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Protein Page:
CDC6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDC6 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: nucleoplasm; Golgi apparatus; spindle pole; cytoplasm; nucleolus; spindle midzone; nucleus; cytosol
Molecular Function: protein binding; nucleotide binding; nucleoside-triphosphatase activity; chromatin binding; kinase binding; ATP binding
Biological Process: positive regulation of cytokinesis; mitosis; traversing start control point of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; positive regulation of chromosome segregation; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle
Reference #:  Q99741 (UniProtKB)
Alt. Names/Synonyms: CDC18 (cell division cycle 18, S.pombe, homolog)-like; Cdc18-related protein; CDC18L; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; p62(cdc6)
Gene Symbols: CDC6
Molecular weight: 62,720 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDC6

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T37‑p, S54‑p, S74‑p, S106‑p
intracellular localization: S54‑p, S74‑p, S106‑p
molecular association, regulation: T37‑p, S54‑p
protein stabilization: S54‑p, S74‑p, S106‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S20-p SFPKRKLsRALNkAk
0 1 K25-ub KLsRALNkAkNSSDA
0 1 K27-ub sRALNkAkNSSDAKL
1 0 T37-p SDAKLEPtNVQTVtC
0 2 T43-p PtNVQTVtCsPRVKA
0 10 S45-p NVQTVtCsPRVKALP
9 7 S54-p RVKALPLsPRKRLGD
0 4 T67-p GDDNLCNtPHLPPCs
0 1 P71 LCNtPHLPPCsPPKQ
6 6 S74-p tPHLPPCsPPKQGKK
0 1 S88-p KENGPPHsHTLkGRR
1 0 K92-ac PPHsHTLkGRRLVFD
1 0 K105-ac FDNQLTIksPSkREL
6 4 S106-p DNQLTIksPSkRELA
1 0 K109-ac LTIksPSkRELAKVH
0 3 S127-p ILSSVRKsQEITTNs
0 1 S134-p sQEITTNsEQRCPLK
0 7 T166-p QAKLVLNtAVPDRLP
0 2 S381-p QFCARKVsAVsGDVR
0 1 S384-p ARKVsAVsGDVRKAL
0 3 S419-p KPLSECKsPsEPLIP
0 2 S421-p LSECKsPsEPLIPKR
0 1 P423 ECKsPsEPLIPKRVG
0 1 T481-p QLKIKEVtLGKLYEA
  mouse

 
S20-p GFPKKKLsNTLKKPN
K25 KLsNTLKKPNSRDCE
- gap
R36 RDCEVKLRNVQPVPT
P42 LRNVQPVPTTPCVDV
T44 NVQPVPTTPCVDVKL
S55-p DVKLLPLsPRKRLGD
T68-p GDDNLCNtPRLsPCs
S72-p LCNtPRLsPCsPPKL
S75-p tPRLsPCsPPKLGKK
S89 KENGPPRSHTWKGCR
K93 PPRSHTWKGCRLVFD
K106 FDDEPTFKASPPKEQ
S108 DEPTFKASPPKEQDR
K111 TFKASPPKEQDRVRQ
S129 RSSSAQRSPESKADP
P136 SPESKADPEQKCPPE
T168 QAKLVLNTAVPDRLP
S383 QFCARKVSAVSGDIR
S386 ARKVSAVSGDIRKAL
S421-p KPLSECKsPSEsPVP
S423 LSECKsPSEsPVPKR
S425-p ECKsPSEsPVPKRVG
T483 RLKIKEVTLGKLYEA
  hamster

 
T20 SFPKKKLTKTASKTS
K25 KLTKTASKTSSSISK
- gap
K36 SISKVQLKKAQAVPS
P42 LKKAQAVPSAPCVDT
A44 KAQAVPSAPCVDTKL
S55-p DTKLLPLsPRKRLGD
T68 GDDNLCNTPHLSPCS
S72 LCNTPHLSPCSPPKL
S75 TPHLSPCSPPKLGKK
S89 KENGPPHSHTRKGCR
K93 PPHSHTRKGCRLVFD
K106 FDDELTVKSSNQKEQ
S108 DELTVKSSNQKEQDQ
K111 TVKSSNQKEQDQVPQ
- gap
- under review  
T167 QAKLVLNTAVPDRLP
S382 QFCARKVSAVSGDIR
S385 ARKVSAVSGDIRKAL
S420 KPLSEGQSPSEAPVP
S422 LSEGQSPSEAPVPKR
- gap
T482 RLKIKEVTLGKLYEA
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