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IKK-beta (human)

Overview IKK-beta a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.10; Kinase, protein; Other group; IKK family Cellular Component: internal side of plasma membrane; IkappaB kinase complex; cytosol; nucleus; lipid raft Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: skeletal muscle contraction; response to drug; I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; response to toxin; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; Toll signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; B cell homeostasis; toll-like receptor signaling pathway; positive regulation of interferon type I production; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway Reference #:  O14920 (UniProtKB) Alt. Names/Synonyms: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKBKB; IKK-B; IKK-beta; IKK2; IKKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta Gene Symbols: IKBKB Molecular weight: 86,564 Da Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IKK-beta 3BRT - A/C=701-730 (human) 3BRV - A/C=701-745 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3BRT 3BRV  |  ENZYME  |  Phospho3D  |  DISEASE  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: S181‑p transcription, altered: S177‑p, S181‑p, Y188‑p, Y199‑p activation: S177‑p, S181‑p, Y188‑p, Y199‑p enzymatic activity, induced: S177‑p, S181‑p intracellular localization: S177‑p, S181‑p molecular association, regulation: S733‑p, S740‑p, S750‑p protein stabilization: S181‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		K163-u	GEQRLIHkIIDLGYA
24	0		S177-p	AKELDQGsLCtsFVG
2	0		T180-a	LDQGsLCtsFVGTLQ
49	0		S181-p	DQGsLCtsFVGTLQy
4	0		Y188-p	sFVGTLQyLAPELLE
4	0		Y199-p	ELLEQQKyTVTVDYW
0	1		S409-p	SPRPQPEsVsCILQE
0	1		S411-p	RPQPEsVsCILQEPK
0	1		S466	LRNNSCLSKMKNsMA
0	1		S471-p	CLSKMKNsMASMSQQ
0	1		S498	QIDLEKYSEQTEFGI
0	3		K555	QRSPMGRKQGGTLDD
0	1		S600-p	LLLQAIQsFEKKVRV
0	1		Y609-p	EKKVRVIyTQLSKTV
0	1		K659-a	KELWNLLkIACSKVR
0	4		S670-p	SKVRGPVsGsPDsMN
0	31		S672-p	VRGPVsGsPDsMNAs
0	2		S675-p	PVsGsPDsMNAsRLS
1	1		S679-p	sPDsMNAsRLSQPGQ
1	0		S682	sMNAsRLSQPGQLMs
1	1		S689-p	SQPGQLMsQPsTASN
1	1		S692-p	GQLMsQPsTASNSLP
1	0		S697	QPsTASNSLPEPAKK
1	0		P701	ASNSLPEPAKKSEEL
1	0		S705	LPEPAKKSEELVAEA
1	0		S733-p	TVREQDQsFTALDWs
1	0		S733-g	TVREQDQsFTALDWs
1	0		S740-p	sFTALDWsWLQTEEE
2	0		S750-p	QTEEEEHsCLEQAS_

	mouse
K163	GEKRLIHKIIDLGYA
S177-p	AKELDQGsLCtsFVG
T180-a	LDQGsLCtsFVGTLQ
S181-p	DQGsLCtsFVGTLQy
Y188-p	sFVGTLQyLAPELLE
Y199-p	ELLEQQKyTVTVDYW
S409	TPRPPPESVSCILQE
S411	RPPPESVSCILQEPK
S466-p	LRNNSCLsKMKNAMA
A471	CLsKMKNAMASTAQQ
K498-u	QIDLEKYkEQTEFGI
K555-u	QRSPMGRkQGGTLDD
S600	LLLQAIQSFEKKVRV
Y609	EKKVRVIYTQLSKTV
K659	KELWNLLKIACSKVR
S670	SKVRGPVSGsPDsMN
S672-p	VRGPVSGsPDsMNVs
S675-p	PVSGsPDsMNVsRLs
S679-p	sPDsMNVsRLsHPGQ
S682-p	sMNVsRLsHPGQLMs
S689-p	sHPGQLMsQPsSACD
S692-p	GQLMsQPsSACDsLP
S697-p	QPsSACDsLPEsDKK
S701-p	ACDsLPEsDKKsEEL
S705-p	LPEsDKKsEELVAEA
S733	TVKEQDRSFTTLDWS
S733	TVKEQDRSFTTLDWS
S740	SFTTLDWSWLQMEDE
C750	QMEDEERCSLEQACD

	rat
K163	GEKRLIHKIIDLGYA
S177-p	AKELDQGsLCTsFVG
T180	LDQGsLCTsFVGTLQ
S181-p	DQGsLCTsFVGTLQY
Y188	sFVGTLQYLAPELLE
Y199	ELLEQQKYTVTVDYW
S409	TPRPQPESVSCVLQE
S411	RPQPESVSCVLQEPK
S466	LRNNSCLSKMKNAMA
A471	CLSKMKNAMASTAQQ
R498	QIDLEKYREQTEFGI
K555	QRSPMGRKQGGTLDD
S600	LLLQAIQSFEKKVRV
Y609	EKKVRVIYSQLSKTV
K659	KELWNLLKIACSKVR
S670	SKVRGPVSGsPDSMN
S672-p	VRGPVSGsPDSMNVS
S675	PVSGsPDSMNVSRLS
S679	sPDSMNVSRLSHPGH
S682	SMNVSRLSHPGHLMS
S689	SHPGHLMSQPSSACD
S692	GHLMSQPSSACDSLP
S697	QPSSACDSLPDSDKK
S701	ACDSLPDSDKKSEEL
S705	LPDSDKKSEELVAEA
S733	TVKQQDRSFTTLDWS
S733	TVKQQDRSFTTLDWS
S740	SFTTLDWSWLQMEDE
C750	QMEDEERCGLEQACD

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