|
IKK-alpha
a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B, leading to their dissociation from NF-kappa-B and ultimately to their degradation. Phosphorylated and activated downstream of growth factor receptors, IL1R, and TNFR by NAK, IRAK and NIK, respectively. Preferentially found as a heterodimer with IKK-beta but also as an homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP. Heterodimers form the active complex. The tripartite complex can also bind to MAP3K14/NIK, MEKK1, IKAP and IKB-alpha-p65-p50 complex. Inhibitors are under development to treat arthritis, inflammation, and apoptotic aspects of cancer. Aspirin (sodium salicylate) selectively binds IKK and reduces inflammation. Misexpression and inhibitors show involvement in insulin sensitization in obese rodents. Mutations in IKK-gamma are found in several immune deficiencies: hyper IgM syndrome, incontinentia pigmenti [embryonic lethal in males, defects in skin, hair, teeth in females] and hypohidrotic ectodermal dysplasia; recurrent infections and defects in teeth, hair, and sweat glands]. Inhibitors: CHS 828, NBD peptide, BMS-345541. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.11.10; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family |
|
Cellular Component: internal side of plasma membrane; intracellular membrane-bound organelle; cytoplasm; nucleolus; IkappaB kinase complex; cytosol; nucleus
|
|
Molecular Function: identical protein binding; protein binding; IkappaB kinase activity; ATP binding; protein kinase activity
|
|
Biological Process: lactation; I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; toll-like receptor 3 signaling pathway; osteoclast differentiation; protein amino acid phosphorylation; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; positive regulation of interferon type I production; morphogenesis of an epithelial sheet; inflammatory response; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; phosphoinositide-mediated signaling; positive regulation of I-kappaB kinase/NF-kappaB cascade; fibroblast growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; response to virus; mammary gland epithelial cell proliferation; Toll signaling pathway; odontogenesis of dentine-containing teeth; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; I-kappaB phosphorylation
|
|
Reference #:
O15111 (UniProtKB)
|
| Alt. Names/Synonyms: CHUK; conserved helix-loop ubiquitous kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkappaB kinase; IkB kinase alpha subunit; IkBKA; IKK-A; IKK-a kinase; IKK-alpha; IKK1; IKKA; Inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; TCF16; Transcription factor 16 |
| Gene Symbols: CHUK |
|
Molecular weight: 84,640 Da
|
|
Basal Isoelectric point: 6.27
Predict pI for various phosphorylation states
|
|
CST Pathways:
Apoptosis
|
B Cell Receptor Signaling
|
Death Receptor Signaling
|
Inhibition of Apoptosis
|
Insulin Receptor Signaling
|
NF-kB Signaling
|
PI3K/Akt Signaling
|
T Cell Receptor Signaling
|
Toll-like Receptors Pathway
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
