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FXR2 (human)

Overview FXR2 RNA-binding protein. Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Belongs to the FMR1 family. Note: This description may include information from UniProtKB. Protein type: RNA binding protein Cellular Component: cytoplasm Molecular Function: protein binding; RNA binding Reference #:  P51116 (UniProtKB) Alt. Names/Synonyms: FMR1L2; fragile X mental retardation syndrome related protein 2; Fragile X mental retardation syndrome-related protein 2; fragile X mental retardation, autosomal homolog 2; fragile X-mental retardation 1-like 2; FXR2 Gene Symbols: FXR2 Molecular weight: 74,223 Da Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FXR2 3H8Z - A=13-136 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S6-p	__MGGLAsGGDVEPG
0	1		Y26-p	RGSNGAFyKGFVKDV
0	1		T70-p	ADYNKEItEGDEVEV
0	1		Y78	EGDEVEVYSRANEQE
0	9		Y113-p	YAACDATyNEIVTLE
0	1		S135-p	NPLATKGsFFKVTMA
0	1		S192-p	EAPVKRAsLLGDMHF
0	1		S222	ATKHLETSKQLAAAF
0	1		K256	ANIQQARKVPGVTAI
0	5		K320-u	VIQEIVDkSGVVRVR
0	1		T350-p	VPFIFVGtRENISNA
0	1		R393	RQIGLGFRPPGsGRG
0	1		R393	RQIGLGFRPPGsGRG
0	1		S397-p	LGFRPPGsGRGSGGs
0	11		R399	FRPPGsGRGSGGsDK
0	1		R399	FRPPGsGRGSGGsDK
0	1		S401	PPGsGRGSGGsDKAG
0	4		S404-p	sGRGSGGsDKAGyst
0	2		K406	RGSGGsDKAGystDE
0	2		Y409-p	GGsDKAGystDEssS
0	9		S410-p	GsDKAGystDEssSS
0	42		T411-p	sDKAGystDEssSSs
0	11		S414-p	AGystDEssSSsLHA
0	3		S415-p	GystDEssSSsLHAT
0	2		S417	stDEssSSsLHATRT
0	1		S418-p	tDEssSSsLHATRTY
0	3		R432-m1	YGGSYGGrGrGRRTG
0	2		R434-m1	GSYGGrGrGRRTGGP
0	1		T438	GrGrGRRTGGPAyGP
0	1		Y443-p	RRTGGPAyGPSsDVs
0	2		S447-p	GPAyGPSsDVstAsE
0	1		S450-p	yGPSsDVstAsEtES
0	5		T451-p	GPSsDVstAsEtESE
0	8		S453-p	SsDVstAsEtESEKR
0	3		T455-p	DVstAsEtESEKREE
0	1		S457	stAsEtESEKREEPN
0	1		T475	PGDRDPPTRGEESRR
0	2		S504-p	RPTSRYNsSSISSVL
0	1		K512-u	SSISSVLkDPDSNPy
0	13		Y519-p	kDPDSNPysLLDtsE
0	2		S520-p	DPDSNPysLLDtsEP
0	1		T524-p	NPysLLDtsEPEPPV
0	1		S525-p	PysLLDtsEPEPPVD
0	1		S533-p	EPEPPVDsEPGEPPP
0	2		S548-p	ASARRRRsRRRRtDE
0	2		T553-p	RRsRRRRtDEDRTVM
0	15		S566-p	VMDGGLEsDGPNMTE
0	15		T598-p	RRNRGNRtDGsIsGd
0	29		S601-p	RGNRtDGsIsGdRQP
0	33		S603-p	NRtDGsIsGdRQPVt
0	1		D605-ca	tDGsIsGdRQPVtVA
0	1		T610-p	sGdRQPVtVADYISR
0	5		S620-p	DYISRAEsQSRQRPP

	mouse
S6	__MGGLASGGDVEPG
Y26	RGSNGAFYKGFVKDV
T70	ADYNKEITEGDEVEV
Y78-p	EGDEVEVySRANEQE
Y113	YAACDATYNEIVTLE
S135	SSLATKGSFFKVTMA
S192-p	EAPVKRAsLLGDMHF
S222-p	ATKHLETsKQLAAAF
K256-u	ANIQQARkVPGVTAI
K320	VIQGIVDKSGVVRVR
T350	VPFIFVGTRENISNA
R393	RQIGAGFRPPGSGrG
R393-m2	RQIGAGFrPPGSGrG
S397	AGFrPPGSGrGGsGG
R399-m1	FrPPGSGrGGsGGGs
R399-m2	FrPPGSGrGGsGGGs
S402-p	PGSGrGGsGGGsDkA
S406-p	rGGsGGGsDkAGYtt
K408-u	GsGGGsDkAGYttDE
Y411	GGsDkAGYttDEssS
T412-p	GsDkAGYttDEssSs
T413-p	sDkAGYttDEssSsS
S416-p	AGYttDEssSsSLHT
S417-p	GYttDEssSsSLHTT
S419-p	ttDEssSsSLHTTRT
S420	tDEssSsSLHTTRTY
R434-m1	YGGSYGGrGRGRRtG
R436	GSYGGrGRGRRtGGP
T440-p	GrGRGRRtGGPAYGP
Y445	RRtGGPAYGPSsDPS
S449-p	GPAYGPSsDPStAsE
S452	YGPSsDPStAsEtEs
T453-p	GPSsDPStAsEtEsE
S455-p	SsDPStAsEtEsEKR
T457-p	DPStAsEtEsEKREE
S459-p	StAsEtEsEKREESN
S477-p	PGDRDPPsRGEESRR
S505	RPTSRYNSSSISSVL
K513	SSISSVLKDPDSNPy
Y520-p	KDPDSNPySLLDTsE
S521	DPDSNPySLLDTsEP
T525	NPySLLDTsEPEPPV
S526-p	PySLLDTsEPEPPVD
S534-p	EPEPPVDsEPGEPPP
S549-p	ASARRRRsRRRRTDE
T554	RRsRRRRTDEDRTVM
S567-p	VMDGALEsDGPNMTE
T599-p	RRNRGNRtDGsIsGD
S602-p	RGNRtDGsIsGDRQP
S604-p	NRtDGsIsGDRQPVT
D606	tDGsIsGDRQPVTVA
T611	sGDRQPVTVADYISR
S621	DYISRAESQSRQRPL

	rat
S6	__MGGLASGGDVEPG
Y26	RGSNGAFYKGFVKDV
T70	ADYNKEITEGDEVEV
Y78	EGDEVEVYSRANEQE
Y113	YAACDATYNEIVTLE
S135	NPLATKGSFFKVTMA
S192	EAPVKRASLLGDMHF
S222	ATKHLETSKQLAAAF
K256	ANIQQARKVPGVTAI
K320	VIQEIVDKSGVVRVR
T350	VPFIFVGTRENISNA
R393-m1	RQIGLGFrPPGSGrG
R393	RQIGLGFRPPGSGrG
S397	LGFrPPGSGrGGSGG
R399-m1	FrPPGSGrGGSGGGS
R399	FrPPGSGRGGSGGGS
G403	GSGrGGSGGGSDKAG
S406	rGGSGGGSDKAGYTT
K408	GSGGGSDKAGYTTDE
Y411	GGSDKAGYTTDESSS
T412	GSDKAGYTTDESSSS
T413	SDKAGYTTDESSSSS
S416	AGYTTDESSSSSLHT
S417	GYTTDESSSSSLHTT
S419	TTDESSSSSLHTTRT
S420	TDESSSSSLHTTRTY
R434-m1	YGGSYGGrGrGRRTG
R436-m1	GSYGGrGrGRRTGGP
T440	GrGrGRRTGGPAYGP
Y445	RRTGGPAYGPSSDPS
S449	GPAYGPSSDPSTASE
S452	YGPSSDPSTASETES
T453	GPSSDPSTASETESE
S455	SSDPSTASETESEKR
T457	DPSTASETESEKREE
S459	STASETESEKREESN
S477	PGDRDPPSRGEESRR
S506	RPTSRYNSSSISSVL
K514	SSISSVLKDPDSNPY
Y521	KDPDSNPYSLLDTSE
S522	DPDSNPYSLLDTSEP
T526	NPYSLLDTSEPEPPV
S527	PYSLLDTSEPEPPVD
S535	EPEPPVDSEPGEPPP
S550	ASARRRRSRRRRTDE
T555	RRSRRRRTDEDRTVM
S568	VMDGGLESDGPNVTE
T600	RRNRGNRTDGsIsGD
S603-p	RGNRTDGsIsGDRQP
S605-p	NRTDGsIsGDRQPVT
D607	TDGsIsGDRQPVTVA
T612	sGDRQPVTVADYISR
S622	DYISRAESQSRQRPP

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