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Protein Page:
PNKD (human)

Overview
PNKD Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. Defects in PNKD are the cause of dystonia type 8 (DYT8). DYT8 is a paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.-.-.-
Cellular Component: mitochondrion; membrane; nucleus
Molecular Function: hydroxyacylglutathione hydrolase activity; zinc ion binding
Biological Process: glutathione biosynthetic process
Reference #:  Q8N490 (UniProtKB)
Alt. Names/Synonyms: brain protein 17; BRP17; DKFZp564N1362; DYT8; FKSG19; FPD1; KIAA1184; KIPP1184; MGC31943; MR-1; MR1; Myofibrillogenesis regulator 1; paroxysmal nonkinesigenic dyskinesia; Paroxysmal nonkinesiogenic dyskinesia protein; PDC; PNKD; Probable hydrolase PNKD; TAHCCP2; Trans-activated by hepatitis C virus core protein 2
Gene Symbols: PNKD
Molecular weight: 42,876 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Select Structure to View Below

PNKD

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S57 KEEPEPLSPELEYIP
0 3 - gap
0 1 - gap
  PNKD iso2  
S57 KEEPEPLSPELEYIP
Y119-p RLSNTGEyEsQRFRA
S121-p SNTGEyEsQRFRASS
  PNKD iso3  
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S57-p KEEPEPLsPELEYIP
- gap
- gap
  PNKD iso2  
S57 KEEPEPLSPELEYIP
Y119-p RVSNTGEyESQRYRA
S121 SNTGEyESQRYRASP
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