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Cdc6 (human)

Overview Cdc6 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: nucleoplasm; spindle pole; cytoplasm; spindle midzone; cytosol; nucleus Molecular Function: protein binding; nucleotide binding; nucleoside-triphosphatase activity; chromatin binding; kinase binding; ATP binding Biological Process: mitosis; traversing start control point of mitotic cell cycle; M/G1 transition of mitotic cell cycle; positive regulation of chromosome segregation; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; cell division; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; DNA replication checkpoint; DNA replication; S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  Q99741 (UniProtKB) Alt. Names/Synonyms: CDC18 (cell division cycle 18, S.pombe, homolog)-like; Cdc18-related protein; CDC18L; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; p62(cdc6) Gene Symbols: CDC6 Molecular weight: 62,720 Da Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Cdc6 2CCH - E/F=89-100 (human) 2CCI - F=71-100, I=73-100 (human)

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	Sites Implicated In
cell cycle regulation: T37‑p, S54‑p, S74‑p, S106‑p intracellular localization: S54‑p, S74‑p, S106‑p molecular association, regulation: T37‑p, S54‑p protein stabilization: S54‑p, S74‑p, S106‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S20-p	SFPKRKLsRALNkAk
0	1		K25-u	KLsRALNkAkNSSDA
0	1		K27-u	sRALNkAkNSSDAKL
1	0		T37-p	SDAKLEPtNVQTVtC
0	1		T43-p	PtNVQTVtCsPRVKA
0	6		S45-p	NVQTVtCsPRVKALP
8	5		S54-p	RVKALPLsPRKRLGD
0	2		T67-p	GDDNLCNtPHLPPCs
0	1		P71	LCNtPHLPPCsPPKQ
5	4		S74-p	tPHLPPCsPPKQGKK
1	0		K92-a	PPHSHTLkGRRLVFD
1	0		K105-a	FDNQLTIksPSkREL
6	3		S106-p	DNQLTIksPSkRELA
1	0		K109-a	LTIksPSkRELAKVH
0	1		S127-p	ILSSVRKsQEITTNS
0	5		T166-p	QAKLVLNtAVPDRLP
0	2		S381-p	QFCARKVsAVsGDVR
0	1		S384-p	ARKVsAVsGDVRKAL
0	2		S419-p	KPLSECKsPsEPLIP
0	2		S421-p	LSECKsPsEPLIPKR
0	1		P423	ECKsPsEPLIPKRVG
0	1		T481-p	QLKIKEVtLGKLYEA

	mouse
S20-p	GFPKKKLsNTLKKPN
K25	KLsNTLKKPNSRDCE
-	gap
R36	RDCEVKLRNVQPVPT
P42	LRNVQPVPTTPCVDV
T44	NVQPVPTTPCVDVKL
S55-p	DVKLLPLsPRKRLGD
T68-p	GDDNLCNtPRLsPCs
S72-p	LCNtPRLsPCsPPKL
S75-p	tPRLsPCsPPKLGKK
K93	PPRSHTWKGCRLVFD
K106	FDDEPTFKASPPKEQ
S108	DEPTFKASPPKEQDR
K111	TFKASPPKEQDRVRQ
S129	RSSSAQRSPESKADP
T168	QAKLVLNTAVPDRLP
S383	QFCARKVSAVSGDIR
S386	ARKVSAVSGDIRKAL
S421-p	KPLSECKsPSEsPVP
S423	LSECKsPSEsPVPKR
S425-p	ECKsPSEsPVPKRVG
T483	RLKIKEVTLGKLYEA

	hamster
T20	SFPKKKLTKTASKTS
K25	KLTKTASKTSSSISK
-	gap
K36	SISKVQLKKAQAVPS
P42	LKKAQAVPSAPCVDT
A44	KAQAVPSAPCVDTKL
S55-p	DTKLLPLsPRKRLGD
T68	GDDNLCNTPHLSPCS
S72	LCNTPHLSPCSPPKL
S75	TPHLSPCSPPKLGKK
K93	PPHSHTRKGCRLVFD
K106	FDDELTVKSSNQKEQ
S108	DELTVKSSNQKEQDQ
K111	TVKSSNQKEQDQVPQ
G128	ILSSAQEGQERKADS
T167	QAKLVLNTAVPDRLP
S382	QFCARKVSAVSGDIR
S385	ARKVSAVSGDIRKAL
S420	KPLSEGQSPSEAPVP
S422	LSEGQSPSEAPVPKR
A424	EGQSPSEAPVPKRVG
T482	RLKIKEVTLGKLYEA

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