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Protein Page:
ATP7B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ATP7B Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Monomer. Interacts with COMMD1/MURR1. Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Membrane protein, multi-pass; Membrane protein, integral; EC 3.6.3.4; Hydrolase; Transporter; Transporter, ion channel
Cellular Component: Golgi membrane; mitochondrion; integral to plasma membrane; basolateral plasma membrane; perinuclear region of cytoplasm; late endosome; cytoplasmic membrane-bound vesicle; trans-Golgi network
Molecular Function: protein binding; copper ion binding; copper-exporting ATPase activity; ATP binding
Biological Process: lactation; cellular copper ion homeostasis; response to copper ion; cellular zinc ion homeostasis; sequestering of calcium ion; copper ion import; copper ion transport; transmembrane transport; intracellular copper ion transport
Reference #:  P35670 (UniProtKB)
Alt. Names/Synonyms: ATP7B; ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide; Copper pump 2; Copper-transporting ATPase 2; PWD; WC1; WD; Wilson disease-associated protein; WND; WND/140 kDa
Gene Symbols: ATP7B
Molecular weight: 157,263 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below

ATP7B

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S340‑p, S341‑p
protein conformation: S340‑p, S341‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 T9-p PEQERQItAREGASR
0 1 S23-p RKILSKLsLPTRAWE
0 2 S132 IAEGKAASWPSRSLP
0 1 L138 ASWPSRSLPAQEAVV
1 0 S340-p GSGTDHRssSSHSPG
1 0 S341-p SGTDHRssSSHSPGS
0 1 S440 TNPLGNHSAGNSMVQ
2 2 S478-p APDILAKsPQsTRAV
2 1 S481-p ILAKsPQsTRAVAPQ
0 1 K489-u TRAVAPQkCFLQIKG
0 1 K607-u ATSKALVkFDPEIIG
0 1 K1028-u IKTVMFDkTGTITHG
0 1 S1066 VVGTAEASSEHPLGV
2 1 S1121-p AHSERPLsAPASHLN
0 1 T1143 EKDAVPQTFSVLIGN
0 1 S1145 DAVPQTFSVLIGNRE
0 2 S1211-p LAVHTLQsMGVDVVL
0 7 K1258-a KVQELQNkGkKVAMV
0 7 K1260-a QELQNkGkKVAMVGD
0 1 T1396 HGHMKPLTASQVsVH
0 1 S1398 HMKPLTASQVsVHIG
0 3 S1401-p PLTASQVsVHIGMDD
2 4 S1453-p DDDGDKWsLLLNGRD
  ATP7B iso2  
T9 PEQERQITAREGASR
S23 RKILSKLSLPTRAWE
S132 IAEGKAASWPSRSLP
L138 ASWPSRSLPAQEAVV
S340 GSGTDHRSSSSHSPG
S341 SGTDHRSSSSHSPGS
S440 TNPLGNHSAGNSMVQ
S478 APDILAKSPQSTRAV
S481 ILAKSPQSTRAVAPQ
K489 TRAVAPQKCFLQIKG
K607 ATSKALVKFDPEIIG
K821 IKTVMFDKTGTITHG
S859 VVGTAEASSEHPLGV
S914 AHSERPLSAPASHLN
T936 EKDAVPQTFSVLIGN
S938 DAVPQTFSVLIGNRE
S1004 LAVHTLQSMGVDVVL
K1051 KVQELQNKGKKVAMV
K1053 QELQNKGKKVAMVGD
T1189 HGHMKPLTASQVSVH
S1191 HMKPLTASQVSVHIG
S1194 PLTASQVSVHIGMDD
S1246 DDDGDKWSLLLNGRD
  mouse

 
T21-p PEQERQVtAKEASRK
A34 RKILSKLALPGRPWE
S142-p AAEGKAAsWPSRSsP
S148-p AsWPSRSsPAQEAVV
- gap
- gap
K442-u INPVRNFkSGNSVPQ
T480 GPGHSSETPSSPGAT
S483 HSSETPSSPGATASQ
K491 PGATASQKCFVQIKG
K609 ATSKAHVKFDPEIVG
K1030 IKTVMFDKTGTITHG
S1068-p VVGTAEAsSEHPLGV
- gap
T1140-p GEGAGPQtFsVLIGN
S1142-p GAGPQtFsVLIGNRE
S1208-p LAIYTLKsMGVDVAL
E1255 KVQELQNEGKKVAMV
K1257 QELQNEGKKVAMVGD
S1393-p HGRMKPLsAsQVsVH
S1395-p RMKPLsAsQVsVHIG
S1398-p PLsAsQVsVHIGMDD
S1450-p EDGGDKWsLLLSDRD
  rat

 
T9 PEQERKVTAKEASRK
A22 RKILSKLALPTRPWG
S131 AAEGKAASWPSRSSP
S137 ASWPSRSSPAQEAVV
S336 GLEKESGSSSVPSLG
S337 LEKESGSSSVPSLGS
- gap
S471 GPGYLSDSPPSPGGT
S474 YLSDSPPSPGGTASQ
K482 PGGTASQKCFVQIKG
K600 ATSKAHVKFDPEIIG
K1021 IKTVMFDKTGTITHG
S1059 VVGTAEASSEHPLGV
- gap
T1131 GEGTGPQTFSVLIGN
S1133 GTGPQTFSVLIGNRE
S1199 LASITLKSMGVDVAL
K1246 KVQELQNKGKKVAMV
K1248 QELQNKGKKVAMVGD
S1382 HGRMKPLSASQVSVH
S1384 RMKPLSASQVSVHVG
S1387 PLSASQVSVHVGMDD
S1439 EDGGDKWSLLLSDRD
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