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Protein Page:
tensin 2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
tensin 2 Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; Phosphatase; EC 3.1.3.-
Cellular Component: focal adhesion; plasma membrane
Molecular Function: protein binding; metal ion binding; phosphoprotein phosphatase activity
Biological Process: negative regulation of cell proliferation; response to muscle activity; collagen metabolic process; multicellular organism growth; cellular homeostasis; multicellular organismal homeostasis; kidney development
Reference #:  Q63HR2 (UniProtKB)
Alt. Names/Synonyms: C1 domain-containing phosphatase and tensin homolog; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TENC1; tensin 2; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain-containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2
Gene Symbols: TENC1
Molecular weight: 152,580 Da
Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

tensin 2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S19-p RALGRRDssRAAsRP
0 1 S20-p ALGRRDssRAAsRPR
0 1 S24-p RDssRAAsRPRKAEP
0 2 S102-p RRIEHLGsTKSLNHS
0 2 S118 QRSTLPRSFsLDPLM
0 14 S120-p STLPRSFsLDPLMER
0 5 Y444 DPSVSVDYNTTEPAV
0 52 S455-p EPAVRWDsyENFNQH
0 5 Y456-p PAVRWDsyENFNQHH
0 24 S466-p FNQHHEDsVDGSLTH
0 30 S481-p TRGPLDGsPyAQVQR
0 1564 Y483-p GPLDGsPyAQVQRPP
0 8 R555 CGVASGGRGAGRETA
0 5 Y626 RRLAYGGYEGSPQGY
0 1 K640 YAEASMEKRRLCRSL
0 1 S646 EKRRLCRSLSEGLYP
0 6 S648 RRLCRSLSEGLYPYP
0 1 K660 PYPPEMGKPATGDFG
0 5 Y673-p FGYRAPGyREVVILE
0 13 Y705-p ALPTAALyGLRLERE
0 62 Y770-p EGHEGCSyTMCPEGR
0 1 Y789 GYPALVTYSYGGAVP
0 1 Y791 PALVTYSYGGAVPSY
0 1 R816 CGSPGEGRGYPsPGA
0 2 S820-p GEGRGYPsPGAHsPR
0 6 S825-p YPsPGAHsPRAGSIs
0 5 S830 AHsPRAGSIsPGsPP
0 8 S832-p sPRAGSIsPGsPPYP
0 12 S835-p AGSIsPGsPPYPQSR
0 11 Y838 IsPGsPPYPQSRKLS
0 1 A872 SAGPLASAESLEPVS
0 1 P884 PVSWREGPSGHSTLP
0 1 T889 EGPSGHSTLPRSPRD
0 4 S906-p CSASSELsGPstPLH
0 5 S909-p SSELsGPstPLHtss
0 30 T910-p SELsGPstPLHtssP
0 4 T914-p GPstPLHtssPVQGK
0 3 S915-p PstPLHtssPVQGKE
0 7 S916-p stPLHtssPVQGKES
0 2 S931 TRRQDTRSPTSAPTQ
0 8 S941-p SAPTQRLsPGEALPP
0 1 P948 sPGEALPPVSQAGTG
0 1 F978 PSPVSPTFPPSSPSD
0 2 S982 SPTFPPSSPSDWPQE
0 1 S991 SDWPQERSPGGHSDG
0 9 S1003-p SDGASPRsPVPTTLP
0 1 T1008 PRsPVPTTLPGLRHA
0 7 S1096-p WGPEQASsPARGISH
0 1 S1247 PCCLRIPSKDPLEET
0 1 K1364 NPDGTTSKIFGFVAK
  tensin 2 iso4  
- gap
- gap
- gap
S112 RRIEHLGSTKSLNHS
S128 QRSTLPRSFSLDPLM
S130 STLPRSFSLDPLMER
Y454 DPSVSVDYNTTEPAV
S465 EPAVRWDSYENFNQH
Y466 PAVRWDSYENFNQHH
S476 FNQHHEDSVDGSLTH
S491 TRGPLDGSPYAQVQR
Y493 GPLDGSPYAQVQRPP
R565 CGVASGGRGAGRETA
Y636 RRLAYGGYEGSPQGY
K650 YAEASMEKRRLCRSL
S656 EKRRLCRSLSEGLYP
S658 RRLCRSLSEGLYPYP
K670 PYPPEMGKPATGDFG
Y683 FGYRAPGYREVVILE
Y715 ALPTAALYGLRLERE
Y780 EGHEGCSYTMCPEGR
Y799 GYPALVTYSYGGAVP
Y801 PALVTYSYGGAVPSY
R826 CGSPGEGRGYPSPGA
S830 GEGRGYPSPGAHSPR
S835 YPSPGAHSPRAGSIS
S840 AHSPRAGSISPGSPP
S842 SPRAGSISPGSPPYP
S845 AGSISPGSPPYPQSR
Y848 ISPGSPPYPQSRKLS
A882 SAGPLASAESLEPVS
P894 PVSWREGPSGHSTLP
T899 EGPSGHSTLPRSPRD
S916 CSASSELSGPSTPLH
S919 SSELSGPSTPLHTSS
T920 SELSGPSTPLHTSSP
T924 GPSTPLHTSSPVQGK
S925 PSTPLHTSSPVQGKE
S926 STPLHTSSPVQGKES
S941 TRRQDTRSPTSAPTQ
S951 SAPTQRLSPGEALPP
P958 SPGEALPPVSQAGTG
F988 PSPVSPTFPPSSPSD
S992 SPTFPPSSPSDWPQE
S1001 SDWPQERSPGGHSDG
S1013 SDGASPRSPVPTTLP
T1018 PRSPVPTTLPGLRHA
S1106 WGPEQASSPARGISH
S1257 PCCLRIPSKDPLEET
K1374 NPDGTTSKIFGFVAK
  mouse

 
S19 RALGRRDSSRATSRP
S20 ALGRRDSSRATSRPR
S24 RDSSRATSRPRKAEP
S102-p RRIEHLGsTKSLNHS
S118-p QRSTLPRsFsLDPLM
S120-p STLPRsFsLDPLMER
Y444-p DPSVSVDyNTTEPAV
S455-p EPAVRWDsyENFNQH
Y456-p PAVRWDsyENFNQHH
S466-p FNQHHEDsVDGALAH
S481-p TRGPLDGsPyAQVQR
Y483-p GPLDGsPyAQVQRVP
R555-m1 CGVASAGrGAGRETA
Y626-p RRPPYGGyEGHPQGY
K640-u YAEASVEkRRLCRsL
S646-p EkRRLCRsLsEGPYP
S648-p RRLCRsLsEGPYPYA
K660-u PYAPELGkPANGDFG
Y673 FGYRPAGYREVVILE
Y705-p ALPTAALyGLRLERE
Y770-p EGHEGCSyAVCSEGR
Y789-p GYPALVTyGyGGAVP
Y791-p PALVTyGyGGAVPSY
R816-m1 CGSPSEGrGYPsPGA
S820-p SEGrGYPsPGAHsPR
S825-p YPsPGAHsPRAGsVs
S830-p AHsPRAGsVsPGsPP
S832-p sPRAGsVsPGsPPyL
S835-p AGsVsPGsPPyLQPR
Y838-p VsPGsPPyLQPRKLG
T872-p STGPLAStESPEPSW
S883-p EPSWRDGsSGHStLP
T888-p DGsSGHStLPRSPRD
S905-p CSASSELsGPstPLH
S908-p SSELsGPstPLHtss
T909-p SELsGPstPLHtssP
T913-p GPstPLHtssPVQGK
S914-p PstPLHtssPVQGKE
S915-p stPLHtssPVQGKES
S931-p RRQDTTRsPSLAPTQ
S941-p LAPTQRLsPGEALPs
S948-p sPGEALPsVVQGVAE
S978-p PSPFSQTsAPGsPNG
S982-p SQTsAPGsPNGWPQE
S991-p NGWPQERsPGGHTNS
S1003-p TNSASPRsPVPTtLP
T1008-p PRsPVPTtLPGLRHA
S1087-p PGSGQQPsPPARSTN
S1238-p PCCLRIPsKDPLEET
K1355-u NPDGATSkIFGFVAK
  rat

 
S19 RALGRRDSSRATSRP
S20 ALGRRDSSRATSRPR
S24 RDSSRATSRPRKAEP
S102 RRIEHLGSTKSLNHS
S118 QRSTLPRSFSLDPLM
S120 STLPRSFSLDPLMER
Y444 DPSVSVDYNMTEPAV
S455 EPAVRWDSYENFNQH
Y456 PAVRWDSYENFNQHH
S466 FNQHHEDSVDGSLAH
S481 TRGPLDGSPyAQVQR
Y483-p GPLDGSPyAQVQRVP
R555 CGVASAGRGAGRETA
Y626 RRPPYGGYEGHPQGY
K640 YTEASVEKRRLCRSL
S646 EKRRLCRSLSEGPYP
S648 RRLCRSLSEGPYPYA
K660 PYAPELGKPANGDFG
Y673 FGYRPAGYREVVILE
Y705 ALPTAALYGLRLERE
Y770 EGHEGCSYAVCPEGR
Y789 GYPALVTYGYGGAVP
Y791 PALVTYGYGGAVPSY
R816 CGSPSEGRGYPSPGA
S820 SEGRGYPSPGAHSPQ
S825 YPSPGAHSPQAGSVS
S830 AHSPQAGSVSPGSPP
S832 SPQAGSVSPGSPPYL
S835 AGSVSPGSPPYLQSR
Y838 VSPGSPPYLQSRKLG
T872 SAGPLASTDSSSLLS
S890 EPSWRDGSSGHSTLP
T895 DGSSGHSTLPRSPRD
S912 CSASSELSGPSTPLH
S915 SSELSGPSTPLHTSS
T916 SELSGPSTPLHTSSP
T920 GPSTPLHTSSPVQGK
S921 PSTPLHTSSPVQGKE
S922 STPLHTSSPVQGKES
S938 RRQDTTRSPSLAPTQ
S948 LAPTQRLSPGEALPS
S955 SPGEALPSVVQGVTE
S985 PSPFSQTSTPSSPNG
S989 SQTSTPSSPNGWPQE
S998 NGWPQERSPGGHTNS
S1010-p TNSASPRsPVPTTLP
T1015 PRsPVPTTLPGLRHA
S1094 PGSGQQSSPPARGTN
S1245 PCCLRIPSKDPLEET
K1362 NPDGTTSKIFGFVAK
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