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Protein Page:
TAL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAL1 a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: transcription factor complex; nuclear chromatin; histone deacetylase complex; nucleus
Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; erythrocyte maturation; positive regulation of chromatin assembly or disassembly; cell fate commitment; megakaryocyte differentiation; embryonic hemopoiesis; astrocyte fate commitment; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; erythrocyte differentiation; spinal cord association neuron differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; platelet formation; angiogenesis; basophil differentiation
Reference #:  P17542 (UniProtKB)
Alt. Names/Synonyms: BHLHA17; Class A basic helix-loop-helix protein 17; SCL; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product; TAL1; TCL5
Gene Symbols: TAL1
Molecular weight: 34,271 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAL1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S172‑p
translation, induced: T90‑p
molecular association, regulation: T90‑p, S172‑p
protein degradation: T90‑p, S122‑p
ubiquitination: T90‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S7-p _MTERPPsEAARsDP
0 1 S12-p PPsEAARsDPQLEGR
2 10 T90-p EARHRVPttELCRPP
0 1 T91-p ARHRVPttELCRPPG
0 1 S107-p APAPAPAsVTAELPG
2 90 S122-p DGRMVQLsPPALAAP
0 2 Y138-p APGRALLysLsQPLA
0 3 S139-p PGRALLysLsQPLAs
0 3 S141-p RALLysLsQPLAsLG
0 1 S146-p sLsQPLAsLGsGFFG
0 1 S149-p QPLAsLGsGFFGEPD
2 2 S172-p NRVKRRPsPYEMEIT
0 1 K212-ac GAFAELRkLIPtHPP
0 2 T216-p ELRkLIPtHPPDkkL
1 1 K221-ac IPtHPPDkkLSkNEI
1 1 K222-ac PtHPPDkkLSkNEIL
0 1 K225-ac PPDkkLSkNEILRLA
0 1 S316-p APKHTARsLHPAMLP
  mouse

 
S7 _MTERPPSEAARSDP
S12 PPSEAARSDPQLEGQ
T90 EARLRVPTTELCRPP
T91 ARLRVPTTELCRPPG
S107 APAPAPASAPAELPG
S122-p DGRMVQLsPPALAAP
Y138 GPGRALLYSLSQPLA
S139 PGRALLYSLSQPLAS
S141 RALLYSLSQPLASLG
S146 SLSQPLASLGSGFFG
S149 QPLASLGSGFFGEPD
S172-p NRVKRRPsPYEMEIS
K212 GAFAELRKLIPtHPP
T216-p ELRKLIPtHPPDkkL
K221-ac IPtHPPDkkLSKNEI
K222-ac PtHPPDkkLSKNEIL
K225 PPDkkLSKNEILRLA
S314 TPKHTSRSLHPALLP
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