a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Ras; G protein, monomeric; G protein
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: perinuclear region of cytoplasm; late endosome; cytoplasm; early endosome; plasma membrane; cytosol; cell junction
Molecular Function: GTPase activity; protein binding; Rap guanyl-nucleotide exchange factor activity; Ras GTPase binding; GTP binding; protein complex binding; protein transporter activity
Biological Process: platelet activation; protein transport; activation of MAPKK activity; nerve growth factor receptor signaling pathway; GTP catabolic process; positive regulation of protein kinase activity; energy reserve metabolic process; positive regulation of Rap GTPase activity; signal transduction; blood coagulation; regulation of insulin secretion; Rap protein signal transduction
Alt. Names/Synonyms: C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1; RAP1; RAP1A; RAP1A, member of RAS oncogene family; Ras-related protein Krev-1; Ras-related protein Rap-1A; RAS-related protein RAP1A; SMGP21
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.