Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Monomer. Interacts with COMMD1/MURR1. Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, ion channel; EC 126.96.36.199; Membrane protein, integral; Vesicle; Hydrolase; Membrane protein, multi-pass
Cellular Component: Golgi membrane; membrane; mitochondrion; perinuclear region of cytoplasm; basolateral plasma membrane; integral to plasma membrane; late endosome; cytoplasmic membrane-bound vesicle; trans-Golgi network
Molecular Function: protein binding; copper ion binding; copper-exporting ATPase activity; ATP binding
Biological Process: lactation; cellular copper ion homeostasis; response to copper ion; metabolic process; cellular zinc ion homeostasis; sequestering of calcium ion; copper ion import; copper ion transport; transmembrane transport; copper ion export; intracellular copper ion transport
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.