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Protein Page:
Rap1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rap1A a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, Ras; Motility/polarity/chemotaxis; G protein, monomeric; G protein
Cellular Component: perinuclear region of cytoplasm; late endosome; cytoplasm; early endosome; plasma membrane; cytosol; cell junction
Molecular Function: GTPase activity; protein binding; Rap guanyl-nucleotide exchange factor activity; Ras GTPase binding; GTP binding; protein complex binding; protein transporter activity
Biological Process: platelet activation; protein transport; activation of MAPKK activity; nerve growth factor receptor signaling pathway; GTP catabolic process; positive regulation of protein kinase activity; energy reserve metabolic process; positive regulation of Rap GTPase activity; signal transduction; blood coagulation; regulation of insulin secretion; Rap protein signal transduction
Reference #:  P62834 (UniProtKB)
Alt. Names/Synonyms: C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1; RAP1; RAP1A; RAP1A, member of RAS oncogene family; Ras-related protein Krev-1; Ras-related protein Rap-1A; RAS-related protein RAP1A; SMGP21
Gene Symbols: RAP1A
Molecular weight: 20,987 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Rap1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K5-ub ___MREYkLVVLGSG
0 58 K31-ub VQGIFVEkYDPTIED
0 4 S39-p YDPTIEDsYRKQVEV
0 1 K117 PMILVGNKCDLEDER
0 1 K149 AFLESSAKSKINVNE
0 76 Y159-p INVNEIFyDLVRQIN
1 0 S180-p KKKPKKKsCLLL___
  mouse

 
K5-ub ___MREYkLVVLGSG
K31-ub VQGIFVEkYDPTIED
S39-p YDPTIEDsYRKQVEV
K117-ub PMILVGNkCDLEDER
K149-ub AFLESSAkSKINVNE
Y159-p INVNEIFyDLVRQIN
S180 KKKPKKKSCLLL___
  rat

 
K5 ___MREYKLVVLGSG
K31-ub VQGIFVEkYDPTIED
S39 YDPTIEDSYRKQVEV
K117 PMILVGNKCDLEDER
K149 AFLESSAKSKINVNE
Y159-p INVNEIFyDLVRQIN
S180 KKKPKKKSCLLL___
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