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Protein Page:
IQGAP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IQGAP1 Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Ras
Cellular Component: microtubule; extrinsic to internal side of plasma membrane; neuron projection; cytoplasm; leading edge; nucleolus; plasma membrane; actin filament; midbody; cell junction; nucleus; lateral plasma membrane
Molecular Function: calmodulin binding; protein serine/threonine kinase activator activity; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; Rac GTPase binding; protein complex binding; calcium ion binding; protein phosphatase binding; protein kinase binding; Ras GTPase activator activity; GTPase inhibitor activity; GTPase activator activity
Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of Ras GTPase activity; negative regulation of dephosphorylation; small GTPase mediated signal transduction; positive regulation of protein kinase activity; negative regulation of catalytic activity; energy reserve metabolic process; signal transduction; regulation of insulin secretion; positive regulation of GTPase activity; regulation of cytokine production
Reference #:  P46940 (UniProtKB)
Alt. Names/Synonyms: HUMORFA01; IQ motif containing GTPase activating protein 1; IQGA1; IQGAP1; KIAA0051; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; SAR1
Gene Symbols: IQGAP1
Molecular weight: 189,252 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IQGAP1

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S1441‑p, S1443‑p
molecular association, regulation: S1443‑p
phosphorylation: S1443‑p
protein conformation: S1443‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 S2-p ______MsAADEVdG
0 1 D8-ca MsAADEVdGLGVARP
0 4 Y17-p LGVARPHyGsVLDNE
0 1 S19-p VARPHyGsVLDNERL
0 1 S86-p AKLGNFFsPkVVsLK
0 1 K88-ub LGNFFsPkVVsLKKI
0 1 S91-p FFsPkVVsLKKIyDR
0 1 Y96-p VVsLKKIyDREQTRY
0 1 Y133-p IGLPKIFyPETTDIy
0 1 Y140-p yPETTDIyDRKNMPR
0 116 Y172-p APQIQDLyGKVDFtE
0 4 T178-p LyGKVDFtEEEINNM
0 1 S200-p GIQMPAFsKIGGILA
0 1 T271 QAKQDKMTNAKNRTE
0 10 S330-p ALFRALQsPALGLRG
0 1 K348-ac QNSDWYLkQLLSDKQ
0 1 K348-ub QNSDWYLkQLLSDKQ
0 1 Y385-p ANSAAQQyQRRLAAV
0 2 K503-ub RYLDELMkLKAQAHA
0 7 K556-ub LDEGDAQktLQALQI
0 1 T557-p DEGDAQktLQALQIP
0 116 Y654-p RSPDVGLyGVIPECG
0 1 T663-p VIPECGEtYHSDLAE
0 1 K684-ac AVGDNNSkWVKHWVK
0 1 Y694-p KHWVKGGyyYyHNLE
0 2 Y695-p HWVKGGyyYyHNLET
0 1 Y697-p VKGGyyYyHNLETQE
0 1 Y736-p ISGVTAAyNREQLWL
0 1 R787-m1 TCIQSQWrGYKQKKA
0 1 K806-sc LAYLRSHkDEVVkIQ
0 2 K811-ub SHkDEVVkIQSLARM
0 1 Y831-p RYRDRLQyFRDHIND
0 1 K841 DHINDIIKIQAFIRA
0 20 Y855-p ANKARDDyKtLINAE
0 6 T857-p KARDDyKtLINAEDP
0 1 S902-p EVITLIRsNQQLEND
0 1 K935-sc QDVVSHSkKLTKKNk
1 0 K940 HSkKLTKKNkEQLSD
1 1 K942-ub kKLTKKNkEQLSDMM
0 5 K959-ac NKQKGGLkALSkEkR
0 5 K963-ac GGLkALSkEkREKLE
0 5 K965-ac LkALSkEkREKLEAY
0 2 S1057-p TVIKMVVsFNRGARG
0 1 K1088-ac DDKSLNIkTDPVDIY
0 2 K1088-m3 DDKSLNIkTDPVDIY
0 1 K1088-ub DDKSLNIkTDPVDIY
0 1 K1088-sc DDKSLNIkTDPVDIY
0 2 K1096-m3 TDPVDIYkSWVNQME
0 3 K1111-ub SQTGEASkLPyDVTP
0 5 Y1114-p GEASkLPyDVTPEQA
0 1 S1133-p EVKTRLDsSIRNMRA
0 1 K1144-ac NMRAVTDkFLsAIVs
0 1 K1144-ub NMRAVTDkFLsAIVs
0 2 S1147-p AVTDkFLsAIVssVD
0 1 S1151-p kFLsAIVssVDkIPy
0 1 S1152-p FLsAIVssVDkIPyG
0 5 K1155-ub AIVssVDkIPyGMRF
0 2 Y1158-p ssVDkIPyGMRFIAk
0 1 K1165-ub yGMRFIAkVLKDSLH
0 1 K1168 RFIAkVLKDSLHEKF
0 1 T1218-p LSAGGQLtTDQRRNL
0 1 S1227-p DQRRNLGsIAkMLQH
0 1 K1230-ac RNLGsIAkMLQHAAs
0 1 K1230-ub RNLGsIAkMLQHAAs
0 1 S1237-p kMLQHAAsNKMFLGD
0 29 Y1284-p DKFNVDEysDLVTLT
0 2 S1285-p KFNVDEysDLVTLTK
0 1 K1389 RTILLNTKRLIVDVI
0 1 K1389-sc RTILLNTkRLIVDVI
0 3 T1434-p RAIRDAKtPDKMKKs
2 3 S1441-p tPDKMKKsKsVkEDs
2 11 S1443-p DKMKKsKsVkEDsNL
0 1 K1445-ac MKKsKsVkEDsNLtL
0 4 K1445-ub MKKsKsVkEDsNLtL
0 2 S1448-p sKsVkEDsNLtLQEK
0 1 T1451-p VkEDsNLtLQEKKEK
0 5 K1465-ub KIQTGLKkLtELGTV
0 2 T1467-p QTGLKkLtELGTVDP
0 11 K1475-ub ELGTVDPkNkyQELI
0 2 K1477-ac GTVDPkNkyQELIND
0 6 K1477-ub GTVDPkNkyQELIND
0 3 Y1478-p TVDPkNkyQELINDI
0 9 T1509-p ELVKLQQtyAALNsK
0 922 Y1510-p LVKLQQtyAALNsKA
0 2 A1511 VKLQQtyAALNsKAT
0 1 S1515-p QtyAALNsKATFYGE
0 6 Y1526-p FYGEQVDyYkSYIkT
0 1 K1528-ac GEQVDyYkSYIkTCL
0 27 K1528-ub GEQVDyYkSYIkTCL
0 1 K1532-ac DyYkSYIkTCLDNLA
0 2 K1532-ub DyYkSYIkTCLDNLA
0 1 K1547-ac SKGKVSKkPREMkGK
0 1 K1552-ac SKkPREMkGKkSKkI
0 1 K1555-ac PREMkGKkSKkISLk
0 1 K1558-ac MkGKkSKkISLkYTA
0 1 K1562-ac kSKkISLkYTAARLH
0 1 K1562-ub kSKkISLkYTAARLH
0 1 K1571-ac TAARLHEkGVLLEIE
0 1 Y1655-p FLLNKKFyGK_____
  mouse

 
S2-p ______MsAAEEVDG
D8 MsAAEEVDGLGVVRP
Y17 LGVVRPHYGSVLDNE
S19 VVRPHYGSVLDNERL
S86 AKLGNFFSPKVVSLK
K88 LGNFFSPKVVSLKKI
S91 FFSPKVVSLKKIYDR
Y96 VVSLKKIYDREQTRY
Y133 IGLPKIFYPETTDIY
Y140 YPETTDIYDRKNMPR
Y172-p APQIQDLyGKVDFtE
T178-p LyGKVDFtEEEINNM
S200 GIQMPAFSKIGGILA
T271-p QAKQDKMtNAKNRTE
S330 TLLKALQSLALGLRG
K348 QNSDWYMKQLQSDLQ
K348 QNSDWYMKQLQSDLQ
Y385 ANSAAQQYQRRLAAV
K503-ub RYLDELMkLKAQAHA
K556 LDEGDAQKTLQALQI
T557 DEGDAQKTLQALQIP
Y654-p RSPDVGLyGVIPECG
T663 VIPECGETYQSDLAE
K684 AAGDNNSKWVKHWVK
Y694 KHWVKGGYHYYHNLE
H695 HWVKGGYHYYHNLET
Y697 VKGGYHYYHNLETQA
Y736 ISGVTAAYNREQLWL
R787 TCIQSQWRGYKQKKA
K806 LAYLHSHKDEVVKIQ
K811 SHKDEVVKIQSLARM
Y831 RYRDRLQYFRDHIND
K841-ub DHINDIIkIQAFIRA
Y855 ANKARDDYKTLINAE
T857 KARDDYKTLINAEDP
S902 EVITLIRSNQQLEND
K935 QDVVSHSKKLTKKNK
K940 HSKKLTKKNKEQLSD
K942 KKLTKKNKEQLSDMM
K959-ac NKQKGGLkALSkEkR
K963-ac GGLkALSkEkREKLE
K965-ac LkALSkEkREKLEAY
S1057-p TVIKMVVsFNRGARG
K1088 DDKSLNIKTDPVDIY
K1088 DDKSLNIKTDPVDIY
K1088 DDKSLNIKTDPVDIY
K1088 DDKSLNIKTDPVDIY
K1096 TDPVDIYKSWVNQME
K1111-ub SQTGEASkLPyDVTP
Y1114-p GEASkLPyDVTPEQA
N1133 EVKTRLDNSIRNMRA
K1144 NMRAVTDKFLSAIVS
K1144 NMRAVTDKFLSAIVS
S1147 AVTDKFLSAIVSSVD
S1151 KFLSAIVSSVDkIPY
S1152 FLSAIVSSVDkIPYG
K1155-ub AIVSSVDkIPYGMRF
Y1158 SSVDkIPYGMRFIAK
K1165 YGMRFIAKVLkDSLH
K1168-ub RFIAKVLkDSLHEKF
T1218 LSAGGQLTTDQRRNL
S1227 DQRRNLGSIAKMLQH
K1230 RNLGSIAKMLQHAAS
K1230 RNLGSIAKMLQHAAS
S1237 KMLQHAASNKMFLGD
Y1284 DKFNVDEYSDLVTLT
S1285 KFNVDEYSDLVTLTK
K1389-ub RTILLNTkRLIVDVI
K1389 RTILLNTKRLIVDVI
T1434-p RAIRDAKtPDKMKKS
S1441 tPDKMKKSKPMKEDN
P1443 DKMKKSKPMKEDNNL
K1445 MKKSKPMKEDNNLSL
K1445 MKKSKPMKEDNNLSL
N1448 SKPMKEDNNLSLQEK
S1451 MKEDNNLSLQEKKEK
K1465-ub KIQTGLKkLTELGTV
T1467 QTGLKkLTELGTVDP
K1475-ub ELGTVDPkNRYQELI
R1477 GTVDPkNRYQELIND
R1477 GTVDPkNRYQELIND
Y1478 TVDPkNRYQELINDI
T1509 ELVKLQQTysALNSK
Y1510-p LVKLQQTysALNSKA
S1511-p VKLQQTysALNSKAT
S1515 QTysALNSKATFYGE
Y1526-p FYGEQVDyYkSYIKT
K1528 GEQVDyYKSYIKTCL
K1528-ub GEQVDyYkSYIKTCL
K1532 DyYkSYIKTCLDNLA
K1532 DyYkSYIKTCLDNLA
K1547 SKGKVSKKPREMKGK
K1552 SKKPREMKGKKSKKI
K1555 PREMKGKKSKKISLK
K1558 MKGKKSKKISLKYTA
K1562 KSKKISLKYTAARLH
K1562 KSKKISLKYTAARLH
K1571 TAARLHEKGVLLEIE
Y1655 FLLNKKFYGK_____
  rat

 
S113 DRDSAAMSAAEEVDG
D119 MSAAEEVDGLGVVRP
Y128 LGVVRPHYGSVLDNE
S130 VVRPHYGSVLDNERL
S197 AKLGNFFSPKVVSLK
K199 LGNFFSPKVVSLKKI
S202 FFSPKVVSLKKIYDR
Y207 VVSLKKIYDREQTRY
Y244 IGLPKIFYPETTDIY
Y251 YPETTDIYDRKNMPR
Y283 APQIQDLYGKVDFTE
T289 LYGKVDFTEEEINNM
S311 GIQMPAFSKIGGILA
T382 QAKQDKMTNAKNRTE
S441 TLLKALQSVALGLRG
K459 QNSDWYLKQLQSDLQ
K459 QNSDWYLKQLQSDLQ
Y496 ANGAAQQYQRRLAAV
K614 RYLDELMKLKAQAHA
K667 LDEGDAQKTLQALQI
T668 DEGDAQKTLQALQIP
Y765 RSPDVGLYGVIPECG
T774 VIPECGETYQSDLAE
K795 AAGDNNSKWVKHWVK
Y805 KHWVKGGYHYYHNLE
H806 HWVKGGYHYYHNLET
Y808 VKGGYHYYHNLETQA
Y847 ISGVTAAYNREQLWL
R898 TCIQSQWRGYKQKKA
K917 LAYLHSHKDEVVKIQ
K922 SHKDEVVKIQSLARM
Y942 RYRDRLQYFRDHIND
K952 DHINDIIKIQAFIRA
Y966 ANKARDDYKTLINAE
T968 KARDDYKTLINAEDP
S1013 EVITLIRSNQQLEND
K1046 QDVVSHSKKLTKkNk
K1051-ac HSKKLTKkNkEQLSD
K1053-ub KKLTKkNkEQLSDMM
K1070 NKQKGGLKALSKEKR
K1074 GGLKALSKEKREKLE
K1076 LKALSKEKREKLEAY
S1168 TVIKMVVSFNRGARG
K1199 DDKSLNIKTDPVDIY
K1199 DDKSLNIKTDPVDIY
K1199 DDKSLNIKTDPVDIY
K1199 DDKSLNIKTDPVDIY
K1207 TDPVDIYKSWVNQME
K1222 SQTGEASKLPYDVTP
Y1225 GEASKLPYDVTPEQA
N1244 EVKTRLDNSIRNMRA
K1255 NMRAVTDKFLSAIVS
K1255 NMRAVTDKFLSAIVS
S1258 AVTDKFLSAIVSSVD
S1262 KFLSAIVSSVDKIPY
S1263 FLSAIVSSVDKIPYG
K1266 AIVSSVDKIPYGMRF
Y1269 SSVDKIPYGMRFIAK
K1276 YGMRFIAKVLKDSLH
K1279 RFIAKVLKDSLHEKF
T1329 LSAGGQLTTDQRRNL
S1338 DQRRNLGSIAKMLQH
K1341 RNLGSIAKMLQHAAS
K1341 RNLGSIAKMLQHAAS
S1348 KMLQHAASNKMFLGD
Y1395 DKFNVDEYSDLVTLT
S1396 KFNVDEYSDLVTLTK
K1500 RTILLNTKRLIVDVI
K1500 RTILLNTKRLIVDVI
T1545 RAIRDAKTPDKMKKS
S1552 TPDKMKKSKPMKEDN
P1554 DKMKKSKPMKEDNNL
K1556 MKKSKPMKEDNNLSL
K1556 MKKSKPMKEDNNLSL
N1559 SKPMKEDNNLSLQEK
S1562 MKEDNNLSLQEKKEK
K1576 KIQTGLKKLTELGTV
T1578 QTGLKKLTELGTVDP
K1586 ELGTVDPKNRYQELI
R1588 GTVDPKNRYQELIND
R1588 GTVDPKNRYQELIND
Y1589 TVDPKNRYQELINDI
T1620 ELVKLQQTYSALNSK
Y1621 LVKLQQTYSALNSKA
S1622 VKLQQTYSALNSKAT
S1626 QTYSALNSKATFYGE
Y1637 FYGEQVDYYKSYIKT
K1639 GEQVDYYKSYIKTCL
K1639 GEQVDYYKSYIKTCL
K1643 DYYKSYIKTCLDNLA
K1643 DYYKSYIKTCLDNLA
K1658 SKGKVSKKPREMKGK
K1663 SKKPREMKGKKSKKI
K1666 PREMKGKKSKKISLK
K1669 MKGKKSKKISLKYTA
K1673 KSKKISLKYTAARLH
K1673 KSKKISLKYTAARLH
K1682 TAARLHEKGVLLEIE
Y1766 FLLNKKFYGK_____
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