Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; nucleotide binding; nucleoside-triphosphatase activity; chromatin binding; kinase binding; ATP binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; positive regulation of cytokinesis; negative regulation of cell proliferation; mitosis; traversing start control point of mitotic cell cycle; negative regulation of DNA replication; regulation of mitotic metaphase/anaphase transition; positive regulation of chromosome segregation; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; DNA replication checkpoint; DNA replication; G1/S transition of mitotic cell cycle
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.