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Protein Page:
CDH2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDH2 Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: cell-cell adherens junction; lamellipodium; apical plasma membrane; integral to membrane; plasma membrane; synapse; fascia adherens; catenin complex; intercellular junction
Molecular Function: protein binding; gamma-catenin binding; beta-catenin binding; calcium ion binding; protein phosphatase binding; alpha-catenin binding
Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; cell migration; muscle cell differentiation; positive regulation of MAPKKK cascade; calcium-dependent cell-cell adhesion; blood vessel morphogenesis; positive regulation of muscle cell differentiation; striated muscle cell differentiation; homophilic cell adhesion; cell adhesion
Reference #:  P19022 (UniProtKB)
Alt. Names/Synonyms: CADH2; cadherin 2, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; calcium-dependent adhesion protein, neuronal; CD325; CDH2; CDHN; CDw325; N-cadherin; N-cadherin 1; NCAD; Neural cadherin; neural-cadherin
Gene Symbols: CDH2
Molecular weight: 99,809 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDH2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y860‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S61-p PLLNVKFsNCNGKRK
0 1 S423 WNAVYRISGGDPTGR
0 2 T454-p VKPIDFEtNRMFVLT
0 1 Y496-p IDVNENPyFAPNPKI
0 1 K667-ub DFAQLNLkIKFLEAG
0 1 T683-p YEVPIIItDsGNPPK
0 1 S685-p VPIIItDsGNPPKSN
0 2 K756-ub RDKERQAkQLLIDPE
0 1 Y773-p VRDNILKyDEEGGGE
0 11 Y785-p GGEEDQDyDLsQLQQ
0 9 S788-p EDQDyDLsQLQQPDT
0 2 K802-ub TVEPDAIkPVGIRRM
1 7 Y820-p PIHAEPQyPVRSAAP
2 0 Y852-p NDPTAPPyDSLLVFD
1 0 Y860-p DSLLVFDyEGSGSTA
2 0 Y884-p SSGGEQDyDyLNDWG
1 0 Y886-p GGEQDyDyLNDWGPR
  mouse

 
S61 PLLNVKFSNCNRKRK
S423-p WNAAYRIsGGDPTGR
T454-p VKPIDFEtNRMFVLT
Y496 IDVNENPYFAPNPKI
K667 DFAQLNLKIKFLEAG
T683 YEVPIIITDSGNPPK
S685 VPIIITDSGNPPKSN
K756-ub RDKERQAkQLLIDPE
Y773 VRDNILKYDEEGGGE
Y785 GGEEDQDYDLsQLQQ
S788-p EDQDYDLsQLQQPDT
K802 TVEPDAIKPVGIRRL
Y820 PIHAEPQYPVRSAAP
Y852-p NDPTAPPyDSLLVFD
Y860 DSLLVFDYEGSGSTA
Y884-p SSGGDQDyDYLNDWG
Y886 GGDQDyDYLNDWGPR
  rat

 
S61 PLLNVKFSNCNRKRK
S423 WNAAYRISGGDPTGR
T454 VKPIDFETNRMFVLT
Y496 IDVNENPYFAPNPKI
K667 DFAQLNLKIKFLEAG
T683 YEVPIVITDSGNPPK
S685 VPIVITDSGNPPKSN
K756 RDKERQAKQLLIDPE
Y773 VRDNILKYDEEGGGE
Y785-p GGEEDQDyDLSQLQQ
S788 EDQDyDLSQLQQPDT
K802 TVEPDAIKPVGIRRL
Y820-p PIHAEPQyPVRSAAP
Y852 NDPTAPPYDSLLVFD
Y860 DSLLVFDYEGSGSTA
Y884 SSGGDQDYDYLNDWG
Y886 GGDQDYDYLNDWGPR
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