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Protein Page:
ATP7B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP7B Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Monomer. Interacts with COMMD1/MURR1. Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Hydrolase; Transporter, ion channel; Vesicle protein; EC 3.6.3.4; Transporter
Chromosomal Location of Human Ortholog: 13q14.3
Cellular Component: Golgi membrane; mitochondrion; membrane; integral to plasma membrane; basolateral plasma membrane; perinuclear region of cytoplasm; late endosome; cytoplasmic membrane-bound vesicle; trans-Golgi network
Molecular Function: protein binding; copper ion binding; copper-exporting ATPase activity; ATP binding
Biological Process: lactation; cellular copper ion homeostasis; response to copper ion; metabolic process; sequestering of calcium ion; cellular zinc ion homeostasis; copper ion import; copper ion transport; transmembrane transport; copper ion export; intracellular copper ion transport
Reference #:  P35670 (UniProtKB)
Alt. Names/Synonyms: ATP7B; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; Copper pump 2; Copper-transporting ATPase 2; PWD; WC1; WD; Wilson disease-associated protein; WND; WND/140 kDa
Gene Symbols: ATP7B
Molecular weight: 157,263 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below

ATP7B

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S340‑p, S341‑p
protein conformation: S340‑p, S341‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T9-p PEQERQItAREGASR
0 1 S15 ItAREGASRKILSKL
0 1 S23-p RKILSKLsLPTRAWE
0 3 S132 IAEGKAASWPSRSLP
0 2 L138 ASWPSRSLPAQEAVV
0 1 S229-p IDIERLQsTNPKRPL
1 0 S340-p GSGTDHRssSSHSPG
1 0 S341-p SGTDHRssSSHSPGS
0 1 A364 TCSTTLIAIAGMTCA
0 1 S440 TNPLGNHSAGNSMVQ
0 1 S444 GNHSAGNSMVQTTDG
2 3 S478-p APDILAKsPQsTRAV
2 2 S481-p ILAKsPQsTRAVAPQ
0 1 K489-ub TRAVAPQkCFLQIKG
0 1 S518-p QKEAGVLsVLVALMA
0 1 K607-ub ATSKALVkFDPEIIG
0 1 K785 RWLEHLAKSKTSEAL
0 1 K794 KTSEALAKLMSLQAT
0 1 K1028-ac IKTVMFDkTGTITHG
0 1 K1028-ub IKTVMFDkTGTITHG
0 1 T1050-p LLLGDVAtLPLRKVL
0 1 S1066 VVGTAEASSEHPLGV
0 1 T1076-p HPLGVAVtKyCKEEL
0 1 Y1078-p LGVAVtKyCKEELGT
2 1 S1121-p AHSERPLsAPASHLN
0 1 T1143 EKDAVPQTFSVLIGN
0 1 S1145 DAVPQTFSVLIGNRE
0 1 S1163 RNGLTISSDVSDAMT
0 1 T1208-p EAALAVHtLQsMGVD
0 2 S1211-p LAVHtLQsMGVDVVL
0 1 T1220-p GVDVVLItGDNRKTA
0 7 K1258-ac KVQELQNkGkKVAMV
0 7 K1260-ac QELQNkGkKVAMVGD
0 1 T1396 HGHMKPLTASQVsVH
0 2 S1398 HMKPLTASQVsVHIG
0 4 S1401-p PLTASQVsVHIGMDD
0 1 S1426-p WDQVSYVsQVSLSSL
2 5 S1453-p DDDGDKWsLLLNGRD
  ATP7B iso2  
T9 PEQERQITAREGASR
S15 ITAREGASRKILSKL
S23 RKILSKLSLPTRAWE
S132 IAEGKAASWPSRSLP
L138 ASWPSRSLPAQEAVV
S229 IDIERLQSTNPKRPL
S340 GSGTDHRSSSSHSPG
S341 SGTDHRSSSSHSPGS
A364 TCSTTLIAIAGMTCA
S440 TNPLGNHSAGNSMVQ
S444 GNHSAGNSMVQTTDG
S478 APDILAKSPQSTRAV
S481 ILAKSPQSTRAVAPQ
K489 TRAVAPQKCFLQIKG
S518 QKEAGVLSVLVALMA
K607 ATSKALVKFDPEIIG
- gap
K632 KTSEALAKLMSLQAT
K821 IKTVMFDKTGTITHG
K821 IKTVMFDKTGTITHG
T843 LLLGDVATLPLRKVL
S859 VVGTAEASSEHPLGV
T869 HPLGVAVTKYCKEEL
Y871 LGVAVTKYCKEELGT
S914 AHSERPLSAPASHLN
T936 EKDAVPQTFSVLIGN
S938 DAVPQTFSVLIGNRE
S956 RNGLTISSDVSDAMT
T1001 EAALAVHTLQSMGVD
S1004 LAVHTLQSMGVDVVL
T1013 GVDVVLITGDNRKTA
K1051 KVQELQNKGKKVAMV
K1053 QELQNKGKKVAMVGD
T1189 HGHMKPLTASQVSVH
S1191 HMKPLTASQVSVHIG
S1194 PLTASQVSVHIGMDD
S1219 WDQVSYVSQVSLSSL
S1246 DDDGDKWSLLLNGRD
  mouse

 
T21-p PEQERQVtAKEAsRK
S26-p QVtAKEAsRKILSKL
A34 RKILSKLALPGRPWE
S142-p AAEGKAAsWPSRSsP
S148-p AsWPSRSsPAQEAVV
S239 IDVNKLESTNLKKET
- gap
- gap
T366-p PGRTAVLtISGITCA
K442-ub INPVRNFkSGNsVPQ
S446-p RNFkSGNsVPQTMGD
T480 GPGHSSETPSSPGAT
S483 HSSETPSSPGATASQ
K491 PGATASQKCFVQIKG
S520 QRHAGILSVLVALMS
K609 ATSKAHVKFDPEIVG
K787-ac RWLEHVAkSKTSEAL
K796-ac KTSEALAkLMSLQAT
K1030 IKTVMFDKTGTITHG
K1030 IKTVMFDKTGTITHG
T1052 LLLADVATLPLRKVL
S1068-p VVGTAEAsSEHPLGV
T1078 HPLGVAVTKYCKEEL
Y1080 LGVAVTKYCKEELGT
- gap
T1140-p GEGAGPQtFsVLIGN
S1142-p GAGPQtFsVLIGNRE
S1160-p RNGLTISsDISDAMT
T1205 EAALAIYTLKsMGVD
S1208-p LAIYTLKsMGVDVAL
T1217 GVDVALITGDNRKTA
E1255 KVQELQNEGKKVAMV
K1257 QELQNEGKKVAMVGD
S1393-p HGRMKPLsAsQVsVH
S1395-p RMKPLsAsQVsVHIG
S1398-p PLsAsQVsVHIGMDD
S1423 WDQVSYVSQVSLSSL
S1450-p EDGGDKWsLLLSDRD
  rat

 
T9 PEQERKVTAKEASRK
S14 KVTAKEASRKILSKL
A22 RKILSKLALPTRPWG
S131-p AAEGKAAsWPSRSSP
S137 AsWPSRSSPAQEAVV
S228 IDINKLESTNLKRAA
S336 GLEKESGSSSVPSLG
S337 LEKESGSSSVPSLGS
T360 PCRTAVLTITGIPRD
- gap
S437 NRVSSGNSVPQAVGD
S471-p GPGYLSDsPPsPGGT
S474-p YLSDsPPsPGGTASQ
K482 PGGTASQKCFVQIKG
S511 QRHAGILSVLVALMS
K600 ATSKAHVKFDPEIIG
K778 RWLEHVAKSKTSEAL
K787 KTSEALAKLMSLQAT
K1021 IKTVMFDKTGTITHG
K1021 IKTVMFDKTGTITHG
T1043 LLLVDVATLSLRKVL
S1059 VVGTAEASSEHPLGV
T1069 HPLGVAVTKYCKEEL
Y1071 LGVAVTKYCKEELGT
- gap
T1131 GEGTGPQTFSVLIGN
S1133 GTGPQTFSVLIGNRE
S1151 RNGLTISSDISDAMT
T1196 EAALASITLKSMGVD
S1199 LASITLKSMGVDVAL
T1208 GVDVALITGDNRKTA
K1246 KVQELQNKGKKVAMV
K1248 QELQNKGKKVAMVGD
S1382 HGRMKPLSAsQVsVH
S1384-p RMKPLSAsQVsVHVG
S1387-p PLSAsQVsVHVGMDD
S1412 WDQVSYVSQVSLSSL
S1439 EDGGDKWSLLLSDRD
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