a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Molecular Function: protein binding; enzyme binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cell fate commitment; positive regulation of chromatin assembly or disassembly; erythrocyte maturation; embryonic hemopoiesis; megakaryocyte differentiation; positive regulation of erythrocyte differentiation; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; positive regulation of protein complex assembly; positive regulation of cell division; spinal cord association neuron differentiation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; platelet formation; angiogenesis; basophil differentiation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.