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Protein Page:
IKKB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IKKB a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.10; Other group; IKK family
Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; nucleus; cytosol; lipid raft
Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to virus; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis
Reference #:  O14920 (UniProtKB)
Alt. Names/Synonyms: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKBKB; IKK-B; IKK-beta; IKK2; IKKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta
Gene Symbols: IKBKB
Molecular weight: 86,564 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKKB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell motility, altered: S181‑p
transcription, altered: S181‑p, Y188‑p, Y199‑p
transcription, induced: S177‑p, S181‑p
activity, induced: S181‑p, Y188‑p, Y199‑p
enzymatic activity, induced: S177‑p, S181‑p
intracellular localization: S177‑p, S181‑p
molecular association, regulation: S177‑p, S181‑p, S733‑p, S740‑p, S750‑p
protein stabilization: S181‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MSWsPsLTTQT
0 1 S6-p __MSWsPsLTTQTCG
0 1 T23-p EMKERLGtGGFGNVI
1 0 K163-ub GEQRLIHkIIDLGYA
27 1 S177-p AKELDQGsLCtsFVG
2 1 T180-p LDQGsLCtsFVGTLQ
52 1 S181-p DQGsLCtsFVGTLQy
4 0 Y188-p sFVGTLQyLAPELLE
4 1 Y199-p ELLEQQKyTVTVDYW
0 1 S239-p HSKVRQKsEVDIVVs
0 1 S246-p sEVDIVVsEDLNGTV
0 1 S256-p LNGTVKFsssLPyPN
0 1 S257-p NGTVKFsssLPyPNN
0 1 S258-p GTVKFsssLPyPNNL
0 1 Y261-p KFsssLPyPNNLNsV
0 1 S267-p PyPNNLNsVLAERLE
0 1 T324-p MVTGTIHtyPVTEDE
0 1 Y325-p VTGTIHtyPVTEDEs
0 1 S332-p yPVTEDEsLQsLKAR
0 1 S335-p TEDEsLQsLKARIQQ
0 1 T344-p KARIQQDtGIPEEDQ
0 1 T368-p LIPDKPAtQCISDGK
0 1 S393-p LVFLFDNsKItyEtQ
0 1 T396-p LFDNsKItyEtQIsP
0 1 Y397-p FDNsKItyEtQIsPR
0 1 T399-p NsKItyEtQIsPRPQ
0 1 S402-p ItyEtQIsPRPQPEs
0 2 S409-p sPRPQPEsVsCILQE
0 2 S411-p RPQPEsVsCILQEPK
0 1 S466 LRNNSCLSKMKNsMA
0 1 S471-p CLSKMKNsMAsMsQQ
0 1 S474-p KMKNsMAsMsQQLKA
0 1 S476-p KNsMAsMsQQLKAKL
0 1 T488-p AKLDFFKtsIQIDLE
0 1 S489-p KLDFFKtsIQIDLEK
0 1 S498 QIDLEKYSEQTEFGI
0 1 S507-p QTEFGITsDKLLLAW
0 3 S550-p DIVDLQRsPMGRKQG
0 3 K555 QRsPMGRKQGGtLDD
0 1 T559-p MGRKQGGtLDDLEEQ
0 1 T583-p EKPRDQRtEGDsQEM
0 1 S587-p DQRtEGDsQEMVRLL
0 2 S600-p LLLQAIQsFEKKVRV
0 2 Y609-p EKKVRVIytQLSKTV
0 1 T610-p KKVRVIytQLSKTVV
0 1 S634-p PKVEEVVsLMNEDEK
0 1 K659-ac KELWNLLkIACSKVR
0 10 S670-p SKVRGPVsGsPDsMN
0 62 S672-p VRGPVsGsPDsMNAs
0 6 S675-p PVsGsPDsMNAsRLs
1 5 S679-p sPDsMNAsRLsQPGQ
1 1 S682-p sMNAsRLsQPGQLMS
1 0 S689 sQPGQLMSQPStAsN
1 0 S692 GQLMSQPStAsNsLP
0 1 T693-p QLMSQPStAsNsLPE
0 1 S695-p MSQPStAsNsLPEPA
1 1 S697-p QPStAsNsLPEPAKK
1 0 P701 AsNsLPEPAKKSEEL
1 0 S705 LPEPAKKSEELVAEA
1 1 S733-p TVREQDQsFtALDWs
1 0 S733-gl TVREQDQsFtALDWs
0 1 T735-p REQDQsFtALDWsWL
1 1 S740-p sFtALDWsWLQTEEE
2 0 S750-p QTEEEEHsCLEQAS_
2078 : Phospho-IKKalpha (Ser176)/IKKbeta (Ser177) (C84E11) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
  mouse

 
S4 ____MSWSPSLPTQT
S6 __MSWSPSLPTQTCG
T23 EMKERLGTGGFGNVI
K163 GEKRLIHKIIDLGYA
S177-p AKELDQGsLCtsFVG
T180-p LDQGsLCtsFVGTLQ
S181-p DQGsLCtsFVGTLQy
Y188-p sFVGTLQyLAPELLE
Y199-p ELLEQQKyTVTVDYW
S239 HSKVRQKSEVDIVVS
S246 SEVDIVVSEDLNGAV
S256 LNGAVKFSSSLPFPN
S257 NGAVKFSSSLPFPNN
S258 GAVKFSSSLPFPNNL
F261 KFSSSLPFPNNLNSV
S267 PFPNNLNSVLAERLE
T324 MVTGTVHTYPVTEDE
Y325 VTGTVHTYPVTEDES
S332 YPVTEDESLQSLKTR
S335 TEDESLQSLKTRIQE
T344 KTRIQENTGILETDQ
T368 LLPDKPATQCISDSK
S393 LVFLLDNSKINYETQ
N396 LLDNSKINYETQITP
Y397 LDNSKINYETQITPR
T399 NSKINYETQITPRPP
T402 INYETQITPRPPPES
S409 TPRPPPESVSCILQE
S411 RPPPESVSCILQEPK
S466-p LRNNSCLsKMKNAMA
A471 CLsKMKNAMASTAQQ
S474 KMKNAMASTAQQLKA
A476 KNAMASTAQQLKAKL
T488 AKLDFFKTSIQIDLE
S489 KLDFFKTSIQIDLEK
K498-ub QIDLEKYkEQTEFGI
S507 QTEFGITSDKLLLAW
S550 DIVDLQRSPMGRkQG
K555-ub QRSPMGRkQGGTLDD
T559 MGRkQGGTLDDLEEQ
T583 EKPRDQRTEGDSQEM
S587 DQRTEGDSQEMVRLL
S600 LLLQAIQSFEKKVRV
Y609 EKKVRVIYTQLSKTV
T610 KKVRVIYTQLSKTVV
S634 PKVEEVVSLMNEDER
K659 KELWNLLKIACSKVR
S670 SKVRGPVSGsPDsMN
S672-p VRGPVSGsPDsMNVs
S675-p PVSGsPDsMNVsRLs
S679-p sPDsMNVsRLsHPGQ
S682-p sMNVsRLsHPGQLMs
S689-p sHPGQLMsQPsSACD
S692-p GQLMsQPsSACDsLP
S693 QLMsQPsSACDsLPE
C695 MsQPsSACDsLPEsD
S697-p QPsSACDsLPEsDKK
S701-p ACDsLPEsDKKsEEL
S705-p LPEsDKKsEELVAEA
S733 TVKEQDRSFTTLDWS
S733 TVKEQDRSFTTLDWS
T735 KEQDRSFTTLDWSWL
S740 SFTTLDWSWLQMEDE
C750 QMEDEERCSLEQACD
2078 : Phospho-IKKalpha (Ser176)/IKKbeta (Ser177) (C84E11) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
  rat

 
S4 ____MSWSPSLPTQT
S6 __MSWSPSLPTQTCG
T23 EMKERLGTGGFGNVI
K163 GEKRLIHKIIDLGYA
S177-p AKELDQGsLCTsFVG
T180 LDQGsLCTsFVGTLQ
S181-p DQGsLCTsFVGTLQY
Y188 sFVGTLQYLAPELLE
Y199 ELLEQQKYTVTVDYW
S239 HSKVRQKSEVDIVVS
S246 SEVDIVVSEDLNGTV
S256 LNGTVKFSSSSPFPN
S257 NGTVKFSSSSPFPNN
S258 GTVKFSSSSPFPNNL
F261 KFSSSSPFPNNLNSV
S267 PFPNNLNSVLAERLE
T324 MVTGTIHTYPVMEDE
Y325 VTGTIHTYPVMEDES
S332 YPVMEDESLQSLKTR
S335 MEDESLQSLKTRIRE
T344 KTRIREDTGILETDQ
T368 LLPDKPATQCISDSK
S393 LVFLFDNSKMSYETQ
S396 LFDNSKMSYETQITP
Y397 FDNSKMSYETQITPR
T399 NSKMSYETQITPRPQ
T402 MSYETQITPRPQPES
S409 TPRPQPESVSCVLQE
S411 RPQPESVSCVLQEPK
S466 LRNNSCLSKMKNAMA
A471 CLSKMKNAMASTAQQ
S474 KMKNAMASTAQQLKA
A476 KNAMASTAQQLKAKL
T488 AKLDFFKTSIQIDLE
S489 KLDFFKTSIQIDLEK
R498 QIDLEKYREQTEFGI
S507 QTEFGITSDKLLLAW
S550 DIVDLQRSPMGRKQG
K555 QRSPMGRKQGGTLDD
T559 MGRKQGGTLDDLEEQ
T583 EKPRDQRTEGDSQDM
S587 DQRTEGDSQDMVRLL
S600 LLLQAIQSFEKKVRV
Y609 EKKVRVIYSQLSKTV
T610 under review
R634 PKVEEVVRLMNEDEK
K659 KELWNLLKIACSKVR
S670 SKVRGPVSGsPDSMN
S672-p VRGPVSGsPDSMNVS
S675 PVSGsPDSMNVSRLS
S679 sPDSMNVSRLSHPGH
S682 SMNVSRLSHPGHLMS
S689 SHPGHLMSQPSSACD
S692 GHLMSQPSSACDSLP
S693 HLMSQPSSACDSLPD
C695 MSQPSSACDSLPDSD
S697 QPSSACDSLPDSDKK
S701 ACDSLPDSDKKSEEL
S705 LPDSDKKSEELVAEA
S733 TVKQQDRSFTTLDWS
S733 TVKQQDRSFTTLDWS
T735 KQQDRSFTTLDWSWL
S740 SFTTLDWSWLQMEDE
C750 QMEDEERCGLEQACD
2078 : Phospho-IKKalpha (Ser176)/IKKbeta (Ser177) (C84E11) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
2694 : Phospho-IKKalpha/beta (Ser176/180) Antibody II
2697 : Phospho-IKK-alpha/beta (Ser176/180) (16A6) Rabbit mAb
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