246-ac NHFVEEFkRKHKKDI
0 7 K246-ub NHFVEEFkRKHKKDI
0 4 S254-p RKHKKDIsQNkRAVR
0 3 K257-ub KKDIsQNkRAVRRLR
0 103 T265-p RAVRRLRtACERAKR
0 1 K319-ac STLEPVEkALRDAkL
0 14 K319-ub STLEPVEkALRDAkL
1 7 K325-ub EkALRDAkLDkAQIH
0 1 K328-ac LRDAkLDkAQIHDLV
0 4 K328-ub LRDAkLDkAQIHDLV
0 1 K345-ub GGSTRIPkVQkLLQD
0 2 K348-ac TRIPkVQkLLQDFFN
0 20 K348-ub TRIPkVQkLLQDFFN
0 5 S362-p NGRDLNKsINPDEAV
0 2 K415-ub GVMTALIkRNSTIPT
0 3 K423-ub RNSTIPTkQTQIFTT
1 26 K451-ub EGERAMTkDNNLLGR
0 19 R469-m1 SGIPPAPrGVPQIEV
0 2 K500-ac KSTGKANkItITNDk
0 11 K500-ub KSTGKANkItITNDk
0 2 T502-p TGKANkItITNDkGR
0 123 K507-ub kItITNDkGRLSkEE
0 50 K512-ub NDkGRLSkEEIERMV
0 2 K524-ac RMVQEAEkykAEDEV
1 84 K524-ub RMVQEAEkykAEDEV
1 24 Y525-p MVQEAEkykAEDEVQ
0 1 K526-ac VQEAEkykAEDEVQR
1 19 K526-ub VQEAEkykAEDEVQR
0 1 S537-p EVQRERVsAkNALES
0 22 K539-ub QRERVsAkNALESYA
0 5 K550-ub ESYAFNMksAVEDEG
0 2 S551-p SYAFNMksAVEDEGL
1 15 K559-ub AVEDEGLkGkISEAD
0 2 K561-m1 EDEGLkGkISEADKK
1 3 K561-m2 EDEGLkGkISEADKK
1 2 K561-m3 EDEGLkGkISEADKK
0 7 K561-ub EDEGLkGkISEADKK
0 1 K567 GkISEADKKKVLDkC
0 2 K573-ub DKKKVLDkCQEVISW
0 1 K589-ub DANTLAEkDEFEHkR
0 3 K595-ac EkDEFEHkRkELEQV
0 3 K595-ub EkDEFEHkRkELEQV
0 36 K597-ub DEFEHkRkELEQVCN
0 2 N604 kELEQVCNPIISGLy
0 59 Y611-p NPIISGLyQGAGGPG
0 14 K628-ub GFGAQGPkGGsGsGP
1 6 S631-p AQGPkGGsGsGPtIE
1 5 S633-p GPkGGsGsGPtIEEV
1 4 T636-p GGsGsGPtIEEVD__
  mouse

 
K3 _____MAKNTAIGID
K3-ub _____MAkNTAIGID
T13 AIGIDLGTTySCVGV
Y15-p GIDLGTTySCVGVFQ
S40 QGNRTTPSyVAFTDT
Y41-p GNRTTPSyVAFTDTE
R49 VAFTDTERLIGDAAk
K56 RLIGDAAKNQVALNP
K56-ub RLIGDAAkNQVALNP
K71-ac QNTVFDAkRLIGRKF
K71-ub QNTVFDAkRLIGRKF
K77 AkRLIGRKFGDAVVQ
S85 FGDAVVQSDMKHWPF
K88 AVVQSDMKHWPFQVV
H89 VVQSDMKHWPFQVVN
Y107 KPKVQVNYkGESRSF
K108 PKVQVNYKGESRSFF
K108-ub PKVQVNYkGESRSFF
R112 VNYkGESRSFFPEEI
R112 VNYkGESRSFFPEEI
K126 ISSMVLTKMKEIAEA
K126-ub ISSMVLTkMKEIAEA
S153 VPAYFNDSQRQATkD
K159 DSQRQATKDAGVIAG
K159-ub DSQRQATkDAGVIAG
K220 DDGIFEVKATAGDtH
T226-p VKATAGDtHLGGEDF
K246-ac SHFVEEFkRKHKKDI
K246 SHFVEEFKRKHKKDI
S254-p RKHKKDIsQNkRAVR
K257-ub KKDIsQNkRAVRRLR
T265-p RAVRRLRtACERAKR
K319 GTLEPVEKALRDAKM
K319 GTLEPVEKALRDAKM
K325 EKALRDAKMDKAQIH
K328 LRDAKMDKAQIHDLV
K328 LRDAKMDKAQIHDLV
K345 GGSTRIPKVQkLLQD
K348 TRIPKVQKLLQDFFN
K348-ub TRIPKVQkLLQDFFN
S362 NGRDLNKSINPDEAV
K415 GVMTALIKRNSTIPT
K423 RNSTIPTKQTQTFTT
R451 EGERAMTRDNNLLGR
R469-m1 SGIPPAPrGVPQIEV
K500 KSTGKANKITITNDk
K500-ub KSTGKANkITITNDk
T502 TGKANkITITNDkGR
K507-ub kITITNDkGRLSkEE
K512-ub NDkGRLSkEEIERMV
R524 RMVQEAERYKAEDEV
R524 RMVQEAERYKAEDEV
Y525 MVQEAERYKAEDEVQ
K526 VQEAERYKAEDEVQR
K526 VQEAERYKAEDEVQR
A537 EVQRDRVAAkNALES
K539-ub QRDRVAAkNALESYA
K550 ESYAFNMKSAVEDEG
S551 SYAFNMKSAVEDEGL
K559 AVEDEGLKGKLSEAD
K561 EDEGLKGKLSEADkK
K561 EDEGLKGKLSEADkK
K561 EDEGLKGKLSEADkK
K561 EDEGLKGKLSEADkK
K567-ac GKLSEADkKKVLDKC
K573 DkKKVLDKCQEVISW
K589 DSNTLADKEEFVHKR
K595 DKEEFVHKREELERV
K595 DKEEFVHKREELERV
E597 EEFVHKREELERVCs
S604-p EELERVCsPIISGLY
Y611 sPIISGLYQGAGAPG
K628-ub GFGAQAPkGASGSGP
S631 AQAPkGASGSGPTIE
S633 APkGASGSGPTIEEV
T636 GASGSGPTIEEVD__
  rat

 
K3 _____MAKKTAIGID
K3 _____MAKKTAIGID
T13 AIGIDLGTTYSCVGV
Y15 GIDLGTTYSCVGVFQ
S40 QGNRTTPSyVAFTDT
Y41-p GNRTTPSyVAFTDTE
R49 VAFTDTERLIGDAAk
K56-ac RLIGDAAkNQVALNP
K56 RLIGDAAKNQVALNP
K71 QNTVFDAKRLIGRKF
K71-ub QNTVFDAkRLIGRKF
K77 AkRLIGRKFGDPVVQ
S85 FGDPVVQSDMKHWPF
K88 PVVQSDMKHWPFQVV
H89 VVQSDMKHWPFQVVN
Y107 KPKVQVNYkGENRSF
K108-ac PKVQVNYkGENRSFY
K108-ub PKVQVNYkGENRSFY
R112 VNYkGENRSFYPEEI
R112 VNYkGENRSFYPEEI
K126 ISSMVLTKMKEIAEA
K126 ISSMVLTKMKEIAEA
S153 VPAYFNDSQRQATkD
K159 DSQRQATKDAGVIAG
K159-ub DSQRQATkDAGVIAG
K220 DDGIFEVKATAGDTH
T226 VKATAGDTHLGGEDF
K246-ac SHFVEEFkRKHKKDI
K246-ub SHFVEEFkRKHKKDI
S254 RKHKKDISQNKRAVR
K257 KKDISQNKRAVRRLR
T265 RAVRRLRTACERAKR
K319-ac GTLEPVEkALRDAKL
K319 GTLEPVEKALRDAKL
K325 EkALRDAKLDkAQIH
K328 LRDAKLDKAQIHDLV
K328-ub LRDAKLDkAQIHDLV
K345 GGSTRIPKVQkLLQD
K348-ac TRIPKVQkLLQDFFN
K348-ub TRIPKVQkLLQDFFN
S362 NGRDLNKSINPDEAV
K415 GVMTALIKRNSTIPT
K423 RNSTIPTKQTQTFTT
R451 EGERAMTRDNNLLGR
R469-m1 SGIPPAPrGVPQIEV
K500-ac KSTGKANkITITNDk
K500 KSTGKANKITITNDk
T502 TGKANkITITNDkGR
K507-ub kITITNDkGRLSKEE
K512 NDkGRLSKEEIERMV
R524 RMVQEAERYKAEDEV
R524 RMVQEAERYKAEDEV
Y525 MVQEAERYKAEDEVQ
K526 VQEAERYKAEDEVQR
K526 VQEAERYKAEDEVQR
A537 EVQRERVAAKNALES
K539 QRERVAAKNALESYA
K550 ESYAFNMKSAVEDEG
S551 SYAFNMKSAVEDEGL
K559 AVEDEGLKGKISEAD
K561 EDEGLKGKISEADKK
K561 EDEGLKGKISEADKK
K561 EDEGLKGKISEADKK
K561 EDEGLKGKISEADKK
K567 GKISEADKKKVLDKC
K573 DKKKVLDKCQEVISW
K589 DSNTLAEKEEFVHKR
K595 EKEEFVHKREELERV
K595 EKEEFVHKREELERV
E597 EEFVHKREELERVCN
N604 EELERVCNPIISGLY
Y611 NPIISGLYQGAGAPG
K628 GFGAQAPKGGsGSGP
S631-p AQAPKGGsGSGPTIE
S633 APKGGsGSGPTIEEV
T636 GGsGSGPTIEEVD__
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