Home

tensin 2 (human)

Overview tensin 2 Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.-; Cell cycle regulation; Cell adhesion; Phosphatase Cellular Component: focal adhesion; plasma membrane; intracellular Molecular Function: protein binding; metal ion binding; phosphoprotein phosphatase activity Biological Process: negative regulation of cell proliferation; response to muscle activity; collagen metabolic process; multicellular organism growth; multicellular organismal homeostasis; cellular homeostasis; kidney development Reference #:  Q63HR2 (UniProtKB) Alt. Names/Synonyms: C1 domain-containing phosphatase and tensin homolog; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TENC1; tensin 2; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain-containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2 Gene Symbols: TENC1 Molecular weight: 152,580 Da Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below tensin 2 2DKQ - A=1263-1409 (human) 2KNO - A=1135-1249 (human) 2L6K - A=1135-1248 (human) 2LOZ - A=1263-1409 (human) 3HQC - A=1264-1409 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2DKQ 2KNO 2L6K 2LOZ 3HQC  |  ENZYME  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S19-p	RALGRRDssRAAsRP
0	1		S20-p	ALGRRDssRAAsRPR
0	1		S24-p	RDssRAAsRPRKAEP
0	1		N90	PPVELRRNtAPVRRI
0	1		T91-p	PVELRRNtAPVRRIE
0	2		S102-p	RRIEHLGsTKSLNHS
0	2		S118	QRSTLPRSFsLDPLM
0	11		S120-p	STLPRSFsLDPLMER
0	1		Y245-p	LGVIVSAyMHySKIS
0	1		Y248-p	IVSAyMHySKISAGA
0	5		Y444-p	DPSVSVDyNTTEPAV
0	50		S455-p	EPAVRWDsyENFNQH
0	5		Y456-p	PAVRWDsyENFNQHH
0	23		S466-p	FNQHHEDsVDGsLTH
0	1		S470-p	HEDsVDGsLTHTRGP
0	29		S481-p	TRGPLDGsPyAQVQR
0	1560		Y483-p	GPLDGsPyAQVQRPP
0	1		T493-p	VQRPPRQtPPAPSPE
0	7		R555	CGVASGGRGAGRETA
0	1		Y623-p	LERRRLAyGGYEGSP
0	5		Y626	RRLAyGGYEGSPQGy
0	1		Y633-p	YEGSPQGyAEASMEK
0	1		K640	yAEASMEKRRLCRsL
0	1		S646-p	EKRRLCRsLsEGLyP
0	5		S648-p	RRLCRsLsEGLyPYP
0	1		Y652-p	RsLsEGLyPYPPEMG
0	1		K660	PYPPEMGKPATGDFG
0	1		Y668	PATGDFGYRAPGyRE
0	5		Y673-p	FGYRAPGyREVVILE
0	11		Y705-p	ALPTAALyGLRLERE
0	1		S769-p	EEGHEGCsyTMCPEG
0	60		Y770-p	EGHEGCsyTMCPEGR
0	1		Y789	GYPALVTYSYGGAVP
0	1		Y818-p	SPGEGRGyPSPGAHs
0	1		S820	GEGRGyPSPGAHsPR
0	5		S825-p	yPSPGAHsPRAGSIs
0	4		S830	AHsPRAGSIsPGsPP
0	7		S832-p	sPRAGSIsPGsPPYP
0	10		S835-p	AGSIsPGsPPYPQSR
0	10		Y838	IsPGsPPYPQSRKLS
0	1		A872	SAGPLASAESLEPVS
0	1		P884	PVSWREGPSGHSTLP
0	1		T889	EGPSGHSTLPRsPRD
0	1		S893-p	GHSTLPRsPRDAPCS
0	4		S906-p	CSASSELsGPstPLH
0	5		S909-p	SSELsGPstPLHtss
0	30		T910-p	SELsGPstPLHtssP
0	4		T914-p	GPstPLHtssPVQGK
0	3		S915-p	PstPLHtssPVQGKE
0	6		S916-p	stPLHtssPVQGKES
0	2		S931	TRRQDTRSPTSAPTQ
0	7		S941-p	SAPTQRLsPGEALPP
0	1		P948	sPGEALPPVSQAGTG
0	1		F978	PSPVSPTFPPSSPSD
0	1		S982	SPTFPPSSPSDWPQE
0	1		S991	SDWPQERSPGGHSDG
0	7		S1003-p	SDGASPRsPVPTTLP
0	1		T1008	PRsPVPTTLPGLRHA
0	6		G1087	PGPGQQPGPWGPEQA
0	1		S1126-p	PEPPTQEsQSNVKFV
0	1		K1157-u	AIALLKDkDPGAFLI
0	1		S1218-p	VKIKGCPsEPyFGSL
0	1		Y1221-p	KGCPsEPyFGSLSAL
0	1		S1247	PCCLRIPSKDPLEET
0	1		K1364	NPDGTTSKIFGFVAK

	mouse
S19	RALGRRDSSRATSRP
S20	ALGRRDSSRATSRPR
S24	RDSSRATSRPRKAEP
S90-p	PPAELRRsTAPVRRI
T91	PAELRRsTAPVRRIE
S102-p	RRIEHLGsTKSLNHS
S118-p	QRSTLPRsFsLDPLM
S120-p	STLPRsFsLDPLMER
Y245	LGVIVSAYMHYSKIS
Y248	IVSAYMHYSKISAGA
Y444-p	DPSVSVDyNTTEPAV
S455-p	EPAVRWDsyENFNQH
Y456-p	PAVRWDsyENFNQHH
S466-p	FNQHHEDsVDGALAH
A470	HEDsVDGALAHTRGP
S481-p	TRGPLDGsPyAQVQR
Y483-p	GPLDGsPyAQVQRVP
T493	VQRVPRQTPPAPSPE
R555-m1	CGVASAGrGAGRETA
Y623	LERRRPPYGGyEGHP
Y626-p	RRPPYGGyEGHPQGY
Y633	yEGHPQGYAEASVEk
K640-u	YAEASVEkRRLCRsL
S646-p	EkRRLCRsLsEGPYP
S648-p	RRLCRsLsEGPYPYA
Y652	RsLsEGPYPYAPELG
K660-u	PYAPELGkPANGDFG
Y668-p	PANGDFGyRPAGYRE
Y673	FGyRPAGYREVVILE
Y705-p	ALPTAALyGLRLERE
S769	EEGHEGCSyAVCSEG
Y770-p	EGHEGCSyAVCSEGR
Y789-p	GYPALVTyGYGGAVP
Y818	SPSEGRGYPsPGAHs
S820-p	SEGRGYPsPGAHsPR
S825-p	YPsPGAHsPRAGsVs
S830-p	AHsPRAGsVsPGsPP
S832-p	sPRAGsVsPGsPPyL
S835-p	AGsVsPGsPPyLQPR
Y838-p	VsPGsPPyLQPRKLG
T872-p	STGPLAStESPEPSW
S883-p	EPSWRDGsSGHStLP
T888-p	DGsSGHStLPRSPRD
S892	GHStLPRSPRDPQCS
S905-p	CSASSELsGPstPLH
S908-p	SSELsGPstPLHtss
T909-p	SELsGPstPLHtssP
T913-p	GPstPLHtssPVQGK
S914-p	PstPLHtssPVQGKE
S915-p	stPLHtssPVQGKES
S931-p	RRQDTTRsPSLAPTQ
S941-p	LAPTQRLsPGEALPs
S948-p	sPGEALPsVVQGVAE
S978-p	PSPFSQTsAPGsPNG
S982-p	SQTsAPGsPNGWPQE
S991-p	NGWPQERsPGGHTNS
S1003-p	TNSASPRsPVPTtLP
T1008-p	PRsPVPTtLPGLRHA
S1087-p	PGSGQQPsPPARSTN
N1117	PEHPLQENQSNVKFV
K1148	AIALLKDKDPGAFLI
T1209	VKIKGCPTEPYFGSL
Y1212	KGCPTEPYFGSLSAL
S1238-p	PCCLRIPsKDPLEET
K1355-u	NPDGATSkIFGFVAK

	rat
S19	RALGRRDSSRATSRP
S20	ALGRRDSSRATSRPR
S24	RDSSRATSRPRKAEP
N90	PPAELRRNTAPVRRI
T91	PAELRRNTAPVRRIE
S102	RRIEHLGSTKSLNHS
S118	QRSTLPRSFSLDPLM
S120	STLPRSFSLDPLMER
Y245	LGVIVSAYMHYSKIS
Y248	IVSAYMHYSKISAGA
Y444	DPSVSVDYNMTEPAV
S455	EPAVRWDSYENFNQH
Y456	PAVRWDSYENFNQHH
S466	FNQHHEDSVDGSLAH
S470	HEDSVDGSLAHTRGP
S481	TRGPLDGSPyAQVQR
Y483-p	GPLDGSPyAQVQRVP
T493	VQRVPRQTPPAPSPE
R555	CGVASAGRGAGRETA
Y623	LERRRPPYGGYEGHP
Y626	RRPPYGGYEGHPQGY
Y633	YEGHPQGYTEASVEK
K640	YTEASVEKRRLCRSL
S646	EKRRLCRSLSEGPYP
S648	RRLCRSLSEGPYPYA
Y652	RSLSEGPYPYAPELG
K660	PYAPELGKPANGDFG
Y668	PANGDFGYRPAGYRE
Y673	FGYRPAGYREVVILE
Y705	ALPTAALYGLRLERE
S769	EEGHEGCSYAVCPEG
Y770	EGHEGCSYAVCPEGR
Y789	GYPALVTYGYGGAVP
Y818	SPSEGRGYPSPGAHS
S820	SEGRGYPSPGAHSPQ
S825	YPSPGAHSPQAGSVS
S830	AHSPQAGSVSPGSPP
S832	SPQAGSVSPGSPPYL
S835	AGSVSPGSPPYLQSR
Y838	VSPGSPPYLQSRKLG
T872	SAGPLASTDSSSLLS
S890	EPSWRDGSSGHSTLP
T895	DGSSGHSTLPRSPRD
S899	GHSTLPRSPRDAQCS
S912	CSASSELSGPSTPLH
S915	SSELSGPSTPLHTSS
T916	SELSGPSTPLHTSSP
T920	GPSTPLHTSSPVQGK
S921	PSTPLHTSSPVQGKE
S922	STPLHTSSPVQGKES
S938	RRQDTTRSPSLAPTQ
S948	LAPTQRLSPGEALPS
S955	SPGEALPSVVQGVTE
S985	PSPFSQTSTPSSPNG
S989	SQTSTPSSPNGWPQE
S998	NGWPQERSPGGHTNS
S1010-p	TNSASPRsPVPTTLP
T1015	PRsPVPTTLPGLRHA
S1094	PGSGQQSSPPARGTN
N1124	PEHPLQENQSSVKFV
K1155	AIALLKDKDPGAFLI
T1216	VKIKGCPTEPYFGSL
Y1219	KGCPTEPYFGSLSAL
S1245	PCCLRIPSKDPLEET
K1362	NPDGTTSKIFGFVAK

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.