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Protein Page:
PNKD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PNKD Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway. Defects in PNKD are the cause of dystonia type 8 (DYT8). DYT8 is a paroxysmal non-kinesigenic dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT8 is characterized by attacks of involuntary movements brought on by stress, alcohol, fatigue or caffeine. The attacks generally last between a few seconds and four hours or longer. The attacks may begin in one limb and spread throughout the body, including the face. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.-.-.-
Cellular Component: membrane; mitochondrion; nucleus
Molecular Function: hydroxyacylglutathione hydrolase activity; zinc ion binding
Biological Process: glutathione biosynthetic process
Reference #:  Q8N490 (UniProtKB)
Alt. Names/Synonyms: brain protein 17; BRP17; DKFZp564N1362; DYT8; FKSG19; FPD1; KIAA1184; KIPP1184; MGC31943; MR-1; MR1; Myofibrillogenesis regulator 1; paroxysmal nonkinesigenic dyskinesia; Paroxysmal nonkinesiogenic dyskinesia protein; PDC; PNKD; Probable hydrolase PNKD; TAHCCP2; Trans-activated by hepatitis C virus core protein 2
Gene Symbols: PNKD
Molecular weight: 42,876 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Select Structure to View Below

PNKD

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 S46 RALQSHSSPEGKEEP
1 4 S57-p KEEPEPLsPELEYIP
0 1 Y83 GLAWYSLYTRTWLGY
0 1 T138 YSYLIIDTQAQLAVA
0 1 S157 DPRAVQASIEKEGVT
0 1 K160 AVQASIEKEGVTLVA
0 1 K160 AVQASIEKEGVTLVA
0 1 Y203-p SPQDGIPyLtHPLCH
0 1 T205-p QDGIPyLtHPLCHQD
1 0 - gap
0 3 - gap
0 1 - gap
1 0 - gap
1 0 - gap
1 0 - gap
  PNKD iso2  
S46-p RALQSHSsPEGKEEP
S57-p KEEPEPLsPELEYIP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S114-p ARQNMRLsNTGEyEs
Y119-p RLsNTGEyEsQRFRA
S121-p sNTGEyEsQRFRASs
S128-p sQRFRASsQsAPsPD
S130-p RFRASsQsAPsPDVG
S133-p ASsQsAPsPDVGSGV
  PNKD iso3  
- gap
- gap
Y59-p FRIGYSLyTRTWLGY
T114 YSYLIIDTQAQLAVA
S133 DPRAVQASIEKEGVT
K136 AVQASIEKEGVTLVA
K136 AVQASIEKEGVTLVA
Y179 SPQDGIPYLTHPLCH
T181 QDGIPYLTHPLCHQD
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S46 RALQSHSSPECKEEP
S57-p KEEPEPLsPELEYIP
Y83 GLAWYSLYTRTWLGY
T138-p YSYLIIDtQAGLAVA
S157-p DPRAVQAsIEkERVN
K160-ac AVQAsIEkERVNLVA
K160-sc AVQAsIEkERVNLVA
Y203 SPQDGIPYLTHPLCH
T205 QDGIPYLTHPLCHQD
- gap
- gap
- gap
- gap
- gap
- gap
  PNKD iso2  
S46 RALQSHSSPECKEEP
S57 KEEPEPLSPELEYIP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S114 ARQNMRVSNTGEyES
Y119-p RVSNTGEyESQRYRA
S121 SNTGEyESQRYRASP
P128 SQRYRASPQQAQFPE
Q130 RYRASPQQAQFPEVG
F133 ASPQQAQFPEVGSGA
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