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Rap1A (human)

Overview Rap1A a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; G protein, monomeric (Ras); G protein Cellular Component: plasma membrane; cytosol Molecular Function: GTPase activity; protein binding; Ras GTPase binding; GTP binding Biological Process: platelet activation; nerve growth factor receptor signaling pathway; activation of MAPKK activity; small GTPase mediated signal transduction; energy reserve metabolic process; blood coagulation; signal transduction; regulation of insulin secretion Reference #:  P62834 (UniProtKB) Alt. Names/Synonyms: C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1; RAP1; RAP1A; RAP1A, member of RAS oncogene family; Ras-related protein Krev-1; Ras-related protein Rap-1A; RAS-related protein RAP1A; SMGP21 Gene Symbols: RAP1A Molecular weight: 20,987 Da Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rap1A 1C1Y - A=1-167 (human) 1GUA - A=1-167 (human) 3KUC - A=1-167 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1C1Y 1GUA 3KUC  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		K5-u	___MREYkLVVLGSG
0	58		K31-u	VQGIFVEkYDPTIED
0	2		S39-p	YDPTIEDsYRKQVEV
0	1		K117	PMILVGNKCDLEDER
0	1		K149	AFLESSAKSKINVNE
0	68		Y159-p	INVNEIFyDLVRQIN
1	0		S180-p	KKKPKKKsCLLL___

	mouse
K5-u	___MREYkLVVLGSG
K31-u	VQGIFVEkYDPTIED
S39-p	YDPTIEDsYRKQVEV
K117-u	PMILVGNkCDLEDER
K149-u	AFLESSAkSKINVNE
Y159-p	INVNEIFyDLVRQIN
S180	KKKPKKKSCLLL___

	rat
K5	___MREYKLVVLGSG
K31-u	VQGIFVEkYDPTIED
S39	YDPTIEDSYRKQVEV
K117	PMILVGNKCDLEDER
K149	AFLESSAKSKINVNE
Y159-p	INVNEIFyDLVRQIN
S180	KKKPKKKSCLLL___

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