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Protein Page:
MBP (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MBP The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: compact myelin; internode region of axon; cell soma; plasma membrane
Molecular Function: protease binding; structural constituent of myelin sheath
Biological Process: myelination; synaptic transmission; central nervous system development; response to toxin; immune response; negative regulation of axonogenesis; axon ensheathment
Reference #:  P02686 (UniProtKB)
Alt. Names/Synonyms: Golli-MBP; MBP; MGC99675; Myelin A1 protein; Myelin basic protein; Myelin membrane encephalitogenic protein
Gene Symbols: MBP
Molecular weight: 33,117 Da
Basal Isoelectric point: 9.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MBP
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S26-p SETNRGEsEKKRNLG
0 1 N31 GEsEKKRNLGELsRt
0 7 S36-p KRNLGELsRttsEDN
0 1 T38-p NLGELsRttsEDNEV
0 2 T39-p LGELsRttsEDNEVF
0 7 S40-p GELsRttsEDNEVFG
0 3 N43 sRttsEDNEVFGEAD
0 6 S96-p PHLIRLFsRDAPGRE
0 1 S112 NTFKDRPSEsDELQT
0 1 S114-p FKDRPSEsDELQTIQ
0 1 K138 LDVMASQKRPsQRHG
3 3 S141-p MASQKRPsQRHGsKy
1 7 S146-p RPsQRHGsKyLATAs
0 1 K147 PsQRHGsKyLATAst
0 1 K147 PsQRHGsKyLATAst
0 1 K147 PsQRHGsKyLATAst
0 4 Y148-p sQRHGsKyLATAstM
0 5 T151 HGsKyLATAstMDHA
2 6 S153-p sKyLATAstMDHARH
1 5 T154-p KyLATAstMDHARHG
3 8 T169-p FLPRHRDtGILDSIG
0 5 S174 RDtGILDSIGRFFGG
0 1 S174 RDtGILDSIGRFFGG
0 2 G180 DSIGRFFGGDRGAPK
1 0 G181 SIGRFFGGDRGAPKR
0 1 R183 GRFFGGDRGAPKRGS
2 3 S190 RGAPKRGSGKDSHHP
0 1 - gap
0 1 - gap
0 6 - gap
0 1 - under review  
0 1 K192 APKRGSGKDSHHPAR
0 1 S194 KRGSGKDSHHPARTA
0 1 A198 GKDSHHPARTAHyGs
1 2 T200 DSHHPARTAHyGsLP
2 2 A201 SHHPARTAHyGsLPQ
0 107 Y203-p HPARTAHyGsLPQkS
0 22 S205-p ARTAHyGsLPQkSHG
0 1 S205 ARTAHyGSLPQkSHG
0 1 K209 HyGsLPQKSHGRtQD
0 21 K209-u HyGsLPQkSHGRtQD
1 26 S210 yGsLPQkSHGRtQDE
0 5 T214-p PQkSHGRtQDENPVV
0 1 T214 PQkSHGRTQDENPVV
0 2 K225 NPVVHFFKNIVTPRt
0 20 K225-u NPVVHFFkNIVTPRt
4 2 T229 HFFkNIVTPRtPPPS
14 17 T232-p kNIVTPRtPPPSQGK
1 1 K239 tPPPSQGKGrGLSLS
3 2 R241-m1 PPSQGKGrGLSLSRF
2 1 R241-m2 PPSQGKGrGLSLSRF
2 1 S244 QGKGrGLSLSRFsWG
4 8 S249-p GLSLSRFsWGAEGQR
0 2 R256 sWGAEGQRPGFGyGG
0 9 R256 sWGAEGQRPGFGyGG
0 26 Y261-p GQRPGFGyGGRAsDY
0 1 R264 PGFGyGGRAsDYKSA
1 1 S266-p FGyGGRAsDYKSAHK
0 4 K276 KSAHKGFKGVDAQGt
1 0 - gap
0 66 - gap
1 3 T283-p KGVDAQGtLsKIFKL
2 2 S285-p VDAQGtLsKIFKLGG
2 3 S295 FKLGGRDSRsGSPMA
1 0 - gap
0 2 S297-p LGGRDSRsGSPMARR
5 4 S299 GRDSRsGSPMARR__
  MBP iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFGG
S41 RDTGILDSIGRFFGG
G47 DSIGRFFGGDRGAPK
G48 SIGRFFGGDRGAPKR
R50 GRFFGGDRGAPKRGS
S57 RGAPKRGSGKVPWLK
K64 SGKVPWLKPGRsPLP
G66 KVPWLKPGRsPLPSH
S68-p PWLKPGRsPLPSHAR
S72 PGRsPLPSHARSQPG
K85 PGLCNMYKDSHHPAR
S87 LCNMYKDSHHPARTA
A91 YKDSHHPARTAHYGS
T93 DSHHPARTAHYGSLP
A94 SHHPARTAHYGSLPQ
Y96 HPARTAHYGSLPQKS
S98 ARTAHYGSLPQKSHG
S98 ARTAHYGSLPQKSHG
K102 HYGSLPQKSHGRTQD
K102 HYGSLPQKSHGRTQD
S103 YGSLPQKSHGRTQDE
T107 PQKSHGRTQDENPVV
T107 PQKSHGRTQDENPVV
K118 NPVVHFFKNIVTPRT
K118 NPVVHFFKNIVTPRT
T122 HFFKNIVTPRTPPPS
T125 KNIVTPRTPPPSQGK
K132 TPPPSQGKGRGLSLS
R134 PPSQGKGRGLSLSRF
R134 PPSQGKGRGLSLSRF
S137 QGKGRGLSLSRFSWG
S142 GLSLSRFSWGAEGQR
R149 SWGAEGQRPGFGYGG
R149 SWGAEGQRPGFGYGG
Y154 GQRPGFGYGGRASDY
R157 PGFGYGGRASDYKSA
S159 FGYGGRASDYKSAHK
K169 KSAHKGFKGVDAQGT
- gap
- gap
T176 KGVDAQGTLSKIFKL
S178 VDAQGTLSKIFKLGG
S188 FKLGGRDSRSGSPMA
- gap
S190 LGGRDSRSGSPMARR
S192 GRDSRSGSPMARR__
  MBP iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFGG
S41 RDTGILDSIGRFFGG
G47 DSIGRFFGGDRGAPK
G48 SIGRFFGGDRGAPKR
R50 GRFFGGDRGAPKRGS
S57 RGAPKRGSGKVPWLK
K64 SGKVPWLKPGRsPLP
G66 KVPWLKPGRsPLPSH
S68-p PWLKPGRsPLPSHAR
S72 PGRsPLPSHARSQPG
K85 PGLCNMYKDSHHPAR
S87 LCNMYKDSHHPARTA
A91 YKDSHHPARTAHYGS
T93 DSHHPARTAHYGSLP
A94 SHHPARTAHYGSLPQ
Y96 HPARTAHYGSLPQKS
S98 ARTAHYGSLPQKSHG
S98 ARTAHYGSLPQKSHG
K102 HYGSLPQKSHGRTQD
K102 HYGSLPQKSHGRTQD
S103 YGSLPQKSHGRTQDE
T107 PQKSHGRTQDENPVV
T107 PQKSHGRTQDENPVV
K118 NPVVHFFKNIVTPRT
K118 NPVVHFFKNIVTPRT
T122 HFFKNIVTPRTPPPS
T125 KNIVTPRTPPPSQGK
K132 TPPPSQGKGAEGQRP
- gap
- gap
- gap
- gap
R138 GKGAEGQRPGFGYGG
R138 GKGAEGQRPGFGYGG
Y143 GQRPGFGYGGRASDY
R146 PGFGYGGRASDYKSA
S148 FGYGGRASDYKSAHK
K158 KSAHKGFKGVDAQGT
- gap
- gap
T165 KGVDAQGTLSKIFKL
S167 VDAQGTLSKIFKLGG
S177 FKLGGRDSRSGSPMA
- gap
S179 LGGRDSRSGSPMARR
S181 GRDSRSGSPMARR__
  MBP iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFGG
S41 RDTGILDSIGRFFGG
G47 DSIGRFFGGDRGAPK
G48 SIGRFFGGDRGAPKR
R50 GRFFGGDRGAPKRGS
S57 RGAPKRGSGKDSHHP
- gap
- gap
- gap
- under review  
K59 APKRGSGKDSHHPAR
S61 KRGSGKDSHHPARTA
A65 GKDSHHPARTAHYGS
T67 DSHHPARTAHYGSLP
A68 SHHPARTAHYGSLPQ
Y70 HPARTAHYGSLPQKS
S72 ARTAHYGSLPQKSHG
S72 ARTAHYGSLPQKSHG
K76 HYGSLPQKSHGRTQD
K76 HYGSLPQKSHGRTQD
S77 YGSLPQKSHGRTQDE
T81 PQKSHGRTQDENPVV
T81 PQKSHGRTQDENPVV
K92 NPVVHFFKNIVTPRT
K92 NPVVHFFKNIVTPRT
T96 HFFKNIVTPRTPPPS
T99 KNIVTPRTPPPSQGK
K106 TPPPSQGKGRGLSLS
R108 PPSQGKGRGLSLSRF
R108 PPSQGKGRGLSLSRF
S111 QGKGRGLSLSRFSWG
S116 GLSLSRFSWGAEGQR
R123 SWGAEGQRPGFGYGG
R123 SWGAEGQRPGFGYGG
Y128 GQRPGFGYGGRASDY
R131 PGFGYGGRASDYKSA
S133 FGYGGRASDYKSAHK
K143 KSAHKGFKGVDAQGT
- gap
- gap
T150 KGVDAQGTLSKIFKL
S152 VDAQGTLSKIFKLGG
S162-p FKLGGRDsRSGSPMA
- gap
S164 LGGRDsRSGSPMARR
S166 GRDsRSGSPMARR__
  mouse

► Hide Isoforms 		 
A26 GEIHRGEAGKKRsVG
S31-p GEAGKKRsVGKLsQT
S36-p KRsVGKLsQTAsEDs
T38 sVGKLsQTAsEDsDV
A39 VGKLsQTAsEDsDVF
S40-p GKLsQTAsEDsDVFG
S43-p sQTAsEDsDVFGEAD
S96-p PHLIRLFsRDAPGRE
S112-p NTFKDRPsESDELQT
S114 FKDRPsESDELQTIQ
K138-u LDVMASQkRPSQRsk
S141 MASQkRPSQRskyLA
S144-p QkRPSQRskyLAtAs
K145-m1 kRPSQRskyLAtAst
K145-a kRPSQRskyLAtAst
K145-u kRPSQRskyLAtAst
Y146-p RPSQRskyLAtAstM
T149-p QRskyLAtAstMDHA
S151-p skyLAtAstMDHARH
T152-p kyLAtAstMDHARHG
T167-p FLPRHRDtGILDsIG
S172-p RDtGILDsIGRFFsG
S172-g RDtGILDsIGRFFsG
S178-p DsIGRFFsGDrGAPK
G179 sIGRFFsGDrGAPKR
R181-m1 GRFFsGDrGAPKRGs
S188-p rGAPKRGsGKDsHtR
- gap
- gap
- gap
- under review  
K190 APKRGsGKDsHtRtt
S192-p KRGsGKDsHtRttHy
T194-p GsGKDsHtRttHyGs
T196-p GKDsHtRttHyGsLP
T197-p KDsHtRttHyGsLPQ
Y199-p sHtRttHyGsLPQks
S201-p tRttHyGsLPQksQH
S201-g tRttHyGsLPQksQH
K205-a HyGsLPQksQHGRtQ
K205-u HyGsLPQksQHGRtQ
S206-p yGsLPQksQHGRtQD
T211-p QksQHGRtQDENPVV
T211-g QksQHGRtQDENPVV
K222-a NPVVHFFkNIVtPRt
K222-u NPVVHFFkNIVtPRt
T226-p HFFkNIVtPRtPPPS
T229-p kNIVtPRtPPPSQGK
K236 tPPPSQGKGGRDSRs
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S241 QGKGGRDSRsGsPMA
- gap
S243-p KGGRDSRsGsPMARR
S245-p GRDSRsGsPMARR__
  MBP iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRsK
S8 MASQKRPSQRsKYLA
S11-p QKRPSQRsKYLATAs
K12 KRPSQRsKYLATAst
K12 KRPSQRsKYLATAst
K12 KRPSQRsKYLATAst
Y13 RPSQRsKYLATAstM
T16 QRsKYLATAstMDHA
S18-p sKYLATAstMDHARH
T19-p KYLATAstMDHARHG
T34-p FLPRHRDtGILDsIG
S39-p RDtGILDsIGRFFSG
S39 RDtGILDSIGRFFSG
S45 DsIGRFFSGDRGAPK
G46 sIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGS
S55 RGAPKRGSGKDSHTR
- gap
- gap
- gap
- under review  
K57 APKRGSGKDSHTRTt
S59 KRGSGKDSHTRTtHY
T61 GSGKDSHTRTtHYGs
T63 GKDSHTRTtHYGsLP
T64-p KDSHTRTtHYGsLPQ
Y66 SHTRTtHYGsLPQKs
S68-p TRTtHYGsLPQKsQH
S68 TRTtHYGSLPQKsQH
K72 HYGsLPQKsQHGRtQ
K72 HYGsLPQKsQHGRtQ
S73-p YGsLPQKsQHGRtQD
T78-p QKsQHGRtQDENPVV
T78 QKsQHGRTQDENPVV
K89 NPVVHFFKNIVtPRt
K89 NPVVHFFKNIVtPRt
T93-p HFFKNIVtPRtPPPS
T96-p KNIVtPRtPPPSQGK
K103 tPPPSQGKGrGLsLS
R105-m1 PPSQGKGrGLsLSRF
R105 PPSQGKGRGLsLSRF
S108-p QGKGrGLsLSRFsWG
S113-p GLsLSRFsWGAEGQk
K120-a sWGAEGQkPGFGyGG
K120-u sWGAEGQkPGFGyGG
Y125-p GQkPGFGyGGrASDY
R128-m1 PGFGyGGrASDYKSA
S130 FGyGGrASDYKSAHK
K140-u KSAHKGFkGAyDAQG
- gap
Y143-p HKGFkGAyDAQGtLs
T148-p GAyDAQGtLsKIFKL
S150-p yDAQGtLsKIFKLGG
S160 FKLGGRDSRSGsPMA
- gap
S162 LGGRDSRSGsPMARR
S164-p GRDSRSGsPMARR__
  MBP iso6  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRsK
S8 MASQKRPSQRsKYLA
S11-p QKRPSQRsKYLATAs
K12 KRPSQRsKYLATAst
K12 KRPSQRsKYLATAst
K12 KRPSQRsKYLATAst
Y13 RPSQRsKYLATAstM
T16 QRsKYLATAstMDHA
S18-p sKYLATAstMDHARH
T19-p KYLATAstMDHARHG
T34-p FLPRHRDtGILDsIG
S39-p RDtGILDsIGRFFSG
S39 RDtGILDSIGRFFSG
S45 DsIGRFFSGDRGAPK
G46 sIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGs
S55-p RGAPKRGsGKVPWLk
K62-u sGKVPWLkQsRsPLP
S64-p KVPWLkQsRsPLPsH
S66-p PWLkQsRsPLPsHAR
S70-p QsRsPLPsHARSRPG
K83-m1 PGLCHMYkDSHTRTt
S85 LCHMYkDSHTRTtHY
T87 HMYkDSHTRTtHYGs
T89 YkDSHTRTtHYGsLP
T90-p kDSHTRTtHYGsLPQ
Y92 SHTRTtHYGsLPQKs
S94-p TRTtHYGsLPQKsQH
S94 TRTtHYGSLPQKsQH
K98 HYGsLPQKsQHGRtQ
K98 HYGsLPQKsQHGRtQ
S99-p YGsLPQKsQHGRtQD
T104-p QKsQHGRtQDENPVV
T104 QKsQHGRTQDENPVV
K115 NPVVHFFKNIVTPRt
K115 NPVVHFFKNIVTPRt
T119 HFFKNIVTPRtPPPS
T122-p KNIVTPRtPPPSQGK
K129 tPPPSQGKGrGLsLS
R131-m1 PPSQGKGrGLsLSRF
R131 PPSQGKGRGLsLSRF
S134-p QGKGrGLsLSRFsWG
S139-p GLsLSRFsWGGRDsR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S145-p FsWGGRDsRsGsPMA
- gap
S147-p WGGRDsRsGsPMARR
S149-p GRDsRsGsPMARR__
  MBP iso8  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRsK
S8 MASQKRPSQRsKYLA
S11-p QKRPSQRsKYLATAs
K12 KRPSQRsKYLATAst
K12 KRPSQRsKYLATAst
K12 KRPSQRsKYLATAst
Y13 RPSQRsKYLATAstM
T16 QRsKYLATAstMDHA
S18-p sKYLATAstMDHARH
T19-p KYLATAstMDHARHG
T34-p FLPRHRDtGILDsIG
S39-p RDtGILDsIGRFFSG
S39 RDtGILDSIGRFFSG
S45 DsIGRFFSGDRGAPK
G46 sIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGS
S55 RGAPKRGSGKDSHTR
- gap
- gap
- gap
- under review  
K57 APKRGSGKDSHTRTt
S59 KRGSGKDSHTRTtHY
T61 GSGKDSHTRTtHYGs
T63 GKDSHTRTtHYGsLP
T64-p KDSHTRTtHYGsLPQ
Y66 SHTRTtHYGsLPQKs
S68-p TRTtHYGsLPQKsQH
S68 TRTtHYGSLPQKsQH
K72 HYGsLPQKsQHGRtQ
K72 HYGsLPQKsQHGRtQ
S73-p YGsLPQKsQHGRtQD
T78-p QKsQHGRtQDENPVV
T78 QKsQHGRTQDENPVV
K89 NPVVHFFKNIVTPRt
K89 NPVVHFFKNIVTPRt
T93 HFFKNIVTPRtPPPS
T96-p KNIVTPRtPPPSQGK
K103 tPPPSQGKGrGLsLS
R105-m1 PPSQGKGrGLsLSRF
R105 PPSQGKGRGLsLSRF
S108-p QGKGrGLsLSRFsWG
S113-p GLsLSRFsWGGRDsR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S119-p FsWGGRDsRsGsPMA
- gap
S121-p WGGRDsRsGsPMARR
S123-p GRDsRsGsPMARR__
  MBP iso10  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRSK
S8 MASQKRPSQRSKYLA
S11 QKRPSQRSKYLATAS
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
Y13 RPSQRSKYLATASTM
T16 QRSKYLATASTMDHA
S18 SKYLATASTMDHARH
T19 KYLATASTMDHARHG
T34 FLPRHRDTGILDSIG
S39 RDTGILDSIGRFFSG
S39 RDTGILDSIGRFFSG
S45 DSIGRFFSGDRGAPK
G46 SIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGS
S55 RGAPKRGSGKDSHTR
- gap
- gap
- gap
- under review  
K57 APKRGSGKDSHTRTT
S59 KRGSGKDSHTRTTHY
T61 GSGKDSHTRTTHYGS
T63 GKDSHTRTTHYGSLP
T64 KDSHTRTTHYGSLPQ
Y66 SHTRTTHYGSLPQKS
S68 TRTTHYGSLPQKSQH
S68 TRTTHYGSLPQKSQH
K72 HYGSLPQKSQHGRTQ
K72 HYGSLPQKSQHGRTQ
S73 YGSLPQKSQHGRTQD
T78 QKSQHGRTQDENPVV
T78 QKSQHGRTQDENPVV
K89 NPVVHFFKNIVtPRt
K89 NPVVHFFKNIVtPRt
T93-p HFFKNIVtPRtPPPS
T96-p KNIVtPRtPPPSQGK
K103 tPPPSQGKDFVPGDH
R127 SFSSSQGRGLsLSRF
R127 SFSSSQGRGLsLSRF
S130-p SSQGRGLsLSRFsWG
S135-p GLsLSRFsWGAEGQk
K142-a sWGAEGQkPGFGyGG
K142-u sWGAEGQkPGFGyGG
Y147-p GQkPGFGyGGRASDY
R150 PGFGyGGRASDYKSA
S152 FGyGGRASDYKSAHK
K162-u KSAHKGFkGAyDAQG
- gap
Y165-p HKGFkGAyDAQGtLs
T170-p GAyDAQGtLsKIFKL
S172-p yDAQGtLsKIFKLGG
S182 FKLGGRDSRSGSPMA
- gap
S184 LGGRDSRSGSPMARR
S186 GRDSRSGSPMARR__
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFSG
S41 RDTGILDSIGRFFSG
S47 DSIGRFFSGDRGAPK
G48 SIGRFFSGDRGAPKR
R50 GRFFSGDRGAPKRGS
S57 RGAPKRGSGKVPWLK
K64 SGKVPWLKQSRSPLP
S66 KVPWLKQSRSPLPSH
S68 PWLKQSRSPLPSHAR
S72 QSRSPLPSHARSRPG
K85 PGLCHMYKDSHTRTT
S87 LCHMYKDSHTRTTHy
T89 HMYKDSHTRTTHyGs
T91 YKDSHTRTTHyGsLP
T92 KDSHTRTTHyGsLPQ
Y94-p SHTRTTHyGsLPQks
S96-p TRTTHyGsLPQksQR
S96 TRTTHyGSLPQksQR
K100 HyGsLPQKsQRtQDE
K100-u HyGsLPQksQRtQDE
S101-p yGsLPQksQRtQDEN
T104-p LPQksQRtQDENPVV
T104 LPQksQRTQDENPVV
K115 NPVVHFFKNIVTPRt
K115-u NPVVHFFkNIVTPRt
T119 HFFkNIVTPRtPPPS
T122-p kNIVTPRtPPPSQGk
K129-m1 tPPPSQGkGrGLSLS
R131-m1 PPSQGkGrGLSLSRF
R131 PPSQGkGRGLSLSRF
S134 QGkGrGLSLSRFSWG
S139 GLSLSRFSWGAEGQK
K146 SWGAEGQKPGFGyGG
K146 SWGAEGQKPGFGyGG
Y151-p GQKPGFGyGGRASDY
R154 PGFGyGGRASDYKSA
S156 FGyGGRASDYKSAHK
K166 KSAHKGFKGAyDAQG
- gap
Y169-p HKGFKGAyDAQGTLS
T174 GAyDAQGTLSKIFKL
S176 yDAQGTLSKIFKLGG
S186 FKLGGRDSRSGSPMA
- gap
S188 LGGRDSRSGSPMARR
S190 GRDSRSGSPMARR__
  rabbit

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K4 ____ASQKRPsQRHG
S7-p _ASQKRPsQRHGSKY
S12 RPsQRHGSKYLATAS
K13 PsQRHGSKYLATAST
K13 PsQRHGSKYLATAST
K13 PsQRHGSKYLATAST
Y14 sQRHGSKYLATASTM
T17 HGSKYLATASTMDHA
S19 SKYLATASTMDHARH
T20 KYLATASTMDHARHG
T35 FLPRHRDTGILDSIG
S40 RDTGILDSIGRFFSS
S40 RDTGILDSIGRFFSS
S46 DSIGRFFSSDRGAPK
S47 SIGRFFSSDRGAPKR
R49 GRFFSSDRGAPKRGs
S56-p RGAPKRGsGKDHAAR
- gap
- gap
- gap
- under review  
K58 APKRGsGKDHAARTt
- gap
A62 GsGKDHAARTtHYGS
T64 GKDHAARTtHYGSLP
T65-p KDHAARTtHYGSLPQ
Y67 HAARTtHYGSLPQKS
S69 ARTtHYGSLPQKSGH
S69 ARTtHYGSLPQKSGH
K73 HYGSLPQKSGHRPQD
K73 HYGSLPQKSGHRPQD
S74 YGSLPQKSGHRPQDE
P78 PQKSGHRPQDENPVV
P78 PQKSGHRPQDENPVV
K89 NPVVHFFKNIVTPRt
K89 NPVVHFFKNIVTPRt
T93 HFFKNIVTPRtPPPS
T96-p KNIVTPRtPPPSQGK
K103 tPPPSQGKGRGTVLS
R105 PPSQGKGRGTVLSRF
R105 PPSQGKGRGTVLSRF
V108 QGKGRGTVLSRFsWG
S113-p GTVLSRFsWGAEGQK
K120 sWGAEGQKPGFGYGG
K120 sWGAEGQKPGFGYGG
Y125 GQKPGFGYGGRAADY
R128 PGFGYGGRAADYKSA
A130 FGYGGRAADYKSAHK
K140 KSAHKGLKGADAQGT
- gap
- gap
T147 KGADAQGTLSRLFKL
S149 ADAQGTLSRLFKLGG
S159 FKLGGRDSRSGsPMA
- gap
S161 LGGRDSRSGsPMARR
S163-p GRDSRSGsPMARR__
  chicken

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRSsFRHG
S8-p MASQKRSsFRHGSKM
S13 RSsFRHGSKMASAsT
K14 SsFRHGSKMASAsTT
K14 SsFRHGSKMASAsTT
K14 SsFRHGSKMASAsTT
M15 sFRHGSKMASAsTTD
S17 RHGSKMASAsTTDHA
S19-p GSKMASAsTTDHARH
T20 SKMASAsTTDHARHG
S34-p GSPRHRDsGLLDSLG
S39 RDsGLLDSLGRFFGG
S39 RDsGLLDSLGRFFGG
G45 DSLGRFFGGDRHVPR
G46 SLGRFFGGDRHVPRR
R48 GRFFGGDRHVPRRGF
F55 RHVPRRGFGKDIHAA
- gap
- gap
- gap
- under review  
K57 VPRRGFGKDIHAARA
- gap
A62 FGKDIHAARAsHVGS
A64 KDIHAARAsHVGSIP
S65-p DIHAARAsHVGSIPQ
V67 HAARAsHVGSIPQRs
S69 ARAsHVGSIPQRsQH
S69 ARAsHVGSIPQRsQH
R73 HVGSIPQRsQHGRPG
R73 HVGSIPQRsQHGRPG
S74-p VGSIPQRsQHGRPGD
P79 QRsQHGRPGDDNPVV
P79 QRsQHGRPGDDNPVV
K90 NPVVHFFKNIVSPRt
K90 NPVVHFFKNIVSPRt
S94 HFFKNIVSPRtPPPM
T97-p KNIVSPRtPPPMQAK
K104 tPPPMQAKGRGLSLT
R106 PPMQAKGRGLSLTRF
R106 PPMQAKGRGLSLTRF
S109 QAKGRGLSLTRFsWG
S114-p GLSLTRFsWGGEGHK
K121 sWGGEGHKPGYGSGK
K121 sWGGEGHKPGYGSGK
S126 GHKPGYGSGKFYEHK
K128 KPGYGSGKFYEHKSA
Y130 GYGSGKFYEHKSAHK
K140 KSAHKGHKGsYHEGQ
S142-p AHKGHKGsYHEGQGT
Y143 HKGHKGsYHEGQGTL
T149 sYHEGQGTLSKIFKL
S151 HEGQGTLSKIFKLGG
S161 FKLGGSGSRPGsRSG
S165-p GSGSRPGsRSGsPVA
S167 GSRPGsRSGsPVARR
S169-p RPGsRSGsPVARR__
  cow

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K4 ____AAQKRPsQRsK
S7-p _AAQKRPsQRsKYLA
S10-p QKRPsQRsKYLASAs
K11 KRPsQRsKYLASAst
K11 KRPsQRsKYLASAst
K11 KRPsQRsKYLASAst
Y12 RPsQRsKYLASAstM
S15 QRsKYLASAstMDHA
S17-p sKYLASAstMDHARH
T18-p KYLASAstMDHARHG
T33-p FLPRHRDtGILDSLG
S38 RDtGILDSLGRFFGs
S38 RDtGILDSLGRFFGs
G44 DSLGRFFGsDRGAPK
S45-p SLGRFFGsDRGAPKR
R47 GRFFGsDRGAPKRGs
S54-p RGAPKRGsGKDGHHA
- gap
- gap
- gap
- under review  
K56 APKRGsGKDGHHAAR
- gap
A62 GKDGHHAARtTHYGS
T64-p DGHHAARtTHYGSLP
T65 GHHAARtTHYGSLPQ
Y67 HAARtTHYGSLPQKA
S69 ARtTHYGSLPQKAQG
S69 ARtTHYGSLPQKAQG
K73 HYGSLPQKAQGHRPQ
K73 HYGSLPQKAQGHRPQ
A74 YGSLPQKAQGHRPQD
P79 QKAQGHRPQDENPVV
P79 QKAQGHRPQDENPVV
K90 NPVVHFFKNIVtPRt
K90 NPVVHFFKNIVtPRt
T94-p HFFKNIVtPRtPPPS
T97-p KNIVtPRtPPPSQGK
K104 tPPPSQGKGrGLsLS
R106-m1 PPSQGKGrGLsLSRF
R106 PPSQGKGRGLsLSRF
S109-p QGKGrGLsLSRFsWG
S114-p GLsLSRFsWGAEGQK
K121 sWGAEGQKPGFGYGG
K121 sWGAEGQKPGFGYGG
Y126 GQKPGFGYGGRAsDY
R129 PGFGYGGRAsDYKSA
S131-p FGYGGRAsDYKSAHK
K141 KSAHKGLKGHDAQGt
- gap
H143 AHKGLKGHDAQGtLs
T148-p KGHDAQGtLsKIFKL
S150-p HDAQGtLsKIFKLGG
S160-p FKLGGRDsRSGsPMA
- gap
S162 LGGRDsRSGsPMARR
S164-p GRDsRSGsPMARR__
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