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Protein Page:
FXR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FXR2 RNA-binding protein. Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Belongs to the FMR1 family. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein
Molecular Function: identical protein binding; protein binding; RNA binding
Reference #:  P51116 (UniProtKB)
Alt. Names/Synonyms: FMR1L2; fragile X mental retardation syndrome related protein 2; Fragile X mental retardation syndrome-related protein 2; fragile X mental retardation, autosomal homolog 2; fragile X-mental retardation 1-like 2; FXR2
Gene Symbols: FXR2
Molecular weight: 74,223 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FXR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MGGLAsGGDVEPG
0 1 Y78 EGDEVEVYSRANEQE
0 9 Y113-p YAACDATyNEIVTLE
0 2 S192-p EAPVKRAsLLGDMHF
0 5 K320-u VIQEIVDkSGVVRVR
0 12 R399-m1 FRPPGSGrGSGGsDK
0 1 S401 PPGSGrGSGGsDKAG
0 4 S404-p SGrGSGGsDKAGyst
0 2 K406 rGSGGsDKAGystDE
0 2 Y409-p GGsDKAGystDEssS
0 10 S410-p GsDKAGystDEssSS
0 44 T411-p sDKAGystDEssSSs
0 13 S414-p AGystDEssSSsLHA
0 3 S415-p GystDEssSSsLHAT
0 2 S417 stDEssSSsLHATRT
0 1 S418-p tDEssSSsLHATRTY
0 4 R432-m1 YGGSYGGrGrGrRTG
0 3 R434-m1 GSYGGrGrGrRTGGP
0 1 R436-m1 YGGrGrGrRTGGPAy
0 1 T438 GrGrGrRTGGPAyGP
0 1 Y443-p rRTGGPAyGPSsDVs
0 2 S447-p GPAyGPSsDVstAsE
0 1 S450-p yGPSsDVstAsEtES
0 5 T451-p GPSsDVstAsEtESE
0 10 S453-p SsDVstAsEtESEKR
0 4 T455-p DVstAsEtESEKREE
0 1 S457 stAsEtESEKREEPN
0 1 T475 PGDRDPPTRGEESRR
0 1 S500-p PPAPRPTsRYNsSSI
0 2 S504-p RPTsRYNsSSISSVL
0 13 Y519-p KDPDSNPysLLDtsE
0 2 S520-p DPDSNPysLLDtsEP
0 1 T524-p NPysLLDtsEPEPPV
0 1 S525-p PysLLDtsEPEPPVD
0 1 S533-p EPEPPVDsEPGEPPP
0 2 S548-p ASARRRRsRRRRtDE
0 2 T553-p RRsRRRRtDEDRTVM
0 19 S566-p VMDGGLEsDGPNMtE
0 1 T572-p EsDGPNMtENGLEDE
0 1 S580-p ENGLEDEsRPQRRNR
0 17 T598-p RRNRGNRtDGsIsGd
0 33 S601-p RGNRtDGsIsGdRQP
0 36 S603-p NRtDGsIsGdRQPVT
0 1 D605-ca tDGsIsGdRQPVTVA
0 2 Y614-p QPVTVADyISRAEsQ
0 7 S620-p DyISRAEsQSRQRPP
  mouse

► Hide Isoforms
 
S6 __MGGLASGGDVEPG
Y78-p EGDEVEVySRANEQE
Y113 YAACDATYNEIVTLE
S192-p EAPVKRAsLLGDMHF
K320 VIQGIVDKSGVVRVR
R399-m1 FRPPGSGrGGsGGGs
S402-p PGSGrGGsGGGsDkA
S406-p rGGsGGGsDkAGYtt
K408-u GsGGGsDkAGYttDE
Y411 GGsDkAGYttDEssS
T412-p GsDkAGYttDEssSs
T413-p sDkAGYttDEssSsS
S416-p AGYttDEssSsSLHT
S417-p GYttDEssSsSLHTT
S419-p ttDEssSsSLHTTRT
S420 tDEssSsSLHTTRTY
R434-m1 YGGSYGGrGrGRRtG
R436-m1 GSYGGrGrGRRtGGP
R438 YGGrGrGRRtGGPAY
T440-p GrGrGRRtGGPAYGP
Y445 RRtGGPAYGPSsDPS
S449-p GPAYGPSsDPStAsE
S452 YGPSsDPStAsEtEs
T453-p GPSsDPStAsEtEsE
S455-p SsDPStAsEtEsEKR
T457-p DPStAsEtEsEKREE
S459-p StAsEtEsEKREESN
S477-p PGDRDPPsRGEESRR
S501 PPVPRPTSRYNSSSI
S505 RPTSRYNSSSISSVL
Y520-p KDPDSNPySLLDTsE
S521 DPDSNPySLLDTsEP
T525 NPySLLDTsEPEPPV
S526-p PySLLDTsEPEPPVD
S534-p EPEPPVDsEPGEPPP
S549-p ASARRRRsRRRRTDE
T554 RRsRRRRTDEDRTVM
S567-p VMDGALEsDGPNMTE
T573 EsDGPNMTENGLEDE
S581 ENGLEDESRPQRRNR
T599-p RRNRGNRtDGsIsGD
S602-p RGNRtDGsIsGDRQP
S604-p NRtDGsIsGDRQPVT
D606 tDGsIsGDRQPVTVA
Y615 QPVTVADYISRAESQ
S621 DYISRAESQSRQRPL
  FXR2 iso5  
S6 __MGGLASGGDVEPG
Y78 EGDEVEVYSRANEQE
Y113 YAACDATYNEIVTLE
S192 EAPVKRASLLGDMHF
K320 VIQEIVDKSGVVRVR
R399 FRPPGSGRGGSGGGS
G403 GSGRGGSGGGSDKAG
S406 RGGSGGGSDKAGYTT
K408 GSGGGSDKAGYTTDE
Y411 GGSDKAGYTTDESSS
T412 GSDKAGYTTDESSSS
T413 SDKAGYTTDESSSSS
S416 AGYTTDESSSSSLHT
S417 GYTTDESSSSSLHTT
S419 TTDESSSSSLHTTRT
S420 TDESSSSSLHTTRTY
R434 YGGSYGGRGRGRRTG
R436 GSYGGRGRGRRTGGP
R438 YGGRGRGRRTGGPAY
T440 GRGRGRRTGGPAYGP
Y445 RRTGGPAYGPSSDPS
S449 GPAYGPSSDPSTASE
S452 YGPSSDPSTASETES
T453 GPSSDPSTASETESE
S455 SSDPSTASETESEKR
T457 DPSTASETESEKREE
S459 STASETESEKREESN
S477 PGDRDPPSRGEESRR
S502 PPVPRPTSRYNSSSI
S506 RPTSRYNSSSISSVL
Y521 KDPDSNPYSLLDTSE
S522 DPDSNPYSLLDTSEP
T526 NPYSLLDTSEPEPPV
S527 PYSLLDTSEPEPPVD
S535 EPEPPVDSEPGEPPP
S550 ASARRRRSRRRRTDE
T555 RRSRRRRTDEDRTVM
S568-p VMDGGLEsDGPNMTE
T574 EsDGPNMTENGLEDE
S582 ENGLEDESRPQRRNR
T600 RRNRGNRTDGSISGD
S603 RGNRTDGSISGDRQP
S605 NRTDGSISGDRQPVT
D607 TDGSISGDRQPVTVA
Y616 QPVTVADYISRAESQ
S622 DYISRAESQSRQRPL
  rat

 
S6 __MGGLASGGDVEPG
Y78 EGDEVEVYSRANEQE
Y113 YAACDATYNEIVTLE
S192 EAPVKRASLLGDMHF
K320 VIQEIVDKSGVVRVR
R399-m1 FRPPGSGrGGSGGGS
G403 GSGrGGSGGGSDKAG
S406 rGGSGGGSDKAGYTT
K408 GSGGGSDKAGYTTDE
Y411 GGSDKAGYTTDESSS
T412 GSDKAGYTTDESSSS
T413 SDKAGYTTDESSSSS
S416 AGYTTDESSSSSLHT
S417 GYTTDESSSSSLHTT
S419 TTDESSSSSLHTTRT
S420 TDESSSSSLHTTRTY
R434-m1 YGGSYGGrGrGRRTG
R436-m1 GSYGGrGrGRRTGGP
R438 YGGrGrGRRTGGPAY
T440 GrGrGRRTGGPAYGP
Y445 RRTGGPAYGPSSDPS
S449 GPAYGPSSDPSTASE
S452 YGPSSDPSTASETES
T453 GPSSDPSTASETESE
S455 SSDPSTASETESEKR
T457 DPSTASETESEKREE
S459 STASETESEKREESN
S477 PGDRDPPSRGEESRR
S502 PPVPRPTSRYNSSSI
S506 RPTSRYNSSSISSVL
Y521 KDPDSNPYSLLDTSE
S522 DPDSNPYSLLDTSEP
T526 NPYSLLDTSEPEPPV
S527 PYSLLDTSEPEPPVD
S535 EPEPPVDSEPGEPPP
S550 ASARRRRSRRRRTDE
T555 RRSRRRRTDEDRTVM
S568-p VMDGGLEsDGPNVTE
T574 EsDGPNVTENGLEDE
S582 ENGLEDESRPQRRNR
T600 RRNRGNRTDGsIsGD
S603-p RGNRTDGsIsGDRQP
S605-p NRTDGsIsGDRQPVT
D607 TDGsIsGDRQPVTVA
Y616 QPVTVADYISRAESQ
S622 DYISRAESQSRQRPP
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