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Protein Page:
tensin 2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
tensin 2 Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; EC 3.1.3.-; Phosphatase
Cellular Component: focal adhesion; plasma membrane
Molecular Function: protein binding; metal ion binding; phosphoprotein phosphatase activity
Biological Process: negative regulation of cell proliferation; response to muscle activity; collagen metabolic process; dephosphorylation; multicellular organism growth; multicellular organismal homeostasis; cellular homeostasis; kidney development
Reference #:  Q63HR2 (UniProtKB)
Alt. Names/Synonyms: C1 domain-containing phosphatase and tensin homolog; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TENC1; tensin 2; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain-containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2
Gene Symbols: TENC1
Molecular weight: 152,580 Da
Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

tensin 2

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S19-p RALGRRDssRAAsRP
0 1 S20-p ALGRRDssRAAsRPR
0 1 S24-p RDssRAAsRPRKAEP
0 1 S33-p PRKAEPHsFREKVFR
0 1 N90 PPVELRRNtAPVRRI
0 2 T91-p PVELRRNtAPVRRIE
0 2 S102-p RRIEHLGsTKSLNHS
0 1 T114 NHSKQRSTLPRsFsL
0 3 S118-p QRSTLPRsFsLDPLM
0 17 S120-p STLPRsFsLDPLMER
0 1 T186-p SEKRHDLtRLNPKVQ
0 1 Y245-p LGVIVSAyMHysKIs
0 1 Y248-p IVSAyMHysKIsAGA
0 1 S249-p VSAyMHysKIsAGAD
0 1 S252-p yMHysKIsAGADQAL
0 5 Y444 DPSVSVDYNTTEPAV
0 53 S455-p EPAVRWDsyENFNQH
0 6 Y456-p PAVRWDsyENFNQHH
0 25 S466-p FNQHHEDsVDGsLtH
0 2 S470-p HEDsVDGsLtHtRGP
0 1 T472-p DsVDGsLtHtRGPLD
0 1 T474-p VDGsLtHtRGPLDGs
0 31 S481-p tRGPLDGsPyAQVQR
0 1539 Y483-p GPLDGsPyAQVQRPP
0 1 T493-p VQRPPRQtPPAPSPE
0 1 S552-p LGGCGVAsGGRGAGR
0 8 R555 CGVAsGGRGAGRETA
0 1 Y623-p LERRRLAyGGYEGSP
0 5 Y626 RRLAyGGYEGSPQGy
0 1 Y633-p YEGSPQGyAEASMEK
0 1 K640 yAEASMEKRRLCRsL
0 2 S646-p EKRRLCRsLSEGLyP
0 6 S648 RRLCRsLSEGLyPYP
0 1 Y652-p RsLSEGLyPYPPEMG
0 1 K660 PYPPEMGKPATGDFG
0 1 Y668 PATGDFGYRAPGyRE
0 5 Y673-p FGYRAPGyREVVILE
0 14 Y705-p ALPTAALyGLRLERE
0 1 S769-p EEGHEGCsyTMCPEG
0 59 Y770-p EGHEGCsyTMCPEGR
0 1 Y789 GYPALVTYSYGGAVP
0 1 Y791 PALVTYSYGGAVPSY
0 1 S811-p RVPHSCGsPGEGRGy
0 1 R816 CGsPGEGRGyPsPGA
0 1 Y818-p sPGEGRGyPsPGAHs
0 5 S820-p GEGRGyPsPGAHsPR
0 8 S825-p yPsPGAHsPRAGsIs
0 7 S830-p AHsPRAGsIsPGsPP
0 9 S832-p sPRAGsIsPGsPPYP
0 14 S835-p AGsIsPGsPPYPQSR
0 11 Y838 IsPGsPPYPQSRKLs
0 1 S845-p YPQSRKLsYEIPTEE
0 1 A872 SAGPLASAESLEPVS
0 1 P884 PVSWREGPSGHSTLP
0 1 T889 EGPSGHSTLPRsPRD
0 2 S893-p GHSTLPRsPRDAPCS
0 4 S906-p CSASSELsGPstPLH
0 5 S909-p SSELsGPstPLHtss
0 31 T910-p SELsGPstPLHtssP
0 5 T914-p GPstPLHtssPVQGK
0 3 S915-p PstPLHtssPVQGKE
0 8 S916-p stPLHtssPVQGKES
0 3 S931-p TRRQDTRsPTSAPTQ
0 9 S941-p SAPTQRLsPGEALPP
0 1 P948 sPGEALPPVSQAGTG
0 1 S962-p GKAPELPsGsGPEPL
0 1 S964-p APELPsGsGPEPLAP
0 1 S972-p GPEPLAPsPVsPtFP
0 1 S975-p PLAPsPVsPtFPPSS
0 1 T977-p APsPVsPtFPPSSPS
0 1 F978 PsPVsPtFPPSSPSD
0 2 S982 sPtFPPSSPSDWPQE
0 2 S991-p SDWPQERsPGGHsDG
0 1 S996-p ERsPGGHsDGAsPRs
0 1 S1000-p GGHsDGAsPRsPVPT
0 10 S1003-p sDGAsPRsPVPTTLP
0 1 T1008 PRsPVPTTLPGLRHA
0 10 S1096-p WGPEQASsPARGISH
0 1 T1118-p LSDNVPQtPEPPTQE
0 1 S1126-p PEPPTQEsQSNVKFV
0 1 K1157-ub AIALLKDkDPGAFLI
0 1 T1182-p GLALKVAtPPPSAQP
0 1 S1218-p VKIKGCPsEPyFGSL
0 1 Y1221-p KGCPsEPyFGSLSAL
0 2 S1247-p PCCLRIPsKDPLEET
0 1 S1342-p RRHYPVNsItFSSTD
0 1 T1344-p HYPVNsItFSSTDPQ
0 1 K1364 NPDGTTSKIFGFVAK
  tensin 2 iso4  
- gap
- gap
- gap
S43 PRKAEPHSFREKVFR
N100 PPVELRRNTAPVRRI
T101 PVELRRNTAPVRRIE
S112 RRIEHLGSTKSLNHS
T124 NHSKQRSTLPRSFSL
S128 QRSTLPRSFSLDPLM
S130 STLPRSFSLDPLMER
T196 SEKRHDLTRLNPKVQ
Y255 LGVIVSAYMHYSKIS
Y258 IVSAYMHYSKISAGA
S259 VSAYMHYSKISAGAD
S262 YMHYSKISAGADQAL
Y454 DPSVSVDYNTTEPAV
S465 EPAVRWDSYENFNQH
Y466 PAVRWDSYENFNQHH
S476 FNQHHEDSVDGSLTH
S480 HEDSVDGSLTHTRGP
T482 DSVDGSLTHTRGPLD
T484 VDGSLTHTRGPLDGS
S491 TRGPLDGSPYAQVQR
Y493 GPLDGSPYAQVQRPP
T503 VQRPPRQTPPAPSPE
S562 LGGCGVASGGRGAGR
R565 CGVASGGRGAGRETA
Y633 LERRRLAYGGYEGSP
Y636 RRLAYGGYEGSPQGY
Y643 YEGSPQGYAEASMEK
K650 YAEASMEKRRLCRSL
S656 EKRRLCRSLSEGLYP
S658 RRLCRSLSEGLYPYP
Y662 RSLSEGLYPYPPEMG
K670 PYPPEMGKPATGDFG
Y678 PATGDFGYRAPGYRE
Y683 FGYRAPGYREVVILE
Y715 ALPTAALYGLRLERE
S779 EEGHEGCSYTMCPEG
Y780 EGHEGCSYTMCPEGR
Y799 GYPALVTYSYGGAVP
Y801 PALVTYSYGGAVPSY
S821 RVPHSCGSPGEGRGY
R826 CGSPGEGRGYPSPGA
Y828 SPGEGRGYPSPGAHS
S830 GEGRGYPSPGAHSPR
S835 YPSPGAHSPRAGSIS
S840 AHSPRAGSISPGSPP
S842 SPRAGSISPGSPPYP
S845 AGSISPGSPPYPQSR
Y848 ISPGSPPYPQSRKLS
S855 YPQSRKLSYEIPTEE
A882 SAGPLASAESLEPVS
P894 PVSWREGPSGHSTLP
T899 EGPSGHSTLPRSPRD
S903 GHSTLPRSPRDAPCS
S916 CSASSELSGPSTPLH
S919 SSELSGPSTPLHTSS
T920 SELSGPSTPLHTSSP
T924 GPSTPLHTSSPVQGK
S925 PSTPLHTSSPVQGKE
S926 STPLHTSSPVQGKES
S941 TRRQDTRSPTSAPTQ
S951 SAPTQRLSPGEALPP
P958 SPGEALPPVSQAGTG
S972 GKAPELPSGSGPEPL
S974 APELPSGSGPEPLAP
S982 GPEPLAPSPVSPTFP
S985 PLAPSPVSPTFPPSS
T987 APSPVSPTFPPSSPS
F988 PSPVSPTFPPSSPSD
S992 SPTFPPSSPSDWPQE
S1001 SDWPQERSPGGHSDG
S1006 ERSPGGHSDGASPRS
S1010 GGHSDGASPRSPVPT
S1013 SDGASPRSPVPTTLP
T1018 PRSPVPTTLPGLRHA
S1106 WGPEQASSPARGISH
T1128 LSDNVPQTPEPPTQE
S1136 PEPPTQESQSNVKFV
K1167 AIALLKDKDPGAFLI
T1192 GLALKVATPPPSAQP
S1228 VKIKGCPSEPYFGSL
Y1231 KGCPSEPYFGSLSAL
S1257 PCCLRIPSKDPLEET
S1352 RRHYPVNSITFSSTD
T1354 HYPVNSITFSSTDPQ
K1374 NPDGTTSKIFGFVAK
  mouse

 
S19 RALGRRDSSRATSRP
S20 ALGRRDSSRATSRPR
S24 RDSSRATSRPRKAEP
S33 PRKAEPHSFREKVFR
S90-p PPAELRRsTAPVRRI
T91 PAELRRsTAPVRRIE
S102-p RRIEHLGsTKSLNHS
T114-p NHSKQRStLPRsFsL
S118-p QRStLPRsFsLDPLM
S120-p StLPRsFsLDPLMER
T186 SEKRHDLTRLNPKVQ
Y245 LGVIVSAYMHYSKIS
Y248 IVSAYMHYSKISAGA
S249 VSAYMHYSKISAGAD
S252 YMHYSKISAGADQAL
Y444-p DPSVSVDyNTTEPAV
S455-p EPAVRWDsyENFNQH
Y456-p PAVRWDsyENFNQHH
S466-p FNQHHEDsVDGALAH
A470 HEDsVDGALAHTRGP
A472 DsVDGALAHTRGPLD
T474 VDGALAHTRGPLDGs
S481-p TRGPLDGsPyAQVQR
Y483-p GPLDGsPyAQVQRVP
T493 VQRVPRQTPPAPSPE
S552 LGGCGVASAGrGAGR
R555-m1 CGVASAGrGAGRETA
Y623 LERRRPPYGGyEGHP
Y626-p RRPPYGGyEGHPQGY
Y633 yEGHPQGYAEASVEk
K640-ub YAEASVEkRRLCRsL
S646-p EkRRLCRsLsEGPYP
S648-p RRLCRsLsEGPYPYA
Y652 RsLsEGPYPYAPELG
K660-ub PYAPELGkPANGDFG
Y668-p PANGDFGyRPAGYRE
Y673 FGyRPAGYREVVILE
Y705-p ALPTAALyGLRLERE
S769 EEGHEGCSyAVCSEG
Y770-p EGHEGCSyAVCSEGR
Y789-p GYPALVTyGyGGAVP
Y791-p PALVTyGyGGAVPSY
S811 RAPHSCGSPSEGrGY
R816-m1 CGSPSEGrGYPsPGA
Y818 SPSEGrGYPsPGAHs
S820-p SEGrGYPsPGAHsPR
S825-p YPsPGAHsPRAGsVs
S830-p AHsPRAGsVsPGsPP
S832-p sPRAGsVsPGsPPyL
S835-p AGsVsPGsPPyLQPR
Y838-p VsPGsPPyLQPRKLG
G845 yLQPRKLGYEISAED
T872-p STGPLAStESPEPSW
S883-p EPSWRDGsSGHStLP
T888-p DGsSGHStLPRSPRD
S892 GHStLPRSPRDPQCS
S905-p CSASSELsGPstPLH
S908-p SSELsGPstPLHtss
T909-p SELsGPstPLHtssP
T913-p GPstPLHtssPVQGK
S914-p PstPLHtssPVQGKE
S915-p stPLHtssPVQGKES
S931-p RRQDTTRsPSLAPTQ
S941-p LAPTQRLsPGEALPs
S948-p sPGEALPsVVQGVAE
T962 EKTPELLTSSRPEQL
S964 TPELLTSSRPEQLDP
S972 RPEQLDPSPFSQTsA
S975 QLDPSPFSQTsAPGs
T977 DPSPFSQTsAPGsPN
S978-p PSPFSQTsAPGsPNG
S982-p SQTsAPGsPNGWPQE
S991-p NGWPQERsPGGHtNS
T996-p ERsPGGHtNSAsPRs
S1000-p GGHtNSAsPRsPVPT
S1003-p tNSAsPRsPVPTtLP
T1008-p PRsPVPTtLPGLRHA
S1087-p PGSGQQPsPPARSTN
P1109 PLPDVTQPPEHPLQE
N1117 PEHPLQENQSNVKFV
K1148 AIALLKDKDPGAFLI
T1173 GLALKVATPPPSAQP
T1209 VKIKGCPTEPYFGSL
Y1212 KGCPTEPYFGSLSAL
S1238-p PCCLRIPsKDPLEET
S1333 RRHYPVNSITFSSTD
T1335 HYPVNSITFSSTDPQ
K1355-ub NPDGATSkIFGFVAK
  rat

 
S19 RALGRRDSSRATSRP
S20 ALGRRDSSRATSRPR
S24 RDSSRATSRPRKAEP
S33 PRKAEPHSFREKVFR
N90 PPAELRRNTAPVRRI
T91 PAELRRNTAPVRRIE
S102 RRIEHLGSTKSLNHS
T114 NHSKQRSTLPRSFSL
S118 QRSTLPRSFSLDPLM
S120 STLPRSFSLDPLMER
T186 SEKRHDLTRLNPKVH
Y245 LGVIVSAYMHYSKIS
Y248 IVSAYMHYSKISAGA
S249 VSAYMHYSKISAGAD
S252 YMHYSKISAGADQAL
Y444 DPSVSVDYNMTEPAV
S455 EPAVRWDSYENFNQH
Y456 PAVRWDSYENFNQHH
S466 FNQHHEDSVDGSLAH
S470 HEDSVDGSLAHTRGP
A472 DSVDGSLAHTRGPLD
T474 VDGSLAHTRGPLDGS
S481 TRGPLDGSPyAQVQR
Y483-p GPLDGSPyAQVQRVP
T493 VQRVPRQTPPAPSPE
S552 LGGCGVASAGRGAGR
R555 CGVASAGRGAGRETA
Y623 LERRRPPYGGYEGHP
Y626 RRPPYGGYEGHPQGY
Y633 YEGHPQGYTEASVEK
K640 YTEASVEKRRLCRSL
S646 EKRRLCRSLSEGPYP
S648 RRLCRSLSEGPYPYA
Y652 RSLSEGPYPYAPELG
K660 PYAPELGKPANGDFG
Y668 PANGDFGYRPAGYRE
Y673 FGYRPAGYREVVILE
Y705 ALPTAALYGLRLERE
S769 EEGHEGCSYAVCPEG
Y770 EGHEGCSYAVCPEGR
Y789 GYPALVTYGYGGAVP
Y791 PALVTYGYGGAVPSY
S811 RAPHSCGSPSEGRGY
R816 CGSPSEGRGYPSPGA
Y818 SPSEGRGYPSPGAHS
S820 SEGRGYPSPGAHSPQ
S825 YPSPGAHSPQAGSVS
S830 AHSPQAGSVSPGSPP
S832 SPQAGSVSPGSPPYL
S835 AGSVSPGSPPYLQSR
Y838 VSPGSPPYLQSRKLG
G845 YLQSRKLGYEAPAED
T872 SAGPLASTALPLSES
S888 EPSWRDGSSGHSTLP
T893 DGSSGHSTLPRSPRD
S897 GHSTLPRSPRDAQCS
S910 CSASSELSGPSTPLH
S913 SSELSGPSTPLHTSS
T914 SELSGPSTPLHTSSP
T918 GPSTPLHTSSPVQGK
S919 PSTPLHTSSPVQGKE
S920 STPLHTSSPVQGKES
S936 RRQDTTRSPSLAPTQ
S946 LAPTQRLSPGEALPS
S953 SPGEALPSVVQGVTE
A967 EKTPELLASSRPEPL
S969 TPELLASSRPEPLDP
S977 RPEPLDPSPFSQTST
S980 PLDPSPFSQTSTPSS
T982 DPSPFSQTSTPSSPN
S983 PSPFSQTSTPSSPNG
S987 SQTSTPSSPNGWPQE
S996 NGWPQERSPGGHTNS
T1001 ERSPGGHTNSASPRs
S1005 GGHTNSASPRsPVPT
S1008-p TNSASPRsPVPTTLP
T1013 PRsPVPTTLPGLRHA
S1092 PGSGQQSSPPARGTN
P1114 PLPDVTQPPEHPLQE
N1122 PEHPLQENQSSVKFV
K1153 AIALLKDKDPGAFLI
T1178 GLALKVATPPPSAQP
T1214 VKIKGCPTEPYFGSL
Y1217 KGCPTEPYFGSLSAL
S1243 PCCLRIPSKDPLEET
S1338 RRHYPVNSITFSSTD
T1340 HYPVNSITFSSTDPQ
K1360 NPDGTTSKIFGFVAK
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