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Protein Page:
TAL1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TAL1 a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; histone deacetylase complex; nuclear chromatin; nucleus
Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity
Biological Process: erythrocyte maturation; cell fate commitment; positive regulation of chromatin assembly or disassembly; megakaryocyte differentiation; embryonic hemopoiesis; astrocyte fate commitment; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; erythrocyte differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; platelet formation; angiogenesis; basophil differentiation
Reference #:  P17542 (UniProtKB)
Alt. Names/Synonyms: BHLHA17; Class A basic helix-loop-helix protein 17; SCL; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product; TAL1; TCL5
Gene Symbols: TAL1
Molecular weight: 34,271 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAL1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S172‑p
translation, induced: T90‑p
molecular association, regulation: T90‑p, S172‑p
protein degradation: T90‑p, S122‑p
ubiquitination: T90‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MTERPPsEAARsDP
0 1 S12-p PPsEAARsDPQLEGR
2 10 T90-p EARHRVPtTELCRPP
2 80 S122-p DGRMVQLsPPALAAP
0 3 Y138-p APGRALLysLsQPLA
0 3 S139-p PGRALLysLsQPLAS
0 3 S141-p RALLysLsQPLASLG
2 2 S172-p NRVKRRPsPYEMEIT
0 2 T216-p ELRKLIPtHPPDkkL
1 1 K221-a IPtHPPDkkLSkNEI
1 1 K222-a PtHPPDkkLSkNEIL
0 1 K225-a PPDkkLSkNEILRLA
  mouse

 
S7 _MTERPPSEAARSDP
S12 PPSEAARSDPQLEGQ
T90 EARLRVPTTELCRPP
S122-p DGRMVQLsPPALAAP
Y138 GPGRALLYSLSQPLA
S139 PGRALLYSLSQPLAS
S141 RALLYSLSQPLASLG
S172-p NRVKRRPsPYEMEIS
T216-p ELRKLIPtHPPDkkL
K221-a IPtHPPDkkLSKNEI
K222-a PtHPPDkkLSKNEIL
K225 PPDkkLSKNEILRLA
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