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Abl (human)

Overview Abl an ubiquitously expressed and highly conserved proto-oncogenic tyrosine kinase. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. Negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. It has been implicated in regulation of cell proliferation, differentiation, apoptosis, cell adhesion and stress response. The Philadephia chromosome translocation t(9;22)(q34;q11) creates a Bcr-Abl fusion protein, responsible for 90% of chronic myelogenous leukemia (CML) and ~25% of acute lymphoblastic leukemia (ALL). Inhibitors: Gleevec (imatinib, Glivec), Dasatinib. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; EC 2.7.10.2; EC 2.7.1.112; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Abl family Cellular Component: nuclear membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; nucleolus; cytosol; nucleus; actin cytoskeleton Molecular Function: protein C-terminus binding; actin monomer binding; protein binding; DNA binding; manganese ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; magnesium ion binding; mitogen-activated protein kinase binding; nicotinate-nucleotide adenylyltransferase activity; SH3 domain binding; ATP binding Biological Process: regulation of cell adhesion; axon guidance; peptidyl-tyrosine phosphorylation; mismatch repair; DNA damage induced protein phosphorylation; positive regulation of apoptosis; regulation of cell cycle; DNA damage response, signal transduction; protein modification process; endocytosis; muscle cell differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of transcription, DNA-dependent; regulation of endocytosis; positive regulation of muscle cell differentiation; autophagy; regulation of autophagy; blood coagulation; actin cytoskeleton organization and biogenesis; cell adhesion; positive regulation of oxidoreductase activity; S-phase-specific transcription in mitotic cell cycle Reference #:  P00519 (UniProtKB) Alt. Names/Synonyms: Abelson murine leukemia viral oncogene homolog 1; ABL; ABL1; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, receptor tyrosine kinase; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; Tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia viral oncogene homolog 1 Gene Symbols: ABL1 Molecular weight: 122,873 Da Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  Cell Cycle: G2/M DNA Damage Checkpoint  |  ErbB/HER Signaling  |  Regulation of Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling  |  Tyrosine Kinases

Select Structure to View Below Abl 1AB2 - A=120-220 (human) 1ABL - A=65-121 (human) 1AWO - A=64-120 (human) 1BBZ - A/C/G=64-121, E=65-121 (human) 1JU5 - C=62-121 (human) 1OPL - A/B=4-512 (human) 1ZZP - A=1007-1130 (human) 2ABL - A=57-218 (human) 2E2B - A/B=229-515 (human) 2F4J - A=227-513 (human) 2FO0 - A=38-512 (human) 2G1T - A/B/C/D=228-512 (human) 2G2F - A=229-512, B=228-512 (human) 2G2H - A/B=229-512 (human) 2G2I - A/B=228-512 (human) 2GQG - A/B=229-500 (human) 2HIW - A/B=228-512 (human) 2HYY - A/B/C/D=228-500 (human) 2HZ0 - A/B=228-497 (human) 2HZ4 - A/B/C=228-500 (human) 2HZI - A/B=229-500 (human) 2O88 - A/B=64-121 (human) 2V7A - A/B=227-512 (human) 3CS9 - A/D/C/B=229-500 (human) 3EG0 - A=60-121 (human) 3EG1 - A/B=60-121 (human) 3EG2 - A=60-121 (human) 3EG3 - A=60-121 (human) 3EGU - A=60-121 (human) 3K2M - A/B=121-232 (human) 3QRI - A/B=229-499 (human) 3QRJ - A/B=229-499 (human) 3QRK - A=229-499 (human) 3T04 - A=112-232 (human) 3UE4 - A/B=229-512 (human) 3UYO - A=112-232 (human) 3PYY - A/B=266-549 (human) 1ABO - A/B=61-121 (mouse) 1ABQ - A=61-121 (mouse) 1FPU - A/B=229-515 (mouse) 1IEP - A/B=229-515 (mouse) 1M52 - A/B=229-515 (mouse) 1OPJ - A/B=229-515 (mouse) 1OPK - A=27-515 (mouse) 2HZN - A=229-515 (mouse) 2QOH - A/B=229-515 (mouse) 2Z60 - A=229-515 (mouse) 3DK3 - A/B=233-514 (mouse) 3DK6 - A/B=233-514 (mouse) 3DK7 - A/B=233-505 (mouse) 3IK3 - A/B=229-513 (mouse) 3K5V - A/B=229-515 (mouse) 3KF4 - A/B=229-515 (mouse) 3KFA - A/B=229-515 (mouse) 3MS9 - A/B=229-515 (mouse) 3MSS - A/D/C/B=229-515 (mouse) 3OXZ - A=229-511 (mouse) 3OY3 - A/B=229-511 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO  |  ENZYME  |  Phospho3D  |  DISEASE 189980 608232  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: T735‑p apoptosis, inhibited: T735‑p cell differentiation, altered: Y226‑p cell growth, altered: Y393‑p transcription, altered: Y393‑p activation: Y70‑p enzymatic activity, induced: Y70‑p, Y139‑p, Y253‑p, Y312‑p, Y393‑p, S446‑p, S618‑p, S619‑p, T735‑p intracellular localization: T735‑p molecular association, regulation: Y70‑p, S618‑p, S619‑p, T735‑p phosphorylation: S618‑p, S619‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	6		-	gap
0	2		S43-p	DFEPQGLsEAARWNs
0	20		S50-p	sEAARWNsKENLLAG
2	12		Y70-p	PNLFVALyDFVASGD
0	195		Y93-p	EKLRVLGyNHNGEWC
0	9		S113-p	NGQGWVPsNyITPVN
2	221		Y115-p	QGWVPsNyITPVNSL
1	211		Y128-p	SLEKHSWyHGPVSRN
2	57		Y139-p	VSRNAAEyLLSSGIN
0	14		Y167-p	QRSISLRyEGRVyHy
1	105		Y172-p	LRyEGRVyHyRINtA
0	2		Y174-p	yEGRVyHyRINtAsD
0	1		T178-p	VyHyRINtAsDGKLy
0	34		S180-p	HyRINtAsDGKLyVs
3	548		Y185-p	tAsDGKLyVsSESRF
0	5		S187-p	sDGKLyVsSESRFNT
1	16		Y215-p	GLITTLHyPAPKRNK
0	29		T224-p	APKRNKPtVyGVsPN
13	314		Y226-p	KRNKPtVyGVsPNyD
0	67		S229-p	KPtVyGVsPNyDKWE
2	258		Y232-p	VyGVsPNyDKWEMER
3	286		Y253-p	HKLGGGQyGEVyEGV
3	335		Y257-p	GGQyGEVyEGVWKKy
1	55		Y264-p	yEGVWKKySLTVAVK
0	2		K274-a	TVAVKTLkEDTMEVE
0	1		K285-u	MEVEEFLkEAAVMKE
1	0		Y312-p	CTREPPFyIITEFMT
0	4		Y320-p	IITEFMTyGNLLDYL
0	73		T392-p	SRLMTGDtytAHAGA
17	1710		Y393-p	RLMTGDtytAHAGAK
1	452		T394-p	LMTGDtytAHAGAKF
0	159		Y413-p	TAPESLAyNKFSIKS
2	0		S446-p	PYPGIDLsQVYELLE
0	1		Y456-p	YELLEKDyRMERPEG
0	292		Y469-p	EGCPEKVyELMRACW
0	4		S535-p	LPTKTRTsRRAAEHR
2	0		V547	EHRDTTDVPEMPHSK
1	11		S569-p	LDHEPAVsPLLPRKE
0	1		T610-p	LIKKKKKtAPtPPKR
0	2		T613-p	KKKKtAPtPPKRsss
1	0		S618-p	APtPPKRsssFREMD
1	0		S619-p	PtPPKRsssFREMDG
0	3		S620-p	tPPKRsssFREMDGQ
0	1		S659-p	DTADPAKsPKPSNGA
0	3		S683-p	SGGSGFRsPHLWKKs
0	1		S690-p	sPHLWKKsStLTSSR
0	1		T692-p	HLWKKsStLTSSRLA
0	2		T700-p	LTSSRLAtGEEEGGG
0	1		S708-p	GEEEGGGssskRFLR
0	2		S709-p	EEEGGGssskRFLRS
0	1		S710-p	EEGGGssskRFLRSC
1	0		K711-a	EGGGssskRFLRSCs
0	20		S718-p	kRFLRSCsASCVPHG
5	1		T735-p	DTEWRSVtLPRDLQS
0	1		K759-a	FGGHKSEkPALPRKR
0	1		T781-p	QVTRGTVtPPPRLVK
0	1		S804	VFKDIMESsPGssPP
0	3		S805-p	FKDIMESsPGssPPN
0	2		S808-p	IMESsPGssPPNLtP
0	3		S809-p	MESsPGssPPNLtPK
0	2		T814-p	GssPPNLtPKPLRRQ
0	4		T844-p	GKGSALGtPAAAEPV
0	24		T852-p	PAAAEPVtPTSKAGS
1	0		K909	PPAASAGKAGGKPSQ
0	2		S917-p	AGGKPSQsPsQEAAG
0	2		S919-p	GKPSQsPsQEAAGEA
0	2		S936-p	GAKTKATsLVdAVNS
0	1		D939-ca	TKATsLVdAVNSDAA
0	2		S949-p	NSDAAKPsQPGEGLK
0	2		S977-p	KPSGTPIsPAPVPST
0	1		T1111-p	AGSGPAAtQDFSKLL

	Abl iso2
S16-p	LGDQRRPsLPALHFI
S62	DFEPQGLSEAARWNS
S69	SEAARWNSKENLLAG
Y89	PNLFVALYDFVASGD
Y112	EKLRVLGYNHNGEWC
S132	NGQGWVPSNYITPVN
Y134	QGWVPSNYITPVNSL
Y147	SLEKHSWYHGPVSRN
Y158	VSRNAAEYLLSSGIN
Y186	QRSISLRYEGRVYHY
Y191	LRYEGRVYHYRINTA
Y193	YEGRVYHYRINTASD
T197	VYHYRINTASDGKLY
S199	HYRINTASDGKLYVS
Y204	TASDGKLYVSSESRF
S206	SDGKLYVSSESRFNT
Y234	GLITTLHYPAPKRNK
T243	APKRNKPTVyGVSPN
Y245-p	KRNKPTVyGVSPNYD
S248	KPTVyGVSPNYDKWE
Y251	VyGVSPNYDKWEMER
Y272	HKLGGGQYGEVYEGV
Y276	GGQYGEVYEGVWKKY
Y283	YEGVWKKYSLTVAVK
K293	TVAVKTLKEDTMEVE
K304	MEVEEFLKEAAVMKE
Y331	CTREPPFYIITEFMT
Y339	IITEFMTYGNLLDYL
T411	SRLMTGDTYTAHAGA
Y412	RLMTGDTYTAHAGAK
T413	LMTGDTYTAHAGAKF
Y432	TAPESLAYNKFSIKS
S465-p	PYPGIDLsQVYELLE
Y475	YELLEKDYRMERPEG
Y488	EGCPEKVYELMRACW
S554	LPTKTRTSRRAAEHR
V566	EHRDTTDVPEMPHSK
S588	LDHEPAVSPLLPRKE
T629	LIKKKKKTAPTPPKR
T632	KKKKTAPTPPKRSSS
S637	APTPPKRSSSFREMD
S638	PTPPKRSSSFREMDG
S639	TPPKRSSSFREMDGQ
S678	DTADPAKSPKPSNGA
S702	SGGSGFRSPHLWKKS
S709	SPHLWKKSSTLTSSR
T711	HLWKKSSTLTSSRLA
T719	LTSSRLATGEEEGGG
S727	GEEEGGGSSSKRFLR
S728	EEEGGGSSSKRFLRS
S729	EEGGGSSSKRFLRSC
K730	EGGGSSSKRFLRSCS
S737	KRFLRSCSASCVPHG
T754	DTEWRSVTLPRDLQS
K778	FGGHKSEKPALPRKR
T800	QVTRGTVTPPPRLVK
S823	VFKDIMESSPGSSPP
S824	FKDIMESSPGSSPPN
S827	IMESSPGSSPPNLTP
S828	MESSPGSSPPNLTPK
T833	GSSPPNLTPKPLRRQ
T863	GKGSALGTPAAAEPV
T871	PAAAEPVTPTSKAGS
K928-a	PPAASAGkAGGKPSQ
S936	AGGKPSQSPSQEAAG
S938	GKPSQSPSQEAAGEA
S955	GAKTKATSLVDAVNS
D958	TKATSLVDAVNSDAA
S968	NSDAAKPSQPGEGLK
S996	KPSGTPISPAPVPST
T1130	AGSGPAATQDFSKLL

	mouse ► Hide Isoforms
-	gap
S43	DFEPQGLSEAARWNS
S50	SEAARWNSKENLLAG
Y70	PNLFVALYDFVASGD
Y93-p	EKLRVLGyNHNGEWC
S113	NGQGWVPSNyITPVN
Y115-p	QGWVPSNyITPVNSL
Y128-p	SLEKHSWyHGPVSRN
Y139-p	VSRNAAEyLLSSGIN
Y167	QRSISLRYEGRVyHy
Y172-p	LRYEGRVyHyRINTA
Y174-p	YEGRVyHyRINTASD
T178	VyHyRINTASDGKLy
S180	HyRINTASDGKLyVS
Y185-p	TASDGKLyVSSESRF
S187	SDGKLyVSSESRFNT
Y215	GLITTLHYPAPKRNK
T224	APKRNKPTIyGVSPN
Y226-p	KRNKPTIyGVSPNyD
S229	KPTIyGVSPNyDKWE
Y232-p	IyGVSPNyDKWEMER
Y253-p	HKLGGGQyGEVyEGV
Y257-p	GGQyGEVyEGVWKKy
Y264-p	yEGVWKKySLTVAVK
K274	TVAVKTLKEDTMEVE
K285	MEVEEFLKEAAVMKE
Y312	CTREPPFYIITEFMT
Y320	IITEFMTYGNLLDYL
T392	SRLMTGDTytAHAGA
Y393-p	RLMTGDTytAHAGAK
T394-p	LMTGDTytAHAGAKF
Y413-p	TAPESLAyNKFSIKS
S446	PYPGIDLSQVYELLE
Y456	YELLEKDYRMERPEG
Y469-p	EGCPEKVyELMRACW
C535	LPTKTRTCRRAAEQK
T547-p	EQKDAPDtPELLHTK
S569-p	LDSEPAVsPLLPRKE
M610	LIKKKKKMAPTPPKR
T613	KKKKMAPTPPKRSSs
S618	APTPPKRSSsFREMD
S619	PTPPKRSSsFREMDG
S620-p	TPPKRSSsFREMDGQ
S658	DAAEPTKSPKASNGA
S682	PGNSGFRSPHMWKKS
S689	SPHMWKKSSTLTGSR
T691	HMWKKSSTLTGSRLA
A699	LTGSRLAAAEEESGM
S707	AEEESGMSSSKRFLR
S708	EEESGMSSSKRFLRS
S709	EESGMSSSKRFLRSC
K710	ESGMSSSKRFLRSCs
S717-p	KRFLRSCsASCMPHG
T734	DTEWRSVTLPRDLPS
K758	FGGHKSEKPALPRKR
M780	QVAKSTAMPPPRLVK
S802-p	EGFKDTEssPGSsPP
S803-p	GFKDTEssPGSsPPS
S806	DTEssPGSsPPSLtP
S807-p	TEssPGSsPPSLtPK
T812-p	GSsPPSLtPKLLRRQ
T844	GSASGMGTPATAEPA
P852	PATAEPAPPSNKVGL
K902	PPPACTGKAGKPAQS
S909	KAGKPAQSPSQEAGE
S911	GKPAQSPSQEAGEAG
S927	PTKTKCTSLAMDAVN
D931	KCTSLAMDAVNTDPT
G941	NTDPTKAGPPGEGLR
S970-p	KPPGTPTsPVSTPST
T1104	ASSGPAATQDFSKLL

	Abl iso2
S16-p	LGDQRRPsLPALHFI
S62	DFEPQGLSEAARWNS
S69	SEAARWNSKENLLAG
Y89	PNLFVALYDFVASGD
Y112	EKLRVLGYNHNGEWC
S132	NGQGWVPSNYITPVN
Y134	QGWVPSNYITPVNSL
Y147	SLEKHSWYHGPVSRN
Y158	VSRNAAEYLLSSGIN
Y186	QRSISLRYEGRVYHY
Y191	LRYEGRVYHYRINTA
Y193	YEGRVYHYRINTASD
T197	VYHYRINTASDGKLY
S199	HYRINTASDGKLYVS
Y204	TASDGKLYVSSESRF
S206	SDGKLYVSSESRFNT
Y234	GLITTLHYPAPKRNK
T243	APKRNKPTIYGVSPN
Y245	KRNKPTIYGVSPNYD
S248	KPTIYGVSPNYDKWE
Y251	IYGVSPNYDKWEMER
Y272	HKLGGGQYGEVYEGV
Y276	GGQYGEVYEGVWKKY
Y283	YEGVWKKYSLTVAVK
K293	TVAVKTLKEDTMEVE
K304	MEVEEFLKEAAVMKE
Y331	CTREPPFYIITEFMT
Y339	IITEFMTYGNLLDYL
T411	SRLMTGDTYTAHAGA
Y412	RLMTGDTYTAHAGAK
T413	LMTGDTYTAHAGAKF
Y432	TAPESLAYNKFSIKS
S465	PYPGIDLSQVYELLE
Y475	YELLEKDYRMERPEG
Y488	EGCPEKVYELMRACW
C554	LPTKTRTCRRAAEQK
T566	EQKDAPDTPELLHTK
S588	LDSEPAVSPLLPRKE
M629	LIKKKKKMAPTPPKR
T632	KKKKMAPTPPKRSSS
S637	APTPPKRSSSFREMD
S638	PTPPKRSSSFREMDG
S639	TPPKRSSSFREMDGQ
S677	DAAEPTKSPKASNGA
S701	PGNSGFRSPHMWKKS
S708	SPHMWKKSSTLTGSR
T710	HMWKKSSTLTGSRLA
A718	LTGSRLAAAEEESGM
S726	AEEESGMSSSKRFLR
S727	EEESGMSSSKRFLRS
S728	EESGMSSSKRFLRSC
K729	ESGMSSSKRFLRSCS
S736	KRFLRSCSASCMPHG
T753	DTEWRSVTLPRDLPS
K777	FGGHKSEKPALPRKR
M799	QVAKSTAMPPPRLVK
S821	EGFKDTESSPGSSPP
S822	GFKDTESSPGSSPPS
S825	DTESSPGSSPPSLTP
S826	TESSPGSSPPSLTPK
T831	GSSPPSLTPKLLRRQ
T863	GSASGMGTPATAEPA
P871	PATAEPAPPSNKVGL
K921	PPPACTGKAGKPAQS
S928	KAGKPAQSPSQEAGE
S930	GKPAQSPSQEAGEAG
S946	PTKTKCTSLAMDAVN
D950	KCTSLAMDAVNTDPT
G960	NTDPTKAGPPGEGLR
S989	KPPGTPTSPVSTPST
T1123	ASSGPAATQDFSKLL

	rat ► Hide Isoforms
-	gap
S43	DFEPQGLSEAARWNS
S50	SEAARWNSKENLLAG
Y70	PNLFVALYDFVASGD
Y93	EKLRVLGYNHNGEWC
S113	NGQGWVPSNYITPVN
Y115	QGWVPSNYITPVNSL
Y128	SLEKHSWYHGPVSRN
Y139	VSRNAAEYLLSSGIN
Y167	QRSISLRYEGRVYHY
Y172	LRYEGRVYHYRINTA
Y174	YEGRVYHYRINTASD
T178	VYHYRINTASDGKLy
S180	HYRINTASDGKLyVS
Y185-p	TASDGKLyVSSESRF
S187	SDGKLyVSSESRFNT
Y215	GLITTLHYPAPKRNK
T224	APKRNKPTIYGVSPN
Y226	KRNKPTIYGVSPNYD
S229	KPTIYGVSPNYDKWE
Y232	IYGVSPNYDKWEMER
Y253	HKLGGGQYGEVYEGV
Y257	GGQYGEVYEGVWKKY
Y264	YEGVWKKYSLTVAVK
K274	TVAVKTLKEDTMEVE
K285	MEVEEFLKEAAVMKE
Y312	CTREPPFYIITEFMT
Y320	IITEFMTYGNLLDYL
T392-p	SRLMTGDtyTAHAGA
Y393-p	RLMTGDtyTAHAGAK
T394	LMTGDtyTAHAGAKF
Y413	TAPESLAYNKFSIKS
S446	PYPGIDLSQVYELLE
Y456	YELLEKDYRMERPEG
Y469	EGCPEKVYELMRACW
C535	LPTKTRTCRKTAEQK
A547	EQKDAPDALELLHTK
S569	LDSEPAVSPLLPRKE
M610	LIKKKKKMAPTPPKR
T613	KKKKMAPTPPKRSSS
S618	APTPPKRSSSFREMD
S619	PTPPKRSSSFREMDG
S620	TPPKRSSSFREMDGQ
S658	DAVEPTKSPKASNGA
S682	PGNSGFRSPHVWKKS
S689	SPHVWKKSSTLTSSR
T691	HVWKKSSTLTSSRLA
A699	LTSSRLAAAEEESGL
S707	AEEESGLSSSKRFLR
S708	EEESGLSSSKRFLRS
S709	EESGLSSSKRFLRSC
K710	ESGLSSSKRFLRSCS
S717	KRFLRSCSASCMPHG
T734	DTEWRSVTLPRDLPS
K758	FGGHKSEKPALPRKR
T780	QVAKSTATPPPRLVK
S802	DVFKDTESSPGSSPP
S803	VFKDTESSPGSSPPS
S806	DTESSPGSSPPSLTP
S807	TESSPGSSPPSLTPK
T812	GSSPPSLTPKLLRRQ
T844	GNASGMGTPATAEPA
A852	PATAEPAAPSNKAGL
K902	PPPSSTGKAGKPAQS
S909	KAGKPAQSPSQDVAG
S911	GKPAQSPSQDVAGEA
S928	ATKTKCTSLSVDAVN
D932	KCTSLSVDAVNSDPT
G942	NSDPTKAGQPGEGLR
S971	KPPGTPTSPVSTPST
T1105	ASSGPAATQDFSKLL

	Abl iso2
S16	LGDQRRPSLPALHFI
S62	DFEPQGLSEAARWNS
S69	SEAARWNSKENLLAG
Y89	PNLFVALYDFVASGD
Y112	EKLRVLGYNHNGEWC
S132	NGQGWVPSNYITPVN
Y134	QGWVPSNYITPVNSL
Y147	SLEKHSWYHGPVSRN
Y158	VSRNAAEYLLSSGIN
Y186	QRSISLRYEGRVYHY
Y191	LRYEGRVYHYRINTA
Y193	YEGRVYHYRINTASD
T197	VYHYRINTASDGKLY
S199	HYRINTASDGKLYVS
Y204	TASDGKLYVSSESRF
S206	SDGKLYVSSESRFNT
Y234	GLITTLHYPAPKRNK
T243	APKRNKPTIYGVSPN
Y245	KRNKPTIYGVSPNYD
S248	KPTIYGVSPNYDKWE
Y251	IYGVSPNYDKWEMER
Y272	HKLGGGQYGEVYEGV
Y276	GGQYGEVYEGVWKKY
Y283	YEGVWKKYSLTVAVK
K293	TVAVKTLKEDTMEVE
K304	MEVEEFLKEAAVMKE
Y331	CTREPPFYIITEFMT
Y339	IITEFMTYGNLLDYL
T411	SRLMTGDTYTAHAGA
Y412	RLMTGDTYTAHAGAK
T413	LMTGDTYTAHAGAKF
Y432	TAPESLAYNKFSIKS
S465	PYPGIDLSQVYELLE
Y475	YELLEKDYRMERPEG
Y488	EGCPEKVYELMRACW
C554	LPTKTRTCRKTAEQK
A566	EQKDAPDALELLHTK
S589	LDSEPAVSPLLPRKE
M630	LIKKKKKMAPTPPKR
T633	KKKKMAPTPPKRSSS
S638	APTPPKRSSSFREMD
S639	PTPPKRSSSFREMDG
S640	TPPKRSSSFREMDGQ
S678	DAVEPTKSPKASNGA
S702	PGNSGFRSPHVWKKC
C709	SPHVWKKCSTLTSSR
T711	HVWKKCSTLTSSRLA
A719	LTSSRLAAAEEESGL
S727	AEEESGLSSSKRFLR
S728	EEESGLSSSKRFLRS
S729	EESGLSSSKRFLRSC
K730	ESGLSSSKRFLRSCS
S737	KRFLRSCSASCMPHG
T754	DTEWRSVTLPRDLPS
K778	FGGHKSEKPALPRKR
T800	QVAKSTATPPPRLVK
S822	DVFKDTESSPGSSPP
S823	VFKDTESSPGSSPPS
S826	DTESSPGSSPPSLTP
S827	TESSPGSSPPSLTPK
T832	GSSPPSLTPKLLRRQ
T864	GNASGMGTPATAEPA
A872	PATAEPAAPSNKAGL
K922	PPPSSTGKAGKPAQS
S929	KAGKPAQSPSQDVAG
S931	GKPAQSPSQDVAGEA
S948	ATKTKCTSLSVDAVN
D952	KCTSLSVDAVNSDPT
G962	NSDPTKAGQPGEGLR
S991	KPPGTPTSPVSTPST
T1125	ASSGPAATQDFSKLL

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