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PKCZ (human)

Overview PKCZ an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.13; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Iota subfamily Cellular Component: nuclear matrix; protein complex; tight junction; apical cortex; membrane; apical plasma membrane; cytoplasm; plasma membrane; nuclear envelope; intercellular junction; cell junction; endosome Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase C activity; zinc ion binding; insulin receptor substrate binding; ATP binding; protein kinase activity Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; platelet activation; negative regulation of insulin receptor signaling pathway; microtubule cytoskeleton organization and biogenesis; signal transduction; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; peptidyl-serine phosphorylation; positive regulation of T-helper 2 cell differentiation; establishment of cell polarity; transforming growth factor beta receptor signaling pathway; positive regulation of insulin receptor signaling pathway; blood coagulation; inflammatory response; negative regulation of protein complex assembly; negative regulation of apoptosis Reference #:  Q05513 (UniProtKB) Alt. Names/Synonyms: KPCZ; nPKC-zeta; PKC-ZETA; PKC2; PRKCZ; Protein kinase C zeta type; protein kinase C, zeta Gene Symbols: PRKCZ Molecular weight: 67,660 Da Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKCZ Substrate Sequence Logo

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	Sites Implicated In
cytoskeletal reorganization: T410‑p, T560‑p enzymatic activity, induced: T410‑p, Y417‑p molecular association, regulation: T410‑p protein conformation: T410‑p, Y428‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T5	___MPSRTGPKMEGS
0	1		T57	LHQQHPLTLKWVDSE
1	0		S113	PCPGEDKSIYRRGAR
0	1		S148	RAYCGQCSERIWGLA
0	1		R160	GLARQGYRCINCKLL
0	1		T179	CHGLVPLTCRKHMDS
2	0		S186	TCRKHMDSVMPsQEP
0	1		S190-p	HMDSVMPsQEPPVDD
1	0		S217	DGIAYISSSRKHDsI
1	0		S218	GIAYISSSRKHDsIK
0	2		S223-p	SSSRKHDsIKDDSED
0	1		S262	IRVIGRGSYAKVLLV
0	1		Y263	RVIGRGSYAKVLLVR
0	2		R375	HERGIIYRDLKLDNV
0	1		S409-p	LGPGDTTstFCGTPN
40	10		T410-p	GPGDTTstFCGTPNy
1	0		Y417-p	tFCGTPNyIAPEILR
1	0		Y428-p	EILRGEEyGFSVDWW
0	1		K513	QTGFSDIKSHAFFRS
1	0		S520	KSHAFFRSIDWDLLE
10	2		T560-p	TSEPVQLtPDDEDAI

	mouse
T5-p	___MPSRtDPKMDRS
T57	LHQQHPLTLKWVDSE
S113-p	PCPGEDKsIYRRGAR
S148	GAYCGQCSERIWGLS
R160-m1	GLSRQGYrCINCKLL
T179	CHVLVPLTCRRHMDs
S186-p	TCRRHMDsVMPSQEP
S190	HMDsVMPSQEPPVDD
S217-p	DGIAYISssRKHDNI
S218-p	GIAYISssRKHDNIK
N223	SssRKHDNIKDDSED
S262	IRVIGRGSYAKVLLV
Y263	RVIGRGSYAKVLLVR
R375-m1	HERGIIYrDLKLDNV
S409-p	LGPGDTTstFCGTPN
T410-p	GPGDTTstFCGTPNY
Y417	tFCGTPNYIAPEILR
Y428	EILRGEEYGFSVDWW
K513-a	QTGFSDIkSHAFFRs
S520-p	kSHAFFRsIDWDLLE
T560-p	TSEPVQLtPDDEDVI

	rat
T5	___MPSRTDPKMDRS
T57-gl	LHQQHPLtLKWVDSE
S113	PCPGEDKSIYRRGAR
S148-gl	RAYCGQCsERIWGLA
R160	GLARQGYRCINCKLL
T179-gl	CHVLVPLtCRRHMDs
S186-p	tCRRHMDsVMPSQEP
S190	HMDsVMPSQEPPVDD
S217	DGIAYISSSRKHDNI
S218	GIAYISSSRKHDNIK
N223	SSSRKHDNIKDDSED
S262-p	IRVIGRGsyAKVLLV
Y263-p	RVIGRGsyAKVLLVR
R375	HERGIIYRDLKLDNV
S409	LGPGDTTStFCGTPN
T410-p	GPGDTTStFCGTPNY
Y417	tFCGTPNYIAPEILR
Y428	EILRGEEYGFSVDWW
K513	QTGFSDIKSHAFFRS
S520	KSHAFFRSIDWDLLE
T560-p	TSEPVQLtPDDEDVI

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