a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 184.108.40.206; Kinase, protein; Other group; IKK family
Cellular Component: internal side of plasma membrane; IkappaB kinase complex; cytosol; nucleus; lipid raft
Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: skeletal muscle contraction; response to drug; I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; response to toxin; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; Toll signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; B cell homeostasis; toll-like receptor signaling pathway; positive regulation of interferon type I production; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.